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2019年

Title Author Journal NBRP RRC ID PubMed PMID
Structural comparisons of phosphoenolpyruvate carboxykinases reveal the evolutionary trajectories of these phosphodiester energy-conversion enzymes. Chiba, Y., Miyakawa, T., Shimane, Y., Takai, K., Tanokura, M., Nozaki, T. J. Biol. Chem. pii: jbc.RA119.010920 (2019). 57725 31662435
A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. Watanabe, N., Kidokoro, M., Suzuki, Y., Tanaka, M., Inoue, S., Tsukamoto, H., Hirayama, N., Hsieh, P.W., Tseng, C.P., Nakagawa, Y., Inokuchi, S. PLoS One 14 (9): e0222331 (2019). 57724 31553741
Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Arai, H.N., Sato, F., Yamamoto, T., Woltjen, K., Kiyonari, H., Yoshimoto, Y., Shukunami, C., Akiyama, H., Kist, R., Sehara-Fujisawa, A. Cell Rep. 29 (3): 603-616.e5 (2019). 57723 31618630
FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics. Kinjo, T., Terai, K., Horita, S., Nomura, N., Sumiyama, K., Togashi, K., Iwata, S., Matsuda, M. Nat. Methods. 16 (10): 1029-1036 (2019). 57649 31501546
Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line. Mitani, A., Kobayashi, T., Hayashi, Y., Matsushita, N., Matsushita, S., Nakao, S., Takahira, N., Shiraishi, A., Ohashi, Y. PLoS One 14 (9): e0222454 (2019). 57648 31509592
KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-beta2 suppression. Fujimoto, S., Hayashi, R., Hara, S., Sasamoto, Y., Harrington, J., Tsujikawa, M., Nishida, K. Regen. Ther. 11: 249-257 (2019). 57647 31538102
DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair. Kawara, H., Akahori, R., Wakasugi, M., Sancar, A., Matsunaga, T. Biochem. Biophys. Res. Commun. 519 (1): 204-210 (2019). 57640 31493872
GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFbeta signaling. Matsumoto, S., Yamamichi, T., Shinzawa, K., Kasahara, Y., Nojima, S., Kodama, T., Obika, S., Takehara, T., Morii, E., Okuyama, H., Kikuchi, A. Nat. Commun. 10(1): 3882 (2019). 57639 31462641
Establishment of immortalized primary cell from the critically endangered Bonin flying fox (Pteropus pselaphon). Tani, T., Eitsuka, T., Katayama, M., Nagamine, T., Nakaya, Y., Suzuki, H., Kiyono, T., Nakagawa, K., Inoue-Murayama, M., Onuma, M., Fukuda, T. PLoS One 14 (8): e0221364 (2019). 57638 31449544
he novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis. Kawasaki, Y., Miyamoto, M., Oda, T., Matsumura, K., Negishi, L., Nakato, R., Suda, S., Yokota, N., Shirahige, K., Akiyama, T. EMBO Rep. 20 (8): e47052 (2019). 57604 31353791
Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7. Kikuchi, J., Hori, M., Iha, H., Toyama-Sorimachi, N., Hagiwara, S., Kuroda, Y., Koyama, D., Izumi, T., Yasui, H., Suzuki, A., Furukawa, Y. Leukemia. 2019 Jul 29. . [Epub ahead of print] 57603 31358854
Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Wu, J., Kung, J., Dong, J., Chang, L., Xie, C., Habib, A., Hawes, S., Yang, N., Chen, V., Liu, Z., Evans, R., Liang, B., Sun, L., Ding, J., Yu, J., Saez-Atienzar, S., Tang, B., Khaliq, Z., Lin, D.T., Le, W., Cai, H. Cell Rep. 28 (5): 1167-1181.e7 (2019). 57558 31365862
Secretion of high amounts of hepatocyte growth factor is a characteristic feature of cancer-associated fibroblasts with EGFR-TKI resistance-promoting phenotype: A study of 18 cases of cancer-associated fibroblasts. Suzuki, E., Yamazaki, S., Naito, T., Hashimoto, H., Okubo, S., Udagawa, H., Goto, K., Tsuboi, M., Ochiai, A., Ishii, G. Pathol. Int. 69 (8): 472-480 (2019). 57557 31339210
Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. Park, S.J., Cho, S.S., Kim, K.M., Yang, J.H., Kim, J.H., Jeong, E.H., Yang, J.W., Han, C.Y., Ku, S.K., Cho, I.J., Ki, S.H. Toxicol. Appl. Pharmacol. 379: 114665 (2019). 57549 31323261
GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior. Hui, K.K., Takashima, N., Watanabe, A., Chater, T.E., Matsukawa, H., Nekooki-Machida, Y., Nilsson, P., Endo, R., Goda, Y., Saido, T.C., Yoshikawa, T., Tanaka, M. Sci. Adv. 5 (4): eaau8237 (2019). 57548 30989111
Oral gram-positive bacterial DNA-based identification of saliva from highly degraded samples. Ohta, J., Sakurada, K. Forensic Sci. Int. Genet. 42: 103-112 (2019). 57546 31302459
Pericentrin-mediated SAS-6 recruitment promotes centriole assembly. Ito, D., Zitouni, S., Jana, S.C., Duarte, P., Surkont, J., Carvalho-Santos, Z., Pereira-Leal, J.B., Ferreira, M.G., Bettencourt-Dias, M. Elife 8. pii: e41418 (2019). 57531 31182187
CKAP4 Regulates Cell Migration via the Interaction with and Recycling of Integrin. Osugi, Y., Fumoto, K., Kikuchi, A. Mol. Cell. Biol. 39 (16). pii: e00073-19 (2019). 57530 31160493
A Highly Versatile Expression System for the Production of Multiply Phosphorylated Proteins. Zhu, P., Gafken, P.R., Mehl, R.A., Cooley, R.B. ACS Chem. Biol. 14 (7): 1564-1572 (2019). 57446 31243963
Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination. Yamanashi, T., Maki, M., Kojima, K., Shibukawa, A., Tsukamoto, T., Chowdhury, S., Yamanaka, A., Takagi, S., Sudo, Y. Sci. Rep. 9 (1): 7863 (2019). 57439 31133660
Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice. Onishi, T., Watanabe, T., Sasaki, M., Kamiya, Y., Horie, M., Tsukano, H., Hishida, R., Kohno, T., Takebayashi, H., Baba, H., Shibuki, K. J. Physiol. 597 (13): 3441-3455 (2019). 57438 31087329
Reduced Folate Carrier: an Entry Receptor for a Novel Feline Leukemia Virus Variant. Miyake, A., Kawasaki, J., Ngo, H., Makundi, I., Muto, Y., Khan, A.H., Smith, D.J., Nishigaki, K. J. Virol. 93 (13). pii: e00269-19 (2019). 57424 30996094
Organoid culture containing cancer cells and stromal cells reveals that podoplanin-positive cancer-associated fibroblasts enhance proliferation of lung cancer cells. Nakamura, H., Sugano, M., Miyashita, T., Hashimoto, H., Ochiai, A., Suzuki, K., Tsuboi, M., Ishii, G. Lung Cancer 134: 100-107 (2019). 57423 31319967
ROS amplification drives mouse spermatogonial stem cell self-renewal. Morimoto, H., Kanastu-Shinohara, M., Ogonuki, N., Kamimura, S., Ogura, A., Yabe-Nishimura, C., Mori, Y., Morimoto, T., Watanabe, S., Otsu, K., Yamamoto, T., Shinohara, T. Life Sci. Alliance 2 (2). pii: e201900374 (2019). 57374 30940732
Thermostable CITase from Thermoanaerobacter thermocopriae shows negative cooperativity. Yang, S.J., Choi, S.J., Park, B.R., Kim, Y.M. Biotechnol. Lett. 41 (4-5): 625-632 (2019). 57067 30927134
High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme. Kamil, M., Shinsato, Y., Higa, N., Hirano, T., Idogawa, M., Takajo, T., Minami, K., Shimokawa, M., Yamamoto, M., Kawahara, K., Yonezawa, H., Hirano, H., Furukawa, T., Yoshimoto, K., Arita, K. Br. J. Cancer. 120 (8): 819-826 (2019). 56570 30867563
Wnt/beta-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development. Fujii, S., Nagata, K., Matsumoto, S., Kohashi, K.I., Kikuchi, A., Oda, Y., Kiyoshima, T., Wada, N. Sci. Rep. 9 (1): 4257 (2019). 55035 30862786
Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling. Nakajo, H., Ishibashi, K., Aoyama, K., Kubota, S., Hasegawa, H., Yamaguchi, N., Yamaguchi, N. Biochem. Biophys. Res. Commun. 511 (4): 765-771 (2019). 55034 30833073
Atg2 mediates direct lipid transfer between membranes for autophagosome formation. Osawa, T., Kotani, T., Kawaoka, T., Hirata, E., Suzuki, K., Nakatogawa, H., Ohsumi, Y., Noda, N.N. Nat. Struct. Mol. Biol. 26 (4): 281-288 (2019). 55033 30911189
Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression. Makino, Y., Jensen, N.H., Yokota, N., Rossner, M.J., Akiyama, H., Shirahige, K., Okada, Y. Sci. Rep. 9 (1): 6063 (2019). 55031 30988352
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Sasako, T., Ohsugi, M., Kubota, N., Itoh, S., Okazaki, Y., Terai, A., Kubota, T., Yamashita, S., Nakatsukasa, K., Kamura, T., Iwayama, K., Tokuyama, K., Kiyonari, H., Furuta, Y., Shibahara, J., Fukayama, M., Enooku, K., Okushin, K., Tsutsumi, T., Tateishi, R., Tobe, K., Asahara, H., Koike, K., Kadowaki, T., Ueki, K. Nat. Commun. 10 (1): 947 (2019). 55030 30814508
Mathematical analysis of gefitinib resistance of lung adenocarcinoma caused by MET amplification. Ito, T., Kumagai, Y., Itano, K., Maruyama, T., Tamura, K., Kawasaki, S., Suzuki, T., Murakami ,Y. Biochem. Biophys. Res. Commun. 511 (3): 544-550 (2019). 55029 30824185
TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma. Zhang, J., Liu, P., Tao, J., Wang, P., Zhang, Y., Song, X., Che, L., Sumazin, P., Ribback, S., Kiss, A., Schaff, Z., Cigliano, A., Dombrowski, F., Cossu, C., Pascale, R.M., Calvisi, D.F., Monga, S.P., Chen, X. Am. J. Pathol. pii: S0002-9440 (18) 30776-4 (2019). 55028 30794805
Type I interferon protects neurons from prions in in vivo models. Ishibashi, D., Homma, T., Nakagaki, T., Fuse, T., Sano, K., Satoh, K., Mori, T., Atarashi, R., Nishida, N. Brain 142 (4): 1035-1050 (2019). 55027 30753318
Type I interferon protects neurons from prions in in vivo models. Ishibashi, D., Homma, T., Nakagaki, T., Fuse, T., Sano, K., Satoh, K., Mori, T., Atarashi, R., Nishida, N. Brain 142 (4): 1035-1050 (2019). 55027 30753318
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. Goto, T., Hara, H., Sanbo, M., Masaki, H., Sato, H., Yamaguchi, T., Hochi, S., Kobayashi, T., Nakauchi, H., Hirabayashi, M. Nat. Commun. 10 (1): 451 (2019). 55026 30723213
Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint. Kakihana, A., Oto, Y., Saito, Y., Nakayama, Y. FASEB J. 33 (3): 3936-3953 (2019). 54549 30496702
NF-kappaB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells. Echizen, K., Horiuchi, K., Aoki, Y., Yamada, Y., Minamoto, T., Oshima, H., Oshima, M. Oncogene. 2019 Jan 30. doi: 10.1038/s41388-019-0702-0. [Epub ahead of print] 54542 30700829
EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity. Kaibori, Y., Saito, Y., Nakayama, Y. FASEB J. 33 (4): 5334-5349 (2019). 54541 30668924
Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice. Horio, N., Murata, K., Yoshikawa, K., Yoshihara, Y., Touhara, K. Nat. Commun. 10 (1): 209 (2019). 54537 30643144
A method of producing genetically manipulated mouse mammary gland. Tagaya, H., Ishikawa, K., Hosokawa, Y., Kobayashi, S., Ueoka, Y., Shimada, M., Ohashi, Y., Mikami, H., Yamamoto, M., Ihara, T., Kumazawa, K., Sugihara, K., Goshima, N., Watanabe, S., Semba, K. Breast Cancer Res. 21 (1): 1 (2019). 54536 30611295
Mitochondrial ribosomal protein PTCD3 mutations cause oxidative phosphorylation defects with Leigh syndrome. Borna, N.N., Kishita, Y., Kohda, M., Lim, S.C., Shimura, M., Wu, Y., Mogushi, K., Yatsuka, Y., Harashima, H., Hisatomi, Y., Fushimi, T., Ichimoto, K., Murayama, K., Ohtake, A., Okazaki, Y. Neurogenetics 20 (1): 9-25 (2019). 54535 30607703
Novel GLI2 mutations identified in patients with Combined Pituitary Hormone Deficiency (CPHD): Evidence for a pathogenic effect by functional characterization. Babu, D., Fanelli, A., Mellone, S., Muniswamy, R., Wasniewska, M., Prodam, F., Petri, A., Bellone, S., Salerno, M.C., Giordano, M. Clin. Endocrinol. (Oxf). 90 (3): 449-456 (2019). 54534 30548673
Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs. Roland, B.P., Naito, T., Best, J.T., Arnaiz-Yepez, C., Takatsu, H., Yu, R.J., Shin, H.W., Graham, T.R. J. Biol. Chem. 294 (6): 1794-1806 (2019). 54533 30530492
Off- and on-target effects of genome editing in mouse embryos. Ayabe, S., Nakashima, K., Yoshiki, A. J. Reprod. Dev. 65 (1): 1-5 (2019). 54529 30518723
The nucleosome remodeling and deacetylase complex protein CHD4 regulates neural differentiation of mouse embryonic stem cells by down-regulating p53. Hirota, A., Nakajima-Koyama, M., Ashida, Y., Nishida, E. J. Biol. Chem. 294 (1): 195-209 (2019). 54479 30409903
TAZ activation by Hippo pathway dysregulation induces cytokine gene expression and promotes mesothelial cell transformation. Matsushita, A., Sato, T., Mukai, S., Fujishita, T., Mishiro-Sato, E., Okuda, M., Aoki, M., Hasegawa, Y., Sekido, Y. Oncogene 38: 1966?1978 (2019). 54478 30401981
Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking. Tsurumi, Y., Hamada, Y., Katoh, Y., Nakayama, K. Mol. Biol. Cell 16: mbcE18100678 (2019). 54403 30649997
Desuppression of TGF-beta signaling via nuclear c-Abl-mediated phosphorylation of TIF1 gamma/TRIM33 at Tyr-524, -610, and -1048. Yuki, R., Tatewaki, T., Yamaguchi, N., Aoyama, K., Honda, T., Kubota, S., Morii, M., Manabe, I., Kuga, T., Tomonaga, T., Yamaguchi, N. Oncogene 38 (5): 637-655 (2019). 54148 30177833
Characterization of cyanobacterial cells synthesizing 10-methyl stearic acid. Machida, S., Suzuki, I. Photosynth. Res. 139 (1-3): 173-183 (2019). 53848 29943360
METHOD OF SCREENING ATP11C OR CDC50A INHIBITOR Nagata, S., Segawa,K. US Patent 2019/0242873, 2019 1443  


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2018年

Title Author Journal NBRP RRC ID PubMed PMID
TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration. Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K.K-W., Takao, M., Akatsu, H., Murayama, S., Sawa, A., Tanaka, M. Biol. Psychiatry. 84(7): 509-521 (2018). 57435 29752072
KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-gamma-mediated effects. Banerjee, P.P., Pang, L., Soldan, S.S., Miah, S.M., Eisenberg, A., Maru, S., Waldman, A., Smith, E.A., Rosenberg-Hasson, Y., Hirschberg, D., Smith, A., Ablashi, D.V., Campbell, K.S., Orange, J.S. Mol. Immunol. pii: S0161-5890 (18) 30835-6 (2018). 56705 30482463
Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death. Miura, H., Kondo, Y., Matsuda, M., Aoki, K. Cell Rep. 24 (10): 2658-2668 (2018). 56704 30184500
New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Kaneko, N., Herranz-Perez, V., Otsuka, T., Sano, H., Ohno, N., Omata, T., Nguyen, H.B., Thai, T.Q., Nambu, A., Kawaguchi, Y., Garcia-Verdugo, J.M., Sawamoto, K. Sci. Adv. 4 (12): eaav0618 (2018). 55797 30547091
Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. Gouko, R., Onuma, M., Eitsuka, T., Katayama, M., Takahashi, K., Nakagawa, K., Inoue-Murayama, M., Kiyono, T., Fukuda, T. Cytotechnology 70 (6): 1619-1630 (2018). 54547 30225752
Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model. Yamada, S., Kimura, M., Saito, Y., Saito, H. J. Clin. Biochem. Nutr. \63 (2): 123-128 (2018). 54546 30279623
Ribosome-induced RNA conformational changes in a viral 3′-UTR sense and regulate translation levels. Hartwick, E.W., Costantino, D.A., MacFadden, A., Nix, J.C., Tian, S., Das, R., Kieft, J.S. Nat. Commun. 9 (1): 5074 (2018). 54506 30498211
Enhancing 3-hydroxypropionic acid production in combination with sugar supply engineering by cell surface-display and metabolic engineering of Schizosaccharomyces pombe. Takayama, S., Ozaki, A., Konishi, R., Otomo, C., Kishida, M., Hirata, Y., Matsumoto, T., Tanaka, T., Kondo, A. Microb. Cell Fact. 17 (1): 176 (2018). 54482 30424766
Cellular density-dependent increases in HIF-1alpha compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Seira, N., Yamagata, K., Fukushima, K., Araki, Y., Kurata, N., Yanagisawa, N., Mashimo, M., Nakamura, H., Regan, J.W., Murayama, T., Fujino, H. Pharmacol. Res. Perspect. 6 (6): e00441 (2018). 54481 30455960
USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. Takahashi, M., Kitaura, H., Kakita, A., Kakihana, T., Katsuragi, Y., Nameta, M., Zhang, L., Iwakura, Y., Nawa, H., Higuchi, M., Komatsu, M., Fujii, M. iScience 9: 433-450. (2018). 54477 30469013
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. Oda, T., Sekimoto, T., Kurashima, K., Fujimoto, M., Nakai, A., Yamashita, T. J. Cell Sci. 131 (9). pii: jcs210724 (2018). 54411 29632240
Pol eta, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress. Kurashima, K., Sekimoto, T., Oda, T., Kawabata, T., Hanaoka, F., Yamashita, T. J. Cell Sci. 131 (12). pii: jcs212183 (2018). 54410 29777036
Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-alpha in the inflamed intestinal epithelia of IBD patients. Kawamoto, A., Nagata, S., Anzai, S., Takahashi, J., Kawai, M., Hama, M., Nogawa, D., Yamamoto, K., Kuno, R., Suzuki, K., Shimizu, H., Hiraguri, Y., Yui, S., Ohshima, S., Tsuchiya, K., Nakamura, T., Ohtsuka, K., Kitagawa, M., Okamoto, R., Watanabe, M. J Crohns Colitis. 2018 Nov 3. doi: 10.1093/ecco-jcc/jjy180. [Epub ahead of print] 54388 30395194
Identification of the physiological substrates of PDIp, a pancreas-specific protein-disulfide isomerase family member. Fujimoto, T., Nakamura, O., Saito, M., Tsuru, A., Matsumoto, M., Kohno, K., Inaba, K., Kadokura, H. J. Biol. Chem. 293 (48): 18421-18433 (2018). 54379 30315102
Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine. Hashimoto, O., Funaba, M., Sekiyama, K., Doi, S., Shindo, D., Satoh, R., Itoi, H., Oiwa, H., Morita, M., Suzuki, C., Sugiyama, M., Yamakawa, N., Takada, H., Matsumura, S., Inoue, K., Oyadomari, S., Sugino, H., Kurisaki, A. Cell Rep. 25 (5): 1193-1203 (2018). 54362 30380411
Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IkappaBalpha in living cells. Rahimova, N., Babazada, H., Higuchi, Y., Yamashita, F., Hashida, M. Biochim. Biophys. Acta Mol. Cell Res. 1866 (2): 190-198 (2018). 54361 30391277
Robust Enhancement of Lentivirus Production by Promoter Activation. Suzuki, N., Yoshida, T., Takeuchi, H., Sakuma, R., Sukegawa, S., Yamaoka, S. Sci. Rep. 8 (1): 15036 (2018). 54331 30310119
Generation of orthotopically functional salivary gland from embryonic stem cells. Tanaka, J., Ogawa, M., Hojo, H., Kawashima, Y., Mabuchi, Y., Hata, K., Nakamura, S., Yasuhara, R., Takamatsu, K., Irie, T., Fukada, T., Sakai, T., Inoue, T., Nishimura, R., Ohara, O., Saito, I., Ohba, S., Tsuji, T., Mishima, K. Nat. Commun. 9 (1): 4216 (2018). 54330 30310071
Single-Unit Imaging of Membrane Protein-Embedded Nanodiscs from Two Oriented Sides by High-Speed Atomic Force Microscopy. Haruyama, T., Sugano, Y., Kodera, N., Uchihashi, T., Ando, T., Tanaka, Y., Konno, H., Tsukazaki, T. Structure pii: S0969-2126 (18) 30331-9 (2018). 54329 30318467
Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Yoshitomi, H., Kobayashi, S., Miyagawa-Hayashino, A., Okahata, A., Doi, K., Nishitani, K., Murata, K., Ito, H., Tsuruyama, T., Haga, H., Matsuda, S., Toguchida, J. Nat. Commun. 9 (1): 3762 (2018). 54228 30232328
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity. Funato, K., Hayashi, T., Echizen, K., Negishi, L., Shimizu, N., Koyama-Nasu, R., Nasu-Nishimura, Y., Morishita, Y., Tabar, V., Todo, T., Ino, Y., Mukasa, A., Saito, N., Akiyama, T. EMBO Rep. 19 (11). pii: e45587 (2018). 54227 30213795
Forkhead box protein A1 confers resistance to transforming growth factor-beta-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation. Hirata, K., Takakura, Y., Shibazaki, M., Morii, M., Honda, T., Oshima, M., Aoyama, K., Iwama, A., Nakayama, Y., Takano, H., Yamaguchi, N., Yamaguchi, N. J Cell Biochem. 2018 Sep 11. doi: 10.1002/jcb.27551. [Epub ahead of print] 54226 30206966
Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer. Tanaka, K., Kanesaka, Y., Takami, M., Suzuki, A., Hosokawa, H., Onodera, A., Kamata, T., Nagato, K., Nakayama, T., Yoshino, I., Motohashi, S. Biochem. Biophys. Res. Commun. 506 (1): 27-32 (2018). 54149 30336981
Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination. Mochizuki, K., Hayashi, Y., Sekinaka, T., Otsuka, K., Ito-Matsuoka, Y., Kobayashi, H., Oki, S., Takehara, A., Kono, T., Osumi, N., Matsui, Y. Cell Rep. 24 (10): 2682-2693.e6 (2018). 54147 30184502
CFAP70 Is a Novel Axoneme-Binding Protein That Localizes at the Base of the Outer Dynein Arm and Regulates Ciliary Motility. Shamoto, N., Narita, K., Kubo, T., Oda, T., Takeda, S. Cells 7 (9). pii: E124 (2018). 54146 30158508
Sensing of Escherichia coli and LPS by mammary epithelial cells is modulated by O-antigen chain and CD14. Vedrine, M., Berthault, C., Leroux, C., Reperant-Ferter, M., Gitton, C., Barbey, S., Rainard, P., Gilbert, F.B., Germon, P. PLoS One 13 (8): e0202664 (2018). 54145 30142177
Chemogenetic Approach Using Ni(II) Complex-Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors. Kubota, R., Nomura, W., Iwasaka, T., Ojima, K., Kiyonaka, S., Hamachi, I. ACS Cent. Sci. 4 (9): 1211-1221 (2018). 54144 30276255
Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. Nakanishi, H., Kurima, K., Pan, B., Wangemann, P., Fitzgerald, T.S., Geleoc, G.S., Holt. J.R., Griffith, A.J. Sci. Rep. 8 (1): 12125 (2018). 53919 30108230
Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis. Marton, J., Peter, M., Balogh, G., Bodi, B., Vida, A., Szanto, M., Bojcsuk, D., Janko, L., Bhattoa, H.P., Gombos, I., Uray, K., Horvath, I., Torok, Z., Balint, B.L., Papp, Z., Vigh, L., Bai, P. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids pii: S1388-1981 (18) 30187-2 (2018). 53915 30077797
Integration Mapping of piggyBac-Mediated CD19 Chimeric Antigen Receptor T Cells Analyzed by Novel Tagmentation-Assisted PCR. Hamada, M., Nishio, N., Okuno, Y., Suzuki, S., Kawashima, N., Muramatsu, H., Tsubota, S., Wilson, M.H., Morita, D., Kataoka, S., Ichikawa, D., Murakami, N., Taniguchi, R., Suzuki, K., Kojima, D., Sekiya, Y., Nishikawa, E., Narita, A., Hama, A., Kojima, S., Nakazawa, Y., Takahashi, Y. EBioMedicine 34: 18-26 (2018). 53914 30082227
In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease. Uenaka, T., Satake, W., Cha, P.C., Hayakawa, H., Baba, K., Jiang, S., Kobayashi, K., Kanagawa, M., Okada, Y., Mochizuki, H., Toda, T. Hum. Mol. Genet. 27 (22): 3974-3985 (2018). 53913 30137437
Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells. Osada, N., Kikuchi, J., Umehara, T., Sato, S., Urabe, M., Abe, T., Hayashi, N., Sugitani, M., Hanazono, Y., Furukawa, Y. Oncotarget 9 (5): 6450-6462 (2018). 53912 29464084
MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro. Mizuno, H., Taketomi, A. BMC Res. Notes 11 (1): 528 (2018) 53894 30064488
Live cell imaging of X chromosome reactivation during somatic cell reprogramming. Tran, T.H.Y., Fukuda, A., Aizawa, S., Bui, P.L., Hayashi, Y., Nishimura, K., Hisatake, K. Biochem. Biophys. Rep. 15: 86-92 (2018). 53893 30094351
Interaction of LEF1 with TAZ is necessary for the osteoblastogenic activity of Wnt3a. Kida, J., Hata, K., Nakamura, E., Yagi, H., Takahata, Y., Murakami, T., Maeda, Y., Nishimura, R. Sci. Rep. 8 (1): 10375 (2018). 53876 29991769
Schizosaccharomyces pombe cardiolipin synthase is part of a mitochondrial fusion protein regulated by intron retention. Vircikova, V., Pokorna L., Tahotna, D., Dzugasova, V., Balazova, M., Griac, P. Biochim Biophys Acta pii: S1388-1981 (18) 30146-X (2018). 53860 29958934
Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta). Fukuda, T., Eitsuka, T., Donai, K., Kurita, M., Saito, T., Okamoto, H., Kinoshita, K., Katayama, M., Nitto, H., Uchida, T., Onuma, M., Sone, H., Inoue-Murayama, M., Kiyono, T. Sci. Rep. 8 (1): 9229 (2018). 53847 29925962
A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. Komatsu, N., Terai, K., Imanishi, A., Kamioka, Y., Sumiyama, K., Jin, T., Okada, Y., Nagai, T., Matsuda, M. Sci. Rep. 8 (1): 8984 (2018). 53846 29895862
Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling. Kikuchi, K., Nakamura, A., Arata, M., Shi, D., Nakagawa, M., Tanaka, T., Uemura, T., Fujimori, T., Kikuchi, A., Uezu, A., Sakamoto, Y., Nakanishi, H. EMBO Rep. 19 (7). pii: e45471 (2018). 53836 29880710
Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors. Takemoto, N., Numata, I., Su’etsugu, M., Miyoshi-Akiyama, T. Nucleic Acids Res. 46 (12): 6152-6165 (2018). 53829 29878158
Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Muta, Y., Fujita, Y., Sumiyama, K., Sakurai, A., Taketo, M.M., Chiba, T., Seno, H., Aoki, K., Matsuda, M., Imajo, M. Nat. Commun. 9 (1): 2174 (2018). 53828 29872037
Corynebacterium kroppenstedtii in granulomatous mastitis: Analysis of formalin-fixed, paraffin-embedded biopsy specimens by immunostaining using low-specificity bacterial antisera and real-time polymerase chain reaction. Fujii, M., Mizutani, Y., Sakuma, T., Tagami, K., Okamoto, K., Kuno, Y., Harada, M., Kubouchi, K., Tsutsumi, Y. Pathol. Int. 68 (7): 409-418 (2018). 53827 29862601
Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking. Hamada, Y., Tsurumi, Y., Nozaki, S., Katoh, Y., Nakayama, K. Mol. Biol. Cell 29 (13): 1628-1639 (2018). 53819 29742051
Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis. Funabashi, T., Katoh, Y., Okazaki, M., Sugawa, M., Nakayama, K. J. Cell Biol. 217 (8): 2867-2876 (2018). 53203 29903877
Hypoxic stress up-regulates Kir2.1 expression by a pathway including hypoxic-inducible factor-1 and dynamin2 in brain capillary endothelial cells. Yamamura, H., Suzuki, Y., Yamamura, H., Asai, K., Giles, W., Imaizumi, Y. Am. J. Physiol. Cell Physiol. 315 (2): C202-C213 (2018). 52896 29768048
Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System. Oasa, S., Mikuni, S., Yamamoto, J., Kurosaki, T., Yamashita, D., Kinjo, M. Sci. Rep. 8 (1): 7488 (2018). 52895 29748590
RUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells. Mitsuda, Y., Morita, K., Kashiwazaki, G., Taniguchi, J., Bando, T., Obara, M., Hirata, M., Kataoka, T.R., Muto, M., Kaneda, Y., Nakahata, T., Liu, P.P., Adachi, S., Sugiyama, H., Kamikubo, Y. Sci. Rep. 8 (1): 6423 (2018). 52893 29686309
Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice. Shibata, W., Kinoshita, H., Hikiba, Y., Sato, T., Ishii, Y., Sue, S., Sugimori, M., Suzuki, N., Sakitani, K., Ijichi, H., Mori, R., Endo, I., Maeda, S. Sci. Rep. 8 (1): 6150 (2018). 52889 29670173
Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, C44Mab-5. Yamada, S., Itai, S., Nakamura, T., Yanaka, M., Kaneko, M.K., Kato, Y. Biochem. Biophys. Rep. 14: 64-68 (2018). 52888 29872736
Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response. Ueda, N., Uemura, Y., Zhang, R., Kitayama, S., Iriguchi, S., Kawai, Y., Yasui, Y., Tatsumi, M., Ueda, T., Liu, T.Y., Mizoro, Y., Okada, C., Watanabe, A., Nakanishi, M., Senju, S., Nishimura, Y., Kuzushima, K., Kiyoi, H., Naoe, T., Kaneko, S. Stem Cell Reports 10 (6): 1935-1946 (2018). 52879 29805109
Application of auxin-inducible degron technology to mouse oocyte activation with PLCzeta. Miura, K., Matoba, S., Ogonuki, N., Namiki, T., Ito, J., Kashiwazaki, N., Ogura, A. J. Reprod. Dev. 64 (4): 319-326 (2018). 51575 29731504
The poly-cistronic expression of four transcriptional factors (CRX, RAX, NEURO-D, OTX2) in fibroblasts via retro- or lentivirus causes partial reprogramming into photoreceptor cells. Fukuda, T., Ishizawa, Y., Donai, K., Sugano, E., Tomita, H. Cell Biol. Int. 42 (5): 608-614 (2018). 51322 29377330
Elavl3 is essential for the maintenance of Purkinje neuron axons. Ogawa, Y., Kakumoto, K., Yoshida, T., Kuwako, K.I., Miyazaki, T., Yamaguchi, J., Konno, A., Hata, J., Uchiyama, Y., Hirai, H., Watanabe, M., Darnell, R.B., Okano, H., Okano, H.J. Sci. Rep. 8 (1): 2722 (2018). 51321 29426875
Internalization of CD239 highly expressed in breast cancer cells: a potential antigen for antibody-drug conjugates. Kikkawa, Y., Enomoto-Okawa, Y., Fujiyama, A., Fukuhara, T., Harashima, N., Sugawara, Y., Negishi, Y., Katagiri, F., Hozumi, K., Nomizu, M., Ito, Y. Sci. Rep. 8 (1): 6612 (2018). 51309 29700410
CLICK: one-step generation of conditional knockout mice. Miyasaka, Y., Uno, Y., Yoshimi, K., Kunihiro, Y., Yoshimura, T., Tanaka, T., Ishikubo, H., Hiraoka, Y., Takemoto, N., Tanaka, T., Ooguchi, Y., Skehel, P., Aida, T., Takeda, J., Mashimo, T. BMC Genomics 19 (1): 318 (2018). 51308 29720086
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death. Kambara, H., Liu, F., Zhang, X., Liu, P., Bajrami, B., Teng, Y., Zhao, L., Zhou, S., Yu, H., Zhou, W., Silberstein, L.E., Cheng, T., Han, M., Xu, Y., Luo, H.R. Cell Rep. 22 (11): 2924-2936 (2018). 51235 29539421
In Vivo Genetic Manipulation of Spermatogonial Stem Cells and Their Microenvironment by Adeno-Associated Viruses. Watanabe, S., Kanatsu-Shinohara, M., Ogonuki, N., Matoba, S., Ogura, A., Shinohara, T. Stem Cell Reports 10 (5): 1551-1564 (2018). 50638 29628393
Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function. Preger-Ben Noon, E., Sabaris, G., Ortiz, D.M., Sager, J., Liebowitz, A., Stern, D.L., Frankel, N. Cell Rep. 22 (11): 3021-3031 (2018). 50635 29539428
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A., Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K.I., Watanabe, T., Soga, T., Shima, H., Maemondo, M., Tanuma, N. Cancer Cell 33 (3): 355-367.e7 (2018). 50634 29533781
RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice. Morita, K., Tokushige, C., Maeda, S., Kiyose, H., Noura, M., Iwai, A., Yamada, M., Kashiwazaki, G., Taniguchi, J., Bando, T., Hirata, M., Kataoka, T.R., Nakahata, T., Adachi, S., Sugiyama, H., Kamikubo, Y. Blood Adv. 2 (5): 509-515 (2018). 50624 29500219
Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation. Otani, K., Niwa, Y., Suzuki, T., Sato, N., Sasazawa, Y., Dohmae, N., Simizu, S. Biochem. Biophys. Res. Commun. 498 (3): 466-472 (2018). 50622 29501745
enChIP systems using different CRISPR orthologues and epitope tags. Fujita, T., Yuno, M., Fujii, H. BMC Res. Notes 11 (1): 154 (2018). 50614 29482606
EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. Kasahara, K., Aoki, H., Kiyono, T., Wang, S., Kagiwada, H., Yuge, M., Tanaka, T., Nishimura, Y., Mizoguchi, A., Goshima, N., Inagaki, M. Nat. Commun. 9 (1): 758 (2018). 50463 29472535
Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma. Hiyama, N., Ando, T., Maemura, K., Sakatani, T., Amano, Y., Watanabe, K., Kage, H., Yatomi, Y., Nagase, T., Nakajima, J., Takai, D. Jpn. J. Clin. Oncol. 48 (4): 303-307 (2018). 50462 29474642
Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors. Chiyonobu, N., Shimada, S., Akiyama, Y., Mogushi, K., Itoh, M., Akahoshi, K., Matsumura, S., Ogawa, K., Ono, H., Mitsunori, Y., Ban, D., Kudo, A., Arii, S., Suganami, T., Yamaoka, S., Ogawa, Y., Tanabe, M., Tanaka, S. Am. J. Pathol. 188 (5): 1213-1224 (2018). 50461 29454748
Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling. Nakashima, M., Watanabe, M., Uchimaru, K., Horie, R. Biol. Cell 110 (5): 109-124 (2018). 50332 29431186
Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages Karasawa, T., Kawashima, A., Usui-Kawanishi, F., Watanabe, S., Kimura, H., Kamata, R., Shirasuna, K., Koyama, Y., Sato-Tomita, A., Matsuzaka, T., Tomoda, H., Park, S.Y., Shibayama, N., Shimano, H., Kasahara, T., Takahashi, M. Arterioscler. Thromb. Vasc. Biol. 38 (4): 744-756 (2018). 50300 29437575
Myeloma Cells are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex which Senses Lipopolysaccharide. Kikuchi, J., Kuroda, Y., Koyama, D., Osada, N., Izumi, T., Yasui, H., Kawase, T., Ichinohe, T., Furukawa, Y. Cancer Res. 78 (7): 1766-1778 (2018). 50076 29363546
The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB. Kova?evi?. I., Sakaue, T., Majolee, J., Pronk, M.C., Maekawa, M., Geerts, D., Fernandez-Borja, M., Higashiyama, S., Hordijk, P.L. J. Cell Biol. 217 (3): 1015-1032 (2018). 50075 29358211
Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury. Jinnou, H., Sawada, M., Kawase, K., Kaneko, N., Herranz-Perez, V., Miyamoto, T., Kawaue, T., Miyata, T., Tabata. Y., Akaike, T., Garcia-Verdugo, J.M., Ajioka, I., Saitoh, S., Sawamoto, K. Cell Stem Cell 22 (1): 128-137.e9. (2018). 50074 29276142
TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling Kawasaki, N., Isogaya, K., Dan, S., Yamori, T., Takano, H., Yao, R., Morishita, Y., Taguchi, L., Morikawa, M., Heldin, C.H. Noda, T., Ehata, S., Miyazono, K., Koinuma, D. Cell Discovery 4 (1): (2018). 50065 29423269
Arsenite-induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells. Suzuki, T., Watanabe, H., Kita, K., Honma, T., Ochi, T. J. Appl. Toxicol. 38 (5): 734-743 (2018) 50039 29350772
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I.R., Ohno, H. J. Exp. Med. 215 (2): 501-519 (2018). 50038 29339448
Pde6brd1 mutation modifies cataractogenesis in Foxe3rct mice. Wada, K., Saito, J., Yamaguchi, M., Seki, Y., Furugori, M., Takahashi, G., Nishito, Y., Matsuda, H., Shitara, H., Kikkawa, Y. Biochem. Biophys. Res. Commun. 496 (1): 231-237 (2018). 50037 29317205
The RNA-splicing endonuclease from the euryarchaeaon Methanopyrus kandleri is a heterotetramer with constrained substrate specificity. Kaneta, A., Fujishima, K., Morikazu, W., Hori, H., Hirata, A. Nucleic. Acids. Res. 46 (4): 1958-1972 (2018). 50036 29346615
Online measurement of the respiratory activity in shake flasks enables the identification of cultivation phases and patterns indicating recombinant protein production in various E. coli host strains. Ihling, N., Bittner, N., Diederichs, S., Schelden, M., Korona, A., Hofler, G.T., Fulton, A., Jaeger, K.E., Honda, K., Ohtake, H., Buchs, J. Biotechnol. Prog. 34 (2): 315-327 (2018). 50031 29314728
The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane. Segawa, K., Kurata, S., Nagata, S. J. Biol. Chem. 293 (6): 2172-2182 (2018). 50029 29276178
Potential usefulness of Brevibacillus for bacterial cancer therapy: intratumoral provision of tumor necrosis factor-α and anticancer effects. Mukai, H., Takahashi, M., Watanabe, Y. Cancer Gene Ther. 25(3-4): 47-57 (2018). 50027 29255215
A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Takahashi, Y., Sato, S., Kurashima, Y., Yamamoto, T., Kurokawa, S., Yuki, Y., Takemura, N., Uematsu, S., Lai, C.Y., Otsu, M., Matsuno, H., Osawa, H., Mizushima, T., Nishimura, J., Hayashi, M., Yamaguchi, T., Kiyono, H. Stem Cell Reports 10 (1): 314-328 (2018). 50020 29233552
Physiological role of urothelial cancer-associated one long noncoding RNA in human skeletogenic cell differentiation. Ishikawa, T., Nishida, T., Ono, M., Takarada, T., Nguyen, H.T., Kurihara, S., Furumatsu, T., Murase, Y., Takigawa, M., Oohashi, T., Kamioka, H., Kubota, S. J. Cell. Physiol. 233 (6): 4825-4840 (2018). 50016 29150954
Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay. Sasaki, M., Anindita, P.D., Phongphaew, W., Carr, M., Kobayashi, S., Orba, Y., Sawa, H. Virus Res. 243: 69-74 (2018). 49649 29074234
Novel biallelic mutations in the PNPT1 gene encoding a mitochondrial-RNA-import protein PNPase cause delayed myelination. Sato, R., Arai-Ichinoi, N., Kikuchi, A., Matsuhashi, T., Numata-Uematsu, Y., Uematsu, M., Fujii, Y., Murayama, K., Ohtake, A., Abe, T., Kure, S. Clin. Genet. 93 (2): 242-247 (2018). 49236 28594066


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2017年

Title Author Journal NBRP RRC ID PubMed PMID
Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids. Onozato, Y., Kaida, A., Harada, H., Miura, M. Cancer Sci. 108 (4): 704-712 (2017). 57376 28135769
Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages. Nakatsumi, H., Matsumoto, M., Nakayama, K.I. Cell Rep. 21 (9): 2471-2486 (2017). 56703 29186685
Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse. Katano, I., Nishime, C., Ito, R., Kamisako, T., Mizusawa, T., Ka, Y., Ogura, T., Suemizu, H., Kawakami, Y., Ito, M., Takahashi, T. Sci. Rep. 7 (1): 17230 (2017). 55032 29222435
RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination. Inano, S., Sato, K., Katsuki, Y., Kobayashi, W., Tanaka, H., Nakajima, K., Nakada, S., Miyoshi, H., Knies, K., Takaori-Kondo, A., Schindler, D., Ishiai, M., Kurumizaka, H., Takata, M. Mol. Cell 66 (5): 622-634.e8 (2017). 54484 28575658
Adoptive Cellular Gene Therapy for the Treatment of Experimental Autoimmune Polychondritis Ear Disease. Zhou, B., Liao, Y., Guo, Y., Tarner, I.H., Liao, C., Chen, S., Kermany, M.H., Tu, H., Zhong, S., Chen, P. ORL J. Otorhinolaryngol. Relat. Spec. 79 (3): 166-177 (2017). 51319 28463837
Requirement of Hsp105 in CoCl2-induced HIF-1α accumulation and transcriptional activation. Mikami, H., Saito, Y., Okamoto, N., Kakihana, A., Kuga, T., Nakayama, Y. Exp. Cell Res. 352 (2): 225-233 (2017). 51318 28185835
A novel method to generate single-cell-derived cancer-associated fibroblast clones. Hashimoto, H., Suda, Y., Miyashita, T., Ochiai, A., Tsuboi, M., Masutomi, K., Kiyono, T., Ishii, G. J. Cancer Res. Clin. Oncol. 143 (8): 1409-1419 (2017). 51316 28364361
Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells. Yoneyama, T., Arai, M.A., Akamine, R., Koryudzu, K., Tsuchiya, A., Sadhu, S.K., Ahmed, F., Itoh, M., Okamoto, R., Ishibashi, M. J. Nat. Prod. 80 (9): 2453-2461 (2017). 51315 28817274
Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions. Morita, K., Maeda, S., Suzuki, K., Kiyose, H., Taniguchi, J., Liu, P.P., Sugiyama, H., Adachi, S., Kamikumo, Y. Blood Adv. 1: 1440-1451 (2017). 51314 29296785
Functional Pituitary Tissue Formation Recapitulating Hypothalamus and Pituitary Development Using ES/iPS Cells. Suga, H., Ozone, C. Organ Regeneration Based on Developmental Biology pp 41-56. 51313  
A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule. Watanabe, N., Suzuki, Y., Yonezu, T., Nakagawa, Y., Shiina, T., Hirayama, N., Inokuchi, S., Inoue, S. Sci. Rep. 7 (1): 6798 (2017). 50081 28754892
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Fibroblasts promote the collective invasion of ameloblastoma tumor cells in a 3D coculture model. Fuchigami, T., Koyama, H., Kishida, M., Nishizawa, Y., Iijima, M., Kibe, T., Ueda, M., Kiyono, T., Maniwa, Y., Nakamura, N., Kishida, S. FEBS Open Bio. 7 (12): 2000-2007 (2017). 49721 29226086
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Metabolic engineering of Schizosaccharomyces pombe via CRISPR-Cas9 genome editing for lactic acid production from glucose and cellobiose. Ozaki, A., Konishi, R., Otomo, C., Kishida, M., Takayama, S., Matsumoto, T., Tanaka, T., Kondo, A. Metab. Eng. Commun. 5: 60-67 (2017). 49575 29188185
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ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages. Kawashima, A., Karasawa, T., Tago, K., Kimura, H., Kamata, R., Usui-Kawanishi, F., Watanabe, S., Ohta, S., Funakoshi-Tago, M., Yanagisawa, K., Kasahara, T., Suzuki, K., Takahashi, M. J. Immunol. 199 (10): 3614-3622 (2017). 49558 29021376
Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor kappaB Subunit RelB in Response to a Lymphotoxin beta Stimulation. Quach, H.T., Kondo, T., Watanabe, M., Tamura, R., Yajima, Y., Sayama, S., Ando, M., Kataoka, T. Biol. Pharm. Bull. 40 (10): 1669-1677 (2017). 49556 28966239
Reciprocal Inflammatory Signaling Between Intestinal Epithelial Cells and Adipocytes in the Absence of Immune Cells. Takahashi, Y., Sato, S., Kurashima, Y., Lai, C.Y., Otsu, M., Hayashi, M., Yamaguchi, T., Kiyono, H. EBioMedicine. 23: 34-45 (2017). 49555 28789943
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Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels. Fujii, Y., Maekawa, S., Morita, M. Sci. Rep. 7 (1): 13115 (2017). 49531 29030562
A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation. Nishimura, K., Aizawa, S., Nugroho, F.L., Shiomitsu, E., Tran, Y.T., Bui, P.L., Borisova, E., Sakuragi, Y., Takada, H., Kurisaki, A., Hayashi, Y., Fukuda, A., Nakanishi, M., Hisatake, K. Stem Cell Reports 8 (3): 787-801 (2017). 49491 28262547
Creation of mutant mice with megabase-sized deletions containing custom-designed breakpoints by means of the CRISPR/Cas9 system. Kato, T., Hara, S., Goto, Y., Ogawa, Y., Okayasu, H., Kubota, S., Tamano, M., Terao, M., Takada, S. Sci. Rep. 7 (1): 59 (2017). 49490 28246396
HMGA1 regulates the Plasminogen activation system in the secretome of breast cancer cells. Resmini, G., Rizzo, S., Franchin, C., Zanin, R., Penzo, C., Pegoraro, S., Ciani, Y., Piazza, S., Arrigoni, G., Sgarra, R., Manfioletti, G. Sci. Rep. 7 (1): 11768 (2017). 49319 28924209
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Human SMOOTHENED inhibits human immunodeficiency virus type 1 infection. Yoshida, T., Hamano, A., Ueda, A., Takeuchi, H., Yamaoka, S. Biochem. Biophys. Res. Commun. 493 (1): 132-138 (2017). 49317 28917838
The parathyroid hormone regulates skin tumour susceptibility in mice. Okumura, K., Saito, M., Yoshizawa, Y., Munakata, H., Isogai, E., Miura, I., Wakana, S., Yamaguchi, M., Shitara, H., Taya, C., Karaplis, A.C., Kominami, R., Wakabayashi, Y. Sci. Rep. 7 (1): 11208 (2017). 49316 28894263
PM01183 inhibits myeloid-derived suppressor cells in vitro and in vivo. Kuroda, H., Mabuchi, S., Kozasa, K., Yokoi, E., Matsumoto, Y., Komura, N., Kawano, M., Hashimoto, K., Sawada, K., Kimura, T. Immunotherapy 9 (10): 805-817 (2017). 49279 28877631
Enhancement of TGF-beta-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP). Kuki, K., Yamaguchi, N., Iwasawa, S., Takakura, Y., Aoyama, K., Yuki, R., Nakayama, Y., Kuga, T., Hashimoto, Y., Tomonaga, T., Yamaguchi, N. Biochem. Biophys. Res. Commun. 490 (3): 1045-1051 (2017). 49278 28666867
A Key Enzyme of the NAD+ Salvage Pathway in Thermus thermophilus: Characterization of Nicotinamidase and the Impact of Its Gene Deletion at High Temperatures. Taniguchi, H., Sungwallek, S., Chotchuang, P., Okano, K., Honda, K. J. Bacteriol. 199 (17). pii: e00359-17 (2017). 49277 28630126
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ALK signaling cascade confers multiple advantages to glioblastoma cells through neovascularization and cell proliferation. Chiba, R., Akiya, M., Hashimura, M., Oguri, Y., Inukai, M., Hara, A., Saegusa, M. PLoS One 12 (8): e0183516 (2017). 49267 28837676
Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity. Bae, C.R., Hino, J., Hosoda, H., Arai, Y., Son, C., Makino, H., Tokudome, T., Tomita, T., Kimura, T., Nojiri, T., Hosoda, K., Miyazato, M., Kangawa, K. Sci. Rep. 7 (1): 9807 (2017). 49261 28852070
Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells. Ito, N., Kii, I., Shimizu, N., Tanaka, H., Shin’ichi, T. Sci. Rep. 7 (1): 8097 (2017). 49256 28808339
Ypt4 and lvs1 regulate vacuolar size and function in Schizosaccharomyces pombe. Rains, A., Bryant, Y., Dorsett, K.A., Culver, A., Egbaria, J., Williams, A., Barnes, M., Lamere, R., Rossi, A.R., Waldrep, S.C., Wilder, C., Kliossis, E., Styers, M.L. Cellular Logistics, 7 (3): e1335270 (2017). 49238 28944093
Single-molecule fluorescence imaging of RalGDS on cell surfaces during signal transduction from Ras to Ral. Yoshizawa, R., Umeki, N., Yanagawa, M., Murata, M., Sako, Y. Biophys. Physicobiol. 14: 75-84 (2017). 49235 28744424
Genetic regulation of the RUNX transcription factor family has antitumor effects. Morita, K., Suzuki. K., Maeda, S., Matsuo, A., Mitsuda, Y., Tokushige, C., Kashiwazaki, G., Taniguchi, J., Maeda, R., Noura, M., Hirata, M., Kataoka, T., Yano, A., Yamada, Y., Kiyose, H., Tokumasu, M., Matsuo, H., Tanaka, S., Okuno, Y., Muto, M., Naka, K., Ito, K., Kitamura, T., Kaneda, Y., Liu, P.P., Bando, T., Adachi, S., Sugiyama, H., Kamikubo, Y. J. Clin. Invest. 127 (7): 2815-2828 (2017). 49234 28530640
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury. Jegal, K.H., Park, S.M., Cho, S.S., Byun, S.H., Ku, S.K., Kim, S.C., Ki, S.H., Cho, I.J. Biochim. Biophys. Acta 1864 (7): 1295-1307 (2017). 49233 28433684
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Shichita, T., Ito, M., Morita, R., Komai, K., Noguchi, Y., Ooboshi, H., Koshida, R., Takahashi, S., Kodama, T., Yoshimura, A. Nat. Med. 23 (6): 723-732 (2017). 49232 28394332
CCAAT/enhancer-binding protein alpha decreases the viability of gastric cancer cells. Tomizawa, M., Shinozaki, F., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Ishige, N. Oncol. Lett. 13 (6): 4322-4326 (2017). 49231 28599433
PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4. Ueno, N., Nishimura, N., Ueno, S., Endo, S., Tatetsu, H., Hirata, S., Hata, H., Matsuoka, M., Mitsuya, H., Okuno, Y. Oncogene 36 (31): 4481-4497 (2017). 49230 28368411
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Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions. Katayama, M., Hirayama, T., Kiyono, T., Onuma, M., Tani, T., Takeda, S., Nishimori, K., Fukuda, T. J. Reprod. Dev. 63 (3): 311-318 (2017). 49216 28331164
GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas. Mikami, Y., Fujii, S., Nagata, K., Wada, H., Hasegawa, K., Abe, M., Yoshimoto, R.U., Kawano, S., Nakamura, S., Kiyoshima, T. J. Cancer Res. Clin. Oncol. 143 (8): 1381-1393 (2017). 49215 28342001
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Establishment and characterization of cell lines derived from complete hydatidiform mole. Yamamoto, E., Niimi, K., Kiyono, T., Yamamoto, T., Nishino, K., Nakamura, K., Kotani, T., Kajiyama, H., Shibata, K., Kikkawa, F. Int. J. Mol. Med. 40 (3): 614-622 (2017). 48886 28713902
Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease. Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K.K., Kurosawa, M., Kim, S.H., Nukina, N., Takimoto, E., Houslay, M.D., Sawa, A. J. Clin. Invest. 127 (4): 1438-1450 (2017). 48884 28263187
Fibroblast-led cancer cell invasion is activated by epithelial-mesenchymal transition through platelet-derived growth factor BB secretion of lung adenocarcinoma. Neri, S., Miyashita, T., Hashimoto, H., Suda, Y., Ishibashi, M., Kii, H., Watanabe, H., Kuwata, T., Tsuboi, M., Goto, K., Menju, T., Sonobe, M., Date, H., Ochiai, A., Ishii, G. Cancer Lett. 395: 20-30 (2017). 48883 28286261
Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Stauffer, B.B., Cui, G., Cottrill, K.A., Infield, D.T., McCarty, N.A. Sci. Rep. 7 (1): 2931 (2017). 48841 28592822
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis. Feng, R., Satoh, Y., Ogasawara, Y., Yoshimura, T., Dairi, T. J. Am. Chem. Soc. 139 (12): 4243-4245 (2017). 48834 28294606
A noncoding RNA containing a SINE-B1 motif associates with meiotic metaphase chromatin and has an indispensable function during spermatogenesis. Nakajima, R., Sato, T., Ogawa, T., Okano, H., Noce, T. PLoS One 12 (6): e0179585 (2017). 48833 28658256
Genetically encoded bioluminescent voltage indicator for multi-purpose use in wide range of bioimaging. Inagaki, S., Tsutsui, H., Suzuki, K., Agetsuma, M., Arai, Y., Jinno, Y., Bai, G., Daniels, M.J., Okamura, Y., Matsuda, T., Nagai, T. Sci. Rep. 7: 42398 (2017). 48814 28205521
The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells. Sakaue, T., Sakakibara, I., Uesugi, T., Fujisaki, A., Nakashiro, K.I., Hamakawa, H., Kubota, E., Joh, T., Imai, Y.K., Izutani, H., Higashiyama, S. Sci. Rep. 7: 42845 (2017). 48813 28216678
An aging-independent replicative lifespan in a symmetrically dividing eukaryote. Spivey, E.C., Jones, S.K., Rybarski, J.R., Saifuddin, F.A., Finkelstein, I.J. Elife 6. pii: e20340 (2017). 48806 28139976
Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication. Fleck, O., Fahnoe, U., Lovschal, K.V., Gasasira, M.U., Marinova, I.N., Kragelund, B.B., Carr, A.M., Hartsuiker, E., Holmberg, C., Nielsen, O. Genes (Basel). 8 (5). pii: E128 (2017). 48805 28441348
UBL/BAG-domain co-chaperones cause cellular stress upon overexpression through constitutive activation of Hsf1. Poulsen, E.G., Kampmeyer, C., Kriegenburg, F., Johansen, J.V., Hofmann, K., Holmberg, C., Hartmann-Petersen, R. Cell Stress Chaperones 22 (1): 143-154 (2017). 48804 27966061
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Gu, M., LaJoie, D., Chen, O.S., von Appen, A., Ladinsky, M.S., Redd, M.J., Nikolova, L., Bjorkman, P.J., Sundquist, W.I., Ullman, K.S., Frost, A. Proc. Natl. Acad. Sci. U.S.A. 114 (11): E2166-E2175 (2017). 48803 28242692
SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Wei, Y., Diao, L.X., Lu, S., Wang, H.T., Suo, F., Dong, M.Q., Du, L.L. Mol. Cell 66 (5): 581-596 (2017). 48799 28552615
APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. Tanaka, N., Mashima, T., Mizutani, A., Sato, A., Aoyama, A., Gong, B., Yoshida, H., Muramatsu, Y., Nakata, K., Matsuura, M., Katayama, R., Nagayama, S., Fujita, N., Sugimoto, Y., Seimiya, H. Mol. Cancer Ther. 16 (4): 752-762 (2017). 48798 28179481
Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-beta-induced cell behaviors of human scar dermal fibroblasts. Horigome, T., Takumi, S., Shirai, K., Kido, T., Hagiwara-Chatani, N., Nakashima, A., Adachi, N., Yano, H., Hirai, Y. J. Dermatol. Sci. 86 (2): 132-141 (2017). 48797 28209294
Genome-wide screen for cell growth regulators in fission yeast. Weston, L., Greenwood, J., Nurse, P. J. Cell Sci. 130 (12): 2049-2055 (2017). 48764 28476936
Chromatin Domain Organization of the TCRb Locus and Its Perturbation by Ectopic CTCF Binding. Rawat, P., Jalan, M., Sadhu, A., Kanaujia, A., Srivastava, M. Mol. Cell. Biol. 37 (9). pii: e00557-16 (2017). 48758 28137913
Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. Shimokawa, C., Kanaya, T., Hachisuka, M., Ishiwata, K., Hisaeda, H., Kurashima, Y., Kiyono, H., Yoshimoto, T., Kaisho, T., Ohno, H. Immunity 46 (5): 863-874 (2017). 48562 28514691
Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms. Tomioka, I., Ishibashi, H., Minakawa, E.N., Motohashi, H.H., Takayama, O., Saito, Y., Popiel, H.A., Puentes, S., Owari, K., Nakatani, T., Nogami, N., Yamamoto, K., Noguchi, S., Yonekawa, T., Tanaka, Y., Fujita, N., Suzuki, H., Kikuchi, H., Aizawa, S., Nagano, S., Yamada, D., Nishino, I., Ichinohe, N., Wada, K., Kohsaka, S., Nagai, Y., Seki, K. eNeuro 4 (2). pii: ENEURO.0250-16 (2017). 48562 28374014
Estimation of the influence of sequencing errors and distribution of random-sequence tags on quantitative sequencing. Hoshino, T., Hamada, Y. J. Biosci. Bioeng. pii: S1389-1723 (17) 30077-30074 (2017). 48084 28457659
Specific glutamic acid residues in targeted proteins induce exaggerated retardations in Phos-tag SDS-PAGE migration. Kinoshita, E., Kinoshita-Kikuta, E., Karata, K., Kawano, T., Nishiyama, A., Yamato, M., Koike, T. Electrophoresis 38 (8): 1139-1146 (2017). 47981 28112428
Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons. Suzuki, S., Akamatsu, W., Kisa, F., Sone, T., Ishikawa, K.I., Kuzumaki, N., Katayama, H., Miyawaki, A., Hattori, N., Okano, H. Biochem. Biophys. Res. Commun. 483 (1): 88-93 (2017). 47980 28057485
CD200-positive cancer associated fibroblasts augment the sensitivity of Epidermal Growth Factor Receptor mutation-positive lung adenocarcinomas to EGFR Tyrosine kinase inhibitors. Ishibashi, M., Neri, S., Hashimoto, H., Miyashita, T., Yoshida, T., Nakamura, Y., Udagawa, H., Kirita, K., Matsumoto, S., Umemura, S., Yoh, K., Niho, S., Tsuboi, M., Masutomi, K., Goto, K., Ochiai, A., Ishii, G. Sci. Rep. 7: 46662 (2017). 47979 28429795
Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25. Kawaguchi, K., Uo, K., Tanaka, T., Komada, M. Sci. Rep. 7: 45037 (2017). 47938 28327663
Application of Stochastic Labeling with Random-Sequence Barcodes for Simultaneous Quantification and Sequencing of Environmental 16S rRNA Genes. Hoshino, T., Inagaki, F. PLoS One 12 (1): e0169431 (2017). 47733 28052139
Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms. Kondo, H., Maksimova, N., Otomo, T., Kato, H., Imai, A., Asano, Y., Kobayashi, K., Nojima, S., Nakaya, A., Hamada, Y., Irahara, K., Gurinova, E., Sukhomyasova, A., Nogovicina, A., Savvina, M., Yoshimori, T., Ozono, K., Sakai, N. Hum. Mol. Genet. 26 (1): 173-183 (2017). 47720 28013294
Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells. Hanawa, M., Takayama, K., Sakurai, F., Tachibana, M., Mizuguchi, H. Stem Cell Rev. 13 (4): 542-551 (2017). 47718 28000155
Interleukin-8 enhances the effect of colchicine on cell death. Yokoyama, C., Yajima, C., Machida, T., Kawahito, Y., Uchida, M., Hisatomi, H. Biochem. Biophys. Res. Commun. 485 (1): 89-94 (2017). 47632 28189686
Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting. Chen, Q., Osada, K., Ge, Z., Uchida, S., Tockary, T.A., Dirisala, A., Matsui, A., Toh, K., Takeda, K.M., Liu, X., Nomoto, T., Ishii, T., Oba, M., Matsumoto, Y., Kataoka, K. Biomaterials 113: 253-265 (2017). 47498 27835820
Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors. Hirano, T., Katoh, Y., Nakayama, K. Mol. Biol. Cell 28 (3): 429-439 (2017). 47487 27932497
Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast. Li, G., Poulsen, M., Fenyvuesvolgyi, C., Yashiroda, Y., Yoshida, M., Simard, J.M., Gallo, R.C., Zhao, R.Y. Proc. Natl. Acad. Sci. U.S.A. 114 (3): E376-E385 (2017). 47477 28049830
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Expression of Tim-1 in primary CNS lymphoma. Kishimoto, W., Nishikori, M., Arima, H., Miyoshi, H., Sasaki, Y., Kitawaki, T., Shirakawa, K., Kato, T., Imaizumi, Y., Ishikawa, T., Ohno, H., Haga, H., Ohshima, K., Takaori-Kondo, A. Cancer Med. 5 (11): 3235-3245 (2017). 47458 27709813
miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway. Kuroda, K., Fukuda, T., Krstic-Demonacos, M., Demonacos, C., Okumura, K., Isogai, H., Hayashi, M., Saito, K., Isogai, E. BMC Cancer 17 (1): 33 (2017). 47457 28061765
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal. Funabashi, T., Katoh, Y., Michisaka, S., Terada, M., Sugawa, M., Nakayama, K. Mol. Biol. Cell 28 (5): 624-633 (2017). 47456 28077622
Expression of Six Proteins Causes Reprogramming of Porcine Fibroblasts into Induced Pluripotent Stem Cells with Both Active X Chromosomes. Fukuda, T., Tani, T., Haraguchi, S., Donai, K., Nakajima, N., Uenishi, H., Eitsuka, T., Miyagawa, M., Song, S., Onuma, M., Hoshino, Y., Sato, E., Honda, A. J. Cell Biochem. 118(3): 537-553 (2017). 45801 27608441
Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer. Nishizawa, Y., Nishida, N., Konno, M., Kawamoto, K., Asai, A., Koseki, J., Takahashi, H., Haraguchi, N., Nishimura, J., Hata, T., Matsuda, C., Mizushima, T., Satoh, T., Doki, Y., Mori, M., Ishii, H. Ann. Surg. Oncol. 24 (3): 841-849 (2017). 41310 27473587


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2016年

Title Author Journal NBRP RRC ID PubMed PMID
TGF-beta induces the differentiation of human CXCL13-producing CD4(+) T cells. Kobayashi, S., Watanabe, T., Suzuki, R., Furu, M., Ito, H., Ito, J., Matsuda, S., Yoshitomi, H. Eur. J. Immunol. 46 (2): 360-371 (2016). 54505 26541894
Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Shimada, M., Goshima, T., Matsuo, H., Johmura, Y., Haruta, M., Murata, K., Tanaka, H., Ikawa, M., Nakanishi, K., Nakanishi, M. Nat. Commun. 7: 12059 (2016). 54485 27389782
FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end. Sato, K., Shimomuki, M., Katsuki, Y., Takahashi, D., Kobayashi, W., Ishiai, M., Miyoshi, H., Takata, M., Kurumizaka, H. Nucleic Acids Res. 44 (22): 10758-10771 (2016). 54483 27694619
Detailed analysis of inversions predicted between two human genomes: errors, real polymorphisms, and their origin and population distribution. Vicente-Salvador, D., Puig, M., Gaya-Vidal, M., Pacheco, S., Giner-Delgado, C., Noguera, I., Izquierdo, D., Martinez-Fundichely, A., Ruiz-Herrera, A., Estivill, X., Aguado, C., Lucas-Lledo, J.I., Caceres, M. Hum. Mol. Genet 26 (3): 567-581 (2016). 51327 28025331
Development of New Formulation Dry Powder for Pulmonary Delivery Using Amino Acids to Improve Stability. Suzuki, Y., Okuda, T., Okamoto, H. Biol. Pharm. Bull. 39 (3): 394-400 (2016). 51326 26725531
Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators. Fukuda, T., Iino, Y., Eitsuka, T., Onuma, M., Katayama, M., Murata, K., Inoue-Murayama, M., Hara, K., Isogai, E., Kiyono, T. Cytotechnology 68 (5): 1937-1947 (2016). 50078 27449922
Rab8b Regulates Transport of West Nile Virus Particles from Recycling Endosomes. Kobayashi, S., Suzuki, T., Kawaguchi, A., Phongphaew, W., Yoshii, K., Iwano, T., Harada, A., Kariwa, H., Orba, Y., Sawa, H. J. Biol. Chem. 291 (12): 6559-6568 (2016). 49650 26817838
ASBEL-TCF3 complex is required for the tumorigenicity of colorectal cancer cells. Taniue, K., Kurimoto, A., Takeda, Y., Nagashima, T., Okada-Hatakeyama, M., Katou, Y., Shirahige, K., Akiyama, T. Proc. Natl. Acad. Sci. U.S.A. 113 (45): 12739?12744 (2016). 49217 27791078
CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast. P?evorovsky, M., Oravcova, M., Zach, R., Jordakova, A., Bahler, J., P?ta, F., Folk P. Cell Cycle 15 (22): 3082-3093 (2016). 48807 27687771
Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Kawashima, S.A., Chen, Z., Aoi, Y., Patgiri, A., Kobayashi, Y., Nurse, P., Kapoor, T.M. Cell 167 (2): 512-524 (2016). 48802 27667686
Engineering an ABC transporter for enhancing resistance to caffeine in Saccharomyces cerevisiae. Wang, M., Deng, W.W., Zhang, Z.Z., Yu, O. J Agric Food Chem. 64 (42): 7973?7978 (2016). 48801 27696877
Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. Subramanian, L., Medina-Pritchard, B., Barton, R., Spiller, F., Kulasegaran-Shylini, R., Radaviciute, G., Allshire, R.C., Arockia Jeyaprakash, A. EMBO Rep. 17 (4):496-507 (2016). 48800 26921242
Importance of Hepatocyte Nuclear Factor 4α in Glycerol-induced Glucose-6-phosphatase Expression in Liver. Yoshida, M., Lee, E.Y., Kohno, T., Tanaka, T., Miyazaki, M., Miki, T. Biomed. Res. 37 (2): 85-93 (2016). 48757 27108878
A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively. Hata, S., Kitamura, F., Yamaguchi, M., Shitara, H., Murakami, M., Sorimachi, H. J. Biol. Chem. 291 (53): 27313-27322 (2016). 48551 27881674
Cell-Surface Protein Profiling Identifies Distinctive Markers of Progenitor Cells in Human Skeletal Muscle. Uezumi, A., Nakatani, M., Ikemoto-Uezumi, M., Yamamoto, N., Morita, M., Yamaguchi, A., Yamada, H., Kasai, T., Masuda, S., Narita, A., Miyagoe-Suzuki, Y., Takeda, S., Fukada, S., Nishino, I., Tsuchida, K. Stem Cell Reports 7 (2): 263-278 (2016). 48087 27509136
An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes. Kurihara, C., Nakade, K., Pan, J., Huang, J., Wasylyk, B., Obata, Y. Biotechnol. Rep. (Amst.) 12: 26-32 (2016). 48009 28352551
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells. Higuchi, M., Kawamura, H., Matsuki, H., Hara, T., Takahashi, M., Saito, S., Saito, K., Jiang, S., Naito, M., Kiyonari, H., Fujii, M. Stem Cell Reports 7 (6): 1116-1129 (2016). 47911 27974222
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression. Kimura, H., Fumoto, K., Shojima, K., Nojima, S., Osugi, Y., Tomihara, H., Eguchi, H., Shintani, Y., Endo, H., Inoue, M., Doki, Y., Okumura, M., Morii, E., Kikuchi, A. J. Clin. Invest. 126 (7): 2689-2705 (2016). 47732 27322059
Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal. Kanatsu-Shinohara, M., Tanaka, T., Ogonuki, N., Ogura, A., Morimoto, H., Cheng, P.F., Eisenman, R.N., Trumpp, A., Shinohara, T. Genes Dev. 30 (23): 2637-2648 (2016). 47719 28007786
Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner. Ikeda, M., Toyoshima, F. Mol. Cell. Biol. 37 (5). pii: e00417-16 (2016). 47717 27956699
Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Sano, T., Kobayashi, T., Negoro, H., Sengiku, A., Hiratsuka, T., Kamioka, Y., Liou, L.S., Ogawa, O., Matsuda, M. Physiol. Rep. 4 (21). pii: e13033 (2016). 47634 27905300
Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture. Matsu-Ura, T., Dovzhenok, A., Aihara, E., Rood, J., Le, H., Ren, Y., Rosselot, A.E., Zhang, T., Lee, C., Obrietan, K., Montrose, M.H., Lim, S., Moore, S.R., Hong, C.I. Mol. Cell 64 (5): 900-912 (2016). 47633 27867006
FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Yamaguchi, A., Takanashi, K. Sci. Rep. 6: 35195 (2016). 47497 27731383
Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection. Iborra, S., Martinez-Lopez, M., Cueto, F.J., Conde-Garrosa, R., Del Fresno, C., Izquierdo, H.M., Abram, C.L., Mori, D., Campos-Martin, Y., Reguera, R.M., Kemp, B., Yamasaki, S., Robinson, M.J., Soto, M., Lowell, C.A., Sancho, D. Immunity 45 (4): 788-801 (2016). 47496 27742545
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane. Tanaka, Y., Ono, N., Shima, T., Tanaka, G., Katoh, Y., Nakayama, K., Takatsu, H., Shin, H.W. Mol. Biol. Cell 27 (24): 3883-3893 (2016). 47495 27733620
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide. Omura, H., Oikawa, D., Nakane, T., Kato, M., Ishii, R., Ishitani, R., Tokunaga, F., Nureki, O. Sci. Rep. 6: 34756 (2016). 47494 27721487
Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging. Shcherbakova, D.M., Baloban, M., Emelyanov, A.V., Brenowitz, M., Guo, P., Verkhusha, V.V. Nat. Commun. 7: 12405 (2016). 47488 27539380
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex. Katoh, Y., Terada, M., Nishijima, Y., Takei, R., Nozaki, S., Hamada, H., Nakayama, K. J. Biol. Chem. 291 (21): 10962-10975 (2016). 47486 26980730
Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity. Endo, T., Noda, N., Kuromi, Y., Kokura, K., Kazuki, Y., Oshimura, M., Ohbayashi, T. Yonago Acta Med. 59 (2): 174-182 (2016). 47470 27493490
Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast. Zhao, D., Liu, X.M., Yu, Z.Q., Sun, L.L., Xiong, X., Dong, M.Q., Du, L.L. J. Cell Sci. 129 (22): 4289-4304 (2016). 47468 27737912
Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling. Chanmee, T., Ontong, P., Izumikawa, T., Higashide, M., Mochizuki, N., Chokchaitaweesuk, C., Khansai, M., Nakajima, K., Kakizaki, I., Kongtawelert, P., Taniguchi, N., Itano, N. J. Biol. Chem. 291 (46): 24105-24120 (2016). 47460 27758869
Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line. Fukuda, T., Tanaka, T., Hamaguchi, Y., Kawanami, T., Nomiyama, T., Yanase, T. PLoS One 11 (10): e0164131 (2016). 47321 27706259
Effect of chitosan on reactor performance and population of specific methanogens in a modified CSTR treating raw POME. Khemkhao, M., Techkarnjanaruk, S., Phalakornkule, C. Biomass and Bioenergy 86: 11-20 (2016). 47291  
B Cell-Based Seamless Engineering of Antibody Fc Domains. Hashimoto, K., Kurosawa, K., Murayama, A., Seo, H., Ohta, K. PLoS One 11 (12): e0167232 (2016). 47287 27907066
ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21. Ishigro, N., Yoshida, H. Neoplasia 18 (10): 626-635 (2016). 47268 27673450
CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability. Minegishi, Y., Sheng, X., Yoshitake, K., Sergeev, Y., Iejima, D., Shibagaki, Y., Monma, N., Ikeo, K., Furuno, M., Zhuang, W., Liu, Y., Rong, W., Hattori, S., Iwata, T. Sci. Rep. 6: 33742 (2016). 47267 27645772
Mitochondrial cereblon functions as a Lon-type protease. Kataoka, K., Nakamura, C., Asahi, T., Sawamura, N. Sci. Rep. 6: 29986 (2016). 47266 27417535
Draft genome sequence of Syntrophomonas wolfei subsp. methylbutyratica strain 4J5T (JCM 14075), a mesophilic butyrate- and 2-methylbutyrate-degrading syntroph. Narihiro, T., Nobu, M.K., Tamaki, H., Kamagata, Y., Liu, W.T. Genome Announc. 4 (2): e00047-16 (2016). 47265 26941138
Comparative genomics of syntrophic branched-chain fatty acid degrading bacteria. Narihiro, T., Nobu, M.K., Tamaki, H., Kamagata, Y., Sekiguchi, Y., Liu, W.T. Microbes environ. 31 (3): 288-292 (2016). 47264 27431485
Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases. Osberg, C., Aksnes, H., Ninzima, S., Marie, M., Arnesen, T. Sci. Rep. 6: 31627 (2016). 47224 27555049
Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B. Foglizzo, M., Middleton, A.J., Day, C.L. J. Mol. Biol. 428 (20): 4073-4086 (2016). 47223 27569044
Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy. Suga, A., Mizota, A., Kato, M., Kuniyoshi, K., Yoshitake, K., Sultan, W., Yamazaki, M., Shimomura, Y., Ikeo, K., Tsunoda, K., Iwata, T. Invest. Ophthalmol. Vis. Sci. 57 (10): 4255-4263 (2016). 47222 27548899
Sequence Diversity, Intersubgroup Relationships, and Origins of the Mouse Leukemia Gammaretroviruses of Laboratory and Wild Mice. Bamunusinghe, D., Naghashfar, Z., Buckler-White, A., Plishka, R., Baliji, S., Liu, Q., Kassner, J., Oler, A.J., Hartley, J., Kozak, C.A. J. Virol. 90 (8): 4186-4198 (2016). 46504 26865715
Influenza virus susceptibility of wild-derived CAST/EiJ mice results from two amino acid changes in the MX1 restriction factor. Nurnberger, C., Zimmermann, V., Gerhardt, M., Staeheli, P. J Virol. 2016 Nov 14;90(23):10682-10692 (2016). 46503 27654285
Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent. Hikasa, H., Sekido, Y., Suzuki, A. Cell Rep. 14 (12): 2950-2961 (2016). 45806 26997273
Conformational plasticity of JRAB/MICAL-L2 provides ‘law and order’ in collective cell migration. Sakane, A., Yoshizawa, S., Nishimura, M., Tsuchiya, Y., Matsushita, N., Miyake, K., Horikawa, K., Imoto, I., Mizuguchi, C., Saito, H., Ueno, T., Matsushita, S., Haga, H., Deguchi, S., Mizuguchi, K., Yokota, H., Sasaki, T. Mol. Biol. Cell 27(20): 3095-3108 (2016). 45803 27582384
SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Murakami-Tonami, Y., Ikeda, H., Yamagishi, R., Inayoshi, M., Inagaki, S., Kishida, S., Komata, Y., Koster, J., Takeuchi, I., Kondo, Y., Maeda, T., Sekido, Y., Murakami, H., Kadomatsu, K. Sci. Rep. 6: 31615 (2016). 45802 27539729
Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Nishino, T., Matsunaga, R., Jikihara, H., Uchida, M., Maeda, A., Qi, G., Abe, T., Kiyonari, H., Tashiro, S., Inagaki-Ohara, K., Shimamoto, F., Konishi, H. Biochim. Biophys. Acta 1861 (11): 1816-1827 (2016). 45608 27616329
Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-alpha/beta1-Independent. Torrado, B., Grana, M., Badano, J.L., Irigoin, F. PLoS One 11 (8): e0162033 (2016). 45607 27579771
Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. Yamaura, K., Kiyonaka, S., Numata, T., Inoue, R., Hamachi, I. Nat. Chem. Biol. 12 (10): 822-830 (2016). 41314 27526031
MEF2D-BCL9 Fusion Gene Is Associated With High-Risk Acute B-Cell Precursor Lymphoblastic Leukemia in Adolescents. Suzuki, K., Okuno, Y., Kawashima, N., Muramatsu, H., Okuno, T., Wang, X., Kataoka, S., Sekiya, Y., Hamada, M., Murakami, N., Kojima, D., Narita, K., Narita, A., Sakaguchi, H., Sakaguchi, K., Yoshida, N., Nishio, N., Hama, A., Takahashi, Y., Kudo, K., Kato, K., Kojima, S. J. Clin. Oncol. 34 (28): 3451-3459 (2016). 41313 27507882
Nonrandom Germline Transmission of Mouse Spermatogonial Stem Cells. Kanatsu-Shinohara, M., Naoki, H., Shinohara, T. Dev. Cell 38 (3): 248-261 (2016). 41312 27505415
A putative adenosine kinase family protein possesses adenosine diphosphatase activity. Tomoike, F., Tsunetou, A., Kim, K., Nakagawa, N., Kuramitsu, S., Masui, R. Biosci. Biotechnol. Biochem. 80 (11): 2138-2143 (2016). 41311 27484886
A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population. Kitagaki, J., Miyauchi, S., Asano, Y., Imai, A., Kawai, S., Michikami, I., Yamashita ,M., Yamada, S., Kitamura, M., Murakami, S. PLoS One 11 (8): e0160765 (2016). 41305 27509131
53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. Meitinger, F., Anzola, J.V., Kaulich, M., Richardson, A., Stender, J.D., Benner, C., Glass, C.K., Dowdy, S.F., Desai, A., Shiau, A.K., Oegema, K. J. Cell Biol. 214 (2): 155-166 (2016). 39660 27432897
Microinjection-based generation of mutant mice with a double mutation and a 0.5 Mb deletion in their genome by the CRISPR/Cas9 system. Hara, S., Kato, T., Goto, Y., Kubota, S., Tamano, M., Terao, M., Takada, S. J. Reprod. Dev. 62 (5): 531-536 (2016). 39659 27396308
High-speed atomic force microscopy reveals strongly polarized movement of clostridial collagenase along collagen fibrils. Watanabe-Nakayama, T., Itami, M., Kodera, N., Ando, T., Konno, H. Sci. Rep. 6: 28975 (2016). 39658 27373458
Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer. Kuo, K.K., Lee, K.T., Chen, K.K., Yang, Y.H., Lin, Y.C., Tsai, M.H., Wuputra, K., Lee, Y.L., Ku, C.C., Miyoshi, H., Nakamura, Y., Saito, S., Wu, C.C., Chai, C.Y., Eckner, R., Steve Lin, C.L., Wang, S.S., Wu, D.C., Lin, C.S., Yokoyama, K.K. Stem Cells 34 (11): 2613-2624 (2016). 39657 27341307
Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma. Lu, F., Zheng, Y., Donkor, P.O., Zou, P., Mu, P. Oncol. Res. 24 (3): 171-179 (2016). 39656 27458098
In vitro synthesis of polyhydroxyalkanoates using thermostable acetyl-CoA synthetase, CoA transferase, and PHA synthase from thermotorelant bacteria. Tajima, K., Han, X., Hashimoto, Y., Satoh, Y., Satoh, T., Taguchi, S. J. Biosci. Bioeng. pii: S1389-1723 (16) 30121-30129 (2016). 39655 27342638
Structural basis for amino acid export by DMT superfamily transporter YddG. Tsuchiya, H., Doki, S., Takemoto, M., Ikuta, T., Higuchi, T., Fukui, K., Usuda, Y., Tabuchi, E., Nagatoishi, S., Tsumoto, K., Nishizawa, T., Ito, K., Dohmae, N., Ishitani, R., Nureki, O. Nature 534 (7607): 417-420 (2016). 39654 27281193
Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes. Ohta, S., Montano-Gutierrez, L.F., Alves, F.L., Ogawa, H., Toramoto, I., Sato, N., Morrison, C.G., Takeda, S., Hudson, D.F., Rappsilber, J., Earnshaw, W.C. Mol. Cell. Proteomics. pii: mcp.M116.057885 (2016).user report 36994 27231315
Novel method for the high-throughput production of phosphorylation site-specific monoclonal antibodies. Kurosawa, N., Wakata, Y., Inobe, T., Kitamura, H., Yoshioka, M., Matsuzawa, S., Kishi, Y., Isobe, M. Sci. Rep. 6: 25174 (2016). 36825 27125496
A genomic region transcribed into a long noncoding RNA interacts with the Prss42/Tessp-2 promoter in spermatocytes during mouse spermatogenesis, and its flanking sequences can function as enhancers. Yoneda, R., Satoh, Y., Yoshida, I., Kawamura, S., Kotani, T., Kimura, A.P. Mol. Reprod. Dev. 83 (6): 541-557 (2016). 36824 27111572
Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids. Kato, T., Yamashita, H., Misawa, T., Nishida, K., Kurihara, M., Tanaka, M., Demizu, Y., Oba, M. Bioorg. Med. Chem. pii: S0968-0896 (16) 30275-9 (2016). 36823 27132868
Generation of Large Numbers of Antigen-Expressing Human Dendritic Cells Using CD14-ML Technology. Imamura, Y., Haruta, M., Tomita, Y., Matsumura, K., Ikeda, T., Yuno, A., Hirayama, M., Nakayama, H., Mizuta, H., Nishimura, Y., Senju, S. PLoS One. 2016 Apr 6;11(4):e0152384 (2016). 36822 27050553
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress. Jegal, K.H., Ko, H.L., Park, S.M., Byun, S.H., Kang, K.W., Cho, I.J., Kim, S.C. Apoptosis 21 (5): 642-656 (2016). 36732 27015669
Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice. Shen, Y.H., Yang, F., Wang, H., Cai, Z.J., Xu, Y.P., Zhao, A., Su, Y., Zhang, G., Zhu, S.X. PLoS One. 11 (1): e0147173 (2016). 36054 26799485
LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling The Expression of a Novel Target Gene, HEYL. Hirano, K., Namihira, M. Stem Cells 34 (7): 1872-1882 (2016). 36050 27018646
A key role of PGC-1alpha transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts. Igarashi, J., Okamoto, R., Yamashita, T., Hashimoto, T., Karita, S., Nakai, K., Kubota, Y., Takata, M., Yamaguchi, F., Tokuda, M., Sakakibara, N., Tsukamoto, I., Konishi, R., Hirano, K. Physiol. Rep. 4 (6). pii: e12742 (2016). 36049 27033444
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency. Reddy, K., Cusack, C.L., Nnah, I.C., Khayati, K., Saqcena, C., Huynh, T.B., Noggle, S.A., Ballabio A., Dobrowolski, R. Cell Rep. 14 (9): 2166-2179 (2016). 36033 26923592
Inhibition of PA endonuclease activity of influenza virus RNA polymerase by Kampo medicines. Shirayama, R., Shoji, M., Sriwilaijaroen, N., Hiramatsu, H., Suzuki, Y., Kuzuhara, T. Drug Discov. Ther. 10 (2): 109-113 (2016). 36032 26902927
beta-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function. Teng, Y.N., Sheu, M.J., Hsieha, Y.W., Wang, R.Y., Chiang, Y.C., Hung, C.C. Phytomedicine 23 (3): 316-323, 2016. 36029 26969385
Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma. Ida, L., Yamaguchi, T., Yanagisawa, K., Kajino, T., Shimada, Y., Suzuki, M., Takahashi, T. Cancer Sci. 107 (2): 155-161 (2016). 36028 26661061
PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes. Sasamoto, Y., Hayashi, R., Park, S.J., Saito-Adachi, M., Suzuki, Y., Kawasaki, S., Quantock, A.J., Nakai, K., Tsujikawa, M., Nishida, K. Sci. Rep. 6: 20807, 2016. 35968 26899008
A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies. Kohda, M., Tokuzawa, Y., Kishita, Y., Nyuzuki, H., Moriyama, Y., Mizuno, Y., Hirata, T., Yatsuka, Y., Yamashita-Sugahara, Y., Nakachi, Y., Kato, H.,., Okuda, A., Tamaru, S., Borna, N.N., Banshoya, K., Aigaki, T., Sato-Miyata, Y., Ohnuma, K., Suzuki, T., Nagao, A., Maehata, H., Matsuda, F., Higasa, K., Nagasaki, M., Yasuda, J., Yamamoto, M., Fushimi, T., Shimura, M., Kaiho-Ichimoto, K., Harashima, H., Yamazaki, T., Mori, M., Murayama, K., Ohtake, A., Okazaki, Y. PLoS Genet. 12 (1): e1005679 (2016). 35951 26741492
MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-beta. Katsura, A., Suzuki, H.I., Ueno, T., Mihira, H., Yamazaki, T., Yasuda, T., Watabe, T., Mano, H., Yamada, Y., Miyazono, K. Genes Cells 21 (1): 99-116 35947 26663584
Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system. Fukuda, S., Nishida-Fukuda, H., Nanba, D., Nakashiro, K., Nakayama, H., Kubota, H., Higashiyama, S. Sci. Rep. 6: 20209 (2016). 35936 26831618
Cytokine-dependent activation of JAK-STAT pathway in Saccharomyces cerevisiae. Yoshimoto, N., Ikeda, Y., Tatematsu, K., Iijima, M., Nakai, T., Okajima, T., Tanizawa, K., Kuroda, S. Biotechnol. Bioeng. 113 (8): 1796-1804 (2016). 35935 26853220
Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma. Yachida, S., Wood, L.D., Suzuki, M., Takai, E., Totoki, Y., Kato, M., Luchini, C., Arai, Y., Nakamura, H., Hama, N., Elzawahry, A., Hosoda, F., Shirota, T., Morimoto, N., Hori, K., Funazaki, J., Tanaka, H., Morizane, C., Okusaka, T., Nara, S., Shimada, K., Hiraoka, N., Taniguchi, H., Higuchi, R., Oshima, M., Okano, K., Hirono, S., Mizuma, M., Arihiro, K., Yamamoto, M., Unno, M., Yamaue, H., Weiss, M.J., Wolfgang, CL., Furukawa, T., Nakagama, H., Vogelstein, B., Kiyono, T., Hruban, R.H., Shibata, T. Cancer Cell pii: S1535-6108 (15) 00476-6 (2016). 35776 26806338
Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells. Niwa, Y., Suzuki, T., Dohmae, N., Simizu, S. Mol. Biol. Cell 27 (5): 744-756 (2016). 35760 26764097
Transcription Factors and Medium Suitable for Initiating the Differentiation of Human Induced Pluripotent Stem Cells to the Hepatocyte Lineage. Tomizawa, M., Shinozaki, F., Motoyoshi, Y., Sugiyama, T., Yamamoto, S., Ishige, N. J. Cell. Biochem. 117 (9): 2001-2009 (2016). 35759 26773721
ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes. Yoshimi, K., Kunihiro, Y., Kaneko, T., Nagahora, H., Voigt, B., Mashimo, T. Nat. Commun. 7: 10431 (2016). 35757 26786405
Maternal IL-6 can cause T cell-mediated juvenile alopecia by non-scarring follicular dystrophy in mice. Smith, S.E., Maus, R.L., Davis, T.R., Sundberg, J.P., Gil, D., Schrum, A.G. Exp. Dermatol. 25 (3): 223-228 (2016). 35678 26660334
An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal. Salah, M., Nishimoto, Y., Kohno, S., Kondoh, A., Kitajima, S., Muranaka, H., Nishiuchi, T., Ibrahim, A., Yoshida, A., Takahashi, C. Mol. Carcinog. 55 (12): 1974-1989 (2016). 35466 26621780
Ligand-inducible dimeric antibody for selecting antibodies against a membrane protein based on mammalian cell proliferation. Miura, T., Nagamune, T., Kawahara, M. Biotechnol. Bioeng. 113 (5): 1113-1123 (2016). 34900 26479395


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2015年

Title Author Journal NBRP RRC ID PubMed PMID
3beta-hydroxysterol delta24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy. Saito, M., Takano, T., Nishimura, T., Kohara, M., Tsukiyama-Kohara, K. PLoS One 10 (4): e0124197 (2015). 57436 25875901
Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics. Naito, T., Takatsu, H., Miyano, R., Takada, N., Nakayama, K., Shin, H.W. J. Biol. Chem. 290 (24): 15004-15017 (2015). 54532 25947375
High-level production of (5S)-hydroxyhexane-2-one by two thermostable oxidoreductases in a whole-cell catalytic approach Diederichs, S., Linn, K., Luckgen, J., Klement, T., Grosch, J.-H., Honda, K., Ohtake, H., Buchs, J. J. Mol. Catalysis B: Enzymatic 121: 37?44 (2015) 53898  
A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5′-flanking region of rat cytochrome P450 (CYP) 3A1 gene. Gamou, T., Habano, W., Terashima, J., Ozawa, S. Drug Metab. Pharmacokinet. 30 (2): 188-97 (2015). 53896 25989892
Reconstitution of mitotic chromatids with a minimum set of purified factors. Shintomi, K., Takahashi, T.S., Hirano, T. Nat. Cell Biol. 17 (8): 1014-1023 (2015). 53895 26075356
Epigenetic Heterogeneity in HIV-1 Latency Establishment. Matsuda, Y., Kobayashi-Ishihara, M., Fujikawa, D., Ishida, T., Watanabe, T., Yamagishi, M. Sci. Rep. 5: 7701 (2015). 53152 25572573
Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase? Tanaka-Hayashi, A., Hayashi, S., Inoue, R., Ito, T., Konno, K., Yoshida, T., Watanabe, M., Yoshimura, T., Mori, H. Amino Acids 47 (1): 79-86 (2015). 48756 25287256
The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage. Tanaka, T., Kanatsu-Shinohara, M., Shinohara, T. J. Reprod. Dev. 61 (4): 305-316 (2015). 48550 25959802
The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development. Heng, J.I., Qu, Z., Ohtaka-Maruyama, C., Okado, H., Kasai, M., Castro, D., Guillemot, F., Tan, S.S. Cereb. Cortex 25 (3): 806-816 (2015). 48548 24084125
Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast. Hu, W., Suo, F., Du, L.L. Genome Biol. Evol. 7 (12): 3496-3510 (2015). 47475 26615217
CRISPR/Cas9-mediated reporter knock-in in mouse haploid embryonic stem cells. Kimura, Y., Oda, M., Nakatani, T., Sekita, Y., Monfort, A., Wutz, A., Mochizuki, H., Nakano, T. Sci. Rep. 5: 10710 (2015) 41306 26039937
Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced gammaH2AX accumulation. Nakatani, T., Yamagata, K., Kimura, T., Oda, M., Nakashima, H., Hori, M., Sekita, Y., Arakawa, T., Nakamura, T., Nakano, T. EMBO Rep. 16 (5): 582-9 (2015). 39501 25694116
Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Nakaguro, M., Kiyonari, S., Kishida, S., Cao, D., Murakami-Tonami, Y., Ichikawa, H., Takeuchi, I., Nakamura, S., Kadomatsu, K. Cancer Sci. 106 (3): 237-243 (2015). 36897 25557119
Synthetic lateral inhibition governs cell-type bifurcation with robust ratios. Matsuda, M., Koga, M., Woltjen, K., Nishida, E., Ebisuya, M. Nat. Commun. 6: 6195 (2015). 36055 25652697
Development of a new real-time PCR system for simultaneous detection of bacteria and fungi in pathological samples. Fukumoto, H., Sato, Y., Hasegawa, H., Saeki, H., Katano, H. Int. J. Clin. Exp. Pathol. 8 (11): 15479-15488 (2015). 35779 26823918
Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells. Shrestha, R., Tatsukawa, H., Shrestha, R., Ishibashi, N., Matsuura, T., Kagechika, H., Kose, S., Hitomi, K., Imamoto, N., Kojima, S. Cell Death Dis. 6: e2002 (2015). 35778 26633708
The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer. Kawano, M., Mabuchi, S., Matsumoto, Y., Sasano, T., Takahashi, R., Kuroda, H., Kozasa, K., Hashimoto, K., Isobe, A., Sawada, K., Hamasaki, T., Morii, E., Kimura, T. Sci. Rep. 5: 18217 (2015). 35671 26666576
TSC-22 up-regulates collagen 3a1 gene expression in the rat heart. Kelloniemi, A., Aro, J., Napankangas, J., Koivisto, E., Mustonen, E., Ruskoaho, H., Rysa, J. BMC Cardiovasc. Disord. 15 (1): 122 (2015). 34894 26464165
Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma. Neri, S., Ishii, G., Hashimoto, H., Kuwata, T., Nagai, K., Date, H., Ochiai, A. Int. J. Cancer. 137 (4): 784-796 (2015). 34846 25648219
Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis. Watanabe, Y., Kazuki, Y., Kazuki, K., Ebiki, M., Nakanishi, M., Nakamura, K., Yoshida Yamakawa, M., Hosokawa, H., Ohbayashi, T., Oshimura, M., Nakashima, K. Mol. Ther. Nucleic Acids. 4: e253 (2015). 34813 26440597
In vitro dihydrouridine formation by tRNA dihydrouridine synthase from Thermus thermophilus, an extreme-thermophilic eubacterium. Kusuba, H., Yoshida, T., Iwasaki, E., Awai, T., Kazayama, A., Hirata, A., Tomikawa, C., Yamagami, R., Hori, H. J. Biochem. 158 (6): 513-521 (2015). 34797 26112661
Histone H3 lysine 36 tri-methylation is established over the Xist promoter by antisense Tsix transcription and contributes to repressing Xist expression. Ohhata, T., Matsumoto, M., Leeb, M., Shibata, S., Sakai, S., Kitagawa, K., Niida, H., Kitagawa, M., Wutz, A. Mol. Cell. Biol. 35 (22): 3909-3920 (2015). 34791 26370508
New type of encephalomyelitis responsive to trimethoprim/sulfamethoxazole treatment in Japan. Sakiyama, Y., Kanda, N., Higuchi, Y., Yoshimura, M., Wakaguri, H., Takata, Y., Watanabe, O., Yuan, J., Tashiro, Y., Saigo, R., Nozuma, S., Yoshimura, A., Arishima, S., Ikeda, K., Shinohara, K., Arata, H., Michizono, K., Higashi, K., Hashiguchi, A., Okamoto, Y., Hirano, R., Shiraishi, T., Matsuura, E., Okubo, R., Higuchi, I., Goto, M., Hirano, H., Sano, A., Iwasaki, T., Matsuda, F., Izumo, S., Takashima, H. Neurol. Neuroimmunol. Neuroinflamm. 2 (5): e143 (2015). 34739 26309903
NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells. Hayashi, Y., Osanai, M., Lee, G.H. Oncol. Rep. 34, 1650-1658 (2015). 34560 26252838
Actin Migration Driven by Directional Assembly and Disassembly of Membrane-Anchored Actin Filaments. Katsuno, H., Toriyama, M., Hosokawa, Y., Mizuno, K., Ikeda, K., Sakumura, Y., Inagaki, N. Cell Rep. 12 (4): 648-660 (2015). 34526 26190109
Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction. Sawamura, N., Wakabayashi, S., Matsumoto, K., Yamada, H., Asahi, T. Biochem Biophys Res Commun. 2015 Jul 15. pii: S0006-291X(15)30298-9 34525 26188093
Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK. Fukuda, M., Takeda, H., Kato, H.E., Doki, S., Ito, K., Maturana, A.D., Ishitani, R., Nureki, O. Nat. Commun. 6: 7097 (2015). 34495 25959928
A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells. Saeki, N., Komatsuzaki, R., Chiwaki, F., Yanagihara, K., Sasaki, H. BMC Cancer 15: 439 (2015). 33974 26016667
Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression. Suzuki, E., Kajita, S., Takahashi, H., Matsumoto, T., Tsuruta, T., Saegusa, M. Lab. Invest. 95 (8): 962-972 (2015). 33973 26030369
Functional role of the C-terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA. Imai, H., Miyoshi, T., Murakami, R., Ito, K., Ishino, Y., Uchiumi, T. Genes Cells 20 (7): 613-624 (2015). 33972 26033302
A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors. Fujikawa, Y., Morisaki, F., Ogura, A., Morohashi, K., Enya, S., Niwa, R., Goto, S., Kojima, H., Okabe, T., Nagano, T., Inoue, H. Chem. Commun. (Camb). 51 (57): 11459-11462 (2015). 33971 26090533
Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition. Olson, L.J., Orsi, R., Peterson, F.C., Parodi, A.J., Kim, J.P., D’Alessio, C., Dahms, N.M. Biochemistry 54 (26): 4097-4111 (2015). 33947 26062005
Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides. Oba, M., Demizu, Y., Yamashita, H., Kurihara, M., Tanaka, M. Bioorg. Med. Chem. 23 (15): 4911-4918 (2015). 33725 26048025
Construction of CoA-dependent 1-butanol synthetic pathway functions under aerobic conditions in Escherichia coli. Kataoka, N., Vangnai, A.S., Pongtharangkul, T., Tajima, T., Yakushi, T., Matsushita, K., Kato, J. J. Biotechnol. 204: 25-32 (2015). 33708 25865277
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Iashikawa, K., Nakada, K., Soda, M., Mano, H., Togayachi, S., Miyoshi, H., Okita, K., Hayashi, J. Sci. Rep. 5: 10434 (2015). 33706 26000717
Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8. Miyazaki, T., Ichikawa, M., Iino, H., Nishikawa, A., Tonozuka, T. J. Struct. Biol. 190 (1): 21-30 (2015). 33603 25712767
Activation of NF-κB by Human Papillomavirus 16 E1 Limits E1-Dependent Viral Replication through Degradation of E1. Nakahara, T., Tanaka, K., Ohno, S., Egawa, N., Yugawa, T., Kiyono, T. J. Virol. 89 (9): 5040-5059 (2015). 33214 25717108
Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta. Yamaguchi, J., Tanaka, T., Eto, N., Nangaku, M. Kidney Int. 88 (2): 262-275 (2015). 33213 25692954
A Naturally Occurring Null Variant of the NMDA Type Glutamate Receptor NR3B Subunit Is a Risk Factor of Schizophrenia. Matsuno, H., Ohi, K., Hashimoto, R., Yamamori, H., Yasuda, Y., Fujimoto, M., Yano-Umeda, S., Saneyoshi, T., Takeda, M., Hayashi, Y. PLoS One 10 (3): e0116319 (2015). 33180 25768306
Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes. Hasan, A.U., Ohmori, K., Konishi, K., Igarashi, J., Hashimoto, T., Kamitori, K., Yamaguchi, F., Tsukamoto, I., Uyama, T., Ishihara, Y., Noma, T., Tokuda, M., Kohno, M. Mol. Cell. Endocrinol. 406:10-18 (2015). 32799 25697344
Chromatin remodelling and autocrine TNF alpha are required for optimal interleukin-6 expression in activated human neutrophils. Zimmermann, M., Aguilera, F.B., Castellucci, M., Rossato, M., Costa, S., Lunardi, C., Ostuni, R., Girolomoni, G., Natoli, G., Bazzoni, F., Tamassia, N., Cassatella, M.A. Nat. Commun. 6: 6061 (2015). 32716 25616107
The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Epting, D., Slanchev, K., Boehlke, C., Hoff, S., Loges, N.T., Yasunaga, T., Indorf, L., Nestel, S., Lienkamp, S.S., Omran, H., Kuehn, E.W., Ronneberger, O., Walz, G., Kramer-Zucker, A. Development 42 (1): 174-184 (2015). 32637 25516973
IL-33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells. Hashiguchi, M., Kashiwakura, Y., Kojima, H., Kobayashi, A., Kanno, Y., Kobata, T. Eur J Immunol. 2015 32636 25504587
Paired related homeobox 1 is associated with the invasive properties of glioblastoma cells. Sugiyama, M., Hasegawa, H., Ito, S., Sugiyama, K., Maeda, M., Aoki, K., Wakabayashi, T., Hamaguchi, M., Natsume, A., Senga, T. Oncol. Rep. 33 (3): 1123-1130 (2015). 32635 25522823
Demethoxycurcumin Modulates Human P-Glycoprotein Function via Uncompetitive Inhibition of ATPase Hydrolysis Activity. Teng, Y.N., Hsieh, Y.W., Hung, C.C., Lin, H.Y. J. Agric. Food Chem. 63 (3): 847-855 (2015). 32575 25594233
Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels. Lorenzi, L.E., Bah, A., Wischnewski, H., Shchepachev, V., Soneson, C., Santagostino, M., Azzalin, C.M.. EMBO J. 34 (1): 115-129 (2015). 32213 25398909
Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter. Lee, Y., Nishizawa, T., Yamashita, K., Ishitani, R., Nureki, O. Nat. Commun. 6: 6112 (2015). 32211 25598322
Rapid Evaluation of Tyrosine Kinase Activity of Membrane-Integrated Human Epidermal Growth Factor Receptor Using the Yeast G gamma Recruitment System. Fukuda, N., Honda, S. ACS Synth. Biol. 4 (4): 421-429 (2015). 31880 25006755
Cabozantinib reverses multidrug resistance of human hepatoma HepG2/adr cells by modulating the function of P-glycoprotein. Xiang, Q.F., Zhang, D.M., Wang, J.N., Zhang, H.W., Zheng, Z.Y., Yu, D.C., Li, Y.J., Xu, J., Chen, Y.J., Shang, C.Z. Liver Int. 35 (3): 1010-1023 (2015). 31701 24621440
YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation. Pennati, M., Sbarra, S., De Cesare, M., Lopergolo, A., Locatelli, S.L., Campi, E., Daidone, M.G., Carlo-Stella, C., Gianni, A.M., Zaffaroni, N. Int. J. Cancer 136 (2): 299-309 (2015). 30914 24866585


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2014年

Title Author Journal NBRP RRC ID PubMed PMID
CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint. Hirokawa, T., Shiotani, B., Shimada, M., Murata, K., Johmura, Y., Haruta, M., Tahara, H., Takeyama, H., Nakanishi, M. Cancer Res. 74 (14): 3880-3889 (2014). 56567 24876101
A candidate enhancer element responsible for high-level expression of the aggrecan gene in chondrocytes. Ikeda, Y., Ito, K., Izumi, Y., Shinomura, T. J. Biochem. 156 (1): 21-28 (2014). 53897 24554731
Oxidative stress-induced JNK1 phosphorylation inhibits hedgehog signalling and osteoblast differentiation. Shiohama, T., Fujii, K., Uchikawa, H., Takatani, T., Mizuochi, H., Kohno, Y. Cell Biol. Int. Rep. 21 (2); 53-62 (2014). 50052  
Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. Yamaguchi, S., Marumoto, T., Nii, T., Kawano, H., Liao, J., Nagai, Y., Okada, M., Takahashi, A., Inoue, H., Sasaki, E., Fujii, H., Okano, S., Ebise, H., Sato, T., Suyama, M., Okano, H., Miura, Y., Tani, K. Cancer Sci. 105 (4): 402-408 (2014). 48012 24521492
Application of a phosphite dehydrogenase gene as a novel dominant selection marker for yeasts. Kanda, K., Ishida, T., Hirota, R., Ono, S., Motomura, K., Ikeda, T., Kitamura, K., Kuroda, A. J. Biotechnol. 182-183: 68-73 (2014). 47472 24786825
Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2. Zhang, J.M., Liu, X.M., Ding, Y.H., Xiong, L.Y., Ren, J.Y., Zhou, Z.X., Wang, H.T., Zhang, M.J., Yu, Y., Dong, M.Q., Du, L.L. PLoS Biol. 12 (9): e1001946 (2014). 47466 25203555
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K., Shin, H.W. J. Biol. Chem. 289 (48): 33543-33556 (2014). 47459 25315773
Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A. Igarashi, H., Hirano, H., Yahagi, A., Saika, T., Ishihara, K. Clin. Immunol. 150 (1): 12-21 (2014). 36027 24316591
Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature. Mabuchi, S., Matsumoto, Y., Kawano, M., Minami, K., Seo, Y., Sasano, T., Takahashi, R., Kuroda, H., Hisamatsu, T., Kakigano, A., Hayashi, M., Sawada, K., Hamasaki, T., Morii, E., Kurachi, H., Matsuura, N., Kimura, T. J. Natl. Cancer Inst. 106 (7). pii: dju147 (2014). 35670 24948742
Survivin-responsive conditionally replicating adenovirus kills rhabdomyosarcoma stem cells more efficiently than their progeny. Tanoue, K., Wang, Y., Ikeda, M., Mitsui, K., Irie, R., Setoguchi, T., Komiya, S., Natsugoe, S., Kosai, K. J. Transl. Med. 12: 27 (2014). 34498 24467821
Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors. Dirisala, A., Osada, K., Chen, Q., Tockary, T.A., Machitani, K., Osawa, S., Liu, X., Ishii, T., Miyata, K., Oba, M., Uchida, S., Itaka, K., Kataoka, K. Biomaterials, 35 (20): 5359-5368 (2014). 33958 24720877
Phenotyping the quality of complex medium components by simple online-monitored shake flask experiments. Diederichs, S., Korona, A., Staaden, A., Kroutil, W., Honda, K., Ohtake, H., Buchs, J. Microb. Cell Fact. 13 (1): 149 (2014). 33604 25376163
Stimulation of melanogenesis by nordihydroguaiaretic Acid in human melanoma cells. Takekoshi, S., Nagata, H., Kitatani, K. Acta Histochem. Cytochem. 47 (5): 203-210 (2014). 33085 25861126
Dbx1 triggers crucial molecular programs required for midline crossing by midbrain commissural axons. Inamata, Y., Shirasaki, R. Development 141 (6): 1260-1271 (2014). 32639 24553291
A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA. Kurihara, M., Shiraishi, A., Satake, H., Kimura, A.P. J. Mol. Biol., 426 (17): 3069-3093 (2014). 32638 25020229
Geranium dielsianum extract powder (MISKAMISKATM) improves the intestinal environment through alteration of microbiota and microbial metabolites in rats. Ikeda, T., Tanaka, Y., Yamamoto, K., Morii, H., Kamisako, T., Ogawa, H. J. Funct. Foods, 11: 12-19 (2014). 32604  
Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-alpha, iNOS and Cox-2 mRNA expression and blocks NF-kappaB promoter activity in murine macrophages. Yamada, H., Kikuchi, S., Inui, T., Takahashi, H., Kimura, K. PLoS One 9 (11): e113834 (2014). 32576 25423092
Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. Furukawa, N., Miyanaga, A., Togawa, M., Nakajima, M., Taguchi, H. AMB Express 4: 76 (2014). 32212 25401076
Crystallization and preliminary X-ray crystallographic analysis of YfcM: an important factor for EF-P hydroxylation. Kobayashi, K., Suzuki, T., Dohmae, N., Ishitani, R., Nureki, O. Acta Crystallogr. F Struct. Biol. Commun. 70 (Pt 9): 1236-1239 (2014). 31850 25195899
Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation. Takanashi, K., Yamaguchi, A. Biochem. Biophys. Res. Commun. 452 (3): 600-607 (2014). 31849 25173930
Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2. Takamatsu, K., Ikeda, T., Haruta, M., Matsumura, K., Ogi, Y., Nakagata, N., Uchino, M., Ando, Y., Nishimura, Y., Senju, S. Stem Cell Res. 13 (3PA): 442-453 (2014). 31847 25460605
ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation. Kojima, K., Amano, Y., Yoshino, K., Tanaka, N., Sugamura, K., Takeshita, T. J. Biol. Chem. 289 (48): 33296-33310 (2014). 31846 25296754
A novel transgenic mouse model carrying human Tribbles related protein 3 (TRB3) gene and its site specific phenotype. Sakai, Y., Fukamachi, K., Futakuchi, M., Miyoshi, I., Tsuda, H., Suzui, M., Hayashi, H. Biol. Pharm. Bull., 37 (6): 1068-1074 (2014). 31844 24882419
Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal. Kanatsu-Shinohara, M., Onoyama, I., Nakayama, K.I., Shinohara, T. Proc. Natl. Acad. Sci. U.S.A., 111 (24): 8826-8831 (2014). 31843 24879440
In vitro and in vivo effects of xanthorrhizol on human breast cancer MCF-7 cells treated with tamoxifen. Noomhorm, N., Chang, C.J., Wen, C.S., Wang, J.Y., Chen, J.L., Tseng, L.M., Chen, W.S., Chiu, J.H., Shyr, Y.M. J. Pharmacol. Sci. 125 (4): 375-385 (2014). 31694 25141924
VPS35 dysfunction impairs lysosomal degradation of alpha-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson’s disease. Miura, E., Hasegawa, T., Konno, M., Suzuki, M., Sugeno, N., Fujikake, N., Geisler, S., Tabuchi, M., Oshima, R., Kikuchi, A., Baba, T., Wada, K., Nagai, Y., Takeda, A., Aoki, M. Neurobiol. Dis. 71: 1-13 (2014). 31693 25107340
Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation. Huang, L., Zhang, S.M., Zhang, P., Zhang, X.J., Zhu, L.H., Chen, K., Gao, L., Zhang, Y., Kong, X.J., Tian, S., Zhang, X.D., Li, H. J. Am. Heart Assoc. 3 (5). pii: e001309 (2014). 31692 25304854
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Gospodaryov, D.V., Lushchak, O.V., Rovenko, B.M., Perkhulyn, N.V., Gerards, M., Tuomela, T., Jacobs, H.T. Biochim. Biophys. Acta. -Bioenergetics 1837 (11): 1861-1869 (2014). 31030 25124484
Phylobiochemical characterization of class-ib aspartate/prephenate aminotransferases reveals evolution of the plant arogenate phenylalanine pathway. Dornfeld, C., Weisberg, A.J., K.C.Ritesh, Dudareva, N., Jelesko, J.G., Maeda, H.A. Plant Cell 26 (7): 3101-3114 (2014). 31029 25070637
Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett’s metaplasia. Wang, D.H., Tiwari, A., Kim, M.E., Clemons, N.J., Regmi, N.L., Hodges, W.A., Berman, D.M., Montgomery, E.A., Watkins, D.N., Zhang, X., Zhang, Q., Jie, C., Spechler, S.J., Souza, R.F. J. Clin. Invest. 124 (9): 3767-80 (2014). 31028 25083987
Identification of a protein glycosylation operon from Campylobacter jejuni JCM 2013 and its heterologous expression in Escherichia coli. Srichaisupakit, A., Ohashi, T., Fujiyama, K. J. Biosci. Bioeng. 118 (3): 256-262 (2014). 30956 24650731
The role of Pak-interacting exchange facto-beta phosphorylation at serines 340 and 583 by PKC gamma in dopamine release. Shirafuji, T., Ueyama, T., Yoshino, K., Takahashi, H., Adachi, N., Ago, Y., Koda, K., Nashida, T., Hiramatsu, N., Matsuda, T., Toda, T., Sakai, N., Saito, N. J. Neurosci., 34 (28): 9268-9280 (2014). 30930 25009260
Crystallization and preliminary X-ray diffraction analysis of YidC, a membrane-protein chaperone and insertase from Bacillus halodurans. Kumazaki, K., Tsukazaki, T., Nishizawa, T., Tanaka, Y., Kato, H.E., Nakada-Nakura, Y., Hirata, K., Mori, Y., Suga, H., Dohmae, N., Ishitani, R., Nureki, O. Acta Crystallogr. F. Struct. Biol. Commun., 70 (Pt 8): 1056-1060 (2014). 30929 25084381
Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. Gur, I., Fujiwara, K., Hasegawa, K., Yoshikawa, K. PLoS One, 9 (6): e99503 (2014). 30917 24911587
Cancer cell specific cytotoxic gene expression mediated by ARF tumor suppressor promoter constructs. Kurayoshi, K., Ozono, E., Iwanaga, R., Bradford, A.P., Komori, H., Ohtani, K. Biochem. Biophys. Res. Commun., 450 (1): 240-246 (2014). 30915 24893334
Screening to identify commonly used chinese herbs that affect ERBB2 and ESR1 gene expression using the human breast cancer MCF-7 cell line. Chiu, J.H., Chang, C.J., Wu, J.C., Liu, H.J., Wen, C.S., Hsu, C.H., Chen, J.L., Tseng, L.M., Chen, W.S., Shyr, Y.M. Evid. Based Complement. Alternat. Med., 965486 (2014). 30913 24987437
Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain. Kato, M., Okanoya, K., Koike, T., Sasaki, E., Okano, H., Watanabe, S., Iriki, A. Brain Lang., 133: 26-38 (2014). 30904 24769279
Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Kawaue, T., Sagou, K., Kiyonari, H., Ota, K., Okamoto, M., Shinoda, T., Kawaguchi, A., Miyata, T. Dev. Growth Differ., 56 (4): 293-304 (2014). 30726 24712911
A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. Matsumoto, S., Fujii, S., Sato, A., Ibuka, S., Kagawa, Y., Ishii, M., Kikuchi, A. EMBO J., 33 (7): 702-718 (2014). 30725 24562386
Structural basis of Sec-independent membrane protein insertion by YidC. Kumazaki, K., Chiba, S., Takemoto, M., Furukawa, A., Nishiyama, K., Sugano, Y., Mori, T., Dohmae, N., Hirata, K., Nakada-Nakura, Y., Maturana, A.D., Tanaka, Y., Mori, H., Sugita, Y., Arisaka, F., Ito, K., Ishitani, R., Tsukazaki, T., Nureki, O. Nature, 509 (7501): 516-520 (2014). 30718 24739968
High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system. Yoshimoto, N., Tatematsu, K., Iijima, M., Niimi, T., Maturana, A.D., Fujii, I., Kondo, A., Tanizawa, K., Kuroda, S. Sci Rep., 4: 4242 (2014). 30717 24577528
Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkc delta. Suzuki, S., Franchi, L., He, Y., Munoz-Planillo, R., Mimuro, H., Suzuki, T., Sasakawa, C., Nunez, G. PLoS Pathog., 10 (2): e1003926 (2014). 30716 24516390
Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors. Ge, Z., Chen, Q., Osada, K., Liu, X., Tockary, T.A., Uchida, S., Dirisala, A., Ishii, T., Nomoto, T., Toh, K., Matsumoto, Y., Oba, M., Kano, M.R., Itaka, K., Kataoka, K. Biomaterials, 35 (10): 3416-3426 (2014). 30715 24439417
Crystallization and preliminary X-ray diffraction studies of a surface mutant of the middle domain of PB2 from human influenza A (H1N1) virus. Tsurumura, T., Qiu, H., Yoshida, T., Tsumori, Y., Tsuge, H. Acta. Crystallogr. F Struct. Biol. Commun., 70 (Pt 1): 72-75 (2014). 30714 24419622
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. Nagao, T., Kurosu, T., Umezawa, Y., Nogami, A., Oshikawa, G., Tohda, S., Yamamoto, M., Miura, O. PLoS One, 9 (1): e84746 (2014). 30713 24404189
Bovine induced pluripotent stem cells are more resistant to apoptosis than testicular cells in response to mono-(2-ethylhexyl) phthalate. Lin, Y.C., Kuo, K.K., Wuputra, K., Lin, S.H., Ku, C.C., Yang, Y.H., Wang, S.W., Wang, S.W., Wu, D.C., Wu, C.C., Chai, C.Y., Lin, C.L., Lin, C.S., Kajitani, M., Miyoshi, H., Nakamura, Y., Hashimoto, S., Matsushima, K., Jin, C., Huang, S.K., Saito, S., Yokoyama, K.K. Int. J. Mol. Sci., 15 (3): 5011-5031 (2014). 30711 24658443
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nagashima, H., Okuyama, Y., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N., So, T. Nat. Immunol., 15 (5): 449-456 (2014). 30710 24681564
The functional influences of common ABCB1 genetic variants on the inhibition of P-glycoprotein by Antrodia cinnamomea extracts. Sheu, M.J., Teng, Y.N., Chen, Y.Y., Hung, C.C. PLoS One, 9 (2):e89622 (2014). 30487 24586917
RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe. Smialowska, A., Djupedal, I., Wang, J., Kylsten, P., Swoboda, P., Ekwall, K. Biochem. Biophys. Res. Commun., 444 (2): 254-259 (2014). 28693 24462781
Mental retardation-related protease, motopsin (prss12), binds to the BRICHOS domain of the integral membrane protein 2a. Mitsui, S., Osako, Y., Yuri, K. Cell Biol. Int., 38 (1): 117-123 (2014). 28604 23955961
Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ. Kogure, H., Handa, Y., Nagata, M., Kanai, N., Guntert, P., Kubota, K., Nameki, N. Nucleic Acids Res., 42 (5):3152-3163 (2014). 28464 24322300


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2013年

Title Author Journal NBRP RRC ID PubMed PMID
Methods to study the proliferation and differentiation of cardiac side population (CSP) cells. Sereti, K.I., Oikonomopoulos, A., Unno, K., Liao, R. Methods Mol. Biol. 1036: 95-106 (2013). 57375 23807790
Establishment of a reporter system to monitor silencing status in induced pluripotent stem cell lines. Donai, K., Kuroda, K., Guo, Y., So, K.H., Sone, H., Kobayashi, M., Nishimori, K., Fukuda, T. Anal. Biochem. 443 (1): 104-112 (2013). 54548 23973628
Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice. Kobayashi, Y., Sano, Y., Vannoni, E., Goto, H., Suzuki, H., Oba, A., Kawasaki, H., Kanba, S., Lipp, H.P., Murphy, N.P., Wolfer, D.P., Itohara, S. Front. Behav. Neurosci. 7: 17 (2013). 49492 23487260
Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A. Miwa, D., Sakaue, T., Inoue, H., Takemori, N., Kurokawa, M., Fukuda, S., Omi, K., Goishi, K., Higashiyama, S. Angiogenesis, 6 (3): 675-688 (2013). 48812 23515950
Spatiotemporal visualization of proHB-EGF ectodomain shedding in living cells. Inoue, H., Sakaue, T., Ozawa, T., Higashiyama, S. J. Biochem., 154 (1): 67-76 (2013). 48811 23598347
Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism. Richard, E.M., Thiyagarajan, T., Bunni, M.A., Basher, F., Roddy, P.O., Siskind, L.J., Nietert, P.J., Nowling, T.K. PLoS One, 8 (9): e75175 (2013). 48755 24040398
Microglia activation precedes the anti-opioid BDNF and NMDA receptor mechanisms underlying morphine analgesic tolerance. Matsushita, Y., Omotuyi, I.O., Mukae, T., Ueda, H. Curr. Pharm. Des. 19 (42): 7355-7361 (2013). 48549 23448475
Global analysis of fission yeast mating genes reveals new autophagy factors. Sun, L.L., Li, M., Suo, F., Liu, X.M., Shen, E.Z., Yang, B., Dong, M.Q., He, W.Z., Du, L.L. PLoS Genet. 9 (8): e1003715 (2013). 47467 23950735
Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor. Bamunusinghe, D., Liu, Q., Lu, X., Oler, A., Kozak, C.A. J. Virol. 87 (17): 9845-9855 (2013). 46505 23824809
Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion. Ylivinkka, I., Hu, Y., Chen, P., Rantanen, V., Hautaniemi, S., Nyman, T.A., Keski-Oja, J., Hyytiainen, M. J. Cell Sci. 126 (Pt 11): 2459-2469 (2013). 35154 23549787
Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo. Kagawa, Y., Matsumoto, S., Kamioka, Y., Mimori, K., Naito, Y., Ishii, T., Okuzaki, D., Nishida, N., Maeda, S., Naito, A., Kikuta, J., Nishikawa, K., Nishimura, J., Haraguchi, N., Takemasa, I., Mizushima, T., Ikeda, M., Yamamoto, H., Sekimoto, M., Ishii, H., Doki, Y., Matsuda, M., Kikuchi, A., Mori, M., Ishii, M. PLoS One, 8 (12): e83629 (2013). 34743 24386239
Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria. Dujeancourt, L., Richter, R., Chrzanowska-Lightowlers, Z.M., Bonnefoy, N., Herbert, C.J. Mitochondrion 13 (6): 871-880 (2013). 33953 23892058
Concerted Action of the Ubiquitin-Fusion Degradation Protein 1 (Ufd1) and Sumo-Targeted Ubiquitin Ligases (STUbLs) in the DNA-Damage Response. Koehler, J.B., Jorgensen, M.L., Beinoraite, G., Thorsen, M., Thon, G. PLoS One, 8 (11): e80442 (2013). 33606 24265825
Two portable recombination enhancers direct donor choice in fission yeast heterochromatin. Jakociunas, T., Holm, L.R., Verhein-Hansen, J., Trusina, A., Thon, G. PLoS Genet., 9 (10): e1003762 (2013). 33605 24204285
Evidence for DNA cleavage caused directly by a transfer RNA-targeting toxin. Shigematsu, M., Ogawa, T., Tanaka, W., Takahashi, K., Kitamoto, H.K., Hidaka, M., Masaki, H. PLoS One. 8 (9): e75512 (2013). 31988 24069426
Death signalobody: inducing conditional cell death in response to a specific antigen. Tone, Y., Kawahara, M., Kawaguchi, D., Ueda, H., Nagamune, T. Hum. Gene Ther. Methods 24 (3):141-150 (2013). 31881 23470213
Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse. Lilue, J., Muller, U.B., Steinfeldt, T., Howard, J.C. Elife, 2: e01298 (2013). 30721 24175088
Involvement of a di-leucine motif in targeting of ABCC1 to the basolateral plasma membrane of polarized epithelial cells. Emi, Y., Harada, Y., Sakaguchi, M. Biochem. Biophys. Res. Commun., 441 (1): 89-95 (2013). 30720 24129190
Enhanced Antitumor Efficacy of Integrin-targeted Oncolytic Adenovirus AxdAdB3-F/RGD on Bladder Cancer. Wang, H., Cai, Z., Yang, F., Luo, J., Satoh, M., Arai, Y., Li, D. Urology, pii: S0090-4295(13) 01369-1 (2013). 30712 24315309
Diacylglycerol kinases terminate diacylglycerol signalling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. Schlam, D., Bohdanowicz, M., Chatgilialoglu, A., Steinberg, B.E., Ueyama, T., Du, G., Grinstein, S., Fairn, G.D. J. Biol. Chem., 288 (32): 23090-23104 (2013). 30709 23814057
Generation of a large number of functional dendritic cells from human monocytes expanded by forced expression of cMYC plus BMI1. Haruta, M., Tomita, Y., Imamura, Y., Matsumura, K., Ikeda, T., Takamatsu, K., Nishimura, Y., Senju, S. Hum. Immunol., 74 (10): 1400-1408 (2013). 30708 23811433
MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner. Shimada, A., Kawasoe, Y., Hata, Y., Takahashi, T.S., Masui, R., Kuramitsu, S., Fukui, K. FEBS J., 280 (14): 3467-3479 (2013). 30705 23679952
Conservation of two distinct types of 100S ribosome in bacteria. Ueta, M., Wada, C., Daifuku, T., Sako, Y., Bessho, Y., Kitamura, A., Ohniwa, R.L., Morikawa, K., Yoshida, H., Kato, T., Miyata, T., Namba, K., Wada, A. Genes Cells, 18 (7): 554-574 (2013). 30704 23663662
A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks. Yu, Y., Ren, J.Y., Zhang, J.M., Suo, F., Fang, X.F., Wu, F., Du, L.L. DNA Repair (Amst)., 12 (6): 433-443 (2013). 30703 23628481
Production of uroporphyrinogen III, which is the common precursor of all tetrapyrrole cofactors, from 5-aminolevulinic acid by Escherichia coli expressing thermostable enzymes. Hibino, A., Petri, R., Buchs, J., Ohtake, H. Appl. Microbiol. Biotechnol., 97 (16): 7337-7344 (2013). 30702 23604563
WDR81 is necessary for purkinje and photoreceptor cell survival. Traka, M., Millen, K.J., Collins, D., Elbaz, B., Kidd, G.J., Gomez, C.M., Popko, B. J. Neurosci., 33 (16): 6834-6844 (2013). 30700 23595742
Unique substrate specificity of purine nucleoside phosphorylases from Thermus thermophilus. Tomoike, F., Kuramitsu, S., Masui, R. Extremophiles, 17 (3): 505-514 (2013). 30698 23546840
Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros. Zhang, B., Romaker, D., Ferrell, N., Wessely, O. Dev. Biol., 376(1): 31-42 (2013). 30695 23352791
Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. Oppikofer, M., Kueng, S., Keusch, J.J., Hassler, M., Ladurner, A.G., Gut, H., Gasser, S.M. EMBO J. 32 (3): 437-449 (2013). 30694 23299941
Direct observation of cell cycle progression in living mouse embryonic stem cells on an extracellular matrix of E-cadherin. Jovic, D., Sakaue-Sawano, A., Abe, T., Cho, C.C., Nagaoka, N., Miyawaki, A., Akaike, T. SpringerPlus, 2: 585 (2013). 30692 25674414
Structure of the lectin mannose 6-phosphate receptor homology (MRH) domain of glucosidase II, an enzyme that regulates glycoprotein folding quality control in the endoplasmic reticulum. Olson, L.J., Orsi, R., Alculumbre, S.G., Peterson, F.C., Stigliano, I.D., Parodi, A.J., D’Alessio, C., Dahms, N.M. J. Biol Chem. ;288 (23): 16460-16475 (2013). 30216 23609449
A macrocyclic peptide that serves as a cocrystallization ligand and inhibits the function of a MATE family transporter. Hipolito, C.J., Tanaka, Y., Katoh, T., Nureki, O., Suga, H. Molecules, 18 (9): 10514-10530 (2013). 29446 23999725
An archaeal homolog of proteasome assembly factor functions as a proteasome activator. Kumoi, K., Satoh, T., Murata, K., Hiromoto, T., Mizushima, T., Kamiya, Y., Noda, M., Uchiyama, S., Yagi, H., Kato, K. PLoS One, 8 (3): e60294 (2013). 29299 23555947
Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8. Matsumoto, A., Shimizu, Y., Takemoto, C., Ueda, T., Uchiumi, T., Ito, K. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 69 (Pt 3): 332-335 29291 23519816
Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat. Atanur, S.S. et al. Cell 154 (3): 691-703 (2013). 28837 23890820
Identification, characterization and preliminary X-ray diffraction analysis of the rolling-circle replication initiator protein from plasmid pSTK1. Carr, S.B., Mecia, L.B., Phillips, S.E., Thomas, C.D. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 69 (Pt 10): 1123-1126 (2013). 28595 24100563
Conformational Polymorphism of m(7)GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus. Tsurumura, T., Qiu, H., Yoshida, T., Tsumori, Y., Hatakeyama, D., Kuzuhara, T., Tsuge, H. PLoS One, 8 (11): e82020 (2013). 28585 24312396
A novel aromatic carboxylic acid inactivates luciferase by acylation of an enzymatically active regulatory lysine residue. Nakagomi, M., Fujimaki, N., Ito, A., Toda, T., Fukasawa, H., Shudo, K., Tomita, R. PLoS One, 8 (9): e75445 (2013). 28584 24066181
Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. Yang, J.H., Shin, B.Y., Han, J.Y., Kim, M.G., Wi, J.E., Kim, Y.W., Cho, I.J., Kim, S.C., Shin, S.M., Ki, S.H. Toxicol. Appl. Pharmacol., 274 (2): 293-301 (2013). 28583 24211276
Transcriptional upregulation of HIF-1 alpha by NF-kappaB/p65 and its associations with beta-catenin/p300 complexes in endometrial carcinoma cells. Yoshida, T., Hashimura, M., Mastumoto, T., Tazo, Y., Inoue, H., Kuwata, T., Saegusa, M. Lab. Invest., 93 (11): 1184-1193 (2013). 28472 24042437
Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. Tanaka, S., Mizushina, Y., Kato, Y., Tamura, M., Shiroishi, T. G3 (Bethesda), 3 (10): 1843-1850 (2013). 28471 23979942
Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma. Shimamura, M., Nakahara, M., Orim, F., Kurashige, T., Mitsutake, N., Nakashima, M., Kondo, S., Yamada, M., Taguchi, R., Kimura, S., Nagayama, Y. Endocrinology, 154 (11): 4423-4430 (2013). 28470 23970782
E-Cadherin ? Fc Chimeric Protein-Based Biomaterial: Breaking the Barriers in Stem Cell Technology and Regenerative Medicine. Nag, K., Akaike, T. Advanced Materials Research, 810: 41-76 (2013). 28467  
Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast. Zhang, M.M., Wu, P.Y., Kelly, F.D., Nurse, P., Hang, H.C. PLoS Biol., 11 (7): e1001597 (2013). 28091 23843742
Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells. Oh-Hashi, K., Hirata, Y., Kiuchi, K. Cell. Mol. Biol. Lett., 18 (3): 398-415 (2013). 28090 23864333
Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat. Jakociunas, T., Domange Jordo, M., Ait Mebarek, M., Bunner, C.M., Verhein-Hansen, J., Oddershede, L.B., Thon, G. Proc. Natl. Acad. Sci. U. S. A., 110 (47): E4465-4473 (2013). 27921 24191010
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Rat Genome Sequencing and Mapping Consortium, Baud, A, et al. Nat. Genet., 45 (7): 767-775 (2013). 27718 23708188
A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure-related gene 6. Mitsui, S., Hidaka, C., Furihata, M., Osako, Y., Yuri, K. Biochem. Biophys. Res. Commun., 436 (4): 638-644 (2013). 27716 23770366
Anti-influenza activity of c60 fullerene derivatives. Shoji, M., Takahashi, E., Hatakeyama, D., Iwai, Y., Morita, Y., Shirayama, R., Echigo, N., Kido, H., Nakamura, S., Mashino, T., Okutani, T., Kuzuhara, T. PLoS One, 8 (6): e66337 (2013). 27715 23785493
Wnt signaling regulates left-right axis formation in the node of mouse embryos. Kitajima, K., Oki, S., Ohkawa, Y., Sumi, T., Meno, C. Dev. Biol., 380 (2): 222-232 (2013). 27714 23707899
Resveratrol inhibits LXR alpha-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. Jin, S.H., Yang, J.H., Shin, B.Y., Seo, K., Shin, S.M., Cho, I.J., Ki, S.H. Toxicol. Appl. Pharmacol., 271 (1): 95-105 (2013). 27713 23651738
Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. Tanaka, Y., Hipolito, C.J., Maturana, A.D., Ito, K., Kuroda, T., Higuchi, T., Katoh, T., Kato, H.E., Hattori, M., Kumazaki, K., Tsukazaki, T., Ishitani, R., Suga, H., Nureki, O. Nature, 496 (7444): 247-251 (2013). 27309 23535598
Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger. Nishizawa, T., Kita, S., Maturana, A.D., Furuya, N., Hirata, K., Kasuya, G., Ogasawara, S., Dohmae, N., Iwamoto, T., Ishitani, R., Nureki, O. Science, 341 (6142): 168-172 (2013). 27307 23704374
Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone. Hung, C.C., Chiou, M.H., Teng, Y.N., Hsieh, Y.W., Huang, C.L., Lane, H.Y. PLoS One. 2013;8(3):e59419. 27188 23527191
Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma. Hayashi, S., Tanaka, J., Okada, S., Isobe, T., Yamamoto, G., Yasuhara, R., Irie, T., Akiyama, C., Kohno, Y., Tachikawa, T., Mishima, K. Exp Cell Res. 2013 May 1;319(8):1220-8. 27187 23500413
MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice. Cogoi, S., Zorzet, S., Rapozzi, V., Geci, I., Pedersen, E.B., Xodo, L.E. Nucleic Acids Res., 41(7):4049-4064 (2013). 27186 23471001
Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast. Eckler, A.M., Wilder, C., Castanon, A., Ferris, V.M., Lamere, R.A., Perrin, B.A., Pearlman, R., White, B,. Byrd, C., Ludvik, N., Nichols, N., Poole-Sumrall, K., Sztul, E., Styers, M.L. PLoS One, 8 (2): e56807 (2013). 27185 23457617
A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination. Fukamachi, K., Tanaka, H., Sakai, Y., Alexander, D.B., Futakuchi, M., Tsuda, H., Suzui, M. Genesis, 51 (4): 268-274 (2013). 27184 23349063
Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone. Hatanaka, Y., Yamauchi, K.. Cereb. Cortex, 23 (1): 105-113 (2013). 27182 22267309
The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains. Takada, T., Ebata, T., Noguchi, H., Keane, T.M., Adams, D.J., Narita, T., Shin-I, T., Fujisawa, H., Toyoda, A., Abe, K., Obata, Y., Sakaki, Y., Moriwaki, K., Fujiyama, A., Kohara, Y., Shiroishi, T. Genome Res., 23 (8): 1329-1338 (2013). 21786 23604024
Display of active beta-glucosidase on the surface of Schizosaccharomyces pombe cells using novel anchor proteins. Tanaka, T., Matsumoto, S., Yamada, M., Yamada, R., Matsuda, F., Kondo, A. Appl. Microbiol. Biotechnol., 97 (10): 4343-4352 (2013). 21120 23385477


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2012年

Title Author Journal NBRP RRC ID PubMed PMID
Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Dancy, B.M., Crump, N.T., Peterson, D.J., Mukherjee, C., Bowers, E.M., Ahn, Y.H., Yoshida, M., Zhang, J., Mahadevan, L.C., Meyers, D.J., Boeke, J.D., Cole, P.A. Chembiochem. 13 (14): 2113-2121 (2012). 55048 22961914
Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of the simian vacuolating virus 40 large T fragment. Fukuda, T., Katayama, M., Yoshizawa, T., Eitsuka, T., Mizukami, H., Nakagawa, K., Ito, H., Komagata, H., Song, S., Roh, S., Hoshino, Y., Sato, E., Hanada, H., Nishimori, K., Miyazawa, T., Uchida, T. Biosci. Biotechnol. Biochem. 76 (7): 1372-1377 (2012). 55037 22785463
Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium. Hayashi, R., Ishikawa, Y., Ito, M., Kageyama, T., Takashiba, K., Fujioka, T., Tsujikawa, M., Miyoshi, H., Yamato, M., Nakamura, Y., Nishida, K. PLoS One 7 (9): e45435 (2012). 53854 23029008
Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation. Boehringer, J., Riedinger, C., Paraskevopoulos, K., Johnson, E.O., Lowe, E.D., Khoudian, C., Smith, D., Noble, M.E., Gordon, C., Endicott, J.A. Biochem. J. 448 (1): 55-65 (2012). 47483 22906049
Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint. Qu, M., Yang, B., Tao, L., Yates, J.R. 3rd, Russell, P., Dong, M.Q., Du, L.L. PLoS Genet. 8 (7): e1002817 (2012). 47465 22792081
Role of activation-induced cytidine deaminase in the progression of follicular lymphoma. Shikata, H., Yakushijin, Y., Matsushita, N., Sakai, A., Sugita, A., Nakamura, N., Yamanouchi, J., Azuma, T., Hato, T., Yasukawa, M. Cancer Sci. 103 (3): 415-421 (2012). 45805 22168746
Hypothermia-induced tyrosine phosphorylation of SIRP alpha in the brain. Maruyama, T., Kusakari S, Sato-Hashimoto M, Hayashi Y, Kotani T, Murata Y, Okazawa H, Oldenborg PA, Kishi S, Matozaki T, Ohnishi H. J. Neurochem., 121 (6): 891-902 (2012). 35683 22468987
Stat3 inhibition in neural lineage cells. Chiba, T., Mack, L., Delis, N., Brill, B., Groner, B. Horm. Mol. Biol. Clin. Investig. 10 (2): 255-263 (2012). 28469 25436682
TATA-binding protein (TBP)-like protein is required for p53-dependent transcriptional activation of upstream promoter of p21Waf1/Cip1 gene. Suzuki, H., Ito, R., Ikeda, K., Tamura, T.A. J. Biol. Chem., 287 (24): 19792-19803 (2012). 28093 22511763
Origins of albino and hooded rats: implications from molecular genetic analysis across modern laboratory rat strains. Kuramoto, T., Nakanishi, S., Ochiai, M., Nakagama, H., Voigt, B., Serikawa, T. PLoS One, 7 (8): e43059 (2012). 27742 22916206
Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia. Saito, Y., Aoki, Y., Muramatsu, H., Makishima, H., Maciejewski, J.P., Imaizumi, M., Rikiishi, T., Sasahara, Y., Kure, S., Niihori, T., Tsuchiya, S., Kojima, S., Matsubara, Y. Leuk Res., 36 (8): 1009-1015 (2012). 27183 22591685
Heat-shock protein 70 from plant biofactories of recombinant antigens activate multiepitope-targeted immune responses. Buriani, G., Mancini, C., Benvenuto, E., Baschieri, S. Plant Biotechnol J., 10 (3): 363-371 (2012). 27181 22221920
The differentiation and isolation of mouse embryonic stem cells toward hepatocytes using galactose-carrying substrata. Meng, Q., Haque, A., Hexig, B., Akaike, T. Biomaterials, 33 (5): 1414-1427 (2012). 27180 22118818
Surveillance of spontaneous breast cancer metastasis by TRAIL-expressing CD34? cells in a xenograft model. Rossini, A., Giussani, M., Giacomini, A., Guarnotta, C., Tagliabue, E., Balsari, A. Breast Cancer Res. Treat., 136 (2): 457-467 (2012). 21542 23053664
Molecular cytogenetic identification and characterization of Robertsonian chromosomes in the large Japanese field mouse (Apodemus speciosus) using FISH. Yamagishi, M., Matsubara, K., Sakaizumi, M. Zoolog. Sci., 29 (10): 709-713 (2012). 21541 23030344
Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Shin, S.Y., Choi, C., Lee, H.G., Lim, Y., Lee, Y.H. Carcinogenesis, 33 (12): 2467-2476 (2012). 21540 23027619
The E1 protein of human papillomavirus type 16 is dispensable for maintenance replication of the viral genome. Egawa, N., Nakahara, T., Ohno, S., Narisawa-Saito, M., Yugawa, T., Fujita, M., Yamato, K., Natori, Y., Kiyono, T. J. Virol., 86 (6): 3276-3283 (2012). 21539 22238312
Structural basis for translation termination by archaeal RF1 and GTP-bound EF1alpha complex. Kobayashi, K., Saito, K., Ishitani, R., Ito, K., Nureki, O. Nucleic Acids Res., 40 (18): 9319-9328 (2012). 21538 22772989
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. Nishimura, R., Wakabayashi, M., Hata, K., Matsubara, T., Honma, S., Wakisaka, S., Kiyonari, H., Shioi, G., Yamaguchi, A., Tsumaki, N., Akiyama, H., Yoneda, T. J. Biol. Chem., 287 (40): 33179-33090 (2012). 21537 22869368
Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method. Araki, Y., Hamafuji, T., Noguchi, C., Shimizu, N. PLoS One, 7 (7): e41787 (2012). 21536 22844523
Development of an optimized tetracycline-inducible expression system to increase the accumulation of interleukin-10 in tobacco BY-2 suspension cells. Bortesi, L., Rademacher, T., Schiermeyer, A., Schuster, F., Pezzotti, M., Schillberg, S. BMC Biotechnol.,12: 40 (2012). 21535 22784336
Differentiation of human embryonic stem cells and human induced pluripotent stem cells into steroid-producing cells. Sonoyama, T., Sone, M., Honda, K., Taura, D., Kojima, K., Inuzuka, M., Kanamoto, N., Tamura, N., Nakao, K. Endocrinology, 153 (9): 4336-4345 (2012). 21534 22778223
Enhanced expression of myogenic differentiation factors and skeletal muscle proteins in human amnion-derived cells via the forced expression of MYOD1. Akizawa, Y., Kanno, H., Kawamichi, Y., Matsuda, Y., Ohta, H., Fujii, H., Matsui, H., Saito, K. Brain Dev., 35 (4): 349-355 (2012). 21533 22727434
In-cell NMR of intrinsically disordered proteins in prokaryotic cells. Ito, Y., Mikawa, T., Smith, B.O. Methods Mol. Biol., 895: 19-31 (2012). 21532 22760309
Nrf2-ARE pathway regulates induction of Sestrin-2 expression. Shin, B.Y., Jin, S.H., Cho, I.J., Ki, S.H. Free Radic. Biol. Med., 53 (4): 834-841 (2012). 21531 22749810
Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell . Shin, J.W., Suzuki, T., Ninomiya, N., Kishima, M., Hasegawa, Y., Kubosaki, A., Yabukami, H., Hayashizaki, Y., Suzuki, H. Nucleic Acids Res., 40 (21): e165 (2012). 21530 22879381
Novel regulatory mechanism and functional implication of plasminogen activator inhibitor-1 (PAI-1) expression in CpG-ODN-stimulated macrophages. Thapa, B., Kim, Y.H., Kwon, H.J., Kim, D.S. Mol. Immunol. 49 (4): 572-581 (2012). 21529 22078208
Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus. Yoo, J., Lee, H.N., Choi, I., Choi, D., Chung, H.K., Kim, K.E., Lee, S., Aguilar, B., Kang, J., Park, E., Lee, Y.S., Maeng, Y.S,. Kim, N.Y., Koh, C.J., Hong, Y.K. PLoS Pathog. 8 (6): e1002770 (2012). 21527 22719258
Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Sakamoto, K., Fujii, T., Kawachi, H., Miki, Y., Omura, K., Morita, K., Kayamori, K., Katsube, K., Yamaguchi, A. Lab. Invest., 92 (5): 688-702 (2012). 21526 22330335
Suppression of feline coronavirus replication in vitro by cyclosporin A. Tanaka, Y., Sato, Y., Osawa, S., Inoue, M., Tanaka, S., Sasaki, T. Vet. Res., 43 (1): 41 (2012). 21525 22546085
Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe. Girdwood, D., Robertson, M., Gordon, C. FEBS Lett., 586 (10): 1522-1528 (2012). 21524 22673520
Discovery and Analysis of Cofactor-dependent Phosphoglycerate Mutase Homologs as Novel Phosphoserine Phosphatases in Hydrogenobacter thermophilus. Chiba, Y., Oshima, K., Arai, H., Ishii, M., Igarashi, Y. J. Biol Chem. 287 (15): 11934-11941 (2012). 21521 22337887
Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors. Chen Q., Osada K, Ishii T, Oba M, Uchida S, Tockary TA, Endo T, Ge Z, Kinoh H, Kano MR, Itaka K, Kataoka K. Biomaterials, 33 (18): 4722-4730 (2012). 21520 22444644
Growth control of genetically modified cells using an antibody/c-Kit chimera. Kaneko, E., Kawahara, M., Ueda, H., Nagamune, T. J. Biosci. Bioeng., 113 (5): 641-646 (2012). 21519 22227120
Crystal structure of hypothetical protein TTHB210, controlled by the σE/anti-σE regulatory system in Thermus thermophilus HB8, reveals a novel homodecamer. Agari, Y., Kuramitsu, S., Shinkai, A. Proteins 80 (3): 958-962 (2012). 21517 22231934
Surface plasmon resonance-biosensor detects the diversity of responses against epidermal growth factor in various carcinoma cell lines. Hiragun, T., Yanase, Y., Kose, K., Kawaguchi, T., Uchida, K., Tanaka, S., Hide, M. Biosens. Bioelectron., 32 (1): 202-207 (2012). 17607 22204782
Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Huang, Y., Sitwala, K., Bronstein, J., Sanders, D., Dandekar, M., Collins, C., Robertson, G., Macdonald, J., Cezard, T., Bilenky, M., Thiessen, N., Zhao, Y., Zeng, T., Hirst, M., Hero, A., Jones, S., Hess, J.L. Blood 119 (2): 388-398 (2012). 12715 22072553
Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats. Yamamoto S., Nakata M, Sasada R, Ooshima Y, Yano T, Shinozawa T, Tsukimi Y, Takeyama M, Matsumoto Y, Hashimoto T. Transgenic Res., 21 (4): 743-755 (2012). 12712 22002084


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2011年

Title Author Journal NBRP RRC ID PubMed PMID
Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication. Sakaue-Sawano, A., Kobayashi, T., Ohtawa, K., Miyawaki, A. BMC Cell Biol. 12: 2 (2011). 49239 21226962
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Sekiya, S., Suzuki, A. Nature 475 (7356): 390-393 (2011). 48008 21716291
Bacillus anthracis tubulin-related protein Ba-TubZ assembles force-generating polymers. Srinivasan, R., Mishra, M., Leong, F.Y., Chiam, K.H., Balasubramanian, M. Cytoskeleton (Hoboken) 68(9): 501-511 (2011). 47485 21780309
Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery. Lee, Y., Miyata, K., Oba, M., Ishii, T., Fukushima, S., Han, M., Koyama, H., Nishiyama, N., Kataoka, K. Angew. Chem. Int. Ed. Engl. 47 (28): 5163-5166 (2008). 34544 18528828
NF-kappaB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. Shimizu, H., Bolati, D., Adijiang, A., Muteliefu, G., Enomoto, A., Nishijima, F., Dateki, M., Niwa, T. Am. J. Physiol. Cell Physiol. 301 (5): C1201-12 (2011). 31848 21832251
Forced notch signaling inhibits commissural axon outgrowth in the developing chick central nerve system. Shi, M., Liu, Z., Lv, Y., Zheng, M., Du, F., Zhao, G., Huang, Y., Chen, J., Han, H., Ding, Y. PLoS One, 6 (1): e14570 (2011). 30488 21283742
Control of singular cell cycle synchronization of mouse ES cells for hepatocyte differentiation on E-cadherin substratum. Jovic, D., Haque, A., Exig, B., Nagaoka, m., Akaike, T. J. Biotechnol. Biomaterial, 1: 6 (2011). 28468  
Pseudouridine at position 55 in tRNA controls the contents of other modified nucleotides for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus. Ishida, K., Kunibayashi, T., Tomikawa, C., Ochi, A., Kanai, T., Hirata, A., Iwashita, C., Hori, H. Nucleic Acids Res., 39 (6): 2304-2318 (2011). 27711 21097467
Phenotype of single hepatocytes expressing an activated version of beta-catenin in liver of transgenic mice. Schreiber S, Rignall B, Braeuning A, Marx-Stoelting P, Ott T, Buchmann A, Hammad S, Hengstler JG, Schwarz M, Kohle C. J. Mol. Histol., 42 (5): 393-400 (2011). 27179 21822615
Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the beta-catenin pathway. Braeuning A, Kohle C, Buchmann A, Schwarz M. Toxicol .Sci., 122 (1): 16-25 (2011). 27178 21498875
YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway. Hung, C.C., Liou, H.H. Invest New Drugs 29 (6): 1337-1346 (2011). 21522 20676745
A single amino acid limits the substrate specificity of Thermus thermophilus uridine-cytidine kinase to cytidine. Tomoike, F., Nakagawa, N., Kuramitsu, S., Masui, R. Biochemistry 50( 21): 4597-4607 (2011). 21516 21539325
Ultrasound-mediated interferon beta gene transfection inhibits growth of malignant melanoma. Yamaguchi, K., Feril, .L.B. Jr., Tachibana, K., Takahashi, A., Matsuo, M., Endo, H., Harada, Y., Nakayama, J. Biochem. Biophys. Res. Commun. 411 (1): 137-142 (2011). 21514 21723255
Adeno-associated virus Rep-mediated targeting of integrase-defective retroviral vector DNA circles into human chromosome 19. Huang, S., Kawabe, Y., Ito, A., Kamihira, M. Biochem. Biophys. Res. Commun. 417 (1): 78-83 (2011). 12714 22138242
RB1CC1 suppresses type II collagen synthesis in chondrocytes, and causes dwarfism. Nishimura, I., Chano, T., Kita, H., Matsusue, Y., Okabe, H. J. Biol. Chem., 286 (51): 43925-43932 (2011). 12713 22049074
RNF43 interacts with NEDL1 and regulates p53-mediated transcription. Shinada, K., Tsukiyama, T., Sho, T., Okumura, F., Asaka, M., Hatakeyama, S. Biochem. Biophys. Res. Commun., 404 (1): 143-147 (2011). 12711 21108931
Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging. Mickler, F.M., Vachutinsky, Y., Oba, M., Miyata, K., Nishiyama, N., Kataoka, K., Brauchle, C., Ruthardt, N. J. Control Release, 156 (3): 364-373 (2011). 12710 21843561
Circadian transcriptional factor DBP regulates expression of Kiss1 in the anteroventral periventricular nucleus. Xu, Z., Kaga, S., Tsubomizu, J., Fujisaki, J., Mochiduki, A., Sakai, T., Tsukamura, H., Maeda, K., Inoue, K., Adachi, A.A. Mol Cell Endocrinol. 339 (1-2): 90-97 (2011). 12709 21458520
Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. O’Brien, L.L., Grimaldi, M., Kostun, Z., Wingert, R.A., Selleck, R., Davidson, A.J. Dev. Biol., 358 (2): 318-330 (2011). 12708 21871448
JNK1 Phosphorylation of Cdt1 Inhibits Recruitment of HBO1 Histone Acetylase and Blocks Replication Licensing in Response to Stress. Miotto, B., Struhl, K. Mol. Cell., 4 4(1): 62-71 (2011). 12707 21856198
G4-DNA Formation in the HRAS Promoter and Rational Design of Decoy Oligonucleotides for Cancer Therapy. Membrino, A., Cogoi, S., Pedersen, E.B., Xodo, L.E. PLoS One. 6 (9): e24421 (2011). 12706 21931711
Inhibition of Ubiquitin ligase F-box and WD repeat domain-containing 7(alpha) (Fbw7(alpha}) causes hepatosteatosis through the Kruppel-like factor 5 (KLF5)/PPAR(gamma)2 pathway, but not SREBP-1c in mice. Kumadaki, S., Karasawa, T., Matsuzaka, T., Ema, M., Nakagawa, Y., Nakakuki, M., Saito, R., Yahagi, N., Iwasaki, H., Sone, H., Takekoshi, K., Yatoh, S., Kobayashi, K., Takahashi, A., Suzuki, H., Takahashi, S., Yamada, N., Shimano, H. J. Biol. Chem., 286 (47): 40835-40846 (2011). 12705 21911492
Water-Soluble Extract of Pacific Krill Prevents Triglyceride Accumulation in Adipocytes by Suppressing PPARgamma and C/EBPalpha Expression. Yamada, H., Ueda, T., Yano, A. PLoS One 6 (7): e21952 (2011). 12704 21760932
Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo. Stigliano, I.D., Alculumbre, S.G., Labriola, C.A., Parodi, A.J., D’Alessio, C. Mol. Biol. Cell 22 (11): 1810-1823 (2011). 12703 21471007
An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki, S., Harada, S., Shiraki, N., Kume, K., Kume, S. BMC Dev. Biol., 11, 13 (2011). 12702 21362171
A genome wide study in fission yeast reveals nine PPR proteins that regulate mitochondrial gene expression. Kuhl, I., Dujeancourt, L., Gaisne, M., Herbert, C.J., Bonnefoy, N. Nucleic Acids Res., 39 (18): 8029-8041 (2011). 12549 21727087
Direct and differential effects of stem cell factor on the neovascularization activity of endothelial progenitor cells. Kim, K.L., Meng, Y., Kim, J.Y., Baek, E.J., Suh, W. Cardiovasc Res. 92 (1): 132-140 (2011). 12245 21636540
Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts. Iwai, Y., Murakami, K., Gomi, Y., Hashimoto, T., Asakawa, Y., Okuno, Y., Ishikawa, T., Hatakeyama, D., Echigo, N., Kuzuhara, T. PLoS One 6 (5): e19825 (2011). 12232 21625478
Mechanisms by which Interleukin-6 Regulates Prostate Specific Antigen Gene Expression in Prostate LNCaP Carcinoma Cells. Tsui K.H., Lin Y.F., Chen Y.H., Chang P.L., Juang H.H. J. Androl. 32 (4): 383-393 (2011). 11935 21051589
The effect of recombinant E-cadherin substratum on the differentiation of endoderm-derived hepatocyte-like cells from embryonic stem cells. Haque, A., Hexig, B., Meng, Q., Hossain, S., Nagaoka, M., Akaike, T. Biomaterials, 32, 2032-2042 (2011). 11934 21163520
Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer. Shimizu, M., Cohen, B., Goldvasser, P., Berman, H., Virtanen, C., Reedijk, M. Cancer Res., 71, 277-286 (2011) . 11933 21199807
Regulation of nonclassical fgf1 release and fgf-dependent cell transformation by CBF1-mediated notch signaling. Kacer, D., McIntire, C., Kirov, A., Kany, E., Roth, J., Liaw, L., Small, D., Friesel, R., Basilico, C., Tarantini, F., Verdi, J., Prudovsky, I. J. Cell. Physiol., 226 (11): 3064-3075 (2011). 11932 21302306


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2010年

Title Author Journal NBRP RRC ID PubMed PMID
Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide. Iwai Y., Takahashi H., Hatakeyama D., Motoshima K., Ishikawa M., Sugita K., Hashimoto Y., Harada Y., Itamura S., Odagiri T., Tashiro M., Sei Y., Yamaguchi K., Kuzuhara T. Bioorg. Med. Chem., 18, 5379-5390 (2010). 6868 20538468
The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element. Cogoi S., Paramasivam M., Membrino A., Yokoyama KK., Xodo L.E. J. Biol. Chem., 285, 22003-22016 (2010). 6867 20457603
Involvement of ubiquitous and tale transcription factors, as well as liganded RXR alpha, in the regulation of human SOX2 gene expression in the NT2/D1 embryonal carcinoma cell line. Milena, M., Gordana, N., Natasa, K.G., Krstic, A., Marija, M., Danijela, D., Milena, S. Arch. Biol. Sci., Belgrade, 62, 199-210 (2010). 6866  
Stimulation of p53 Transactivation Ability by Nicastrin in Mouse Fibroblasts. Koshida, T., Kitagawa, M., Iwase, K., Takiguchi, M., Hiwasa, T. SRX Biology, 2010 , Article ID 606391 6865  
Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj. Wang S., Kawashima N., Sakamoto K., Katsube K., Umezawa A., Suda H. Biochem. Biophys. Res. Commun., 400, 39-45 (2010). 6863 20691157
Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumors. Maldonado AR., Klanke C., Jegga AG., Aronow BJ., Mahller YY., Cripe TP., Crombleholme TM. J. Gene. Med., 12, 613-623 (2010). 6862 20603890
Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development. Marchetti G., Escuin S., van der Flier A., De Arcangelis A., Hynes RO., Georges-Labouesse E. Eur. J. Neurosci., 31, 399-409, (2010). 6856 20105241
An accumulative site-specific gene integration system using Cre recombinase-mediated cassette exchange. Kameyama Y., Kawabe Y., Ito A., Kamihira M. Biotechnol. Bioeng., 105, 1106-1114 (2010). 6855 19998287
Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene. Campion Y., Neel H., Gostan T., Soret J., Bordonne R. EMBO J. 29 (11): 1817-1829 (2010). 6197 20400941
Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles. Vachutinsky Y., Oba M., Miyata K., Hiki S., Kano M.R., Nishiyama N., Koyama H., Miyazono K., Kataoka K. J. Control. Release (2010). 6195 20138936
Genetic variation of melatonin productivity in laboratory mice under domestication. Kasahara T., Abe K., Mekada K., Yoshiki A., Kato T. Proc. Natl. Acad. Sci. U S A., 107, 6412-6417 (2010). 5992 20308563
Myogenic differentiation in atrium-derived adult cardiac pluripotent cells and the transcriptional regulation of GATA4 and myogenin on ANP promoter. Kamrul Hasan M, Komoike Y., Tsunesumi SI., Nakao R., Nagao H., Ma.tsuoka R., Kawaguchi N. Genes Cells, 15, 439-453 (2010). 5831 20384792
Tumor necrosis factor-related apoptosis-inducing ligand 1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus. Tamura K., Mawaribuchi S., Yoshimoto S., Shiba T., Takamatsu N., Ito M. Blood, 115, 850-859 (2010). 5825 19965624
Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats. Tanaka H., Fukamachi K., Futakuchi M., Alexander D.B., Long N., Tamamushi S., Minami K., Seino S., Ohara H., Joh T., Tsuda H. Cancer Sci., 101, 341-346 (2010). 5824 19917056
N7-Methylguanine at position 46 (m7G46) in tRNA from Thermus thermophilus is required for cell viability at high temperatures through a tRNA modification network. Tomikawa C., Yokogawa T., Kanai T., Hori H. Nucleic Acids Res., 38, 942-957 (2010). 5823 19934251
Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Sasai, M., Linehan, M.M., Iwasaki, A. Science 329 (5998): 1530-1534 (2010). 52880 20847273
Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis. Gong, S., Kus, L., Heintz, N. Nat. Protoc., 5 (10), 1678-1696 (2010). 48832 20885380
Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe. Wen, J., Brogna, S. EMBO J. 29 (9): 1537-1551 (2010). 47473 20360683
Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells. Lee, Y.J., Hung, S.C., Chu, M.S. Stem Cells and Cloning: Advances and Applications, 3: 165-173 (2010). 28466 24198522
Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine. Honda A., Hirose M., Hatori M., Matoba S., Miyoshi H., Inoue K., Ogura A. J. Biol. Chem., 285, 31362-31369 (2010). 12725 20670936
Omnipotent role of archaeal elongation factor 1 alpha (EF1alpha) in translational elongation and termination, and quality control of protein synthesis. Saito, K., Kobayashi, K., Wada, M., Kikuno, I., Takusagawa, A., Mochizuki, M., Uchiumi, T., Ishitani, R., Nureki, O., Ito, K. Proc. Natl. Acad. Sci. U S A., 107 (45): 19242-19247 (2010). 12717 20974926
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1 alpha complex. Kobayashi, K., Kikuno, I., Kuroha, K., Saito, K., Ito, K., Ishitani, R., Inada, T., Nureki, O. Proc. Natl. Acad. Sci. U S A., 107 (41): 17575-17579 (2010). 12716 20876129
Efficient Gene Transduction in HER2-Expressing Cells by Two Recombinant Adenovirus Vectors with HER2 Promotor and Cre/loxP System. Nodagashira T., Odagiri H., Ikenaga S.K., Murayama M., Sato T., Hakamada K. Hirosaki Med. J., 61: 26-34 (2010). 11963  
Transcriptional regulation of cGMP-dependent protein kinase II (cGK-II) in chondrocytes. Yuasa, K., Uehara, S., Nagahama, M., Tsuji, A. Biosci. Biotechnol. Biochem., 74 (1), 44-49 (2010). 11946 20057151
Human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand target both tumor cells and tumor vasculature. Lavazza, C., Carlo-Stella, C., Giacomini, A., Cleris, L., Righi, M., Sia, D., Di Nicola, M., Magni, M., Longoni, P., Milanesi, M., Francolini, M., Gloghini, A., Carbone, A., Formelli, F., Gianni, A.M. Blood, 115 (11), 2231-2240 (2010). 11945 20075160
Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1. Oba M, Vachutinsky Y, Miyata K, Kano MR, Ikeda S, Nishiyama N, Itaka K, Miyazono K, Koyama H, Kataoka K. Mol. Pharm. 7 (2), 501-509 (2010). 11943 20178335
A novel single-stranded DNA-specific 3′-5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways. Shimada, A., Masui, R., Nakagawa, N., Takahata, Y., Kim, K., Kuramitsu, S., Fukui, K. Nucleic Acids Res., 38 (17), 5692-5705 (2010). 11941 20457749
Identification of DAF1/CD55, a novel definitive endoderm marker. Shiraki, N., Harada, S., Ogaki, S., Kume, K., Kume, S. Cell Struct. Funct., 35 (2), 73-80 (2010). 11940 20526042
Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation. Dodgson, J., Brown, W., Rosa, C.A., Armstrong, J. Eukaryot. Cell, 9, 1788-1797 (2010). 11938 20870879
Polyplex micelles prepared from omega-cholesteryl PEG-polycation block copolymers for systemic gene delivery. Oba M., Miyata K., Osada K., Christie R.J., Sanjoh M., Li W., Fukushima S., Ishii T., Kano M.R., Nishiyama N., Koyama H., Kataoka K. Biomaterials, 32 (2): 652-663 (2010) 11936 20932567
Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates. Masaike Y., Takagi T., Hirota M., Yamada J., Ishihara S., Yung T.M., Inoue T., Sawa C., Sagara H., Sakamoto S., Kabe Y., Takahashi Y., Yamaguchi Y., Handa H. Mol. Pharmacol., 77, 262-269 (2010). 11017 19903825


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2009年

Title Author Journal NBRP RRC ID PubMed PMID
Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. Deurholt T., van Til N.P., Chhatta A.A., ten Bloemendaal L., Schwartlander R., Payne C., Plevris J.N., Sauer I.M., Chamuleau R.A., Elferink R.P., Seppen J., Hoekstra R. BMC Biotechnol., 9: 89 (2009). 6193 19845959
Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells. Kugawa F., Suzuki T., Miyata M., Tomono K., Tamanoi F. Pharmazie, 64, 296-300 (2009). 6192 19530439
An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas. Fukamachi K., Tanaka H., Hagiwara Y., Ohara H., Joh T., Iigo M., Alexander D.B., Xu J., Long, N., Takigahira M., Yanagihara K., Hino O., Saito I., Tsuda H. Biochem. Biophys. Res. Commun., 390, 636-641 (2009). 5822 19818733
Glucosidase II beta subunit modulates N-glycan trimming in fission yeasts and mammals. Stigliano I.D., Caramelo J.J., Labriola C.A., Parodi A.J., D’Alessio C. Mol. Biol. Cell, 20, 3974-3984 (2009). 5821 19605557
Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco. Bortesi L., Rossato M., Schuster F., Raven N., Stadlmann J., Avesani L., Falorni A., Bazzoni F., Bock R., Schillberg S., Pezzotti M. BMC Biotechnol., 9: 22 (2009). 5819 19298643
Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue. Kuzuhara T., Kise D., Yoshida H., Horita T., Murazaki Y., Nishimura A., Echigo N., Utsunomiya H., Tsuge H. J. Biol. Chem. 284, 6855-6860 (2009) 4754 19144639
Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription. Yamasaki T., Takahashi A., Pan J., Yamaguchi N., Yokoyama K.K. J. Biol. Chem., 284, 8567-8581 (2009) 4753 19176525
Adenovirus-mediated gene expression of the human c-FLIP(L) gene protects pig islets against human CD8(+) cytotoxic T lymphocyte-mediated cytotoxicity. Tanemura M., Saga A., Kawamoto K., Machida T., Deguchi T., Nishida T., Sawa Y., Doki Y., Mori M., Ito T. Transplant. Proc., 41, 319-322 (2009). 4752 19249545
Cytosine deaminase-uracil phosphoribosyltransferase and interleukin (IL)-12 and IL-18: a multimodal anticancer interface marked by specific modulation in serum cytokines. Khatri A., Husaini Y., Ow K., Chapman J., Russell P.J. Clin. Cancer Res., 15, 2323-2334 (2009). 4751 19318483
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Tomida S., Mamiya T., Sakamaki H., Miura M., Aosaki T., Masuda M., Niwa M., Kameyama T., Kobayashi J., Iwaki Y., Imai S., Ishikawa A., Abe K., Yoshimura T., Nabeshima T., Ebihara S. Nat. Genet., 41 (6): 688-695 (2009). 4750 19465912
Chondromodulin-1 directly suppresses growth of human cancer cells. Mera H., Kawashima H., Yoshizawa T., Ishibashi O., Ali M.M., Hayami T., Kitahara H., Yamagiwa H., Kondo N., Ogose A., Endo N., Kawashima H. BMC Cancer, 9, 166 (2009). 4749 19480713
Quick method of multimeric protein production for biologically active substances such as human GM-CSF (hGM-CSF). Shinya E., Owaki A., Norose Y., Sato S., Takahashi H. Biochem. Biophys. Res. Commun., 386, 40-44 (2009). 4748 19497303
Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. Jung H., Bhangoo S., Banisadr G., Freitag C., Ren D., White F.A., Miller R.J. J. Neurosci., 29, 8051-8062 (2009). 4747 19553445
RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake, Y., Nakamura, M., Nabetani, A., Shimamura, S., Tamura, M., Yonehara, S., Saito, M., Ishikawa, F. Mol. Cell 36 (2):193-206 (2009). 47433 19854130
Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus in vitro Song, K., Rao, N., Chen, M., Cao, Y. Frontiers of Medicine in China, 3, 158-163 (2009). 4600  
Thermus thermophilus-derived protein tags that aid in preparation of insoluble viral proteins. Kondo N., Ebihara A., Ru H., Kuramitsu S., Iwamoto A., Rao Z., Matsuda Z. Anal. Biochem., 385, 278-285 (2009). 3801 19084492
Crystallization and X-ray diffraction analysis of the RNA primer/promoter-binding domain of influenza A virus RNA-dependent RNA polymerase PB2. Kuzuhara T., Kise D., Yoshida H., Horita T., Murazaki Y., Utsunomiya H., Tsuge H. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun., 65 (Pt 2): 144-146 (2009). 3800 19194006
Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS. Clapcote, S.J., Duffy, S., Xie, G., Kirshenbaum, G., Bechard, A.R., Rodacker Schack, V., Petersen, J., Sinai, L., Saab, B.J., Lerch, J.P., Minassian, B.A., Ackerley, C.A., Sled, J.G., Cortez, M.A., Henderson, J.T., Vilsen, B., Roder, J.C. Proc. Natl. Acad. Sci .U S A. 106 (33): 14085-14090 (2009). 21528 19666602
Oncolytic gene therapy combined with double suicide genes for human bile duct cancer in nude mouse models. Kojima, Y., Honda, K., Hamada, H., Kobayashi, N. J. Surg. Res. 157 (1): e63-70 (2009). 21523 19345377
The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression. Ohoka, N., Kato. S., Takahashi. Y., Hayashi, H., Sato, R. Mol. Endocrinol., 23, 759-771 (2009). 21513 19324970
Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. Lee, J., Kanatsu-Shinohara, M., Morimoto, H., Kazuki, Y., Takashima, S., Oshimura, M., Toyokuni, S., Shinohara, T. Cell Stem. Cell, 5, 76-86 (2009). 12759 19570516
Detection and genetic characterisation of qnrB in hospital isolates of Klebsiella pneumoniae in Singapore. Teo, J.W., Ng, K.Y., Lin, R.T. Int. J. Antimicrob. Agents., 33, 177-180 (2009). 12023 18993034
Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation. Yanagino, T., Yuasa, K., Nagahama, M., Matsuda, Y., Tsuji, A. J. Cell. Biochem. 106 (4): 580-588 (2009). 12022 19142862
Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Takashima, S., Takehashi, M., Lee, J., Chuma, S., Okano, M., Hata, K., Suetake, I., Nakatsuji, N., Miyoshi H, Tajima S, Tanaka Y, Toyokuni S, Sasaki, H., Kanatsu-Shinohara, M., Shinohara, T. Biol. Reprod., 81, 155-164 (2009). 11972 19228594
Introduction of tau mutation into cultured Rat1-R12 cells by gene targeting, using recombinant adeno-associated virus vector. Shimada H., Numazawa K., Sasaki T., Kato N., Ebisawa T. Cell. Mol. Neurobiol., 29, 699-705 (2009). 11971 19305950
Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH. Hayashi, H., Suruga, K., Yamashita, Y. Am. J. Physiol. Cell Physiol., 296, C1279-1290 (2009). 11970 19321737
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain. Cano M.E., Rodriguez-Martinez J.M., Aguero J., Pascual A., Calvo J., Garcia-Lobo J.M., Velasco C., Francia M.V., Martinez-Martinez L. J. Clin. Microbiol., 47, 2033-2039 (2009). 11968 19386836
Establishment of a cell line derived from a mouse fetal liver that has the characteristic to promote the hepatic maturation of mouse embryonic stem cells by a coculture method. Fukumitsu K., Ishii T., Yasuchika K., Amagai Y., Kawamura-Saito M., Kawamoto T., Kawase E., Suemori H., Nakatsuji N., Ikai I., Uemoto S. Tissue Eng. Part A., 15, 3847-3856 (2009). 11967 19558317
Selection and growth regulation of genetically modified cells with hapten-specific antibody/receptor tyrosine kinase chimera. Tanaka, K., Kawahara, M., Ueda, H., Nagamune, T. Biotechnol. Progr., 25, 1138-1145 (2009). 11966 19569211
Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. Kuzuhara T., Iwai Y., Takahashi H., Hatakeyama D., Echigo N. PLoS Curr., 1, RRN1052 (2009). 11965 20025206
Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy. Long N., Hardiville S., Pierce A., Fukamachi K., Futakuchi M., Alexander D.B., Shirai T., Tsuda H. Asian Pac. J. Cancer Prev., 10, 939-960 (2009). 11964 20104994


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2008年

Title Author Journal NBRP RRC ID PubMed PMID
qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Cavaco L.M., Hasman H., Xia S., Aarestrup F.M. Antimicrob. Agents. Chemother., 53, 603-608 (2008). 6189 19029321
Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Kohyama J., Kojima T., Takatsuka E., Yamashita T., Namiki J., Hsieh J., Gage F.H., Namihira M., Okano H., Sawamoto K., Nakashima K. Proc. Natl. Acad. Sci. U. S. A., 105, 18012-18017 (2008). 6188 19004774
p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor. Ogawa E., Okuyama R., Egawa T., Nagoshi H., Obinata M., Tagami H., Ikawa S., Aiba S. J. Biol. Chem., 283, 34241-34249 (2008). 6187 18849344
JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. Gurzov E.N., Ortis F., Bakiri L., Wagner E.F, Eizirik,D.L. PLoS One., 3, e3030 (2008). 6186 18716665
Enhancement of cell function through heterotypic cell-cell interactions using E-cadherin-expressing NIH3T3 cells. Ito A., Kiyohara T., Kawabe Y., Ijima H., Kamihira M. J. Biosci. Bioeng., 105, 679-682 (2008). 6185 18640611
Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. Sakamoto K., Tamamura Y., Katsube K., Yamaguchi A. J. Cell Sci., 121, 1613-1623 (2008). 6184 18430783
Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera. Sogo T., Kawahara M., Tsumoto K., Kumagai I., Ueda H., Nagamune T. J. Immunol. Methods, 337, 16-23(2008). 4759 18589435
Design of the artificial acellular feeder layer for the efficient propagation of mouse embryonic stem cells. Nagaoka M., Hagiwara Y., Takemura K., Murakami Y., Li J., Duncan S.A., Akaike T. J. Biol. Chem., 283, 26468-26476 (2008). 4758 18614540
Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function. Zhu P., Hata R., Cao F., Gu F., Hanakawa Y., Hashimoto K., Sakanaka M. FASEB J., 22, 3866-3877 (2008). 4757 18685078
Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres. Tatsumi Y., Ezura K., Yoshida K., Yugawa T., Narisawa-Saito M., Kiyono T., Ohta S., Obuse C., Fujita M. Genes Cells, 13, 1045-1059 (2008). 4756 18761675
Interaction of KLRG1 with E-cadherin: new functional and structural insights. Rosshart S., Hofmann M., Schweier O., Pfaff A.K., Yoshimoto K., Takeuchi T., Molnar E., Schamel W.W., Pircher H. Eur. J. Immunol., 38, 3354-3364 (2008). 4755 19009530
Improved tools for efficient mapping of fission yeast genes: identification of microtubule nucleation modifier mod22-1 as an allele of chromatin- remodelling factor gene swr1. Anders, A., Watt, S., Bahler, J., Sawin, K.E. Yeast 25 (12): 913-925 (2008). 47469 19160458
Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. Jung H., Toth P.T., White F.A., Miller R.J. J. Neurochem., 104, 254-263 (2008). 3815 17944871
Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity. Tanaka F., Tominaga K., Shiota M., Ochi M., Kuwamura H., Tanigawa T., Watanabe T., Fujiwara Y., Oshitani N., Higuchi K., Iwao H., Arakawa T. Cancer Gene Ther., 15, 51-59 (2008). 3814 17992202
Identification of angiogenin as the osteoclastic bone resorption-inhibitory factor in bovine milk. Morita Y., Matsuyama H., Serizawa A., Takeya T., Kawakami H. Bone, 42, 380-387 (2008). 3813 18055286
Characterization of a neuregulin-1 gene promoter: positive regulation of type I isoforms by NF-kappaB. Frensing T., Kaltschmidt C., Schmitt-John T. Biochim. Biophys. Acta – Gene Regul. Mech., 1779, 139-144 (2008). 3812 18082154
Dimerization-based homogeneous fluorosensor proteins for the detection of specific dsDNA. Yoshitake K., Waki S., Ueda H. Biosens. Bioelectron., 23, 1266-1271 (2008). 3811 18178076
Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan. Yamane K., Wachino J., Suzuki S., Arakawa Y. Antimicrob. Agents Chemother., 52, 1564-1566 (2008). 3810 18285488
Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. McMahon, H.E., Hashimoto, O., Mellon, P.L., Shimasaki, S. Endocrinology, 149, 2807-2815 (2008). 3808 18308851
Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Hung C.C., Chen C.C., Lin C.J., Liou H.H. Pharmacogenet. Genomics, 18, 390-402 (2008). 3807 18408562
Repair of 2′-C-cyano-2′-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair. Wang Y., Liu X., Matsuda A., Plunkett W. Cancer Res., 68, 3881-3889 (2008). 3806 18483273
Covalent split protein fragment-DNA hybrids generated through N-terminus-specific modification of proteins by oligonucleotides. Takeda S., Tsukiji S., Ueda H., Nagamune T. Org. Biomol. Chem., 6, 2187-2194 (2008). 3805 18528581
Different initial steps of apoptosis induced by two types of antineoplastic drugs. Takagi Y., Hidaka M., Sanada M., Yoshida H., Sekiguchi M. Biochem. Pharmacol., 76, 303-311 (2008). 3804 18573489
IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. Kimura M. FEBS Lett., 582, 2833-2837 (2008). 3803 18671972
Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1. Murata T., Shinozuka Y., Obata Y., Yokoyama K.K. Anal. Biochem., 376, 115-121 (2008). 3652 18307971
Involvement of the estrogen receptor beta in genistein-induced expression of p21(waf1/cip1) in PC-3 prostate cancer cells. Matsumura, K., Tanaka, T., Kawashima, H., Nakatani, T. Anticancer Res., 28 (2A): 709-714 (2008). 30727 18507011
Expression of transforming growth factor-beta1 and connective tissue growth factor in the capsule in a rat immobilized knee model. Hagiwara Y., Chimoto E., Takahashi I., Ando A., Sasano Y., Itoi E. Upsala. J. Med. Sci., 113, 221-234 (2008). 12026 18509817
Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking. Oba M., Aoyagi K., Miyata K., Matsumoto Y., Itaka K., Nishiyama N., Yamasaki Y., Koyama H., Kataoka K. Mol. Pharm., 5, 1080-1092 (2008). 12025 19434856
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin. Kanatsu-Shinohara, M., Takehashi, M., Takashima, S., Lee, J., Morimoto, H., Chuma, S., Raducanu, A., Nakatsuji, N., Fassler, R., Shinohara, T. Cell Stem Cell, 3 (5): 533-542 (2008). 11962 18983968
Differentiation of mouse hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice with liver fibrosis. Suetsugu A., Nagaki M., Aoki H., Motohashi T., Kunisada T., Moriwaki H. Transplantation, 86, 1178-1186 (2008). 11961 19005397


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2007年

Title Author Journal NBRP RRC ID PubMed PMID
First detection of plasmid-mediated quinolone resistance (qnrA and qnrS) in Escherichia coli strains isolated from humans in Scandinavia. Cavaco L.M., Hansen D.S., Friis-Moller A., Aarestrup F.M., Hasman H., Frimodt-Moller N. J. Antimicrob. Chemother., 59, 804-805 (2007). 6198 17284539
Plasmid-mediated quinolone resistance determinant qnrS1 detected in Salmonella enterica serovar Corvallis strains isolated in Denmark and Thailand. Cavaco L.M., Hendriksen R.S., Aarestrup F.M. J. Antimicrob. Chemother., 60, 704-706 (2007). 6183 17635876
Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line. Higuchi, M., Tsubata, C., Kondo, R., Yoshida, S., Takahashi, M., Oie, M., Tanaka, Y., Mahieux, R., Matsuoka, M., Fujii, M. J. Virol. 81 (21): 11900-11907 (2007). 54476 17715223
Interactions between peptides containing nucleobase amino acids and T7 phages displaying S. cerevisiae proteins. Watanabe S., Tomizaki K.Y., Takahashi T., Usui K., Kajikawa K., Mihara H. Biopolymers, 88, 131-140 (2007). 3824 17206624
The administration of naked plasmid DNA into the liver induces antitumor innate immunity in a murine liver metastasis model. Yonenaga Y., Mori A., Fujimoto A., Nagayama S., Tachibana T., Onodera H., Uemoto S. J. Gene Med., 9, 299-307 (2007). 3823 17397091
Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12. Takasaki I., Takarada S., Fukuchi M., Yasuda M., Tsuda M., Tabuchi Y. J. Cell. Biochem., 102, 1472-1485 (2007). 3822 17440958
E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers. Wakayama M., Abei M., Kawashima R., Seo E., Fukuda K., Ugai H., Murata T., Tanaka N., Hyodo I., Hamada H., Yokoyama K.K. Clin. Cancer Res., 13, 3043-3050 (2007). 3821 17505007
PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts. Ali M.M., Yoshizawa T., Ishibashi O., Matsuda A., Ikegame M., Shimomura J., Mera H., Nakashima K., Kawashima H. J. Cell Sci., 120 (Pt 15), 2565-2573 (2007). 3820 17623776
Thrombin-induced cell proliferation and platelet-derived growth factor-AB release from A172 human glioblastoma cells. Hayakawa Y., Kurimoto M., Nagai, S., Kurosaki K., Tsuboi Y., Hamada H., Hayashi N., Endo S. J. Thromb. Haemost., 5, 2219-2226 (2007). 3819 17958740
Transduction of phosphatase and tensin homolog deleted on chromosome 10 into eosinophils attenuates survival, chemotaxis, and airway inflammation. Adachi T., Hanaka S., Masuda T., Yoshihara H., Nagase H., Ohta K. J. Immunol., 179, 8105-8111 (2007). 3818 18056352
A dileucine motif in its cytoplasmic domain directs beta-catenin-uncoupled E-cadherin to the lysosome. Miyashita Y., Ozawa M. J. Cell Sci., 120, 4395-4406 (2007). 3817 18057030
Emergence of complex rearrangements at translocation breakpoints in a transgenic mouse; implications for mechanisms involved in the formation of chromosome rearrangements. Kasai F., Yoshihara M., Matsukuma S., O’Brien P., Ferguson-Smith M.A. Cytogenet. Genome Res., 119, 83-90 (2007). 3816 18160786
JDP2 suppresses adipocyte differentiation by regulating histone acetylation. Nakade K., Pan J., Yoshiki A., Ugai H., Kimura M., Liu B., Li H., Obata Y., Iwama M., Itohara S., Murata T., Yokoyama K.K. Cell Death Differ., 14, 1398-1405 (2007). 2284 17464331
Expression of pIX gene induced by transgene promoter: possible cause of host immune response in first-generation adenoviral vectors. Nakai M., Komiya K., Murata M., Kimura T., Kanaoka M., Kanegae Y., Saito I. Hum. Gene Ther., 18, 925-936 (2007). 2283 17907966
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Dali-Youcef N., Mataki C., Coste A., Messaddeq N., Giroud S., Blanc S., Koehl C., Champy M.F., Chambon P., Fajas L., Metzger D., Schoonjans K., Auwerx J. Proc. Natl. Acad. Sci. U S A., 104, 10703-10708 (2007). 2282 17556545
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. Tomimatsu N., Tahimic C.G., Otsuki A., Burma S., Fukuhara A., Sato K., Shiota G., Oshimura M., Chen D.J., Kurimasa A. J. Biol. Chem., 282, 10138-10145 (2007). 2281 17272272
Notch Ligand Delta-Like 1 Is Essential for Postnatal Arteriogenesis. Limbourg A., Ploom M., Elligsen D., Sorensen I., Ziegelhoeffer T., Gossler A., Drexler H., Limbourg F.P. Circ. Res., 100, 363-371 (2007). 1897 17234965
Adenovirus-mediated gene delivery into mouse spermatogonial stem cells. Takehashi, M., Kanatsu-Shinohara, M., Inoue, K., Ogonuki, N., Miki, H., Toyokuni, S, Ogura A., Shinohara, T. Proc. Natl. Acad. Sci. U. S. A., 104 (8): 2596-2601 (2007). 12030 17299052
Strong enhancement of recombinant cytosine deaminase activity in Bifidobacterium longum for tumor-targeting enzyme/prodrug therapy. Hamaji Y, Fujimori M, Sasaki T, Matsuhashi H, Matsui-Seki K, Shimatani-Shibata Y, Kano Y, Amano Y, Taniguchi S. Biosci. Biotechnol. Biochem., 71, 874-883 (2007). 12029 17420581
Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins. Oba M., Fukushima S., Kanayama N., Aoyagi K., Nishiyama N., Koyama H., Kataoka K. Bioconjug. Chem., 18, 1415-1423 (2007). 12028 17595054
Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome. Wang H.Y., Chang H.T., Pai T.W., Wu C.I., Lee Y.H., Chang Y.H., Tai H.L., Tang C.Y., Chou W.Y., Chang M.D. BMC Mol. Biol., 8:89 (2007). 12027 17927842
PTEN reduces cuff-induced neointima formation and proinflammatory cytokines. Koide, S., Okazaki, M., Tamura, M., Ozumi, K., Takatsu, H., Kamezaki, F., Tanimoto, A., Tasaki, H., Sasaguri, Y., Nakashima, Y., Otsuji, Y. Am. J. Physiol. Heart Circ. Physiol., 292, 2824-2831 (2007). 11042 17277022
PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC. Ossipova, O., Tabler, J., Green, J.B., Sokol, S.Y. Development, 134 (23), 4297-4306 (2007). 11023 17993468


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2006年

Title Author Journal NBRP RRC ID PubMed PMID
Suppression of PTEN expression during aggregation with retinoic acid in P19 mouse embryonal carcinoma cells. Lee J.H., Shin S.Y., Kim S., Choo J., Lee Y.H. Biochem. Biophys. Res. Commun., 347, 715-722 (2006). 6182 16842746
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. Shin S.Y., Bahk Y.Y., Ko J., Chung I.Y., Lee Y.S., Downward J., Eibel H., Sharma P.M., Olefsky J.M., Kim Y.H., Lee B., Lee Y.H. EMBO J., 25, 1093-1103 (2006). 6181 16456537
E-cadherin-coated plates maintain pluripotent ES cells without colony formation. Nagaoka M., Koshimizu U., Yuasa S., Hattori F., Chen H., Tanaka T., Okabe M., Fukuda K., Akaike T. PLoS One, 1, (2006). 4762 17183641
Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure. Nakamura H., Kimura T., Koyama S., Ogita K., Tsutsui T., Shimoya K., Taniguchi T., Koyama M., Kaneda Y., Murata Y. FEBS Lett., 580, 2717-2722 (2006). 3888 16647058
Canonical notch signaling functions as a commitment switch in the epidermal lineage. Blanpain C., Lowry W.E., Pasolli H.A., Fuchs E. Gene. Dev., 20, 3022-3035 (2006). 3887 17079689
The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Sakaki-Yumoto M., Kobayashi C., Sato A., Fujimura S., Matsumoto Y., Takasato M., Kodama T., Aburatani H., Asashima M., Yoshida N., Nishinakamura R. Development, 133, 3005-3013 (2006). 2279 16790473
Combination gene therapy of HGF and truncated type II TGF-beta receptor for rat liver cirrhosis after partial hepatectomy.† Ozawa, S., Uchiyama, K., Nakamori, M., Ueda, K., Iwahashi, M., Ueno, H., Muragaki, Y., Ooshima, A., Yamaue, H. Surgery, 139, 563-573 (2006). 2278 16627068
Transgenic mouse for conditional, tissue-specific Cox-2 overexpression Kamei, K., Ishikawa, T., Herschman, H.R. Genesis, 44, 177-182 (2006). 2277 16604526
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. Grundemann C., Bauer M., Schweier O., von Oppen N., Lassing U., Saudan P., Becker K.F., Karp K., Hanke T., Bachmann M.F., Pircher H. J. Immunol., 176, 1311-1315 (2006). 2276 16424155
CTLA-4Ig suppresses liver injury by inhibiting acquired immune responses in a mouse model of fulminant hepatitis. Nakayama Y., Shimizu Y., Hirano K., Ebata K., Minemura M., Watanabe A., Sugiyama T. Hepatology, 42, 915-924 (2006). 2275 16175605
Activation of connective tissue growth factor gene by the c-Maf and Lc-Maf transcription factors. Omoteyama K., Ikeda H., Imaki J., Sakai M. Biochem. Biophys. Res. Commun., 339, 1089-1097 (2006). 1905 16343439
A Novel Yeast-Based Reporter Assay System for the Sensitive Detection of Genotoxic Agents Mediated by a DNA Damage-Inducible LexA-GAL4 Protein. Ichikawa K., Eki T. J. Biochem. (Tokyo)., 139, 105-112 (2006). 1904 16428325
Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. Jin, C., Kato, K., Chimura, T., Yamasaki, T., Nakade, K., Murata, T., Li, H., Pan, J., Zhao, M., Sun, K., Chiu, R., Ito, T., Nagata, K., Horikoshi, M., Yokoyama, K.K. Nat. Struct. Mol. Biol., 13, 331-338 (2006). 1902 16518400
The boosting effect of co-transduction with cytokine genes on cancer vaccine therapy using genetically modified dendritic cells expressing tumor-associated antigen. Ojima T., Iwahashi M., Nakamura M., Matsuda K., Naka T., Nakamori M., Ueda K., Ishida K., Yamaue H. Int. J. Oncol., 28, 947-953 (2006). 1900 16525645
Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Ueda S., Fukamachi K., Matsuoka Y., Takasuka N., Takeshita F., Naito A., Iigo M., Alexander D.B., Moore M.A., Saito I., Ochiya T., Tsuda H. Carcinogenesis, 27, 2497-2510 (2006). 1899 16774944
Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells Cao, F., Hata, R., Zhu, P., Ma, Y.J., Tanaka, J., Hanakawa, Y., Hashimoto, K., Niinobe, M., Yoshikawa, K., Sakanaka, M. J. Neurochem., 98, 459?470 (2006). 1898 16805839
Relationship between the P53 functional status of human tumor cell lines and their chemosensitivities to different anticancer drug. TAN Yajun,LOU Bin,CHEN Yu. Chin. Edu. Gen. Pract., 4 (2006). 12039  
Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Ichwan S.J., Yamada S., Sumrejkanchanakij P., Ibrahim-Auerkari E., Eto K., Ikeda M.A. Oncogene, 25, 1216-1224 (2006). 12038 16247456
Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats. Tanaka S., Ide M., Shibutani T., Ohtaki H., Numazawa S., Shioda S., Yoshida T. J. Neurosci. Res., 83, 557-566 (2006). 12037 16429444
Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system. Maeda M., Namikawa K., Kobayashi I., Ohba N., Takahara Y., Kadono C., Tanaka A,, Kiyama H. Brain Res., 1081, 34-43 (2006). 12036 16529724
Src homology 2 (SH2)-containing 5′-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Yogo K., Mizutamari M., Mishima K., Takenouchi H., Ishida-Kitagawa N., Sasaki T., Takeya T. Endocrinology, 147, 3307-3317 (2006). 12035 16601135
Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6. Nonomura Y., Nagasaka K., Hagiyama H., Sekine C., Nanki T., Tamamori-Adachi M., Miyasaka N., Kohsaka H. Arthritis Rheum., 54, 2074-2083 (2006). 12034 16802342
Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy. Suzuki T., Delgado-Escueta A.V., Alonso M.E., Morita R., Okamura N., Sugimoto Y., Bai D., Medina M.T., Bailey JN, Rasmussen A, Ramos-Peek J, Cordova S, Rubio-Donnadieu F, Ochoa A., Jara-Prado A., Inazawa J., Yamakawa K. Neurosci. Lett., 405, 126-131 (2006). 12033 16876319
Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives. Hoekstra R., Deurholt T., ten Bloemendaal L., Desille M., van Wijk A.C., Clement B., Oude Elferink R.P., van Gulik T.M., Chamuleaut R.A. Cell Transplant., 15, 423-433 (2006). 12032 16970284
Retrovirus-mediated conditional immortalization and analysis of established cell lines of osteoclast precursor cells. Kawata S., Suzuki J., Maruoka M., Mizutamari M., Ishida-Kitagawa N., Yogo K., Jat P.S., Shishido T. Biochem. Biophys. Res. Commun., 350, 97-104 (2006). 12031 17005159


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2005年

Title Author Journal NBRP RRC ID PubMed PMID
Characterization and gene transfer in mesenchymal stem cells derived from human umbilical-cord blood. Lu F.Z., Fujino M., Kitazawa Y., Uyama T., Hara Y., Funeshima N., Jiang J.Y., Umezawa A., Li X.K. J. Lab. Clin. Med., 146, 271-278 (2005). 4763 16242526
Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis. Hashimoto M., Koda M., Ino H., Yoshinaga K., Murata A., Yamazaki M., Kojima K., Chiba K., Mori C., Moriya H. Acta Neuropathol., 109, 165-180 (2005). 3910 15592854
Overexpression of granulocyte-macrophage colony-stimulating factor in mouse liver enhances the susceptibility of lipopolysaccharide leading to massive apoptosis of hepatocytes Hirano, K., Shimizu, Y., Nakayama, Y., Minemura, M., Yasumura, S., Sugiyama, T. Liver Int., 25, 1027-1035 (2005). 2274 16162163
Gene therapy for hepatocellular carcinoma using sonoporation enhanced by contrast agents Sakakima Y., Hayashi S., Yagi Y., Hayakawa A., Tachibana K., Nakao A. Cancer Gene Ther., 12, 884-889 (2005). 2273 15891773
G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes. Nishida M., Tanabe S., Maruyama Y., Mangmool S., Urayama K., Nagamatsu Y., Takagahara S., Turner J.H., Kozasa T., Kobayashi H., Sato Y., Kawanishi T., Inoue R., Nagao T., Kurose H. J. Biol. Chem., 280, 18434-18441 (2005). 2016 15743761
Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. Fujii T., Onohara N., Maruyama Y., Tanabe S., Kobayashi H., Fukutomi M., Nagamatsu Y., Nishihara N., Inoue R., Sumimoto H., Shibasaki F., Nagao T., Nishida M., Kurose H. J. Biol. Chem., 280, 23041-23047 (2005). 2015 15826947
C/EBPalpha functionally and physically interacts with GABP to activate the human myeloid IgA Fc receptor (Fc alphaR, CD89) gene promoter. Shimokawa T., Ra C. Blood, 106, 2534-2542 (2005). 2014 15928042
Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. Gu F., Hata R., Ma Y.J., Tanaka J., Mitsuda N., Kumon Y., Hanakawa Y., Hashimoto K., Nakajima K., Sakanaka M. J. Neurosci. Res., 81, 163-171 (2005). 2013 15948155
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital. Numazawa S., Shindo S., Maruyama K., Chibana F., Kawahara Y., Ashino T., Tanaka S., Yoshida T. FEBS Lett., 579, 3560-3564 (2005). 2012 15953603
Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nishiyama N., Iriyama A., Jang W.D., Miyata K., Itaka K., Inoue Y., Takahashi H., Yanagi Y., Tamaki Y., Koyama H., Kataoka K. Nat. Mater., 4, 934-941 (2005). 2010 16299510
Distinct roles of EGF repeats for the Notch signaling system. Sakamoto K., Chao W.S., Katsube K., Yamaguchi A. Exp. Cell Res., 302, 281-291 (2005). 1614 15561108
Delection of the PDGFR-beta Gene Affects Key Fibroblast Functions Important for Wound Healing Gao Z., Sasaoka T., Fujimori T., Oya T., Ishii Y., Sabit H., Kawaguchi M., Kurotaki Y., Naito M., Wada T., Ishizawa S., Kobayashi M., Nabeshima Y., Sasahara M. J. Biol. Chem., 280, 9375-9389 (2005). 1613 15590688
Functional characterization of a conditionally immortalized mouse epididymis caput epithelial cell line MEPC5 using temperature-sensitive simian virus 40 large T-antigen. Tabuchi Y, Toyama Y, Toshimori K, Komiyama M, Mori C, Kondo T. Biochem. Biophys. Res. Commun., 329, 812-823 (2005). 1611 15752729
Interference with the IL-1-signaling pathway improves the toxicity profile of systemically applied adenovirus vectors. Shayakhmetov D.M., Li Z.Y., Ni S., Lieber A. J. Immunol., 174, 7310-7319 (2005). 1609 15905578
A database of recombinant viruses and recombinant viral vectors available from the RIKEN DNA bank. Ugai H., Murata T., Nagamura Y., Ugawa Y., Suzuki E., Nakata H., Kujime Y., Inamoto S., Hirose M., Inabe K., Terashima M., Yamasaki T., Liu B., Nakade K., Pan J., Kimura M., Saito I., Hamada H., Obata Y., Yokoyama K.K. J. Gene Med., 7, 1148-1157 (2005). 1607 15945121
Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Katayama K., Fujita N., Tsuruo T. Mol. Cell. Biol., 25, 5725-5737 (2005). 1606 15964826
Adenovirus-mediated p53 gene transfer to the bile duct by direct administration into the bile in a rat cholangitis model. Kojima Y., Honda K., Kotegawa H., Kushihata F., Kobayashi N., Liu B., Yokoyama K.K. J. Surg. Res., 128, 126-131 (2005). 1605 16005898
Adenovirus-mediated gene delivery of interleukin-10, but not transforming growth factor beta, ameliorates the induction of Graves’ hyperthyroidism in BALB/c mice. Saitoh O., Mizutori Y., Takamura N., Yamasaki H., Kita A., Kuwahara H., Nagayama Y. Clin. Exp. Immunol., 141, 405-411 (2005). 1604 16045729
Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs. Yanagihara M., Katano M., Takahashi-Sasaki N., Kimata K., Taira K., Andoh T. Cancer Sci., 96, 620-6 (2005). 1603 16128748
Effective gene therapy of biliary tract cancers by a conditionally replicative adenovirus expressing uracil phosphoribosyltransferase: significance of timing of 5-fluorouracil administration. Seo E., Abei M., Wakayama M., Fukuda K., Ugai H., Murata T., Todoroki T., Matsuzaki Y., Tanaka N., Hamada H., Yokoyama K.K. Cancer Res., 65, 546-552 (2005). 1528 15695398
Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. Ikeno Y., Konno N., Cheon S.H., Bolchi A., Ottonello S., Kitamoto K., Arioka M. J. Biol. Chem., 280, 28044-28052, (2005). 1479 15927955
Identification of HIV-1 epitopes that induce the synthesis of a R5 HIV-1 suppression factor by human CD4+ T cells isolated from HIV-1 immunized hu-PBL SCID mice. Yoshida A., Tanaka R., Kodama A., Yamamoto N., Ansari A.A., Tanaka Y. Clin. Dev. Immunol., 12, 235-242 (2005). 12700 16584108
Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro. Koga S., Yogo K., Yoshikawa K., Samori H., Goto M., Uchida T., Ishida N., Takeya T. J. Biol. Chem., 280, 31564-31571 (2005). 12044 16020549
Adenovirus-mediated expression of heparin cofactor II inhibits thrombin-induced cellular responses in fibroblasts and vascular smooth muscle cells. Hayakawa Y., Hirashima Y., Yamamoto H., Hayashi N., Kurimoto M., Kuwayama N., Endo S. Thromb. Res., 116, 357-363 (2005). 12043 16038721
Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cell. Nakano, N., Urasawa, K., Takagi, Y., Saito, T., Kaneta, S., Ishikawa, S., Higashi, H., Tsutsui, H., Hatakeyama, M., Kitabatake, A. Biochem. Biophys. Res. Commun., 338, 1661-1667 (2005). 12042 16259944
Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Underwood, J.G., Boutz, P.L., Dougherty, J.D., Stoilov, P., Black, D.L. Mol. Cell. Biol., 25 (22), 10005-10016 (2005). 12041 16260614
Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9. Kawagoe, H., Grosveld, G.C. Blood 106 (13): 4269-4277 (2005). 11033 16105979
Accumulation of infectious mutants in stocks during the propagation of fiber-modified recombinant adenoviruses. Ugai H., Inabe K., Yamasaki T., Murata T., Obata Y., Hamada H., Yokoyama K.K. Biochem. Biophys. Res. Commun. 337, 806-814 (2005).   16214112


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2004年

Title Author Journal NBRP RRC ID PubMed PMID
Adenovirus-mediated p53 gene transfer to the biliary tract in a rat cholangitis model. Kojima Y., Honda K., Yokoyama K.K, Kushihata F., Kobayashi N. J. Japan Biliary Assoc., 18, 174-181 (2004). 2018  
Immature dendritic cells reduce proinflammatory cytokine production by a coculture of macrophages and apoptotic cells in a cell-to-cell contact-dependent manner. Takahashi M., Kurosaka K., Kobayashi Y. J. Leukoc. Biol., 75, 865-873 (2004). 2017 14761936
Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. Nishitai G., Shimizu N., Negishi T., Kishimoto H., Nakagawa K., Kitagawa D., Watanabe T., Momose H., Ohata S., Tanemura S., Asaka S., Kubota J., Saito R., Yoshida H., Mak T.W., Wada T., Penninger J.M., Azuma N., Nishina H., Katada T. J. Biol. Chem., 279, 1621-1626 (2004). 1599 14585831
S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. Okada M., Hatakeyama T., Itoh H., Tokuta N., Tokumitsu H., Kobayashi R. J. Biol. Chem., 279, 4221-4233 (2004). 1598 14638689
A simple method for the simultaneous detection of E1A and E1B in adenovirus stocks. Suzuki E., Murata T., Watanabe S., Kujime Y., Hirose M., Pan J., Yamazaki T., Ugai H., Yokoyama K.K. Oncol. Rep., 11, 173-178 (2004). 1597 14654922
Xenopus death receptor-M1 and -M2, new members of the tumor necrosis factor receptor superfamily, trigger apoptotic signaling by differential mechanisms. Tamura K., Noyama T., Ishizawa YH., Takamatsu N., Shiba T., Ito M. J. Biol. Chem., 279, 7629-7635 (2004) 1596 14668340
Model of unidirectional transluminal gene transfer. Arap MA, Lahdenranta J, Hajitou A, Marini FC 3rd, Wood CG, Wright KC, Fueyo J, Arap W, Pasqualini R. Mol. Ther., 9, 305-310 (2004). 1595 14759814
Identification of a POU factor involved in regulating the neuron-specific expression of the gene encoding diapause hormone and pheromone biosynthesis-activating neuropeptide in Bombyx mori. Zhang T.Y., Kang L., Zhang Z.F., Xu W.H. Biochem. J., 380, 255-263 (2004). 1594 14766018
Gene therapy eradicating distant disseminated micro-metastases by optimal cytokine expression in the primary lesion only: novel concepts for successful cytokine gene therapy. Nagano S., Yuge K., Fukunaga M., Terazaki Y., Fujiwara H., Komiya S., Kosai K. Int. J. Oncol., 24, 549-558 (2004). 1593 14767539
Separate control of Rep and Cap expression using mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production. Mizukami H., Okada T., Ogasawara Y., Matsushita T., Urabe M., Kume A., Ozawa K. Mol. Biotechnol., 27, 7-14 (2004). 1591 15122043
Dendritic cell vaccine therapy by immunization with fusion cells of interleukin-2 gene-transduced, spleen-derived dendritic cells and tumour cells. Ogawa F., Iinuma H., Okinaga K. Scand. J. Immunol., 59, 432-439 (2004). 1590 15140052
Cell specificity and efficiency of the Semliki forest virus vector- and adenovirus vector-mediated gene expression in mouse cerebellum. Sato Y., Shiraishi Y., Furuichi T. J. Neurosci. Methods, 137, 111-121 (2004). 1589 15196833
Development of donor-specific immunoregulatory T-cells after local CTLA4Ig gene transfer to pancreatic allograft. Miao G., Ito T., Uchikoshi F., Akamaru Y., Kiyomoto T., Komodo H., Song J., Nozawa M., Matsuda H. Transplantation, 78, 59-64 (2004). 1588 15257039
Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients. Takamura T., Sakurai M., Ota T., Ando H., Honda M., Kaneko S. Diabetologia, 47, 638-647 (2004). 1587 15298340
Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family. Embry A.C., Glick J.L., Linder M.E., Casey P.J. Mol. Pharmacol., 66, 1325-1331 (2004). 1586 15308761
Alteration of the timing of implantation by in vivo gene transfer: delay of implantation by suppression of nuclear factor kappaB activity and partial rescue by leukemia inhibitory factor. Nakamura H., Kimura T., Ogita K., Koyama S., Tsujie T., Tsutsui T., Shimoya K., Koyama M., Kaneda Y., Murata Y. Biochem. Biophys. Res. Commun., 321, 886-892 (2004). 1585 15358109
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. Matsuura K., Wada H., Nagai T., Iijima Y., Minamino T., Sano M., Akazawa H., Molkentin J.D., Kasanuki H., Komuro I. J. Cell Biol., 167, 351-363 (2004). 1584 15492039
Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice. Yoshioka T., Okada T., Maeda Y., Ikeda U., Shimpo M., Nomoto T., Takeuchi K., Nonaka-Sarukawa M., Ito T., Takahashi M., Matsushita T., Mizukami H., Hanazono Y., Kume A., Ookawara S., Kawano M., Ishibashi S., Shimada K., Ozawa K. Gene Ther., 11, 1772-1779 (2004). 1583 15496963
An antigen-mediated selection system for mammalian cells that produce glycosylated single-chain Fv. Pihkala P., Kawahara M., Ueda H., Nagamune T. Biochem. Biophys. Res. Commun., 324, 1165-1172 (2004). 1582 15504336
Induction of mouse c-src in RAW264 cells is dependent on AP-1 and NF-kappaB and important for progression to multinucleated cell formation. Kumagai N., Ohno K., Tameshige R., Hoshijima M., Yogo K., Ishida N., Takeya T. Biochem. Biophys. Res. Commun., 325, 758-768 (2004). 1581 15541355
Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression Dyson M.R., Shadbolt S.P., Vincent K.J., Perera R.L., McCafferty J. BMC Biotechnol., 4, 1-18 (2004). 1580 15598350
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. Ikeda F., Nishimura R., Matsubara T., Tanaka S., Inoue J., Reddy S.V., Hata K., Yamashita K., Hiraga T., Watanabe T., Kukita T., Yoshioka K., Rao A., Yoneda T. J. Clin. Invest., 114, 475-484 (2004). 1377 15314684
Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Aihara M., Sugawara K., Torii S., Hosaka M., Kurihara H., Saito N., Takeuchi T. Lab. Invest., 84, 1581-1592 (2004). 1370 15502861
Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide’s enhancement of viral oncolysis. Wakimoto H., Fulci G., Tyminski E., Chiocca E.A. Gene. Ther., 11, 214-223 (2004). 12740 14712306
Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes. Nagata, H., Takekoshi, S., Takeyama, R., Homma, T., Osamura, R.Y. Pigment Cell Res. 17, 66-73 (2004). 12052 14717847
A method for oral DNA delivery with N-acetylated chitosan. Kai E., Ochiya T. Pharm. Res., 21, 838-843 (2004). 12051 15180343
Effects of the phytoestrogen coumestrol on RANK-ligand-induced differentiation of osteoclasts. Kanno S., Hirano S., Kayama F. Toxicology., 203, 211-220 (2004). 12049 15363596
Functional activity of human hepatoma cells transfected with adenovirus-mediated hepatocyte nuclear factor (HNF)-4 gene. Naiki T., Nagaki M., Shidoji Y., Kojima H., Moriwaki H. Cell Transplant., 13, 393-403 (2004). 12048 15468681


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2003年

Title Author Journal NBRP RRC ID PubMed PMID
Spontaneous mutations in the human gene for p53 in recombinant adenovirus during multiple passages in human embryonic kidney 293 cells. Ugai H., Suzuki E., Inabe K., Murata T., Hamada H., Yokoyama K.K. Biochem. Biophys. Res. Commun., 300, 448-456. (2003). 2042 12504105
Reduction of Natural Adenovirus Tropism to the Liver by both Ablation of Fiber-Coxsackievirus and Adenovirus Receptor Interaction and Use of Replaceable Short Fiber. Nakamura T., Sato K., Hamada H. J. Virol., 77, 2512-2521 (2003). 2041 12551989
Differential Requirement of G{alpha}12, G{alpha}13, G{alpha}q, and G{beta gamma} for Endothelin-1-Induced c-Jun NH2-Terminal Kinase and Extracellular Signal-Regulated Kinase Activation. Arai K., Maruyama Y., Nishida M., Tanabe S., Takagahara S., Kozasa T., Mori Y., Nagao T., Kurose H. Mol. Pharmacol., 63, 478-488 (2003). 2040 12606754
Prevention of autoantibody-mediated Graves’-like hyperthyroidism in mice with IL-4, a Th2 cytokine. Nagayama Y., Mizuguchi H., Hayakawa T., Niwa M., McLachlan S.M., Rapoport B. J. Immunol., 170, 3522-3527 (2003). 2039 12646613
Recombinant adenovirus vector bearing antisense macrophage migration inhibitory factor cDNA prevents acute lipopolysaccharide-induced liver failure in mice. Iwaki T., Sugimura M., Nishihira J., Matsuura T., Kobayashi T., Kanayama N. Lab. Invest., 83, 561-570 (2003). 2037 12695559
Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness. Kudo T., Kure S., Ikeda K., Xia A.P., Katori Y., Suzuki M., Kojima K., Ichinohe A., Suzuki Y., Aoki Y., Kobayashi T., Matsubara Y. Hum. Mol. Genet., 12, 995-1004 (2003). 2036 12700168
Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model. Suzuki K., Aoki K., Ohnami S., Yoshida K., Kazui T., Kato N., Inoue K., Kohara M., Yoshida T. Gene Ther., 10, 765-773 (2003). 2035 12704415
Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Furukawa T., Sunamura M., Motoi F., Matsuno S., Horii A. Am. J. Pathol., 162, 1807-1815 (2003). 2032 12759238
Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. Guo J., Pichurin P., Nagayama Y., Rapoport B., McLachlan S.M. Clin. Exp. Immunol., 132, 408-415 (2003). 2031 12780686
Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities. Morita N., Yasumori T., Nakayama K. Biochem. Pharmacol., 65, 1843-1852 (2003). 2030 12781336
Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Okada M., Itoh H., Hatakeyama T., Tokumitsu H., Kobayashi R. Biochem. J., 374, 433-441 (2003). 2029 12803546
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. Furuyama T., Kitayama K., Yamashita H., Mori N. Biochem. J., 375, 365-371 (2003). 2028 12820900
Effect of an adenoviral vector that expresses the canine p53 gene on cell growth of canine osteosarcoma and mammary adenocarcinoma cell lines. Yazawa M., Setoguchi A., Hong S.H., Uyama R., Nakagawa T., Kanaya N., Nishimura R., Sasaki N., Masuda K., Ohno K., Tsujimoto H. Am. J. Vet. Res., 64, 880-888 (2003). 2027 12856773
Adenoviral interleukin-12 gene transduction into human bronchial epithelial cells: up-regulation of pro-inflammatory cytokines and its prevention by corticosteroids. Ogawa H., Nishimura N., Nishioka Y., Azuma M., Yanagawa H., Sone S. Clin. Exp. Allergy., 33, 921-929 (2003). 2026 12859448
E1A, E1B double-restricted adenovirus for oncolytic gene therapy of gallbladder cancer. Fukuda K., Abei M., Ugai H., Seo E., Wakayama M., Murata T., Todoroki T., Tanaka N., Hamada H., Yokoyama K.K. Cancer Res., 63, 4434-4440 (2003). 2025 12907616
Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells. Nishioka K., Fujimori Y., Hashimoto-Tamaoki T., Kai S., Qiu H., Kobayashi N., Tanaka N., Westerman K.A, Leboulch P., Hara H. Int. J. Oncol., 23, 925-32 (2003). 2024 12963970
Involvement of fatty acid pathways and cortical interaction of the pronuclear complex in Caenorhabditis elegans embryonic polarity. Nonomura Y., Kohsaka H., Nagasaka K., Miyasaka N. BMC Dev. Biol., 3, 8 (2003). 2023 14527340
Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis. Nonomura Y., Kohsaka H., Nagasaka K., Miyasaka N. J. Immunol., 171, 4913-4919 (2003). 2022 14568973
Inducible liver injury in the transgenic rat by expressing liver-specific suicide gene. Kawasaki M., Fujino M., Li X.K., Kitazawa Y., Funeshima N., Takahashi R., Ueda M., Amano T., Hakamata Y., Kobayashi E. Biochem. Biophys. Res. Commun., 311, 920-928 (2003). 2021 14623269
Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human rirway epithelial cells. Ishizuka S., Yamaya M., Suzuki T., Takahashi H., Ida S., Sasaki T., Inoue D., Sekizawa K., Nishimura H., Sasaki H. J. Infect. Dis., 188, 1928-1939 (2003). 2020 14673774
Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model. Tanaka K., Towata S., Nakao K., Mizuguchi H., Hayakawa T., Niwa M., Ishii N., Nagayama Y. Clin. Endocrinol., 59, 734-742 (2003). 2019 14974915
Region-specific and epileptogenic-dependent expression of six subtypes of alpha2,3-sialyltransferase in the adult mouse brain. Matsuhashi H., Horii Y., Kato K. J. Neurochem., 84, 53-66 (2003). 12057 12485401
Ex vivo and systemic transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of FK506 therapy prolongs islet graft survival. Akamaru Y., Ito T., Uchikoshi F., Maeda A., Tori M., Kiyomoto T., Komoda H., Miao G., Matsuda H. Transpl. Immunol., 11, 91-100 (2003). 12056 12727480
Induction of protective immune responses against R5 human immunodeficiency virus type 1 (HIV-1) infection in hu-PBL-SCID mice by intrasplenic immunization with HIV-1-pulsed dendritic cells: possible involvement of a novel factor of human CD4(+) T-cell origin. Yoshida A., Tanaka R., Murakami T., Takahashi Y., Koyanagi Y., Nakamura M., Ito M., Yamamoto N., Tanaka Y. J. Virol., 77, 8719-8728 (2003). 12055 12885891
Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. Takagi Y., Takahashi M., Sanada M., Ito R., Yamaizumi M., Sekiguchi M. DNA Repair (Amst)., 2, 1135-1146 (2003). 12054 13679151
Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor-mediated inhibition of c-Jun phosphorylation. Hirasawa N., Izumi S., Linwong W., Ohuchi K. FEBS Lett., 554, 489-493 (2003). 12053 14623117


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2002年

Title Author Journal NBRP RRC ID PubMed PMID
Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization. Noguchi H., Kobayashi N., Westerman K.A., Sakaguchi M., Okitsu T., Totsugawa T., Watanabe T., Matsumura T., Fujiwara T., Ueda T., Miyazaki M., Tanaka N., Leboulch P. Hum. Gene Ther., 13, 321-334 (2002). 4767 11812287
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice. Kanatsu-Shinohara M., Ogura A., Ikegawa M., Inoue K., Ogonuki N., Tashiro K., Toyokuni S., Honjo T., Shinohara T. Proc. Natl. Acad. Sci. U. S. A., 99, 1383-1388 (2002). 2061 11818536
A novel murine model of Graves’ hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. Nagayama Y., Kita-Furuyama M., Ando T., Nakao K., Mizuguchi H., Hayakawa T., Eguchi K., Niwa M. J. Immunol., 168, 2789-2794 (2002). 2060 11884447
Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase. Mizuguchi H., Hayakawa T. Cancer Gene Ther., 9, 236-242 (2002). 2059 11896439
Interleukin (IL)-12 gene transduction and expression into human bronchial epithelial cells (BEAS-2B) by adenovirus vector. Ogawa H., Nishimura N., Nishioka Y., Azuma M., Yanagawa H., Sone S. J. Med. Invest., 49, 74-82 (2002). 2058 11901765
Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade. Himeji D., Horiuchi T., Tsukamoto H., Hayashi K., Watanabe T., Harada M. Blood, 99, 4070-4078 (2002). 2057 12010809
TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. Kaartinen V., Haataja L., Nagy A., Heisterkamp N., Groffen J. Int. J. Mol. Med., 9, 563-70 (2002). 2056 12011971
Stability of a Recombinant Adenoviral Vector: Optimization of Conditions for Storage, Transport and Delivery Ugai H., Watanabe S., Suzuki E., Tsutsui-Nakata H., Yokoyama K., Murata T. Jpn. J. Cancer Res., 93, 598-603 (2002). 2055 12036457
Over-expression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Mishima A., Suzuki A., Enaka M., Hirose T., Mizuno K., Ohnishi T., Mohri H., Ishigatsubo Y., Ohno S. Genes Cells., 7, 581-596 (2002). 2054 12059961
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. Suzuki A., Ishiyama C., Hashiba K., Shimizu M., Ebnet K., Ohno S. J. Cell Sci., 115, 3565-3573 (2002). 2052 12186943
Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Nakata T., Yokota T., Emi M., Minami S. Gene. Chromosome. Canc., 35, 30-37 (2002). 2051 12203787
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Hirai S., Kawaguchi A., Hirasawa R., Baba M., Ohnishi T., Ohno S. Development, 129, 4483-4495 (2002). 2050 12223406
Developmental alteration of nerve injury induced glial cell line-derived neurotrophic factor (GDNF) receptor expression is crucial for the determination of injured motoneuron fate. Honma M., Namikawa K., Mansur K., Iwata T., Mori N., Iizuka H., Kiyama H. J. Neurochem., 82, 961-975 (2002). 2049 12358802
Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Nagai-Tamai Y., Mizuno K., Hirose T., Suzuki A., Ohno S. Genes Cells, 7, 1161-1171 (2002). 2048 12390250
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy. Maruyama Y., Nishida M., Sugimoto Y., Tanabe S., Turner J.H., Kozasa T., Wada T., Nagao T., Kurose H. Circ. Res., 91, 961-969 (2002). 2047 12433842
A homogeneous and noncompetitive immunoassay based on the enhanced fluorescence resonance energy transfer by leucine zipper interaction. Ohiro Y., Arai R., Ueda H., Nagamune T. Anal. Chem., 74, 5786-5792 (2002). 2046 12463362
Immobilized E-cadherin model can enhance cell attachment and differentiation of primary hepatocytes but not proliferation. Nagaoka M., Ise H., Akaike T. Biotechnol. Lett., 24, 1857-1862 (2002). 1555  
Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray. Naiki T., Nagaki M., Shidoji Y., Kojima H., Imose M., Kato T., Ohishi N., Yagi K., Moriwaki H. J. Biol. Chem., 277, 14011-14019(2002). 12065 11834723
Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells. Takekoshi K., Ishii K., Shibuya S., Kawakami Y., Isobe K., Nakai T. Biochem. Pharmacol., 63, 977-984 (2002). 12064 11911850
Cytoplasmic RNA vector derived from nontransmissible Sendai virus. Production and use. Iida A., Hasegawa M. Methods Mol. Med., 69, 361-370 (2002). 12063 11987789
Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein. Fujise H., Annoura T., Sasawatari S., Ikeda T., Ueda K. Chemosphere., 46, 1505-1511 (2002). 12062 12002483
Interleukin-12-gene transduction makes DCs from tumor-bearing mice an effective inducer of tumor-specific immunity in a peritoneal dissemination model. Furumoto K., Mori A., Yamasaki S., Inoue N., Yang W., Nakau M., Yasuda S., Arii S., Imamura M. Immunol. Lett., 83, 13-20 (2002). 12060 12057850
Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors. Nakamura T., Sasaki T., Fujimori M., Yazawa K., Kano Y., Amano J., Taniguchi S. Biosci. Biotechnol. Biochem., 66, 2362-2366 (2002). 12059 12506973
Method for identification of mutant glutathione S-transferases conferring enhanced resistance to the anti-cancer drug chlorambucil. Hirota K., Hanyu Y. J. Biosci. Bioeng., 93, 618-621 (2002). 12058 16233260


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2001年

Title Author Journal NBRP RRC ID PubMed PMID
Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated Cre/loxP system. Nagayama Y., Nishihara E., Namba H., Yokoi H., Hasegawa M., Mizuguchi H., Hayakawa T., Hamada H., Yamashita S., Niwa M. Cancer Gene Ther., 8, 36-44 (2001). 4788 11219492
Enhanced efficiency by centrifugal manipulation of adenovirus-mediated interleukin 12 gene transduction into human monocyte-derived dendritic cells. Nishimura N., Nishioka Y., Shinohara T., Sone S. Hum. Gene Ther., 12, 333-346 (2001). 4787 11242526
Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer’s V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. Niikura T., Hashimoto Y., Okamoto T., Abe Y., Yasukawa T., Kawasumi M., Hiraki T., Kita Y., Terashita K., Kouyama K., Nishimoto I. J. Neurosci., 21, 1902-1910 (2001). 4786 11245675
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S. J. Cell Biol., 152, 1183-1196 (2001). 4785 11257119
Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. Nakajima A., Seroogy C.M., Sandora M.R., Tarner I.H., Costa G.L., Taylor-Edwards C., Bachmann M.H., Contag C.H., Fathman C.G. J. Clin. Invest., 107, 1293-301 (2001). 4783 11375419
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Kitagawa M., Oyama T., Kawashima T., Yedvobnick B., Kumar A., Matsuno K., Harigaya K. Mol. Cell Biol., 21, 4337-4346 (2001). 4782 11390662
Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome. Yokoo T., Ohashi T., Utsunomiya Y., Shen J.S., Hisada Y., Eto Y., Kawamura T., Hosoya T. Blood, 98, 57-64 (2001). 4781 11418463
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. Ohba Y., Ikuta K., Ogura A., Matsuda J., Mochizuki N., Nagashima K., Kurokawa K., Mayer B.J., Maki K., Miyazaki J., Matsuda M. EMBO J., 20, 3333-3341 (2001). 4779 11432821
Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport. Ozawa K., Kondo T., Hori O., Kitao Y., Stern D.M., Eisenmenger W., Ogawa S., Ohshima T. J. Clin. Invest., 108, 41-50 (2001). 4778 11435456
Overexpression of EC-SOD suppresses endothelial-cell-mediated LDL oxidation. Takatsu H., Tasaki H., Kim H.N., Ueda S., Tsutsui M., Yamashita K., Toyokawa T., Morimoto Y., Nakashima Y., Adachi T. Biochem. Biophys. Res. Commun., 285, 84-91 (2001). 4777 11437376
An unfolded putative transmembrane polypeptide, which can leado endoplasmic reticulum stress, is a substrate of Parkin. Imai Y., Soda M., Inoue H., Hattori N., Mizuno Y., Takahashi R. Cell, 105, 891-902 (2001). 4776 11439185
Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit. Costa G.L., Sandora M.R., Nakajima A., Nguyen E.V., Taylor-Edwards C., Slavin A.J., Contag C.H., Fathman C.G., Benson J.M. J. Immunol., 167, 2379-2387 (2001). 4775 11490028
Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer. Noguchi M., Imaizumi K., Kawabe T., Wakayama H., Horio Y., Sekido Y., Hara T., Hashimoto N., Takahashi M., Shimokata K., Hasegawa Y. Cancer Gene Ther., 8, 421-429 (2001). 4774 11498762
Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Fukazawa T., Fujiwara T., Uno F., Teraishi F., Kadowaki Y., Itoshima T., Takata Y., Kagawa S., Roth J.A., Tschopp J., Tanaka N. Oncogene, 20, 5225-5231 (2001). 4772 11526513
PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Yamanaka T., Horikoshi Y., Suzuki A., Sugiyama Y., Kitamura K., Maniwa R., Nagai Y., Yamashita A., Hirose T., Ishikawa H., Ohno S. Genes Cells, 6, 721-731 (2001). 4771 11532031
Cre/loxP-based reversible immortalization of human hepatocytes. Kobayashi N., Noguchi H., Westerman K.A., Watanabe T., Matsumura T., Totsugawa T., Fujiwara T., Leboulch P., Tanaka N. Cell Transplant., 10, 383-386 (2001). 4770 11549058
Inflamed glomeruli-specific gene activation that uses recombinant adenovirus with the Cre/loxP system. Yokoo T., Ohashi T., Utsunomiya Y., Shiba H., Shen J.S., Hisada Y., Eto Y., Kawamura T., Hosoya T. J. Am. Soc. Nephrol., 12, 2330-2337 (2001). 4769 11675409
Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. Kaartinen V., Nagy A. Genesis., 31, 126-129 (2001). 4768 11747203
Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays. Shirota Y., Kaneko S., Honda M., Kawai H.F., Kobayashi K. Hepatology, 33, 832-840 (2001). 4760 11283847
Successful retroviral gene transfer of simian virus 40 T antigen and herpes simplex virus-thymidine kinase into human hepatocytes. Kobayashi, N., Noguchi, H., Westerman, K.A., Watanabe, T., Matsumura, T., Totsugawa, T., Fujiwara, T., Leboulch, P., Tanaka, N.. Cell Transplant, 10 (4-5): 377-381 (2001). 27177 11549057
Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth. Baba, M., Hirai, S., Kawakami, S., Kishida, T., Sakai, N., Kaneko, S., Yao, M., Shuin, T., Kubota, Y., Hosaka, M., Ohno, S. Oncogene, 20 (22): 2727-2736 (2001). 12747 11420685
Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21(Cip1) gene into the joints. Nonomura Y., Koike R., Nishio J., Tsubata R., Kohsaka H., Kubota T., Miyasaka N. Int. Immunol., 13, 723-731 (2001). 12698 11369699
Ca(2+) mobilization, tyrosine hydroxylase activity, and signaling mechanisms in cultured porcine adrenal medullary chromaffin cells: effects of leptin. Takekoshi K., Ishii K., Kawakami Y., Isobe K., Nanmoku T., Nakai T. Endocrinology, 142, 290-298 (2001). 12156 11145592
alpha-fetoprotein-producing hepatoma cell lines share common expression profiles of genes in various categories demonstrated by cDNA microarray analysis. Kawai H.F., Kaneko S., Honda M., Shirota Y., Kobayashi K. Hepatology, 33, 676-691 (2001). 12155 11230749
Differential gene expression between chronic hepatitis B and C hepatic lesion. Honda, M., Kaneko, S., Kawai, H., Shirota, Y., Kobayashi, K. Gastroenterology., 120, 955-966 (2001). 12154 11231949
alpha-Synuclein forms a complex with transcription factor Elk-1. Iwata A., Miura S., Kanazawa I., Sawada M., Nukina N. J. Neurochem., 77, 239-252 (2001). 12153 11279280
Ulcerative proctitis, rectal prolapse, and intestinal pseudo-obstruction in transgenic mice overexpressing hepatocyte growth factor/scatter factor. Takayama H., Takagi H., Larochelle W.J., Kapur R.P., Merlino G. Lab. Invest., 81, 297-305 (2001). 12152 11310823
Antitumor Effect on Murine Renal Cell Carcinoma by Autologous Tumor Vaccines Genetically Modified with Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-6 Cells. Kinoshita Y., Kono T., Yasumoto R., Kishimoto T., Wang C.Y., Haas G.P., Nishisaka N. J. Immunother (1991)., 24, 205-211 (2001). 12151 11395635
Brain responses to acute withdrawal in phenobarbital-dependent rats. Tanaka S., Okuno Y., Numazawa S., Yamamoto T., Shioda S., Yoshida T. Eur. J. Pharmacol., 421, 101-108 (2001). 12150 11399265
Rapidly functional immobilization of immortalized human hepatocytes using cell adhesive GRGDS peptide-carrying cellulose microspheres. Kobayashi N., Taguchi T., Noguchi H., Okitsu T., Totsugawa T., Watanabe T., Matsumura T., Fujiwara T., Urata H., Kishimoto N., Hayashi N., Nakaji S., Murakami T., Tanaka N. Cell Transplant., 10, 387-392 (2001). 12069 11549059
alpha-Synuclein affects the MAPK pathway and accelerates cell death. Iwata A., Maruyama M., Kanazawa I., Nukina N. J. Biol. Chem., 276, 45320-45329 (2001). 12068 11560921
Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. Takekoshi K., Ishii K., Nanmoku T., Shibuya S., Kawakami Y., Isobe K., Nakai T. Endocrinology, 142, 4861-4871 (2001). 12066 11606454


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2000年

Title Author Journal NBRP RRC ID PubMed PMID
The effects of cell adhesion on the growth and protein productivity of animal cells. Nishijima K., Fujiki T., Kojima H., Iijima S. Cytotechnology, 33, 147 – 155 (2000). 28092 19002822
Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. Miyazaki M., Takemura N., Watanabe S., Hata N., Misawa Y., Okuyama H. Biochim. Biophys. Acta -Mol. Cell Biol. Lip., 1483, 101-110 (2000). 12179 10601699
Endogenously Generated Nitric Oxide by Nitric-Oxide Synthase Gene Transfer Inhibits Cellular Proliferation. Maeda Y., Ikeda U., Oya K., Shimpo M., Ueno S., Okada K., Saito T., Mano H., Ozawa K., Shimada K. J. Pharmacol. Exp. Ther., 292, 387-393 (2000). 12178 10604975
Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons. Araki T., Yamada M., Ohnishi H., Sano S., Uetsuki T., Hatanaka H. Neurochem., 74, 659-668 (2000). 12177 10646517
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Kobayashi N., Fujiwara T., Westerman K.A., Inoue Y., Sakaguchi M., Noguchi H., Miyazaki M., Cai J., Tanaka N., Fox I.J., Leboulch P. Science, 287, 1258-1262 (2000). 12176 10678831
The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine. Kusakabe K., Xin K.Q., Katoh H., Sumino K., Hagiwara E., Kawamoto S., Okuda K., Miyagi Y., Aoki I., Nishioka K., Klinman D., Okuda K. J. Immunol., 164, 3102-3111 (2000). 12175 10706700
Role of c-jun expression increased by heat shock- and ceramide-activated caspase-3 in HL-60 cell apoptosis. Possible involvement of ceramide in heat shock-induced apoptosis. Kondo T., Matsuda T., Kitano T., Takahashi A., Tashima M., Ishikura H., Umehara H., Domae N., Uchiyama T., Okazaki T. J. Biol. Chem., 275, 7668-7676 (2000). 12174 10713077
Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. Kondo T., Matsuda T., Tashima M., Umehara H., Domae N., Yokoyama K., Uchiyama T., Okazaki T. J. Biol. Chem., 275, 8872-8879 (2000). 12173 10722733
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko M.S., Kitchen J.R., Wang X., Threat T.A., Wang X., Hasegawa A., Sun T., Grahovac M.J., Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S., Paonessa P.D., Sauls A.D., DePalma G.E., Sharara R., Rowe L.B., Eppig J., Morrell C., Doi H. Development, 127, 1737-1749 (2000). 12172 10725249
Differential suppression of liver-specific genes in regenerating rat liver induced by extended hepatectomy. Kurumiya Y., Nozawa K., Sakaguchi K., Nagino M., Nimura Y., Yoshida S. J. Hepatol., 32, 636-644 (2000). 12170 10782913
Glioma/glioblastoma-specific adenoviral gene expression using the nestin gene regulator. Kurihara H., Zama A., Tamura M., Takeda J., Sasaki T., Takeuchi T. Gene Ther., 7, 686-693 (2000). 12169 10800092
Enhancement of adenovirus-mediated gene transfer into dermal fibroblasts in vitro and in vivo by polyethylene glycol 6000. Ohsawa T., Nakamura T., Mihara M., Sato K. J. Dermatol., 27, 244-251 (2000). 12168 10824488
Effects of natriuretic peptides (ANP, BNP, CNP) on catecholamine synthesis and TH mRNA levels in PC12 cells. Takekoshi K., Ishii K., Isobe K., Nomura F., Nammoku T., Nakai T. Life Sci., 66, PL303-311 (2000). 12167 10834306
kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell. Takekoshi K., Ishii K., Kawakami Y., Isobe K., Nakai T. FEBS Lett., 477, 273-277 (2000). 12165 10908734
Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses. Furumoto K., Arii S., Yamasaki S., Mizumoto M., Mori A., Inoue N., Isobe N., Imamura M. Int. J. Cancer., 87, 665-672 (2000). 12164 10925360
Interleukin-10 gene transfer improves the survival rate of mice inoculated with Escherichia coli. Takakuwa T., Endo S., Shirakura Y., Yokoyama M., Tamatani M., Tohyama M., Aozasa K., Inada K. Crit. Care. Med., 28, 2685-2689 (2000). 12162 10966236
Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase. Rokutan K., Teshima S., Kawai T., Kawahara T., Kusumoro K., Mizushima T., Kishi K. J. Gastroenterol., 35, 673-681 (2000). 12161 11023038
Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen. Setoguchi K., Misaki Y., Araki Y., Fujio K., Kawahata K., Kitamura T., Yamamoto K. J. Immunol., 165, 5980-5986 (2000). 12160 11067961
G alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nishida M., Maruyama Y., Tanaka R., Kontani K., Nagao T., Kurose H. Nature, 408, 492-495 (2000). 12159 11100733
Transfection of the plasma-type platelet-activating factor acetylhydrolase gene attenuates glutamate-induced apoptosis in cultured rat cortical neurons. Hirashima Y., Ueno H., Karasawa K., Yokoyama K., Setaka M., Takaku A. Brain Res., 885, 128-132 (2000). 12158 11121539
A speedy method to detect inserted DNA fragment in cell lines transpected with retroviral vectors. Ding, L-H, Iimura E., Saijo K., Hamada H., Ohno T. Cytotechnology, 34, 243-252 (2000). 12157 19003400


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1999年以前

Title Author Journal NBRP RRC ID PubMed PMID
[Japanese text only] Miura, M., Tanaka, S., Koike T. Brain 21, 2, 221-227 (1999). 33954  
Biochemical functions and mRNA expression of rat hepatocytes in a bioartifical liver module. Okada S., Kono Y., Shiraki K. Yonago Acta medica, 42, 103-112 (1999). 12196  
Adenovirus-mediated gene expression in the septal cells of cirrhotic rat livers. Nakamura T., Akiyoshi H., Saito I., Sato K. J. Hepatol., 30, 101-106 (1999). 12195 9927156
Wy-14,643, a peroxisome proliferator, inhibits compensative cell proliferation and hepatocyte growth factor mRNA expression in the rat liver. Motoki Y., Tamura H., Watanabe T., Suga T. Cancer Lett., 135, 145-150 (1999). 12194 10096422
IL-6 synthesis by rheumatoid synoviocytes is autonomously upregulated at the transcriptional level. Miyazawa K., Mori A., Okudaira H. J. Allergy Clin. Immunol., 103, S437-444 (1999). 12193 10329846
CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. Arai A., Nosaka Y., Kohsaka H., Miyasaka N., Miura O. Blood., 93, 3713-3722 (1999). 12192 10339478
Adenovirus-mediated transfer of wild-type p53 gene results in apoptosis or growth arrest in human cultured gastric carcinoma cells. Tatebe S., Matsuura T., Endo K., Teramachi K., Nakamura T., Sato K., Ito H. Int. J. Oncol., 15, 229-235 (1999). 12191 10402231
Immunotherapy for lung metastases of murine renal cell carcinoma: synergy between radiation and cytokine-producing tumor vaccines. Nishisaka N., Maini A., Kinoshita Y., Yasumoto R., Kishimoto T., Jones R.F., Morse P., Hillman G.G., Wang C.Y., Haas G.P. J. Immunother., 22, 308-314 (1999). 12190 10404432
Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). Yagasaki F., Jinnai I., Yoshida S., Yokoyama Y., Matsuda A., Kusumoto S., Kobayashi H., Terasaki H., Ohyashiki K., Asou N., Murohashi I., Bessho M., Hirashima K. Gene. Chromosome. Canc., 26, 192-202 (1999). 12189 10502316
Angiotensin II stimulates platelet-derived growth factor-B chain expression in newborn rat vascular smooth muscle cells and neointimal cells through Ras, extracellular signal-regulated protein kinase, and c-Jun N-terminal protein kinase mechanisms. Deguchi J., Makuuchi M., Nakaoka T., Collins T., Takuwa Y. Circ. Res., 85, 565-574 (1999). 12188 10506481
Hepatoprotective action of adenovirus-transferred HNF-3gamma gene in acute liver injury caused by CCl4. Nakamura T., Akiyoshi H., Shiota G., Isono M., Nakamura K., Moriyama M., Sato K. FEBS Let., 459, 1-4 (1999). 12187 10508906
CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3. Nosaka Y., Arai A., Miyasaka N., Miura O. J. Biol. Chem., 274, 30154-30162 (1999). 12186 10514505
Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis. Zanella C.L., Timblin C.R., Cummins A., Jung M., Goldberg J., Raabe R., Tritton T.R., Mossman B.T. Am. J. Physiol., 277, 684-693 (1999). 12185 10516208
DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid. Sakai T., Horii T., Hisaeda H., Zhang M., Ishii K., Nakano Y., Maekawa Y., Izumi K., Nitta Y., Miyazaki J., Himeno K. Parasitol. Int., 48, 27-33 (1999). 12182 11269323
Stretch activates jun N-terminal Kinase/Stress-activated protein kinase in vascular smooth muscle cells through mechanisms involving autocrine ATP stimulation of purinoceptors. Hamada K., Takuwa N., Yokoyama K., Takuwa Y. J. Biol. Chem., 273, 6334-6340 (1998). 12210 9497362
Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1. Miyazawa K., Mori A., Yamamoto K., Okudaira H. Am. J. Pathol., 152, 793-803 (1998). 12209 9502421
Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes. Miyazawa K., Mori A., Yamamoto K., Okudaira H. J. Biol. Chem., 273, 7620-7627 (1998). 12208 9516466
Expression of mRNA coding for four catecholamine-synthesizing enzymes in human adrenal pheochromocytomas. Isobe K., Nakai T., Yukimasa N., Nanmoku T., Takekoshi K., Nomura F. Eur. J. Endocrinol., 138, 383-387 (1998). 12207 9578504
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Altered activities of transcription factors and their related gene expression in cardiac tissues of diabetic rats. Nishio Y., Kashiwagi A., Taki H., Shinozaki K., Maeno Y., Kojima H., Maegawa H., Haneda M., Hidaka H., Yasuda H., Horiike K., Kikkawa R. Diabetes., 47, 1318-1325 (1998). 12205 9703334
Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats. Fujino T., Hasebe N., Fujita M., Takeuchi K., Kawabe J., Tobise K., Higashiyama S., Taniguchi N., Kikuchi K. Cardiovasc. Res., 38, 365-374 (1998). 12204 9709397
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase. Miyazawa K., Mori A., Miyata H., Akahane M., Ajisawa Y., Okudaira H. J. Biol. Chem., 273, 24832-24838 (1998). 12203 9733787
Oxygen tension regulates heme oxygenase-1 gene expression in mammalian cell lines. Takahashi S., Takahashi Y., Yoshimi T., Miura T. Cell Biochem. Funct., 16, 183-193 (1998). 12202 9747510
A novel protein containing Cdc10/SWI6 motifs regulates expression of mRNA encoding catecholamine biosynthesizing enzymes. Yamakuni T., Yamamoto T., Hoshino M., Song S.Y., Yamamoto H., Kunikata-Sumitomo M., Minegishi A., Kubota M., Ito M., Konishi S. J. Biol. Chem., 273, 27051-27054 (1998). 12201 9765218
Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B, AP-1, and c-Jun/ATF-2 in cultured guinea-pig gastric epithelial cells. Rokutan K., Teshima S., Miyoshi M., Kawai T., Nikawa T., Kishi K. J. Gastroenterol., 33, 646-655 (1998). 12200 9773928
Adenovirus-transferred HNF-3 gamma conserves some liver functions in primary cultured hepatocytes of adult rats. Nakamura T., Mura T., Saito K., Ohsawa T., Akiyoshi H., Sato K. Biochem. Biophys. Res. Commun., 253, 352-357 (1998). 12199 9878541
A newly developed adenovirus-mediated transfer of a wild-type p53 gene increases sensitivity to cis-diamminedichloroplatinum (II) in p53-deleted ovarian cancer cells. Kanamori Y., Kigawa J., Minagawa Y., Irie T., Oishi T., Shimada M., Takahashi M., Nakamura T., Sato K., Terakawa N. Eur. J. Cancer., 34, 1802-1806 (1998). 12198 9893672
Heat shock protein expression in hearts hypertrophied by genetic and nongenetic hypertension. Iwabuchi K., Tajima M., Isoyama S. Heart Vessels., 13, 30-39 (1998). 12197 9923563
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A short form of leptin receptor performs signal transduction. Murakami T., Yamashita T., Iida M., Kuwajima M., Shima K. Biochem. Biophys. Res. Commun., 231, 26-29 (1997). 12218 9070213
Leptin receptor of Zucker fatty rat performs reduced signal transduction. Yamashita T., Murakami T., Iida M., Kuwajima M., Shima K. Diabetes, 46, 1077-1080 (1997). 12216 9166683
Increases in the mRNA levels of gamma-glutamyltransferase and heme oxygenase-1 in the rat lung after ozone exposure. Takahashi Y., Takahashi S., Yoshimi T., Miura T., Mochitate K., Kobayashi T. Biochem. Pharmacol., 53, 1061-1064 (1997). 12215 9174121
Decreased hepatocyte growth factor level by Wy-14,643, non-genotoxic hepatocarcinogen in F-344 rats. Motoki Y., Tamura H., Morita R., Watanabe T., Suga T. Carcinogenesis, 18, 1303-1309 (1997). 12214 9230272
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TSC-36 (follistatin-related polypeptide) gene expression in estrogen receptor positive osteoblastic cell line, CDO7F. Ohashi T., Sato S., Yoshiki A., Kusakabe M. Calcified. Tissue Int., 61, 400-403 (1997). 12212 9351882
Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells. Ito K., Ueda Y., Kokubun M., Urabe M., Inaba T., Mano H., Hamada H., Kitamura T., Mizoguchi H., Sakata T., Hasegawa M., Ozawa K. Blood, 90, 3884-3892 (1997).   9354655
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HLA-G gene polymorphism in a Japanese population. Yamashita T., Fujii T., Watanabe Y., Tokunaga K., Tadokoro K., Juji T., Taketani Y. Immunogenetics., 44, 186-191 (1996). 12225 8662085
Suppressed expression of phenobarbital-inducible hepatic cytochrome P-450s in Eisai-hyperbilirubinuria rats (EHBR/Eis). Oguro T., Kaneko E., Kaneko Y., Numazawa S., Imaoka S., Funae Y., Mikami T., Yoshida T. J. Pharmacol. Exp. Ther., 277, 1676-1684 (1996). 12224 8667238
A cardiotonic steroid bufalin-induced differentiation of THP-1 cells. Involvement of Na+, K(+)-ATPase inhibition in the early changes in proto-oncogene expression. Numazawa S., Inoue N., Nakura H., Sugiyama T., Fujino E., Shinoki M., Yoshida T., Kuroiwa Y. Biochem. Pharmacol., 52, 321-329 (1996). 12223 8694857
An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells. Nakamura N., Chin H., Miyasaka N., Miura O. J. Biol. Chem., 271, 19483-19488 (1996). 12222 8702638
Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase and dopamine beta hydroxylase, through 3′,5′-cyclic adenosine monophosphate- and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells. Isobe K., Yukimasa N., Nakai T., Takuwa Y. Neuropeptides., 30, 167-175 (1996). 12221 8771559
Construction and characterization of adenoviral vector expressing biologically active brain-derived neurotrophic factor. Kojima H., Inuzuka S., Miwa T., Furukawa S., Hayashi K., Kanegae Y., Saito I., Ohishi N., Takamori M., Yagi K. Biochem. Biophys. Res. Commun., 212, 712-717 (1995). 12229 7542888
Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. Sawai H., Okazaki T., Yamamoto H., Okano H., Takeda Y., Tashima M., Sawada H., Okuma M., Ishikura H., Umehara H., et al. J. Biol. Chem., 270, 27326-27331 (1995). 12228 7592995
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Chimeric YACs were generated at unreduced rates in conditions that suppress coligation. Wada M., Abe K., Okumura K., Taguchi H., Kohno K., Imamoto F., Schlessinger D., Kuwano M. Nucleic. Acids. Res., 22, 1651-1654 (1994). 12230 8202367

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2019.11.12