SARS-CoV-2 genes
| Catalog no. | Name of resource | Short description |
|---|---|---|
| RDB20274 | pENTR4-GFP-Nsp14-BGHpA | A Gateway entry vector of SARS-CoV-2 Nsp14 N-terminally tagged with EGFP. |
| RDB19690 | pT7-CoV-S(W152L E484K D614G G769V)-pA | Mammalian expression and T7 In Vitro Transcription dual vector of SARS-CoV-2 Spike(W152L E484K D614G G769V). Bacterial high copy number plasmid. |
| RDB19689 | pT7-CoV-S(D614G)-pA | Mammalian expression and T7 In Vitro Transcription dual vector of SARS-CoV-2 Spike(D614G). Bacterial high copy number plasmid. |
| RDB19688 | pT7-CoV-S-pA | Mammalian expression and T7 In Vitro Transcription dual vector of SARS-CoV-2 Spike. Bacterial high copy number plasmid. |
| RDB19686 | pMWT7-CoV-ORF1a-pA | Mammalian expression and T7 In Vitro Transcription dual ussage vector of SARS-CoV-2 ORF1a. Bacterial low copy number plasmid. |
| RDB19685 | pMWT7-CoV-ORF1a(IA)-pA | Mammalian expression and T7 In Vitro Transcription dual ussage vector of SARS-CoV-2 ORF1a(IA strain). Bacterial low copy number plasmid. |
| RDB19554 | pUC-IA-ORF4-10 | Plasmid vector of SARS-CoV2 cDNA encoding from ORF4 to ORF10. |
| RDB19551 | pBS2SK+IA-ORF2 | Plasmid vector of SARS-CoV2 cDNA encoding ORF2 (Spike protein). |
COVID-19 relevant human genes
| Gene | Involvement in the Disease |
|---|---|
| ACE2 | Receptor of spike protein of SARS-CoV-2 (PMID: 32225175) |
| TMPRSS2 | Priming the SARS-CoV-2 S protein for virus entry into cells (PMID: 32142651). Cleaving spike protein of SARS-CoV and helping the virus entry by promoting fusion with the host cell membrane (PMID: 21994442). |
| TMPRSS11D (HAT) | Cleaving spike protein of SARS-CoV and activating spike protein for cell-cell fusion (PMID: 21994442, 33671076) |
| TMPRSS13 | Enhancing cellular uptake and subsequent replication of SARS-CoV-2 (PMID: 33671076) |
| ADAM17 (TACE) | Cleaving ACE2 but probably by a different way than TMPRSS2 (PMID: 24227843) |
| CTSL | Activating the membrane fusion function of the SARS-CoV spike protein (PMID: 18562523) |
| FURIN | A candidate enzyme cleaving SARS-CoV-2 S protein that contains four redundant FURIN cut sites (PMID: 32057769) |
| IL6 | Cytokine that functions in inflammation and the maturation of B cells |
| IL6R | A subunit of the interleukin6 (IL6) receptro complex |
| IL6ST | Signal transducer shared by many cytokines |
| OAS1 | Genes involved in critical illness in COVID-19 revealed by a genome-wide association study (PMID: 33307546) |
| OAS2 | Genes involved in critical illness in COVID-19 revealed by a genome-wide association study (PMID: 33307546) |
| TYK2 | Genes involved in critical illness in COVID-19 revealed by a genome-wide association study (PMID: 33307546) |
| DPP9 | Genes involved in critical illness in COVID-19 revealed by a genome-wide association study (PMID: 33307546) |
| IFNAR2 | Genes involved in critical illness in COVID-19 revealed by a genome-wide association study (PMID: 33307546) |
| SPINT2 (HAI-2) | A candidate regulator of the TMPRSS2 function (PMID: 33789993) |
Human genes in the KEGG Pathway
Link to KEGG Pathway – Coronavirusdisease-COVID-19
List of gene resources
- Human [open/close]
Human gene expressing in endothelium
The following genes were picked up using TISSUE ATLAS of the Human Protein Atlas (Uppsala University) with the keyword “endothelium”.
- Human [open/close]
ACE ACOT7 ADIPOQ ADIRF ALG1L AMOT ANGPT1 ANGPTL1 ANGPTL2 ANPEP ASB7 ATL2 BAG2 BSG C12orf76 C1orf216 C22orf42 C4BPA C9 CABP7 CACNA1C CD34 CD36 CD74 CD93 CD99 CLEC14A COBLL1 COL4A1 COL4A2 COL8A1 COL8A2 COX16 EDN3 EMILIN1 ENG ERG ESM1 FBLN5 FCGR2B FLT4 FMNL3 FOXC2 FOXN3 GAS2L3 GIMAP7 GJA1 GJA4 GJA5 GNS GP1BA GP1BB IL27 ITGAM ITGAX KDR KNG1 LAMB2 LSP1 LYVE1 MAGEB10 MAST1 MCAM METAP1D MMRN1 MS4A10 MTURN NQO2 PGM5 PLXDC1 PODXL PPFIA1 PPP3CC PSG1 PSG11 PSG3 PSG4 PSG5 PSG6 PSG7 PSG8 PSG9 PTGIR PTH2R PTPN6 REEP2 REX1BD RPS6KA3 S1PR1 SELE SLC12A1 SLC22A13 SLC2A1 SLC40A1 SLC9A3R2 SLFN12 STAB2 SULF2 SYNJ2BP-COX16 SYNPO TAL2 TCTEX1D1 TFPI TMEM43 TMSB4X VCAM1 VTN VWF ZCCHC11 ZDHHC6
(GSB0049e 2020.10.03 T.M.)
2024.11.19
