HLA Clones

概要

HLA抗原は、臓器移植ならびに輸血の際の拒絶反応に関係する蛋白質です。

特に、日本人に頻度の高いHLAクラスI抗原をコードするcDNAクローンを愛知県がんセンター研究所の赤塚美樹博士より寄託して頂きました。他のクラスのヒトHLAやbeta-2 microglobulin (β2m)のcDNAクローンも利用可能です。


HLA Clone List

HLA Class I – cDNA clone

Allele Cat. no. Name of Clone Frequency in Japanese population (*)
A*01:01 RDB03368 Human HLA-A*01:01 cDNA 0.439
A*01:01 HGY082896 IRAL007D24
A*02:01 RDB02866 Human HLA-A*02:01:01 cDNA 11.223
A*02:06 RDB02867 Human HLA-A*02:06 cDNA 9.432
A*02:07 RDB02868 Human HLA-A*02:07 cDNA 3.241
A*03:01 RDB03367 Human HLA-A*03:01 cDNA 0.434
A*11:01 RDB02869 Human HLA-A*11:01:01 cDNA 8.9
A*24:02 RDB02871 Human HLA-A*24:02:01 cDNA 36.266
A*24:20 RDB03365 Human HLA-A*24:20 cDNA 0.768
A*25:01 HGX004917 IRAK012E21 0.001
A*26:01 RDB02870 Human HLA-A*26:01 cDNA 7.592
A*26:03 RDB03366 Human HLA-A*26:03 cDNA 2.509
A*31:01 RDB02872 Human HLA-A*31:01:02 cDNA 8.642
A*33:03 RDB02873 Human HLA-A*33:03 cDNA 7.399
  HGY080967 IRAL002G23
RDB01176 pA01

*Major Histocompatibility Complex 30 (1): 17-19 (2023).
 

Allele Cat. no. Name of Clone Frequency in Japanese population (*)
B*07:02 RDB02874 Human HLA-B*07:02:01 cDNA 5.475
B*08:01 RDB03369 Human HLA-B*08:01 cDNA 0.018
B*15:01 RDB02875 Human HLA-B*15:01:01 cDNA 7.92
B*15:10 HGX010665 IRAK026L01
B*35:01 RDB02876 Human HLA-B*35:01:01 cDNA 8.357
B*38:01 RDB03370 Human HLA-B*38:01 cDNA 0.007
B*39:01 RDB03371 Human HLA-B*39:01:01 cDNA 3.387
B*40:01 RDB02877 Human HLA-B*40:01:02 cDNA 5.56
B*40:02 RDB02878 Human HLA-B*40:02 cDNA 7.801
B*44:03 RDB02879 Human HLA-B*44:03:01 cDNA 6.669
B*46:01 RDB02880 Human HLA-B*46:01 cDNA 4.502
B*48:01 RDB03372 Human HLA-B*48:01 cDNA 2.893
B*51:01 RDB02881 Human HLA-B*51:01:01 cDNA 8.743
B*52:01 RDB02882 Human HLA-B*52:01:01 cDNA 11.015
B*54:01 RDB03373 Human HLA-B*54:01 cDNA 7.577
B*55:02 RDB03374 Human HLA-B*55:02 cDNA 2.473
B*59:01 RDB03375 Human HLA-B*59:01 cDNA 2.012
  HGY088861 IRAL022C13
RDB01180 pB55

*Major Histocompatibility Complex 30 (1): 17-19 (2023).
 

Allele Cat. no. Name of Clone Frequency in Japanese population (*)
C*01:02 RDB02883 Human HLA-C*01:02 cDNA 17.225
C*01:03 RDB03376 Human HLA-C*01:03 cDNA 0.34
C*03:03 RDB02884 Human HLA-C*03:03:01 cDNA 13.753
C*03:04 RDB02885 Human HLA-C*03:04:01 cDNA 12.205
C*04:01 RDB02886 Human HLA-C*04:01:01 cDNA 4.324
C*06:02 RDB03377 Human HLA-C*06:02 cDNA 0.816
C*07:01 HGX011896 IRAK029M08 0.065
C*07:02 RDB02887 Human HLA-C*07:02 cDNA 12.705
C*07:02 HGY088291 IRAL020M03
C*08:01 RDB02888 Human HLA-C*08:01 cDNA 7.382
C*12:01 RDB01179 pC68
C*12:02 RDB02889 Human HLA-C*12:02:02 cDNA 11.003
C*12:03 HGX007733 IRAK019F13 0.087
C*14:02 RDB03378 Human HLA-C*14:02:01 cDNA 6.853
C*14:03 RDB02890 Human HLA-C*14:03 cDNA 6.514
C*15:02 RDB03379 Human HLA-C*15:02:01 cDNA 3.054
C*16:01 HGY082329 IRAL005N17 0.004
C*16:01 HGY085701 IRAL014E05
  HGY088506 IRAL021E10

*Major Histocompatibility Complex 30 (1): 17-19 (2023).
 

Allele Cat. no. Name of Clone
E*01:01 HGY081676 IRAL004D04
E*01:01 HGY085250 IRAL013C02
E*01:03 HGY096623 IRAL041J07
F*01:01 HGX054355 IRAK135O19
F*01:01 HGY090322 IRAL025N10
  HGY013281 IRAK033D09
  HGY094732 IRAL036N20

 

HLA Class I – genomic DNA clone

Antigen Allele Cat. No. Name of Clone
HLA-B44 B*44:01 RDB01178 AM2.60
HLA-Cx 52 (Cw 12) C*12:01 RDB01177 pAC201
HLA-G RDB01246 HLA-G.7.0 E

HLA Class II

Allele Cat. no. Name of Clone
DRB1*04:10 HGY096962 IRAL042G18
DRB1*07:01 HGY082333 IRAL005N21
DRB1*13:02 HGY088361 IRAL020P01
DRB1*13:03 HGY088606 IRAL021I14
DRB1*15:01 HGX027583 IRAK068P23
DRB3*01:01 HGX005065 IRAK012L01
DRB4*01:03 HGY086487 IRAL016D15
DRB5*01:01 HGY090353 IRAL025O17
DRB5*01:02 RDB01222 TOK H5 DR beta
DQB1*03:02 HGY091784 IRAL029H16
DPB1*01:01 HGX010616 IRAK026I24
DPB1*17:01 HGY093632 IRAL034B08
DPB1*23:01 HGY088362 IRAL020P02
DRA*01:02 HGX025864 IRAK064K24
DQA1*05:01 HGX005175 IRAK012P15
DQA1*05:03 RDB01239 DQA10501 AMALA-4
DPA1*02:01 HGY088364 IRAL020P04
DMA*01:01 HGY087766 IRAL019G22
DMA*01:01 HGY094834 IRAL037B10
DMB*01:01 HGX010628 IRAK026J12
DOA*01:01 HGX010612 IRAK026I20
DOB*01:01 HGY087568 IRAL018P08
  RDB01235 K^b DRB1 0803
  RDB01236 K^b DRB1 1201
  RDB01237 K^b DRB1 1302
  HGY096628 IRAL041J12
  RDB01238 DRB30301 EMJ-4
RDB01223 YT158
RDB01228 pg DQ1B
RDB01230 pg DQ1BS
RDB01242 DQB10503 EK2-4
  RDB01234 DPB0202
RDB01232 DRA2EH
  HGX044148 IRAK110G04
  HGX069737 IRAK174F17
RDB01241 DQA10101 KAS116 3-6
  RDB01233 DPA 02022

Link to HLA gene resources

Gene Symbol Product Name Synonyms
HLA-A major histocompatibility complex, class I, A HLAA
HLA-B major histocompatibility complex, class I, B AS|B-4901|HLAB
HLA-C major histocompatibility complex, class I, C D6S204|HLA-JY3|HLAC|HLC-C|MHC|PSORS1
HLA-E major histocompatibility complex, class I, E HLA-6.2|QA1
HLA-F major histocompatibility complex, class I, F CDA12|HLA-5.4|HLA-CDA12|HLAF
HLA-G major histocompatibility complex, class I, G MHC-G
HLA-DMA major histocompatibility complex, class II, DM alpha D6S222E|DMA|HLADM|RING6
HLA-DMB major histocompatibility complex, class II, DM beta D6S221E|RING7
HLA-DOA major histocompatibility complex, class II, DO alpha HLA-DNA|HLA-DZA|HLADZ
HLA-DOB major histocompatibility complex, class II, DO beta DOB|HLA_DOB
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 DP(W3)|DP(W4)|HLA-DP1A|HLADP|HLASB|PLT1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 DPB1|HLA-DP|HLA-DP1B|HLA-DPB
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) DP2B|DPB2|DPbeta2|HLA-DP2B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 CELIAC1|DQ-A1|HLA-DQA
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 CELIAC1|HLA-DQB|IDDM1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 HLA-DQB1|HLA-DXB
HLA-DRA major histocompatibility complex, class II, DR alpha HLA-DRA1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 DRB1|HLA-DR1B|HLA-DRB|SS1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 HLA-DR1B|HLA-DR3B
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 DR4|DRB4|HLA-DR4B
HLA-DRB5 major histocompatibility complex, class II, DR beta 5

関連情報

HLA抗原についての詳しい情報は日本組織適合性学会ホームページをご参照下さい。

HLA情報も付属した日本人由来不死化細胞株 (EBV transformed B cell : HEV) は、細胞材料開発室から提供しています。

Journals

  • Akatsuka Y., Morishima Y., Kuzushima K., Kodera Y., Takahashi T. (2007) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
    Cancer Science 98 (8): 1139-1146.
  • Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. (2004) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
    Br. J. Haematol. 124 (5): 629-635.
  • Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. (2003) Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens.J. Exp. Med. 197 (11): 1489-1500.
  • Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA (2002) Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines.
    Tissue Antigens, 59 (6): 502-511.
  • Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. (2002) Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
    Transplantation, 74: 1773-1780.
  • Ando H, Miyata Y, Takata H, Inoko H. (1993) Identification of alloantisera reacting with HLA-C blank (Cx52) using a mouse L-cell transfected with the HLA-Cw*1201 allele.
    Hum Immunol. 36 (2): 76-80
  • Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. (1992) Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
    Immunogenetics 36 (5): 319-325.
  • Zemmour J, Parham P. (1991) HLA class I nucleotide sequences, 1991.
    Tissue Antigens 37 (4): 174-180.
    Erratum in: Tissue Antigens. 1992 Nov;40(5):221-228.
  • Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants.
    Eu.r J Immunol. 21 (10): 2341-2347.
  • Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) HLA-DQ-restricted CD4+ T cells specific to streptococcal antigen present in low but not in high responders.
    J Immunol. 146 (8): 2560-2567.
  • Tamaki J. (1992)[Analysis of polymorphism at the human class I MHC locus, HLA-G]
    Hokkaido Igaku Zasshi (Hokkaido J. Med. Sci.) 67 (5): 583-594. Japanese.
  • Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. (1990) Expression of the human MHC, HLA-DQW6 genes alters the immune response in C57BL/6 mice.
    J Immunol. 1990 Jul 1;145(1):353-60.
  • Takata H, Inoko H, Ando A, Haranaka M, Watanabe B, Tsuji K, Iri H. (1988) Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.
    Immunogenetics 28 (4): 265-270.

Links

 

(GSB0016j 2004.08.23 T.M.)

2024.07.24



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