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p53, p63 and p73


p53, p63 and p73

Human and Mouse Resources

Locus Gene Products Alternative Name
TP53 tumor protein p53 FLJ92943; LFS1; P53; TRP53
TP63 tumor protein p63 AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
TP73 tumor protein p73 P73
Trp53 transformation related protein 53 Tp53|bbl|bfy|bhy|p44|p53

 


Target genes

Human and Mouse Resources

Locus Gene Products Alternative Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ABC20; CD243; CLCS; GP170; MDR1; MGC163296; P-GP; PGY1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; MRP; MRP1
AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT; MGC99656; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 AMID; DKFZp686L1298; PRG3; RP11-367H5.2
ANTXR1 anthrax toxin receptor 1 ATR; FLJ10601; FLJ11298; FLJ21776; TEM8
APAF1 apoptotic peptidase activating factor 1 APAF-1; CED4; DKFZp781B1145
APCS amyloid P component, serum MGC88159; PTX2; SAP
AQP1 aquaporin 1 (Colton blood group) AQP-CHIP; CHIP28; CO; MGC26324
ATR ataxia telangiectasia and Rad3 related FRP1; MEC1; SCKL; SCKL1
BAI1 brain-specific angiogenesis inhibitor 1 FLJ41988; GDAIF
BAI2 brain-specific angiogenesis inhibitor 2 BAI2
BAK1 BCL2-antagonist/killer 1 BAK; BAK-LIKE; BCL2L7; CDN1; MGC117255; MGC3887
BAX BCL2-associated X protein BCL2L4
BBC3 BCL2 binding component 3 FLJ42994; JFY-1; JFY1; PUMA
BCL2 B-cell CLL/lymphoma 2 Bcl-2
BCL2L1 BCL2-like 1 BCL-XL/S; BCL2L; BCLX; BCLXL; BCLXS; Bcl-X; DKFZp781P2092; bcl-xL; bcl-xS
BCL3 B-cell CLL/lymphoma 3 BCL4; D19S37
BIRC5 baculoviral IAP repeat containing 5 API4; EPR-1
RNGTT RNA guanylyltransferase and 5′-phosphatase CAP1A; DKFZp686J2031; HCE; HCE1; hCAP
TP53TG5 TP53 target 5 C20orf10; CLG01
CABLES1 Cdk5 and Abl enzyme substrate 1 CABL1; CABLES; FLJ35924; HsT2563; IK3-1
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) ICE; IL1BC; P45
CAV1 caveolin 1, caveolae protein, 22kDa BSCL3; CGL3; MSTP085; VIP21
CCND1 cyclin D1 BCL1; D11S287E; PRAD1; U21B31
CHEK1 CHK1 checkpoint homolog (S. pombe) CHK1
CHEK2 CHK2 checkpoint homolog (S. pombe) CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53
CHUK conserved helix-loop-helix ubiquitous kinase IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa CTNNB; DKFZp686D02253; FLJ25606; FLJ37923
CX3CL1 chemokine (C-X3-C motif) ligand 1 ABCD-3; C3Xkine; CXC3; CXC3C; NTN; NTT; SCYD1; fractalkine; neurotactin
DDB2 damage-specific DNA binding protein 2, 48kDa DDBB; FLJ34321; UV-DDB2
DKK1 dickkopf homolog 1 (Xenopus laevis) DKK-1; SK
DUSP1 dual specificity phosphatase 1 CL100; HVH1; MKP-1; MKP1; PTPN10
DUSP12 dual specificity phosphatase 12 DUSP1; YVH1
EGFR epidermal growth factor receptor ERBB; ERBB1; HER1; PIG61; mENA
EGR1 early growth response 1 AT225; G0S30; KROX-24; NGFI-A; TIS8; ZIF-268; ZNF225
EPHA2 EPH receptor A2 ARCC2; ECK
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
EZH2 enhancer of zeste homolog 2 (Drosophila) ENX-1; ENX1; EZH1; KMT6; KMT6A; MGC9169
FAS Fas (TNF receptor superfamily, member 6) ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
FDXR ferredoxin reductase ADXR
GADD45A growth arrest and DNA-damage-inducible, alpha DDIT1; GADD45
GML glycosylphosphatidylinositol anchored molecule like protein LY6DL
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; H-RASIDX; HAMSV; HRAS1; K-RAS; N-RAS; RASH1
IFI16 interferon, gamma-inducible protein 16 IFNGIP1; MGC9466; PYHIN2
IGFBP3 insulin-like growth factor binding protein 3 BP-53; IBP3
IL8 interleukin 8 CXCL8; GCP-1; GCP1; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1
MKI67 antigen identified by monoclonal antibody Ki-67 KIA
KLK3 kallikrein-related peptidase 3 APS; KLK2A1; PSA; hK3
KLKB1 kallikrein B, plasma (Fletcher factor) 1 KLK3; PPK
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) MAD1; PIG9; TP53I9; TXBP181
MDM2 Mdm2 p53 binding protein homolog (mouse) HDMX; MGC5370; MGC71221; hdm2
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain CD263; DCR1; DCR1-TNFR; LIT; MGC149501; MGC149502; TRAIL-R3; TRAILR3; TRID
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type ATR; MGC20496; cblB; cob
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) CLG4; CLG4A; MMP-II; MONA; TBE-1
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) COCA1; FCC1; HNPCC; HNPCC1; LCFS2
MYC v-myc myelocytomatosis viral oncogene homolog (avian) MRTL; bHLHe39; c-Myc
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NF-ATc4; NFAT3
NFIC nuclear factor I/C (CCAAT-binding transcription factor) CTF; CTF5; MGC20153; NF-I; NFI
NLRC4 NLR family, CARD domain containing 4 CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF
NME1 non-metastatic cells 1, protein (NM23A) expressed in AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) ARC; FLJ35304; MYP; NOP; NOP30
NOS2 nitric oxide synthase 2, inducible HEP-NOS; INOS; NOS; NOS2A
NTHL1 nth endonuclease III-like 1 (E. coli) NTH1; OCTS3
PCNA proliferating cell nuclear antigen MGC8367
PIAS3 protein inhibitor of activated STAT, 3 FLJ14651; ZMIZ5
PLK1 polo-like kinase 1 PLK; STPK13
PLK3 polo-like kinase 3 CNK; FNK; PRK
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 APR; NOXA
PML promyelocytic leukemia MYL; PP8675; RNF71; TRIM19
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa CDC2; POLD
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit AMPK; HAMPKb; MGC17785
PTEN phosphatase and tensin homolog 10q23del; BZS; DEC; GLM2; MGC11227; MHAM; MMAC1; PTEN1; TEP1
PTTG1 pituitary tumor-transforming 1 EAP1; HPTTG; MGC126883; MGC138276; PTTG; TUTR1
RB1 retinoblastoma 1 OSRC; RB; p105-Rb; pRb; pp110
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) MGC131774; NFKB3; p65
RHOA ras homolog gene family, member A ARH12; ARHA; RHO12; RHOH12
RRM2B ribonucleotide reductase M2 B (TP53 inducible) DKFZp686M05248; MGC102856; MGC42116; MTDPS8A; MTDPS8B; P53R2
S100B S100 calcium binding protein B NEF; S100; S100-B; S100beta
SIVA1 SIVA1, apoptosis-inducing factor CD27BP; SIVA; Siva-1; Siva-2
SSTR2 somatostatin receptor 2 SSTR2
STAT1 signal transducer and activator of transcription 1, 91kDa CANDF7; DKFZp686B04100; ISGF-3; STAT91
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) APRF; FLJ20882; HIES; MGC16063
EPCAM epithelial cell adhesion molecule DIAR5; EGP-2; EGP314; EGP40; ESA; GA733-2; HNPCC8; KS1/4; KSA; M4S1; MIC18; MK-1; TACSTD1; TROP1
TBXAS1 thromboxane A synthase 1 (platelet) BDPLT14; CYP5; CYP5A1; FLJ52771; GHOSAL; THAS; TS; TXAS; TXS
TERT telomerase reverse transcriptase DKCA2; DKCB4; EST2; TCS1; TP2; TRT; hEST2; hTRT
TGFA transforming growth factor, alpha TFGA
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a APO2; CD261; DR4; MGC9365; TRAILR-1; TRAILR1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b CD262; DR5; KILLER; KILLER/DR5; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
TP53 tumor protein p53 FLJ92943; LFS1; P53; TRP53
TP53I3 tumor protein p53 inducible protein 3 PIG3
TP73 tumor protein p73 P73
TP63 tumor protein p63 AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
TRIM22 tripartite motif containing 22 GPSTAF50; RNF94; STAF50
TYMS thymidylate synthetase HST422; MGC88736; TMS; TS
UNC5B unc-5 homolog B (C. elegans) UNC5H2; p53RDL1
VEGFA vascular endothelial growth factor A MGC70609; MVCD1; VEGF; VPF
WRN Werner syndrome, RecQ helicase-like DKFZp686C2056; RECQ3; RECQL2; RECQL3
XPC xeroderma pigmentosum, complementation group C RAD4; XP3; XPCC
Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B Abcb1|Mdr1|Mdr1b|Pgy-1|Pgy1|mdr
Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Abcc1a|Abcc1b|MRP|Mdrap|Mrp1
Akt1 thymoma viral proto-oncogene 1 Akt|PKB|PKB/Akt|PKBalpha|Rac
Cav1 caveolin 1, caveolae protein Cav|Cav-1
Cav2 caveolin 2 AI447843
Ccnd1 cyclin D1 AI327039|Cyl-1|PRAD1|bcl-1|cD1
Chek1 checkpoint kinase 1 homolog (S. pombe) C85740|Chk1|rad27
Chek2 CHK2 checkpoint homolog (S. pombe) CHK2|Cds1|HUCDS1|Rad53
Egfr epidermal growth factor receptor 9030024J15Rik|AI552599|Erbb|Errp|Wa5|wa-2|wa2
Egr1 early growth response 1 A530045N19Rik|ETR103|Egr-1|Krox-1|Krox-24|Krox24|NGF1-A|NGFI-A|NGFIA|TIS8|Zenk|Zfp-6|Zif268|egr
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Erbb-2|HER-2|HER2|Neu|c-erbB2|c-neu|mKIAA3023
Mdm2 transformed mouse 3T3 cell double minute 2 1700007J15Rik|AA415488|Mdm-2
Myc myelocytomatosis oncogene AU016757|Myc2|Niard|Nird|bHLHe39
Plk1 polo-like kinase 1 (Drosophila) Plk|STPK13
Rb1 retinoblastoma 1 Rb|Rb-1|pRb
Stat1 signal transducer and activator of transcription 1 2010005J02Rik|AA408197
Stat3 signal transducer and activator of transcription 3 1110034C02Rik|AW109958|Aprf

 

Other resources

Locus RDB no. External DB Name of Clone RunningTitle Type
APCS 1820 Porcine serum amyloid P component Porcine serum amyloid P component cDNA DNA clone

(T.M. Aug, 2008)

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Renilla Luciferase

RDB no. human promoter HeLa HepG2 B16 MCF-7 C2C12 C2C12+DM LNCaP LNCaP+dex Saos-2 Saos-2serum starvation 293 K562 K562 +TPA NIH3T3 p53 over-expression in HepG2
5507 p53 +++
5529 p73 tumor protein +
5479 collagenase type IV +++ + + +++
5485 early growth response protein 1 +++ ++ +++ +++
5534 telomerase reverse transcriptase,catalytic subunit +
5910 proatate-specific antigen/kallikrein 3 + + + +
5546 proatate-specific antigen/kallikrein 3 +

 

Firefly Luciferase

‘Activity’ indicates a value of the fold induction compared with empty vector.
-, less than 2
+, 2 to 5
++, 5 to 10
actual value, more than 10

Locus symbol RDB No. Name of clone Gene of insert Other Aliases Size of inserted DNA Activity in pdf
HeLa HepG2 Hep3B
pGL3 Control pGL3 Control Vector (SV40 promoter) 372.4 159.9 226.6
ABCB1 7315 pGL4-phABCB1 Promoter collection, Human ABCB1 promoter CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; MGC163296 1,219 bp + PDF
AKT1 7331 pGL4-phAKT1 Promoter collection, Human AKT1 promoter AKT; PKB; RAC; PRKBA; MGC99656; PKB-ALPHA; RAC-ALPHA 1,152 bp + + PDF
ANTXR1 7333 pGL4-phANTXR1 Promoter collection, Human ANTXR1 promoter ATR; TEM8; FLJ10601; FLJ11298; FLJ21776 1,189 bp 88.5 30.0 36.0 PDF
APAF1 7316 pGL4-phAPAF1 Promoter collection, Human APAF1 promoter CED4; APAF-1; DKFZp781B1145 1,152 bp 31.0 101.0 43.0 PDF
APCS 7317 pGL4-phAPCS Promoter collection, Human APCS promoter SAP; PTX2; MGC88159 1,163 bp + + + PDF
ATR 7334 pGL4-phATR Promoter collection, Human ATR promoter FRP1; MEC1; SCKL; SCKL1 1,147 bp 105.5 408.0 308.0 PDF
B2M 7479 pGL4-phB2M Promoter collection, Human B2M promoter 1,420 bp 339.5 ++ + PDF
BAI1 7401 pGL4-phBAI1 Promoter collection, Human BAI1 promoter GDAIF; FLJ41988 1,368 bp + + + PDF
BAK1 7318 pGL4-phBAK1 Promoter collection, Human BAK1 promoter BAK; CDN1; BCL2L7; MGC3887; BAK-LIKE; MGC117255 1,193 bp 22.0 91.0 34.0 PDF
BCL2 7567 pGL4-phBCL2 Promoter collection, Human BCL2 promoter Bcl-2 1,347 bp 21.0 ++ ++ PDF
BCL2L1 7335 pGL4-phBCL2L1 Promoter collection, Human BCL2L1 promoter BCLX; BCL2L; BCLXL; BCLXS; Bcl-X; bcl-xL; bcl-xS; BCL-XL/S; DKFZp781P2092 1,214 bp ++ 56.0 147.0 PDF
BTG2 7402 pGL4-phBTG2 Promoter collection, Human BTG2 promoter PC3; TIS21; MGC126063; MGC126064 1,356 bp 285.0 1162.0 271.0 PDF
CABLES1 7337 pGL4-phCABLES1 Promoter collection, Human CABLES1 promoter IK3-1; CABLES; HsT2563; FLJ35924 1,222 bp + PDF
CASP1 7338 pGL4-phCASP1 Promoter collection, Human CASP1 promoter ICE; P45; IL1BC 1,169 bp ++ 16.0 20.0 PDF
CAV1 7364 pGL4-phCAV1 Promoter collection, Human CAV1 promoter CGL3; BSCL3; VIP21; MSTP085 1,309 bp + + PDF
CCND1 7299 pGL4-phCCND1 Promoter collection, Human CCND1 promoter BCL1; PRAD1; U21B31; D11S287E 1,191 bp + 170.0 ++ PDF
CHEK1 7319 pGL4-phCHEK1 Promoter collection, Human CHEK1 promoter CHK1 1,208 bp 83.5 31.0 110.0 PDF
CHEK2 7407 pGL4-phCHEK2 Promoter collection, Human CHEK2 promoter CDS1; CHK2; LFS2; RAD53; HuCds1; PP1425 1,312 bp 57.0 80.0 34.0 PDF
CHUK 7383 pGL4-phCHUK Promoter collection, Human CHUK promoter IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha 1,315 bp 767.0 820.0 944.0 PDF
CX3CL1 7340 pGL4-phCX3CL1 Promoter collection, Human CX3CL1 promoter NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin 1,236 bp + PDF
DKK1 7341 pGL4-phDKK1 Promoter collection, Human DKK1 promoter SK; DKK-1 1,166 bp 20.5 35.0 44.0 PDF
DUSP1 7368 pGL4-phDUSP1 Promoter collection, Human DUSP1 promoter HVH1; MKP1; CL100; MKP-1; PTPN10 1,165 bp 173.8 176.8 1083.5 PDF
DUSP12 7384 pGL4-phDUSP12 Promoter collection, Human DUSP12 promoter YVH1; DUSP1 1,310 bp 1593.0 1221.0 1937.0 PDF
EGFR 7398 pGL4-phEGFR Promoter collection, Human EGFR promoter ERBB; HER1; mENA; ERBB1; PIG61 1,340 bp 31.0 26.0 65.0 PDF
EGR1 7369 pGL4-phEGR1 Promoter collection, Human EGR1 promoter TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268 1,310 bp 1594.3 605.0 5730.0 PDF
EPHA2 7342 pGL4-phEPHA2 Promoter collection, Human EPHA2 promoter ECK; ARCC2 1,163 bp 26.0 152.0 81.0 PDF
EZH2 7370 pGL4-phEZH2 Promoter collection, Human EZH2 promoter ENX1; EZH1; KMT6; ENX-1; KMT6A; MGC9169 1,205 bp ++ ++ 65.5 PDF
FAS 7349 pGL4-phFAS Promoter collection, Human FAS promoter APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6 1,331 bp + ++ PDF
FDXR 7385 pGL4-phFDXR Promoter collection, Human FDXR promoter ADXR 1,353 bp 756.0 2295.0 921.0 PDF
GADD45A 7320 pGL4-phGADD45A Promoter collection, Human GADD45A promoter DDIT1; GADD45 1,225 bp 214.5 675.0 313.0 PDF
GML 7371 pGL4-phGML Promoter collection, Human GML promoter LY6DL 1,308 bp + ++ PDF
IFI16 7372 pGL4-phIFI16 Promoter collection, Human IFI16 promoter PYHIN2; IFNGIP1; MGC9466 1,316 bp ++ ++ 61.5 PDF
IGFBP3 7568 pGL4-phIGFBP3 Promoter collection, Human IGFBP3 promoter IBP3; BP-53 1,202 bp 119.0 49.5 22.2 PDF
IL8 7322 pGL4-phIL8 Promoter collection, Human IL8 promoter NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1 1,263 bp 376.5 1675.0 568.0 PDF
KLK3 7324 pGL4-phKLK3 Promoter collection, Human KLK3 promoter APS; PSA; hK3; KLK2A1 1,182 bp + ++ ++ PDF
KLKB1 7373 pGL4-phKLKB1 Promoter collection, Human KLKB1 promoter PPK; KLK3 1,304 bp ++ ++ ++ PDF
MAD1L1 7374 pGL4-phMAD1L1 Promoter collection, Human MAD1L1 promoter MAD1; PIG9; TP53I9; TXBP181 1,379 bp 472.0 450.0 901.0 PDF
MDM2 7403 pGL4-phMDM2 Promoter collection, Human MDM2 promoter HDMX; hdm2; MGC5370; MGC71221 1,319 bp ++ 48.0 30.0 PDF
MMP2 7314 pGL4-phMMP2 Promoter collection, Human MMP2 promoter CLG4; MONA; CLG4A; TBE-1; MMP-II 1,160 bp + ++ ++ PDF
MYC 7325 pGL4-phMYC Promoter collection, Human MYC promoter MRTL; c-Myc; bHLHe39 1,267 bp ++ ++ 10.0 PDF
NFATC4 7376 pGL4-phNFATC4 Promoter collection, Human NFATC4 promoter NFAT3; NF-ATc4 1,315 bp 33.0 19.0 47.0 PDF
NFIC 7399 pGL4-phNFIC Promoter collection, Human NFIC promoter CTF; NFI; CTF5; NF-I; MGC20153 1,152 bp 53.0 26.0 59.0 PDF
NLRC4 7406 pGL4-phNLRC4 Promoter collection, Human NLRC4 promoter CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1 1,318 bp + + PDF
NME1 7326 pGL4-phNME1 Promoter collection, Human NME1 promoter NB; AWD; NBS; GAAD; NM23; NDPKA; NDPK-A; NM23-H1 1,243 bp 606.5 /Td> 622.0 709.0 PDF
PCNA 7365 pGL4-phPCNA Promoter collection, Human PCNA promoter MGC8367 1,203 bp 50.0 46.8 214.0 PDF
PLK1 7327 pGL4-phPLK1 Promoter collection, Human PLK1 promoter PLK; STPK13 1,221 bp 11.0 24.0 15.0 PDF
PML 7343 pGL4-phPML Promoter collection, Human PML promoter MYL; RNF71; PP8675; TRIM19 1,305 bp 15.5 115.0 174.0 PDF
POLD1 7344 pGL4-phPOLD1 Promoter collection, Human POLD1 promoter CDC2; POLD 1,308 bp 200.0 145.0 238.0 PDF
PRKAB1 7328 pGL4-phPRKAB1 Promoter collection, Human PRKAB1 promoter AMPK; HAMPKb; MGC17785 1,173 bp 559.5 1031.0 702.0 PDF
PTEN 7400 pGL4-phPTEN Promoter collection, Human PTEN promoter BZS; DEC; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MGC11227 1,442 bp + 75.0 ++ PDF
PTTG1 7329 pGL4-phPTTG1 Promoter collection, Human PTTG1 promoter EAP1; PTTG; HPTTG; TUTR1; MGC126883; MGC138276 1,222 bp 43.5 14.0 29.0 PDF
RB1 7345 pGL4-phRB1 Promoter collection, Human RB1 promoter RB; pRb; OSRC; pp110; p105-Rb 1,333 bp 175.0 375.0 526.0 PDF
RELA 7366 pGL4-phRELA Promoter collection, Human RELA promoter p65; NFKB3; MGC131774 1,149 bp 136.8 73.0 399.0 PDF
RHOA 7404 pGL4-phRHOA Promoter collection, Human RHOA promoter ARHA; ARH12; RHO12; RHOH12 1,316 bp 258.0 296.0 422.0 PDF
RRM2B 7346 pGL4-phRRM2B Promoter collection, Human RRM2B promoter P53R2; MGC42116; MGC102856; DKFZp686M05248 1,323 bp ++ 24.3 72.5 PDF
SSTR2 7378 pGL4-phSSTR2 Promoter collection, Human SSTR2 promoter 1,320 bp 48.0 57.0 116.0 PDF
STAT1 7405 pGL4-phSTAT1 Promoter collection, Human STAT1 promoter ISGF-3; STAT91; DKFZp686B04100 1,313 bp 46.5 198.0 103.0 PDF
TBXAS1 7347 pGL4-phTBXAS1 Promoter collection, Human TBXAS1 promoter TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; FLJ52771 1,321 bp ++ 46.3 25.5 PDF
TERT 7379 pGL4-phTERT Promoter collection, Human TERT promoter TP2; TRT; EST2; TCS1; hEST2 1,341 bp 76.0 27.0 90.0 PDF
TGFA 7348 pGL4-phTGFA Promoter collection, Human TGFA promoter TFGA 1,305 bp 23.3 36.0 124.0 PDF
TNFRSF10B 7380 pGL4-phTNFRSF10B Promoter collection, Human TNFRSF10B promoter DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5 1,305 bp 40.0 65.0 228.0 PDF
TP53 7330 pGL4-phTP53 Promoter collection, Human TP53 promoter P53; LFS1; TRP53; FLJ92943 1,187 bp 56.0 93.0 133.0 PDF
TP73 7381 pGL4-phTP73 Promoter collection, Human TP73 promoter P73 1,332 bp 10.0 14.0 41.0 PDF
TRIM22 7382 pGL4-phTRIM22 Promoter collection, Human TRIM22 promoter RNF94; STAF50; GPSTAF50 1,317 bp ++ + + PDF
VEGFA 7681 pGL4-phVEGFA Promoter collection, Human VEGFA promoter VPF; VEGF; MVCD1; MGC70609 1,305 bp 125.5 27.0 20.7 PDF
WRN 7569 pGL4-phWRN Promoter collection, Human WRN promoter RECQ3; RECQL2; RECQL3; DKFZp686C2056 1,320 bp + PDF
XPC 7351 pGL4-phXPC Promoter collection, Human XPC promoter XP3; RAD4; XPCC 1,301 bp 141.0 341.8 482.5 PDF
From Entrez gene on 29.Sep.2010

 

Reporter element

Name of wild-type clone Running title Wild-type Mutant Map
forward reverse forward reverse
pp53-Box RE-TK hRluc(F) Reporter construct of p53-Box response element 5593 5656 5594 5657

(T.M. Dec, 2008)

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p53 Status of Cell Line

Cell line Origin Status (link)
A2780 Human ovarian tumour cell p53 status wt, elevated
p14(ARF) protein status +
p53 gene status [wt]
Rb gene status [wt]
A375 p14(ARF) gene status deficient
p14(ARF) protein status LTD
p53 protein status +
p53 gene status [wt]
Rb gene status [wt]
A549 p53 gene status wt
p16(INK4) protein LTD
pRb protein +
p14(ARF) protein status LTD
p14(ARF) gene status +
p14(ARF) protein status LTD
p53 gene status [wt]
Rb gene status [wt]
ATN-1 p53 gene status [wt (RCB1440) ]
Rb gene status [wt (RCB1440) ]
BALL-1 p53 gene status [Asp281Gly (RCB0256) ]
Rb gene status [wt (RCB0256) ]
Bre80 p14(ARF) gene status +
p14(ARF) protein status +
p53 gene status wt
BT-549 Human breast carcinoma p16(INK4) protein +++++
p16(INK4) protein +
pRb protein LTD
p53 gene status
p53 gene status [Arg249Ser]
Rb gene status [deletion in coding region]
C33A p53 gene status Mutant, Arg273Cys
p53 gene status Mutant, Arg273Cys
HPV genome
p16(INK4) protein +
pRb protein LTD
p53 gene status +/Mutant
p14(ARF) gene status +
p14(ARF) protein status +
p53 gene status [Arg273Cys]
Rb gene status [mutation in an intron]
CHP-126 p53 gene status [wt (RCB0486) ]
Rb gene status [wt (RCB0486) ]
CHP-134 p53 gene status [wt (RCB0487) ]
Rb gene status [wt (RCB0487) ]
COLO 679 p53 gene status [wt (RCB0989) ]
Rb gene status [wt (RCB0989) ]
CTB-1 p53 gene status [wt (RCB1316) ]
Rb gene status [wt (RCB1316) ]
CW-2 p53 gene status [wt (RCB0778) ]
Rb gene status [wt (RCB0778) ]
ECC10 p53 gene status [wt (RCB0983) ]
Rb gene status [Gln685stop (RCB0983) ]
ECC12 p53 gene status [Val216Met (RCB1009) ]
Rb gene status [deletion (RCB1009) ]
ECC4 p53 gene status [deletion (RCB0982) ]
Rb gene status [Arg661Trp (RCB0982) ]
EC-GI-10 p53 gene status [Tyr234Cys, Arg273Leu (RCB0774) ]
Rb gene status [wt (RCB0774) ]
EoL-1 cell p53 gene status [wt (RCB0641) ]
Rb gene status [wt (RCB0641) ]
ETK-1 p53 gene status [Arg175His (RCB1289) ]
Rb gene status [wt (RCB1289) ]
G401 p53 status wt
p14(ARF) protein status LTD
p53 gene status [wt]
Rb gene status [wt]
GCIY p53 gene status [Glu11Gln, His179Gln (RCB0555) ]
Rb gene status [wt (RCB0555) ]
GI-1 p53 gene status [Cys275Tyr (RCB0763) ]
Rb gene status [Arg552stop (RCB0763) ]
GM 639 DM p14(ARF) gene status +
p14(ARF) protein status +
p53 gene status wt/LT
GM 847 DM p14(ARF) gene status +
p14(ARF) protein status +
p53 gene status wt/LT
GOTO-P3 p53 gene status [wt (RCB0721) ]
Rb gene status [wt (RCB0721) ]
GR-ST p53 gene status [Met246Thr (RCB1182) ]
Rb gene status [mutation in an intron (RCB1182) ]
H1299 p53 gene status Null, deletion
p14(ARF) protein status +++
p53 gene status Null
p14(ARF) gene status +
p14(ARF) protein status ++
HAL-01 p53 gene status [wt (RCB0540) ]
Rb gene status [wt (RCB0540) ]
HCE-T p53 gene status [wt (RCB1384) ]
Rb gene status [wt (RCB1384) ]
HCT116 p53 gene status wt
p16(INK4) protein LTD
pRb protein +
p53 status wt
p14(ARF) protein status LTD
p53 protein status +
p53 gene status [wt]
Rb gene status [wt]
HCT116 TP53 -/- p53 status KO
p14(ARF) protein status LTD
HDF p14(ARF) gene status +
p14(ARF) protein status LTD
p53 gene status wt
HEK293 Human embryonic kidney p53 gene status wt/E1b55k
pRb genotype +/E1A
p16(INK4) protein +
pRb protein +/E1A
p16(INK4) protein ++++
p14(ARF) gene status +
p14(ARF) protein status +
p53 gene status wt/E1b55k
HeLa Human cervical carcinoma HPV genome HPV-18/+
p53 gene status wt/E6
pRb genotype +/E7
p16(INK4) protein ++++
p14(ARF) gene status +
p14(ARF) protein status ++
p53 gene status wt/E6
H-EMC-SS p53 gene status [wt (RCB0508) ]
Rb gene status [wt (RCB0508) ]
Hep3B Human hepatoma p53 gene status partial deletion
p53 protein status LTD
P16 genotype +
p16(INK4) protein +
pRb protein LTD
p53 gene status -/deficient
HepG2 Human hepatoma p53 gene status wt (Southern blott)
p53 protein status +
P16 genotype +
p16(INK4) protein +
pRb protein +
p14(ARF) gene status +
p14(ARF) protein status LTD
HGC-27 p53 gene status [flameshift after Pro153 (RCB0500) ]
Rb gene status [wt (RCB0500) ]
HMV-II p53 gene status [Asn268Ile (RCB0777) ]
Rb gene status [wt (RCB0777) ]
HT29 p53 gene status Mutant, Arg273His
p16(INK4) protein LTD
pRb protein +
p16(INK4) protein LTD
p53 protein status +
pRb protein +
p14(ARF) protein status +
p14(ARF) protein status ++
p53 gene status [Arg273His]
Rb gene status [wt]
HTC/C3 p53 gene status [Pro152Leu (RCB0452) ]
Rb gene status [wt (RCB0452) ]
HuH-7 Human hepatoma p53 gene status Mutant, Tyr220Cys
p16(INK4) protein LTD
p53 protein status +, truncated
pRb protein +
p53 gene status [Tyr220Cys (RCB1366) ]
Rb gene status [wt (RCB1366) ]
IA-LM p53 gene status [wt (RCB0554) ]
Rb gene status [wt (RCB0554) ]
IIICF/c p14(ARF) gene status
p14(ARF) protein status LTD
p53 gene status Null
J82 p14(ARF) gene status +
p14(ARF) protein status ++
p53 gene status Mutant
p53 gene status [Lys320Asn, deletion in coding region]
Rb gene status [mutation in an intron]
KGN p53 gene status [wt (RCB1154) ]
Rb gene status [wt (RCB1154) ]
KP4 p53 gene status [wt (RCB1005) ]
Rb gene status [wt (RCB1005) ]
KU812 p53 gene status
p53 gene status [wt (RCB0495) ]
Rb gene status [wt (RCB0495) ]
LC-1F p53 gene status [Met237Ile (RCB0439) ]
Rb gene status [wt (RCB0439) ]
LC-2/ad p53 gene status [deletion in coding region (RCB0440) ]
Rb gene status [wt (RCB0440) ]
LOVO Human colon carcinoma p16(INK4) protein LTD
p53 protein status LTD
pRb protein +
p16(INK4) protein LTD
p53 protein status LTD
pRb protein +
p53 gene status [wt]
Rb gene status [wt]
LS 174 T Human colon carcinoma p16(INK4) protein LTD
pRb protein +
p53 gene status wt
p53 gene status [wt]
Rb gene status [wt]
Lu-134-A p53 gene status [Pro278Leu (RCB0466) ]
Rb gene status [Try75stop (RCB0466) ]
Lu-135 p53 gene status [Gly244Cys (RCB0468) ]
Rb gene status [flame shift after Arg661 (RCB0468) ]
Lu-139 p53 gene status [Val157Phe (RCB0469) ]
Rb gene status [flame shift after Gly617 (RCB0469) ]
Lu-165 p53 gene status [deletion in an intron (RCB1184) ]
Rb gene status [flame shift after Val157 (RCB1184) ]
MCF-7 Human breast carcinoma p16(INK4) protein LTD
pRb protein +
p16(INK4) protein LTD
pRb protein +
p14(ARF) protein status LTD
p53 protein status +
p53 status +/wt
p53 gene status wt
p53 gene status [wt]
Rb gene status [wt]
MD468 p53 gene status +/Mutant
MDA-MB-453 p53 gene status [wt (RCB1192) ]
Rb gene status [wt (RCB1192) ]
MFH-ino p53 gene status [wt (RCB0749) ]
Rb gene status [wt (RCB0749) ]
MKN28 p53 gene status [Ile251Leu (RCB1000) ]
Rb gene status [wt (RCB1000) ]
MKN45 p53 gene status Arg110Cys
p53 gene status [wt (RCB1001) ]
Rb gene status [wt (RCB1001) ]
MMAc-SF p53 gene status [wt (RCB1200) ]
Rb gene status [wt (RCB1200) ]
NB16 p53 gene status [Arg175His (RCB0478) ]
Rb gene status [wt (RCB0478) ]
NB69 p53 gene status [wt (RCB0480) ]
Rb gene status [wt (RCB0480) ]
NBsusSR p53 gene status [wt (RCB0803) ]
Rb gene status [wt (RCB0803) ]
NEC8 p53 gene status [wt (RCB0489) ]
Rb gene status [wt (RCB0489) ]
NOS-1 p53 gene status [Arg273His (RCB1032) ]
Rb gene status [wt (RCB1032) ]
OCUB-M p53 gene status [Gly244Ser (RCB0881) ]
Rb gene status [flame shift after Ile42 (RCB0881) ]
OMC-1 p53 gene status [wt (RCB0753) ]
Rb gene status [wt (RCB0753) ]
OS-RC-2 p53 gene status [wt (RCB0735) ]
Rb gene status [wt (RCB0735) ]
PC-14 p53 gene status [Arg248Gln (RCB0446) ]
Rb gene status [wt (RCB0446) ]
RCC10RGB p53 gene status [wt (RCB1151) ]
Rb gene status [wt (RCB1151) ]
RKO p14(ARF) gene status +
p14(ARF) protein status LTD
p53 gene status wt
p53 gene status [wt]
Rb gene status [wt]
RKO p53.13 p14(ARF) gene status +
p14(ARF) protein status LTD
p53 gene status wt/DN
Saos 2 p14(ARF) gene status +
p14(ARF) protein status +
p14(ARF) protein status +
p16(INK4) protein +/-
p53 gene status Null
p53 gene status deletion coding region
p53 protein status LTD
pRb protein +/truncated
p53 gene status [wt]
Rb gene status [deletion in coding region]
T98G p14(ARF) protein status LTD
pRb protein +
p14(ARF) gene status
p14(ARF) protein status LTD
p53 gene status Mutant
p53 gene status [Met237Ile]
Rb gene status [wt]
TC-YIK p53 gene status [deletion in coding region (RCB0443) ]
Rb gene status [wt (RCB0443) ]
TGBC11TKB p53 gene status [Arg273Cys, flame shift after Lys382 (RCB1148) ]
Rb gene status [wt (RCB1148) ]
TGBC1TKB p53 gene status [flame shift after Cys176 (RCB1129) ]
Rb gene status [wt (RCB1129) ]
TGBC24TKB p53 gene status [flame shift after Cys242 (RCB1196) ]
Rb gene status [wt (RCB1196) ]
TIG3 p14(ARF) protein status LTD
U2OS osteosarcoma p53 gene status wt
p53 protein status +
p16(INK4) protein LTD
p14(ARF) protein status LTD
p53 gene status wt
p14(ARF) protein status LTD
p14(ARF) gene status +
p14(ARF) protein status LTD
p53 gene status [wt]
Rb gene status [wt]
U373 glioblastoma p53 gene status negative, codon 273 mutation
U87 glioblastoma p53 gene status wt
p14(ARF) protein status LTD
WI-38 normal fibloblast p16(INK4) protein +
p16(INK4) protein +
pRb protein +

LTD, less than detection.
Data in [ ], from Cancer Cell Line Project, COSMIC, Wellcome Trust Sanger Institute. (http://www.sanger.ac.uk/genetics/CGP/cosmic/)

Reference

  • Bressac B, Galvin KM, Liang TJ, Isselbacher KJ, Wands JR, Ozturk M. Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 87 (5): 1973-1977, 1990.
  • Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 282 (5393): 1497-501.
  • Crook T, Wrede D, Vousden KH. p53 point mutation in HPV negative human cervical carcinoma cell lines. Oncogene 6 (5): 873-875, 1991.
  • Diller L, Kassel J, Nelson CE, Gryka MA, Litwak G, Gebhardt M, Bressac B, Ozturk M, Baker SJ, Vogelstein B, et al. p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol. 1990 Nov;10(11):5772-5781.
  • Edwards SJ, Dix BR, Myers CJ, Dobson-Le D, Huschtscha L, Hibma M, Royds J, Braithwaite AW. Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes. J Virol. 2002 Dec;76(24):12483-90.
  • Goodrum FD, Ornelles DA. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol. 72 (12): 9479-9490, 1998.
  • GRAHAM, F.L., SMILEY, J., RUSSELL, W.C., and NAIRN, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59.74.
  • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54 (18): 4855-4878, 1994.
  • Higashi, H., I. Suzuki-Takahashi, E. Yoshida, S. Nishimura, and M. Kitagawa. 1997. Expression of p16INK4a suppresses the unbounded and anchorage- independent growth of a glioblastoma cell line that lacks p16INK4a. Biochem. Biophys. Res. Commun. 231:743.750.
  • Hsu IC, Tokiwa T, Bennett W, Metcalf RA, Welsh JA, Sun T, Harris CC. p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis 4 (5): 987-992, 1993.
  • Huschtscha, L. I., J. R. Noble, A. A. Neumann, E. L. Moy, P. Barry, J. R. Melki, S. J. Clark, and R. R. Reddel. 1998. Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells. Cancer Res. 58:3508-3512.
  • Jia LQ, Osada M, Ishioka C, Gamo M, Ikawa S, Suzuki T, Shimodaira H, Niitani T, Kudo T, Akiyama M, Kimura N, Matsuo M, Mizusawa H, Tanaka N, Koyama H, Namba M, Kanamaru R, Kuroki T. Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog. 19 (4): 243-253, 1997.
  • Kessis TD, Slebos RJ, Nelson WG, Kastan MB, Plunkett BS, Han SM, Lorincz AT, Hedrick L, Cho KR. Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. Proc Natl Acad Sci U S A. 90 (9): 3988-3992, 1993.
  • Lehman TA, Bennett WP, Metcalf RA, Welsh JA, Ecker J, Modali RV, Ullrich S, Romano JW, Appella E, Testa JR, et al. p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. Cancer Res. 51 (15): 4090-4096, 1991.
  • Masuda H, Miller C, Koeffler HP, Battifora H, Cline MJ. Rearrangement of the p53 gene in human osteogenic sarcomas. Proc Natl Acad Sci U S A. 84 (21): 7716-7719, 1987.
  • Mitsudomi T, Steinberg SM, Nau MM, Carbone D, D’Amico D, Bodner S, Oie HK, Linnoila RI, Mulshine JL, Minna JD, et al. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 7 (1): 171-180, 1992.
  • OKAMOTO, A., DEMETRICK, D.J., SPILLARE, E.A., HAGIWARA, K., HUSSAIN, S.P., BENNETT, W.P., FORRESTER, K., GERWIN, B., SERRANO, M., and BEACH, D.H. (1994). Mutations and altered expression of p16INK4 in human cancer. Proc. Natl. Acad. Sci. U.S.A. 91, 11045.11049.
  • Ries SJ, Brandts CH, Chung AS, Biederer CH, Hann BC, Lipner EM, McCormick F, Korn WM. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). Nat Med. 2000 Oct;6(10):1128-1133.
  • Rodrigues NR, Rowan A, Smith ME, Kerr IB, Bodmer WF, Gannon JV, Lane DP. p53 mutations in colorectal cancer. Proc Natl Acad Sci U S A. 87 (19): 7555-7559, 1990.
  • Rogan EM, Bryan TM, Hukku B, Maclean K, Chang AC, Moy EL, Englezou A, Warneford SG, Dalla-Pozza L, Reddel RR. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol Cell Biol. 1995 Sep;15(9):4745-4753.
  • Rothmann T, Hengstermann A, Whitaker NJ, Scheffner M, zur Hausen H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J. Virol. 72 (12): 9470-9478, 1998.
  • Sandig V, Brand K, Herwig S, Lukas J, Bartek J, Strauss M. Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med. 3 (3): 313-319, 1997.
  • Scheffner M, Mnger K, Byrne JC, Howley PM. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc Natl Acad Sci U S A. 88 (13): 5523-5527, 1991.
  • SCHNEIDER-GADICKE, A., and SCHWARZ, E. (1986). Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J. 5, 2285.2292.
  • Steegenga WT, Riteco N, Bos JL. Infectivity and expression of the early adenovirus proteins are important regulators of wild-type and DeltaE1B adenovirus replication in human cells. Oncogene 18 (36): 5032-5043, 1999.
  • Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH, Peters G. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.EMBO J. 1998 Sep 1;17(17):5001-5014.
  • Tam SW, Shay JW, Pagano M. Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. Cancer Res. 54 (22): 5816-5820, 1994.
  • Tominaga O, Nita ME, Nagawa H, Fujii S, Tsuruo T, Muto T. Expressions of cell cycle regulators in human colorectal cancer cell lines. Jpn J Cancer Res. 88 (9): 855-860, 1997.
  • Turnell AS, Grand RJ, Gallimore PH. The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status. J. Virol. 73 (3): 2074-2083, 1999.
  • Ullrich SJ, Sakaguchi K, Lees-Miller SP, Fiscella M, Mercer WE, Anderson CW, Appella E. Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53. Proc Natl Acad Sci U S A. 90 (13): 5954-5958, 1993.
  • Waldman T, Kinzler KW, Vogelstein B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55 (22): 5187-5190, 1995.
  • Whitaker NJ, Bryan TM, Bonnefin P, Chang AC, Musgrove EA, Braithwaite AW, Reddel RR. Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells. Oncogene 11 (5): 971-976, 1995.

(T.M. Aug, 2008)

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p53 Mutant

Amino acid sequence of human T53 (NCBI NM_000546.4)

1 MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI 50
51 EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ 100
101 KTYQGSYGFR LGFLHSGTAK SVTCTYSPAL NKMFCQLAKT CPVQLWVDST 150
151 PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN 200
201 LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP 250
251 ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 300
301 PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL 350
351 KDAQAGKEPG GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD 393

Dominant Negative and Recessive p53 Mutants

codon no. wt AA mut AA Transdominance Recessive mutation
53 Cys Stop no
68 Glu Gly no
83 Ala Glu no
86 Ala Glu no
86 Ala Thr no
91 Trp Stop no
91 Trp Stop no
98 Pro His no
98 Pro Leu no
98 Pro Ser no
99 Ser Phe no
99 Ser Tyr no
108 Gly Ser no
110 Arg Cys mt
110 Arg Leu mt
111 Leu Arg no
115 His Tyr no
117 Gly Glu no
119 Ala Val no
124 Cys Arg no
125 TYSPALNKM TM no
126 Tyr Asp no
126 Tyr Ser no
127 Ser Pro Weak
127 Ser Tyr no
132 Lys Arg mt
132 Lys Asn Weak
133 Met Arg no
135 Cys Phe Weak
135 Cys Phe no
135 Cys Trp no
138 Ala Lys no
139 Lys Asn no
139 Lys Glu no
143 Val Ala mt
144 Gln Pro no
146 Trp Stop no
150 Thr Ile no
151 Pro Arg Weak
151 Pro His Weak
151 Pro His no
151 Pro Ser no
152 Pro Leu no
152 Pro Leu no
152 Pro Thr no
155 Thr Ile no
156 Arg His Yes
156 Arg Pro no
158 Arg Cys no
158 Arg Gly no
158 Arg His no
158 Arg His no
158 Arg Pro Weak
161 Ala Asp no
161 Ala Gly no
161 Ala Val no
162 Ile Phe no
163 Tyr Asn no
163 Tyr Cys no
163 Tyr His no
167 Gln Arg no
167 Gln Stop no
168 His Arg no
168 His Gln no
168 His Tyr Yes
170 Thr Arg no
173 Val Gly no
173 Val Leu no
173 Val Met no
175 Arg His Weak
175 Arg His Yes
175 Arg His Yes
175 RCPHHERCSD RCSD Weak
176 Cys Arg Weak
176 Cys Phe no
176 Cys Ser no
176 Cys Tyr no
177 Pro His Yes
177 Pro His Yes
177 Pro Phe Yes
177 Pro Ser Yes
177 Pro Ser Yes
178 His Pro Yes
179 His Arg Yes
179 His Asn Yes mt
179 His Pro mt
179 His Tyr Yes
180 Glu Lys no
181 Arg Cys no
181 Arg Gly no
181 Arg His no
181 Arg Leu no
181 Arg Pro Yes
190 Pro His no
193 His Leu no
196 Arg Gln no
196 Arg Stop no
197 Val Leu no
199 Gly Arg no
201 Leu Stop no
202 Arg Ser no
213 Arg Gln no
213 Arg Stop no
213 Arg Stop no
213 Arg Stop no
214 His Arg mt
215 Ser Cys no
216 ValValVal ValVal Weak
219 Pro His no
219 Pro Leu no
220 Tyr Cys no mt
220 Tyr His no
220 Tyr His no
224 Glu Lys no
227 Ser Cys no
228 Asp Val no
230 Thr Ser no
234 Tyr Cys mt
234 Tyr His no
236 Tyr Asp Weak
236 Tyr Ser no
239 Asn Ser Yes
240 SerSerCysMet Val Yes
241 Ser Ala Yes
241 Ser Phe Yes
241 Ser Phe Yes mt
241 Ser Thr Yes
242 Cys Phe Weak
242 Cys Tyr Yes
242 Cys Tyr Yes
244 Gly Ala mt
244 Gly Asp Yes
244 Gly Asp Yes
244 Gly Ser Yes
244 Gly Ser Yes
245 Gly Arg Yes
245 Gly Asp Yes
245 Gly Asp Yes
245 Gly Asp Yes
245 Gly Asp Yes
245 Gly Ser Yes
245 Gly Ser Yes
245 Gly Ser Yes
245 Gly Val no
246 Met Arg Yes
246 Met Arg Yes
246 Met Ile Weak
246 Met Leu Yes
248 Arg Gln Yes
248 Arg Gln Yes mt
248 Arg Gly mt
248 Arg Leu mt
248 Arg Trp Yes
248 Arg Trp Yes
248 Arg Trp Yes
249 Arg Ser Yes
249 Arg Ser Yes mt
250 Pro Leu no
250 PILTIIT PIIT Weak
251 Ile Leu mt
252 Leu Ile Weak
252 Leu Phe no
257 Leu Gln Weak
257 Leu Pro Weak
257 Leu Pro Yes
257 Leu Pro no
258 Glu Lys no
259 Asp Asn no
259 Asp Tyr Weak
259 Asp Val no
262 Gly Asp no
262 Gly Cys no
264 Leu Arg no
265 Leu Pro Weak
266 Gly Arg no
266 Gly Arg no
266 Gly Glu no
266 Gly Glu no
266 Gly Val no
270 Phe Ser no
272 Val Gly no
272 Val Leu mt
272 Val Met mt
273 Arg Cys Yes
273 Arg Cys Yes
273 Arg Cys Yes
273 Arg His Yes mt
273 Arg His Yes
273 Arg Leu Yes
273 Arg Pro Weak
274 Val Phe Yes
275 Cys Phe no
275 Cys Tyr no
276 Ala Val no
277 Cys Tyr Yes
277 Cys Tyr no
278 Pro His Weak
278 Pro Ser Weak
278 Pro Ser no
279 Gly Arg Yes
279 Gly Glu Yes
279 Gly Glu Yes
279 Gly Glu Yes
279 Gly Val Yes
280 Arg Gly Yes
280 Arg Ile Yes
280 Arg Ser Yes
280 Arg Ser Yes
280 Arg Thr Yes
281 Asp Asn Yes
281 Asp Asn Yes
281 Asp Glu Yes
281 Asp Gly Yes
281 Asp Tyr Yes
281 Asp Tyr Yes mt
282 Arg Gln no
282 Arg Trp no mt
283 Arg His no
285 Glu Lys mt
286 Glu Gly no
286 Giu Lys no
298 Glu Stop mt
305 Lys Asn no
305 Lys Met no
306 Arg Glu no
306 Arg Stop no
306 Arg Stop no
308 Leu Met no
323 Leu Pro no
327 Tyr Stop no
331 Gln Stop no
331 Gln Stop no
337 Arg Pro no
337 Arg Ser no
338 FEMFRELNEA FA no
342 Arg Stop no
347 Ala Gly no

 

Reference

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(T.M. Jan, 2009)

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(GSB0020e, T.M. 2006.02.13)

2019.01.31