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BRCからのお知らせ

HLA Clones


概要

HLA抗原は、臓器移植ならびに輸血の際の拒絶反応に関係する蛋白質です。

特に、日本人に頻度の高いHLAクラスI抗原をコードするcDNAクローンを愛知県がんセンター研究所の赤塚美樹博士より寄託して頂きました。赤塚先生には新しいクローンが同定され次第、寄託して頂いております。各HLAクローンについてのさらに詳しい情報は、HLA Clone Listをご覧下さい。


関連情報

HLA抗原についての詳しい情報は日本組織適合性学会ホームページをご参照下さい。

HLA情報も付属した日本人由来不死化細胞株 (EBV transformed B cell : HEV) は、細胞材料開発室から提供しています。


提供形態

HLAクローンは、プラスミドDNAを抽出し、DNAの制限酵素切断パターンの電気泳動ならびに挿入遺伝子の末端塩基配列の検定の後、DNA溶液(1 μg) として利用者に室温で送付しています。できるだけ早くご使用下さい。


書類の入手と記入

次の書式に記入してください:

提供手数料:(1本あたり)

非営利学術目的8,640円
営利目的17,280円
  • 提供手数料は非営利学術目的利用と営利目的利用で異なります。「非営利学術目的利用」および「営利目的利用」の区分ならびに「提供手数料」は、「提供手数料一覧」をご参照ください。
  • 請求書は遺伝子材料発送とは別に送付いたしますので、指定の銀行口座にお振込みください。 特別な様式の請求書・納品書・領収書を必要とされる場合は、申込の際にその様式の書類を必ず同封して申込みください。 振込み手数料につきましては、依頼者負担にてお願い致します。

遺伝子材料提供の概要はこちら

書類の送付先、問い合わせ先

〒305-0074  茨城県つくば市高野台3-1-1
  理化学研究所バイオリソース研究センター
  遺伝子材料開発室
  E-mail: dnabank.brc@riken.jp
  TEL: 029-836-3612 (平日の9:00~12:00 / 13:00~17:00)
  FAX: 029-836-9120


HLA Clone List

HLA Class I

Antigen Allele Cat. No. Name of Clone Frequency in Japanese population
freq.1 (%) freq.2 (%) freq.3 (%) freq.4 (%)
HLA-A1 A*01:01 RDB03368 Human HLA-A*01:01 cDNA 1.8 0.2 0.57 0.25
HLA-A2 A*02:06 RDB02867 Human HLA-A*02:06 cDNA 8.4 10.4 8.99 8.74
HLA-A2 A*02:07 RDB02868 Human HLA-A*02:07 cDNA 4.0 3.4 2.87 3.39
HLA-A2 A*02:01:01 RDB02866 Human HLA-A*02:01:01 cDNA 10.6 10.9 10.71 11.64
HLA-A3 A*03:01 RDB03367 Human HLA-A*03:01 cDNA r 0.8 0.57 0.25
HLA-A11 A*11:01:01 RDB02869 Human HLA-A*11:01:01 cDNA 11.1 8.1 10.71 10.22
HLA-A24 RDB01176 pA01
HLA-A24 A*24:02:01 RDB02871 Human HLA-A*24:02:01 cDNA 32.7 35.6 36.52 36.20
HLA-A24 A*24:20 RDB03365 Human HLA-A*24:20 cDNA vr vr 0.83
HLA-A26 A*26:01 RDB02870 Human HLA-A*26:01 cDNA 6.2 9.8 11.28 7.66
HLA-A26 A*26:03 RDB03366 Human HLA-A*26:03 cDNA 1.3 2.1 1.91 1.47
HLA-A31 A*31:01:02 RDB02872 Human HLA-A*31:01:02 cDNA 9.3 7.7 6.88 9.14
HLA-A33 A*33:03 RDB02873 Human HLA-A*33:03 cDNA 12.8 7.9 7.84 6.68
98.2 96.9 98.85 96.47
Antigen Allele Cat. No. Name of Clone Frequency in Japanese population
freq.1 (%) freq.2 (%) freq.3 (%) freq.4 (%)
HLA-B7 B*07:02:01 RDB02874 Human HLA-B*07:02:01 cDNA 5.2 5.2 3.63 5.70
HLA-B8 B*08:01 RDB03369 Human HLA-B*08:01 cDNA
HLA-B15 B*15:01:01 RDB02875 Human HLA-B*15:01:01 cDNA 6.5 7.2 9.37 7.51
HLA-B35 B*35:01:01 RDB02876 Human HLA-B*35:01:01 cDNA 7.8 8.6 8.80 7.76
HLA-B38 B*38:01 RDB03370 Human HLA-B*38:01 cDNA
HLA-B39 B*39:01:01 RDB03371 Human HLA-B*39:01:01 cDNA 3.5 r 4.02 3.44
HLA-B40 B*40:01:02 RDB02877 Human HLA-B*40:01:02 cDNA 6.1 5.1 5.35 5.40
HLA-B40 B*40:02 RDB02878 Human HLA-B*40:02 cDNA 6.1 8.2 8.41 8.25
HLA-B44 B*44:01 RDB01178 AM2.60
HLA-B44 B*44:03:01 RDB02879 Human HLA-B*44:03:01 cDNA 12.2 6.9 6.69 6.24
HLA-B46 B*46:01 RDB02880 Human HLA-B*46:01 cDNA 6.1 3.8 3.44 4.96
HLA-B48 B*48:01 RDB03372 Human HLA-B*48:01 cDNA 4.3 2.7 5.54 2.65
HLA-B51 B*51:01:01 RDB02881 Human HLA-B*51:01:01 cDNA 7.0 7.9 6.88 8.35
HLA-B52 B*52:01:01 RDB02882 Human HLA-B*52:01:01 cDNA 10.4 13.7 0.19 10.90
HLA-B54 B*54:01 RDB03373 Human HLA-B*54:01 cDNA 7.0 6.5 7.07 8.79
HLA-B55 B*55:02 RDB03374 Human HLA-B*55:02 cDNA 2.2 3.2 2.87 1.92
HLA-B55 RDB01180 pB55
HLA-B59 B*59:01 RDB03375 Human HLA-B*59:01 cDNA 0.9 1.7 1.72 1.96
85.3 80.7 73.98 83.83
Antigen Allele Cat. No. Name of Clone Frequency in Japanese population
freq.1 (%) freq.2 (%) freq.3 (%) freq.4 (%)
HLA-Cw1 C*01:02 RDB02883 Human HLA-C*01:02 cDNA 17.0 16.63
HLA-Cw1 C*01:03 RDB03376 Human HLA-C*01:03 cDNA r
HLA-Cw3 C*03:03:01 RDB02884 Human HLA-C*03:03:01 cDNA 7.8 13.19
HLA-Cw3 C*03:04:01 RDB02885 Human HLA-C*03:04:01 cDNA 11.3 13.77
HLA-Cw4 C*04:01:01 RDB02886 Human HLA-C*04:01:01 cDNA 6.5 4.40
HLA-Cw6 C*06:02 RDB03377 Human HLA-C*06:02 cDNA 1.7 1.34
HLA-Cw7 C*07:02 RDB02887 Human HLA-C*07:02 cDNA 11.3 10.33
HLA-Cw8 C*08:01 RDB02888 Human HLA-C*08:01 cDNA 10.9 9.75
HLA-Cw12 C*12:02:02 RDB02889 Human HLA-C*12:02:02 cDNA 10.4 11.09
HLA-Cw14 C*14:02:01 RDB03378 Human HLA-C*14:02:01 cDNA 5.7 4.78
HLA-Cw14 C*14:03 RDB02890 Human HLA-C*14:03 cDNA 12.2 7.07
HLA-Cw15 C*15:02:01 RDB03379 Human HLA-C*15:02:01 cDNA 1.7 4.40
HLA-Cx 52 (Cw 12) C*12:01 RDB01177 pAC201
HLA-Cx52 (Cw12) C*12:01 RDB01179 pC68
96.5 96.75
HLA-G RDB01246 HLA-G.7.0 E

Freq.1: frequency in Japanese population (N=117), Tokunaga K. et al. Immunogenetics 1997; 46(3)199-205.

Freq.2: frequency in Japanese population (N=493), Tanaka H. et al. Clinical Transplants 1996; 139-144.

Freq.3: frequency in Japanese population (N=523), Nakajima, et al. MHC Vol.8 No.1 p1-32.

Freq.4: frequency in Japanese population (N=1018), Azuma F., et al., MHC, p166, 2004.

r: rare; vr: very rare.


Gene Symbol Product Name Synonyms
HLA-A major histocompatibility complex, class I, A HLAA
HLA-B major histocompatibility complex, class I, B AS|B-4901|HLAB
HLA-C major histocompatibility complex, class I, C D6S204|HLA-JY3|HLAC|HLC-C|MHC|PSORS1
HLA-E major histocompatibility complex, class I, E HLA-6.2|QA1
HLA-F major histocompatibility complex, class I, F CDA12|HLA-5.4|HLA-CDA12|HLAF
HLA-G major histocompatibility complex, class I, G MHC-G

HLA Class II

Antigen Allele Cat. No. Name of Clone
HLA DR beta 5 RDB01222 TOK H5 DR beta
HLA-DR beta 4 RDB01223 YT158
HLA-DQA1 RDB01227 pgDQ4A
HLA-DQB1 RDB01228 pg DQ1B
HLA-DQB1 RDB01230 pg DQ1BS
HLA-DRA RDB01232 DRA2EH
HLA-DPA1 RDB01233 DPA 02022
HLA-DPB1 RDB01234 DPB0202
HLA-DRB1 RDB01235 K^b DRB1 0803
HLA-DRB1 RDB01236 K^b DRB1 1201
HLA-DRB1 RDB01237 K^b DRB1 1302
HLA-DRB3 RDB01238 DRB30301 EMJ-4
HLA-DQA1 RDB01239 DQA10501 AMALA-4
HLA-DQB1 RDB01240 DQB10301 AMALA-4
HLA-DQA1 RDB01241 DQA10101 KAS116 3-6
HLA-DQB1 RDB01242 DQB10503 EK2-4

 


Gene Symbol Product Name Synonyms
HLA-DMA major histocompatibility complex, class II, DM alpha D6S222E|DMA|HLADM|RING6
HLA-DMB major histocompatibility complex, class II, DM beta D6S221E|RING7
HLA-DOA major histocompatibility complex, class II, DO alpha HLA-DNA|HLA-DZA|HLADZ
HLA-DOB major histocompatibility complex, class II, DO beta DOB|HLA_DOB
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 DP(W3)|DP(W4)|HLA-DP1A|HLADP|HLASB|PLT1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 DPB1|HLA-DP|HLA-DP1B|HLA-DPB
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) DP2B|DPB2|DPbeta2|HLA-DP2B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 CELIAC1|DQ-A1|HLA-DQA
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 CELIAC1|HLA-DQB|IDDM1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 HLA-DQB1|HLA-DXB
HLA-DRA major histocompatibility complex, class II, DR alpha HLA-DRA1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 DRB1|HLA-DR1B|HLA-DRB|SS1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 HLA-DR1B|HLA-DR3B
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 DR4|DRB4|HLA-DR4B
HLA-DRB5 major histocompatibility complex, class II, DR beta 5


References for HLA

  • Akatsuka Y., Morishima Y., Kuzushima K., Kodera Y., Takahashi T. (2007) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
    Cancer Science 98 (8): 1139-1146.
  • Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. (2004) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
    Br. J. Haematol. 124 (5): 629-635.
  • Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. (2003) Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens.J. Exp. Med. 197 (11): 1489-1500.
  • Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA (2002) Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines.
    Tissue Antigens, 59 (6): 502-511.
  • Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. (2002) Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
    Transplantation, 74: 1773-1780.
  • Ando H, Miyata Y, Takata H, Inoko H. (1993) Identification of alloantisera reacting with HLA-C blank (Cx52) using a mouse L-cell transfected with the HLA-Cw*1201 allele.
    Hum Immunol. 36 (2): 76-80
  • Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. (1992) Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
    Immunogenetics 36 (5): 319-325.
  • Zemmour J, Parham P. (1991) HLA class I nucleotide sequences, 1991.
    Tissue Antigens 37 (4): 174-180.
    Erratum in: Tissue Antigens. 1992 Nov;40(5):221-228.
  • Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants.
    Eu.r J Immunol. 21 (10): 2341-2347.
  • Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) HLA-DQ-restricted CD4+ T cells specific to streptococcal antigen present in low but not in high responders.
    J Immunol. 146 (8): 2560-2567.
  • Tamaki J. (1992)[Analysis of polymorphism at the human class I MHC locus, HLA-G]
    Hokkaido Igaku Zasshi (Hokkaido J. Med. Sci.) 67 (5): 583-594. Japanese.
  • Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. (1990) Expression of the human MHC, HLA-DQW6 genes alters the immune response in C57BL/6 mice.
    J Immunol. 1990 Jul 1;145(1):353-60.
  • Takata H, Inoko H, Ando A, Haranaka M, Watanabe B, Tsuji K, Iri H. (1988) Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.
    Immunogenetics 28 (4): 265-270.

Related Information

Find more MHCI clones by KEGG

 

(GSB0016j 2004.08.23 T.M.)

2018.11.15