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BRC News

p53-dependent apoptosis

p53-dependent apoptosis

The inactivation of p53 by Mdm2 is counteracted by mechanisms involving post-translational modification of p53, or the Mdm2 inhbibitor ARF. Through its activity as a sequence-specific transcriptional activator, p53 increases the expression of pro-apoptotic Bcl-2 family proteins. Potential transcriptionindependent functions of p53 co-operate with the Bcl-2 protein to induce the release of apoptogenic factors (depicted as circles) from the mitochondrial outer membrane. Released apoptogenic factors facilitate the activation of the effector caspases through the Apaf-1-caspase 9-apoptosome. ATM, ataxia telangiectasia mutated protein ; ATR, ataxia telangiectasia-related ; PML, promyelocytic leukaemia protein ; ARF, alternative reading frame of p16 protein. (Contributed by Dr. Koji Nakade)

Human Resources

Icon Locus Gene Products Alternative Name
Apaf1 APAF1 apoptotic peptidase activating factor 1 APAF-1|CED4|DKFZp781B1145
ATM ATM ataxia telangiectasia mutated AT1|ATA|ATC|ATD|ATDC|ATE|DKFZp781A0353|MGC74674|TEL1|TELO1
ATR ATR ataxia telangiectasia and Rad3 related FRP1|MEC1|SCKL|SCKL1
Bax BAX BCL2-associated X protein BCL2L4
PUMA BBC3 BCL2 binding component 3 FLJ42994|JFY-1|JFY1|PUMA
Caspase 9 CASP9 caspase 9, apoptosis-related cysteine peptidase APAF-3|APAF3|CASPASE-9c|ICE-LAP6|MCH6
ARF CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16
CHK1 CHEK1 CHK1 checkpoint homolog (S. pombe) CHK1
CHK2 CHEK2 CHK2 checkpoint homolog (S. pombe) CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53
MDM2 MDM2 Mdm2 p53 binding protein homolog (mouse) HDMX|MGC5370|MGC71221|hdm2
Noxa PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 APR|NOXA
PML PML promyelocytic leukemia MYL|PP8675|RNF71|TRIM19
p53 TP53 tumor protein p53 FLJ92943|LFS1|P53|TRP53

Other Resources

Locus RDB no. Type Name of clone Running title
Trp53 1285 DNA clone p53-LTR pUC18 (Anti Sense#9) Expression vector, Antisense p53, cDNA
Trp53 1284 DNA clone p53-LTR pUC18 (Sense#3) Expression vector, Sense p53, cDNA
chk1 2949 DNA clone chk1+ Plasmid clone of fission yeast Chk1
Chek1 6946 H3042B08 Chek1, NIA/NIH Mouse 15K cDNA Clone

(GSB0012e, T.M. 2004.04.01)