Outline
Alleles of human HLA class I, which are frequently observed in Japanese people, cloned into an expression vector were deposited by Dr. Yoshiki Akatsuka, Aichi Cancer Ctr. Res. Inst. The other classes of human HLA and beta-2 microglobulin (β2m) cDNA clones are also available.
HLA Clone List
HLA Class I – cDNA clone
| Allele | Cat. no. | Name of Clone | Frequency in Japanese population (*) |
|---|---|---|---|
| A*01:01 | RDB03368 | Human HLA-A*01:01 cDNA | 0.439 |
| A*01:01 | HGY082896 | IRAL007D24 | |
| A*02:01 | RDB02866 | Human HLA-A*02:01:01 cDNA | 11.223 |
| A*02:06 | RDB02867 | Human HLA-A*02:06 cDNA | 9.432 |
| A*02:07 | RDB02868 | Human HLA-A*02:07 cDNA | 3.241 |
| A*03:01 | RDB03367 | Human HLA-A*03:01 cDNA | 0.434 |
| A*11:01 | RDB02869 | Human HLA-A*11:01:01 cDNA | 8.9 |
| A*24:02 | RDB02871 | Human HLA-A*24:02:01 cDNA | 36.266 |
| A*24:20 | RDB03365 | Human HLA-A*24:20 cDNA | 0.768 |
| A*25:01 | HGX004917 | IRAK012E21 | 0.001 |
| A*26:01 | RDB02870 | Human HLA-A*26:01 cDNA | 7.592 |
| A*26:03 | RDB03366 | Human HLA-A*26:03 cDNA | 2.509 |
| A*31:01 | RDB02872 | Human HLA-A*31:01:02 cDNA | 8.642 |
| A*33:03 | RDB02873 | Human HLA-A*33:03 cDNA | 7.399 |
| HGY080967 | IRAL002G23 | ||
| RDB01176 | pA01 |
*Major Histocompatibility Complex 30 (1): 17-19 (2023).
| Allele | Cat. no. | Name of Clone | Frequency in Japanese population (*) |
|---|---|---|---|
| B*07:02 | RDB02874 | Human HLA-B*07:02:01 cDNA | 5.475 |
| B*08:01 | RDB03369 | Human HLA-B*08:01 cDNA | 0.018 |
| B*15:01 | RDB02875 | Human HLA-B*15:01:01 cDNA | 7.92 |
| B*15:10 | HGX010665 | IRAK026L01 | |
| B*35:01 | RDB02876 | Human HLA-B*35:01:01 cDNA | 8.357 |
| B*38:01 | RDB03370 | Human HLA-B*38:01 cDNA | 0.007 |
| B*39:01 | RDB03371 | Human HLA-B*39:01:01 cDNA | 3.387 |
| B*40:01 | RDB02877 | Human HLA-B*40:01:02 cDNA | 5.56 |
| B*40:02 | RDB02878 | Human HLA-B*40:02 cDNA | 7.801 |
| B*44:03 | RDB02879 | Human HLA-B*44:03:01 cDNA | 6.669 |
| B*46:01 | RDB02880 | Human HLA-B*46:01 cDNA | 4.502 |
| B*48:01 | RDB03372 | Human HLA-B*48:01 cDNA | 2.893 |
| B*51:01 | RDB02881 | Human HLA-B*51:01:01 cDNA | 8.743 |
| B*52:01 | RDB02882 | Human HLA-B*52:01:01 cDNA | 11.015 |
| B*54:01 | RDB03373 | Human HLA-B*54:01 cDNA | 7.577 |
| B*55:02 | RDB03374 | Human HLA-B*55:02 cDNA | 2.473 |
| B*59:01 | RDB03375 | Human HLA-B*59:01 cDNA | 2.012 |
| HGY088861 | IRAL022C13 | ||
| RDB01180 | pB55 |
*Major Histocompatibility Complex 30 (1): 17-19 (2023).
| Allele | Cat. no. | Name of Clone | Frequency in Japanese population (*) |
|---|---|---|---|
| C*01:02 | RDB02883 | Human HLA-C*01:02 cDNA | 17.225 |
| C*01:03 | RDB03376 | Human HLA-C*01:03 cDNA | 0.34 |
| C*03:03 | RDB02884 | Human HLA-C*03:03:01 cDNA | 13.753 |
| C*03:04 | RDB02885 | Human HLA-C*03:04:01 cDNA | 12.205 |
| C*04:01 | RDB02886 | Human HLA-C*04:01:01 cDNA | 4.324 |
| C*06:02 | RDB03377 | Human HLA-C*06:02 cDNA | 0.816 |
| C*07:01 | HGX011896 | IRAK029M08 | 0.065 |
| C*07:02 | RDB02887 | Human HLA-C*07:02 cDNA | 12.705 |
| C*07:02 | HGY088291 | IRAL020M03 | |
| C*08:01 | RDB02888 | Human HLA-C*08:01 cDNA | 7.382 |
| C*12:01 | RDB01179 | pC68 | |
| C*12:02 | RDB02889 | Human HLA-C*12:02:02 cDNA | 11.003 |
| C*12:03 | HGX007733 | IRAK019F13 | 0.087 |
| C*14:02 | RDB03378 | Human HLA-C*14:02:01 cDNA | 6.853 |
| C*14:03 | RDB02890 | Human HLA-C*14:03 cDNA | 6.514 |
| C*15:02 | RDB03379 | Human HLA-C*15:02:01 cDNA | 3.054 |
| C*16:01 | HGY082329 | IRAL005N17 | 0.004 |
| C*16:01 | HGY085701 | IRAL014E05 | |
| HGY088506 | IRAL021E10 |
*Major Histocompatibility Complex 30 (1): 17-19 (2023).
| Allele | Cat. no. | Name of Clone |
|---|---|---|
| E*01:01 | HGY081676 | IRAL004D04 |
| E*01:01 | HGY085250 | IRAL013C02 |
| E*01:03 | HGY096623 | IRAL041J07 |
| F*01:01 | HGX054355 | IRAK135O19 |
| F*01:01 | HGY090322 | IRAL025N10 |
| HGY013281 | IRAK033D09 | |
| HGY094732 | IRAL036N20 |
HLA Class I – genomic DNA clone
| Antigen | Allele | Cat. No. | Name of Clone |
|---|---|---|---|
| HLA-B44 | B*44:01 | RDB01178 | AM2.60 |
| HLA-Cx 52 (Cw 12) | C*12:01 | RDB01177 | pAC201 |
| HLA-G | RDB01246 | HLA-G.7.0 E |
HLA Class II
| Allele | Cat. no. | Name of Clone |
|---|---|---|
| DRB1*04:10 | HGY096962 | IRAL042G18 |
| DRB1*07:01 | HGY082333 | IRAL005N21 |
| DRB1*13:02 | HGY088361 | IRAL020P01 |
| DRB1*13:03 | HGY088606 | IRAL021I14 |
| DRB1*15:01 | HGX027583 | IRAK068P23 |
| DRB3*01:01 | HGX005065 | IRAK012L01 |
| DRB4*01:03 | HGY086487 | IRAL016D15 |
| DRB5*01:01 | HGY090353 | IRAL025O17 |
| DRB5*01:02 | RDB01222 | TOK H5 DR beta |
| DQB1*03:02 | HGY091784 | IRAL029H16 |
| DPB1*01:01 | HGX010616 | IRAK026I24 |
| DPB1*17:01 | HGY093632 | IRAL034B08 |
| DPB1*23:01 | HGY088362 | IRAL020P02 |
| DRA*01:02 | HGX025864 | IRAK064K24 |
| DQA1*05:01 | HGX005175 | IRAK012P15 |
| DQA1*05:03 | RDB01239 | DQA10501 AMALA-4 |
| DPA1*02:01 | HGY088364 | IRAL020P04 |
| DMA*01:01 | HGY087766 | IRAL019G22 |
| DMA*01:01 | HGY094834 | IRAL037B10 |
| DMB*01:01 | HGX010628 | IRAK026J12 |
| DOA*01:01 | HGX010612 | IRAK026I20 |
| DOB*01:01 | HGY087568 | IRAL018P08 |
| RDB01235 | K^b DRB1 0803 | |
| RDB01236 | K^b DRB1 1201 | |
| RDB01237 | K^b DRB1 1302 | |
| HGY096628 | IRAL041J12 | |
| RDB01238 | DRB30301 EMJ-4 | |
| RDB01223 | YT158 | |
| RDB01228 | pg DQ1B | |
| RDB01230 | pg DQ1BS | |
| RDB01242 | DQB10503 EK2-4 | |
| RDB01234 | DPB0202 | |
| RDB01232 | DRA2EH | |
| HGX044148 | IRAK110G04 | |
| HGX069737 | IRAK174F17 | |
| RDB01241 | DQA10101 KAS116 3-6 | |
| RDB01233 | DPA 02022 |
Link to HLA gene resources
| Gene Symbol | Product Name | Synonyms |
|---|---|---|
| HLA-A | major histocompatibility complex, class I, A | HLAA |
| HLA-B | major histocompatibility complex, class I, B | AS|B-4901|HLAB |
| HLA-C | major histocompatibility complex, class I, C | D6S204|HLA-JY3|HLAC|HLC-C|MHC|PSORS1 |
| HLA-E | major histocompatibility complex, class I, E | HLA-6.2|QA1 |
| HLA-F | major histocompatibility complex, class I, F | CDA12|HLA-5.4|HLA-CDA12|HLAF |
| HLA-G | major histocompatibility complex, class I, G | MHC-G |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | D6S222E|DMA|HLADM|RING6 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | D6S221E|RING7 |
| HLA-DOA | major histocompatibility complex, class II, DO alpha | HLA-DNA|HLA-DZA|HLADZ |
| HLA-DOB | major histocompatibility complex, class II, DO beta | DOB|HLA_DOB |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | DP(W3)|DP(W4)|HLA-DP1A|HLADP|HLASB|PLT1 |
| HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 | DPB1|HLA-DP|HLA-DP1B|HLA-DPB |
| HLA-DPB2 | major histocompatibility complex, class II, DP beta 2 (pseudogene) | DP2B|DPB2|DPbeta2|HLA-DP2B |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | CELIAC1|DQ-A1|HLA-DQA |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | CELIAC1|HLA-DQB|IDDM1 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | HLA-DQB1|HLA-DXB |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | HLA-DRA1 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | DRB1|HLA-DR1B|HLA-DRB|SS1 |
| HLA-DRB3 | major histocompatibility complex, class II, DR beta 3 | HLA-DR1B|HLA-DR3B |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | DR4|DRB4|HLA-DR4B |
| HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | – |
Related information
Journals
- Akatsuka Y., Morishima Y., Kuzushima K., Kodera Y., Takahashi T. (2007) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
Cancer Science 98 (8): 1139-1146. - Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. (2004) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
Br. J. Haematol. 124 (5): 629-635. - Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. (2003) Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens.J. Exp. Med. 197 (11): 1489-1500.
- Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA (2002) Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines.
Tissue Antigens, 59 (6): 502-511. - Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. (2002) Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
Transplantation, 74: 1773-1780. - Ando H, Miyata Y, Takata H, Inoko H. (1993) Identification of alloantisera reacting with HLA-C blank (Cx52) using a mouse L-cell transfected with the HLA-Cw*1201 allele.
Hum Immunol. 36 (2): 76-80 - Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. (1992) Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
Immunogenetics 36 (5): 319-325. - Zemmour J, Parham P. (1991) HLA class I nucleotide sequences, 1991.
Tissue Antigens 37 (4): 174-180. Erratum in: Tissue Antigens. 1992 Nov;40(5):221-228. - Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants.
Eu.r J Immunol. 21 (10): 2341-2347. - Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) HLA-DQ-restricted CD4+ T cells specific to streptococcal antigen present in low but not in high responders.
J Immunol. 146 (8): 2560-2567. - Tamaki J. (1992)[Analysis of polymorphism at the human class I MHC locus, HLA-G]
Hokkaido Igaku Zasshi (Hokkaido J. Med. Sci.) 67 (5): 583-594. Japanese. - Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. (1990) Expression of the human MHC, HLA-DQW6 genes alters the immune response in C57BL/6 mice.
J Immunol. 1990 Jul 1;145(1):353-60. - Takata H, Inoko H, Ando A, Haranaka M, Watanabe B, Tsuji K, Iri H. (1988) Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.
Immunogenetics 28 (4): 265-270.
Links
- Find more MHCI clones by KEGG
- EBV transformed B cell lines derived from Japanese (HEV) with information of HLA haplotypes
- Japanese Society for Histocomaptibility and Immunogenetics
- International Histocompatibility Workshop Group
- HLA Infomatics Group – The Anthony Nolan Trust
(GSB0016e 2004.08.23 T.M.)
2024.07.24
