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RIKEN BioResource Research Center DNA Bank Mail News No. 124 (2022.01.18)
[hp] https://dna.brc.riken.jp/en/mailen/mailnewsen
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This E-mail news is sent to those who use the RIKEN BRC Gene Engineering Division (DNA Bank) and those who have subscribed to the E-mail news.
— CONTENTS —
1. New Year’s greetings
2. Focused Resource
1. New Year’s greetings
We hope that the coming year is a good one for you.
Thank you very much for using DNA Bank’s bioresources in the last year.
We are sincerely grateful for your support to our activity.
We will continue to do our best to support your research this year.
We look forward to your new request in the coming year.
2. Focused Resource
Gene expression characterizing HIV-1 infected cells
Human CD4 T cells, which play a role in the control of immune system, are the primary target of HIV-1. By infection of HIV1-GFP reporter virus to “humanized mouse” model in which human immune system including CD4 T cell was reconstructed, the research group discovered that characteristic factors of HIV-1-producing cells include CXCL13 gene high expression group and interferon induction gene low expression group by multidimensional analysis method. This is expected to contribute to a better understanding of the characteristics of latent HIV-1 infected cells, which are essential for the treatment of AIDS.
CSII-CMV-MCS-IRES2-Bsd (cat # RDB04385), pCMV-VSV-G-RSV-Rev (cat # RDB04393), and pCAG-HIVgp (cat # RDB04394) were used to generate lentiviral vectors expressing CXCR5, a receptor for CXCL13.
Article
Aso, H. et al., Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In Vivo. Cell Rep. 32 (2): 107887, 2020. PMID: 32668246.
Press Release
Multiomics investigation revealing the characteristics of HIV-1-infected cells in vivo – Clues for the development of an HIV-1 cure – (University of Tokyo & AMED, 2020.07.15)
https://www.amed.go.jp/en/news/release_20200715.html
clone information
CSII-CMV-MCS-IRES2-Bsd (cat# RDB04385)
pCMV-VSV-G-RSV-Rev (cat# RDB04393)
pCAG-HIVgp (cat# RDB04394)
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RIKEN BioResource Research Center DNA Bank
3-1-1 Koyadai, Tsukuba Ibaraki, 305-0074 Japan
[e-mail] dna_sec.brc@riken.jp
[hp] https://dna.brc.riken.jp/en/
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2022.01.18
