SARS-CoV-2 relevant human genes

SARS-CoV-2 relevant human genes

Gene Involvement in the Disease
ACE2 Receptor of spike protein of SARS-CoV-2 (PMID: 32225175)
TMPRSS2 Priming the SARS-CoV-2 S protein for virus entry into cells (PMID: 32142651). Cleaving spike protein of SARS-CoV and helping the virus entry by promoting fusion with the host cell membrane (PMID: 21994442).
TMPRSS11D (HAT) Cleaving spike protein of SARS-CoV and activating spike protein for cell-cell fusion (PMID: 21994442, 33671076)
TMPRSS13 Enhancing cellular uptake and subsequent replication of SARS-CoV-2 (PMID: 33671076)
ADAM17 (TACE) Cleaving ACE2 but probably by a different way than TMPRSS2 (PMID: 24227843)
CTSL Activating the membrane fusion function of the SARS-CoV spike protein (PMID: 18562523)
FURIN A candidate enzyme cleaving SARS-CoV-2 S protein that contains four redundant FURIN cut sites (PMID: 32057769)
IL6 Cytokine that functions in inflammation and the maturation of B cells
IL6R A subunit of the interleukin6 (IL6) receptro complex
IL6ST Signal transducer shared by many cytokines
OAS1 Genes involved in critical illness in Covid-19 revealed by a genome-wide association study (PMID: 33307546)
OAS2 Genes involved in critical illness in Covid-19 revealed by a genome-wide association study (PMID: 33307546)
TYK2 Genes involved in critical illness in Covid-19 revealed by a genome-wide association study (PMID: 33307546)
DPP9 Genes involved in critical illness in Covid-19 revealed by a genome-wide association study (PMID: 33307546)
IFNAR2 Genes involved in critical illness in Covid-19 revealed by a genome-wide association study (PMID: 33307546)
SPINT2 (HAI-2) A candidate regulator of the TMPRSS2 function (PMID: 33789993)

Human genes in the KEGG Pathway

Link to KEGG Pathway – Coronavirusdisease-COVID-19
List of gene resources


Human gene expressing in endothelium

The following genes were picked up using TISSUE ATLAS of the Human Protein Atlas (Uppsala University) with the keyword “endothelium”.


(GSB0049e 2020.10.03 T.M.)

2021.08.27



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