Gene Engineering Division – DNA BANK –

The 2015 Nobel Prize in Chemistry

Genetic resources for genes involved in the DNA repair are available.
Looking forward to receiving your request.

Base excision repair

Link to KEGG Pathway – Base excision repair

List of gene resources

• Human [open/close]

  Gene
  APEX1	APEX2	FEN1	HMGB1
  LIG1	LIG3	MBD4	MPG
  MUTYH	NEIL1	NEIL2	NEIL3
  NTHL1	OGG1	PARP1	PARP2
  PARP3	PCNA	POLB	POLD1
  POLD2	POLD3	POLD4	POLE
  POLE3	POLE4	POLL	SMUG1
  TDG	UNG	XRCC1

• Mouse [open/close]

  Gene
  Apex1	Fen1	Hmgb1	Lig1
  Lig3	Mpg	Mutyh	Neil3
  Ogg1	Parp1	Parp2	Parp3
  Parp4	Pcna	Polb	Pold1
  Pold2	Pold3	Pold4	Pole
  Pole2	Pole3	Pole4	Poll
  Smug1	Tdg	Ung	Xrcc1

• S. pombe [open/close]

  Gene
  adl1	apn2	cdc1	cdc17
  cdc20	cdc27	cdc6	cdm1
  dpb2	dpb4	myh1	nth1
  pcn1	rad2	thp1	ung1

• Thermus thermophilus HB8 [open/close]

  Gene
  A/G-specific adenine glycosylase MutY	DNA ligase
  DNA polymerase I	DNA-3-methyladenine glycosidase
  endonuclease III	endonuclease IV
  formamidopyrimidine-DNA glycosylase	single-stranded DNA specific exonuclease RecJ

• Aeropyrum pernix [open/close]

  Gene
  3-methyladenine DNA glycosylase	ATP-dependent DNA ligase
  DNA polymerase sliding clamp A	DNA polymerase sliding clamp B1
  endonuclease IV	nth endonuclease III
  U/G and T/G mismatch-specific DNA glycosylase

Nucleotide excision repair

Link to KEGG Pathway – Nucleotide excision repair

List of gene resources

• Human [open/close]

  Gene
  BIVM-ERCC5	CCNH	CDK7	CETN2
  CUL4A	CUL4B	DDB1	DDB2
  ERCC1	ERCC2	ERCC3	ERCC4
  ERCC5	ERCC6	ERCC8	GTF2H1
  GTF2H2	GTF2H2C	GTF2H2C_2	GTF2H3
  GTF2H4	GTF2H5	LIG1	MNAT1
  PCNA	POLD1	POLD2	POLD3
  POLD4	POLE	POLE2	POLE3
  POLE4	RAD23A	RAD23B	RBX1
  RFC1	RFC2	RFC3	RFC4
  RFC5	RPA1	RPA2	RPA3
  RPA4	XPA	XPC

• Mouse [open/close]

  Gene
  Rbx1	Cul4b	Cul4a	Ddb1
  Ddb2	Xpc	Rad23b	Rad23a
  Cetn2	Ercc8	Ercc6	Cdk7
  Mnat1	Ccnh	Ercc3	Ercc2
  Gtf2h5	Gtf2h1	Gtf2h2	Gtf2h3
  Gtf2h4	Ercc5	Xpa	Rpa1
  Rpa2	Rpa3	Ercc4	Ercc1
  Pold1	Pold2	Pold3	Pold4
  Pole	Pole2	Pole3	Pole4
  Pcna	Rfc1	Rfc4	Rfc2
  Rfc5	Rfc3	Lig1

• S. pombe [open/close]

  Gene
  adl1	cdc1	cdc17	cdc20
  cdc27	cdc6	cdm1	ckn1
  ddb1	dpb2	dpb4	mcs2
  mcs6	pcn1	pcu4	pmh1
  ptr8	rad13	rad15	rad16
  rbx1	rfc1	rfc2	rfc3
  rfc4	rfc5	rhp14	rhp23
  rhp26	rhp41	rhp42	srs2
  ssb1	ssb2	ssb3	ssl1
  swi10	tfb1	tfb2	tfb4
  tfb5

• Thermus thermophilus HB8 [open/close]

  Gene
  ATP-dependent DNA helicase UvrD	DNA ligase
  DNA polymerase I	excinuclease ABC subunit B
  transcription-repair coupling factor	uvrA
  uvrC

• Aeropyrum pernix [open/close]

  Gene
  DNA polymerase sliding clamp A	DNA polymerase sliding clamp B1
  DNA repair helicase Rad3	repair endonuclease XPF
  ssDNA-binding protein	ATP-dependent DNA ligase

• KEGG Orthology[open/close]

  Gene
  E6.5.1.2,ligA,ligB	CDK7	POLE	POLE2
  POLE3	POLD1	POLD2	polA
  ERCC6,CSB,RAD26	TFIIH2,GTF2H2,SSL1	TFIIH3,GTF2H3,TFB4	TFIIH4,GTF2H4,TFB2
  POLD3	POLD4	POLE4	uvrD,pcrA
  uvrA	uvrB	uvrC	mfd
  RBX1,ROC1	PCNA	CCNH	RFA1,RPA1,rpa
  DDB2	ERCC8,CKN1,CSA	CUL4	DDB1
  RFA2,RPA2	RPA3	RPA4	LIG1
  RFC1	RFC2_4	RFC3_5	XPC
  RAD23,HR23	CETN2	ERCC6,CSB,RAD26	MNAT1
  ERCC3,XPB	ERCC2,XPD	TTDA,GTF2H5,TFB5	ERCC5,XPG,RAD2
  XPA	ERCC4,XPF	ERCC1

Mismatch repair

Link to KEGG Pathway – Mismatch repair

List of gene resources

• Human [open/close]

  Gene
  EXO1	LIG1	MLH1	MLH3
  MSH2	MSH3	MSH6	PCNA
  PMS2	POLD1	POLD2	POLD3
  POLD4	RFC1	RFC2	RFC3
  RFC4	RFC5	RPA1	RPA2
  RPA3	RPA4	SSBP1

• Mouse [open/close]

  Gene
  Exo1	Lig1	Mlh1	Mlh3
  Msh2	Msh3	Msh6	Pcna
  Pms2	Pold1	Pold2	Pold3
  Pold4	Rfc1	Rfc2	Rfc3
  Rfc4	Rfc5	Rpa1	Rpa2
  Rpa3	Ssbp1

• S. pombe [open/close]

  Gene
  adl1	cdc1	cdc17	cdc27
  cdc6	cdm1	exo1	mlh1
  msh2	msh3	msh6	pcn1
  pms1	rfc1	rfc2	rfc3
  rfc4	rfc5	srs2	ssb1
  ssb2	ssb3

• Thermus thermophilus HB8 [open/close]

  Gene
  ATP-dependent DNA helicase UvrD	DNA ligase
  DNA mismatch repair protein MutL	DNA mismatch repair protein MutS
  DNA mismatch repair protein MutS	DNA polymerase III holoenzyme subunit tau
  DNA polymerase III subunit alpha	DNA polymerase III subunit beta
  DNA polymerase III subunit delta	DNA polymerase III subunit delta’
  DNA polymerase III subunit epsilon	single-stranded DNA binding protein
  single-stranded DNA specific exonuclease RecJ

• Aeropyrum pernix [open/close]

  Gene
  ATP-dependent DNA ligase	DNA polymerase sliding clamp A
  DNA polymerase sliding clamp B1	ssDNA-binding protein

• KEGG Orthology[open/close]

  Gene
  dam	DPO3A1,dnaE	DPO3B,dnaN	DPO3D1,holA
  DPO3E,dnaQ	DPO3G,dnaX	E6.5.1.2,ligA,ligB	EXO1
  exoX	holB	holC	holD
  holE	LIG1	MLH1	MLH3
  MSH2	MSH3	MSH6	mutH
  mutL	mutS	mutS2	PCNA
  PMS2	polC	POLD1	POLD2
  POLD3	POLD4	recJ	RFA1,RPA1,rpa
  RFA2,RPA2	RFC1	RFC2_4	RFC3_5
  rnhA-dnaQ	RPA3	RPA4	sbcB,exoI
  ssb	uvrD,pcrA	xseA	xseB

References

1. The Nobel Prize in Chemistry 2015
2. KEGG Pathway – Base excision repair
3. KEGG Pathway – Nucleotide excision repair
4. KEGG Pathway – Mismatch repair

 

(GSB0022e 2015.10.07 T.M.)

2019.04.09