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BRC News

G1 cdks and cdk inhibitors


G1 cdks and cdk inhibitors

Somatic cell cycles consist of alternating DNA synthetic (S) and mitotic (M) phases, separated by gap phases (G1 and G2). Mammalian cells respond to extracellular mitogens and antiproliferative cytokines from the time that they exit mitosis (vertical arrow at top) until they reach the restriction point, after which they can complete the cell division cycle in the absence of extracellular growth factors. Cyclin D-dependent kinases accumulate in response to mitogenic signals and initiate the phosphorylation of Rb, a process that is completed by cyclin E-cdk2. Once cells enter S phase, cyclin E is degraded and cyclin A enters into complexes with cdk2. INK4 proteins oppose the activities of the various cyclin D-dependent kinases, whereas Cip/Kip proteins specifically inhibit cyclin E-cdk2 and cyclin A-cdk2. (Contributed by Dr. Koji Nakade)


Reporters

List of gene resources

Locus RDB no. Type Name of clone Running title
CDKN1B 5508 DNA clone pKM2L-phKIP1 Promoter Bank clone, Human p27 cyclin-dependent kinase inhibitor (kip1) promoter
CDKN1B 4645 ShuttleVector pAxCALNLhp27(forward) Shuttle vector to generate rAd expressing human CDKN1B
CDKN1B 4642 ShuttleVector pAxCALNLhp27(reverse) Shuttle vector to generate rAd expressing human CDKN1B
CDKN1B 2069 ShuttleVector pAxCAhp27 (As) Shuttle vector to generate rAd expressing human CDKI p27
CDKN1B 2011 ShuttleVector pAxCAhp27 Shuttle vector to generate rAd expressing human CDKI p27
CDKN1B 2010 Recombinant Adenovirus AxCAhp27 Recombinant adenovirus expressing human CDKI p27 regulated by CAG promoter
Cdkn1b 2856 DNA clone HA-P27 Expression vector of HA-tagged mouse p27/Kip1
CDKN1A 5893 DNA clone pKM2L-phP21 Promoter Bank clone, Human p21 cyclin dependent kinase inhibitor/WAF1/CIP1 promoter
CDKN1A 3576 ShuttleVector pAxCALNLhp21(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDKN1A 1999 ShuttleVector pAxCAhp21 Shuttle vector to generate rAd expressing human CDKI p21
Cdk4 6971 H3147D06 Cdk4, NIA/NIH Mouse 15K cDNA Clone (full CDS)
CDK2 5250 ShuttleVector pAxCALNLhCDK2(reverse) Shuttle vector to generate rAd expressing human CDK2
CDK2 5249 ShuttleVector pAxCALNLhCDK2(forward) Shuttle vector to generate rAd expressing human CDK2
CDK2 4061 ShuttleVector pAxCALNLhCDK2 Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK2 3492 ShuttleVector pAxCALNLhCDK2(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK2 3472 ShuttleVector pAxCALNLhCDK2(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
Cdk2 6947 H3117F10 Cdk2, NIA/NIH Mouse 15K cDNA Clone (full CDS)
CDC25C 5908 DNA clone pKM2L-phCDC25C(2) Promoter Bank clone, Human cdc25C promoter
CDC25C 5841 ShuttleVector pAxit-phCDC25C-rLuc (R) Shuttle vector to generate recombinant adenovirus harboring renilla luciferase reporter.
CDC25C 5840 ShuttleVector pAxit-phCDC25C-rLuc (F) Shuttle vector to generate recombinant adenovirus harboring renilla luciferase reporter.
CDC25C 5468 DNA clone pKM2L-phCDC25C Promoter Bank clone, Human cdc25C promoter
CDC25B 2668 ShuttleVector pAxCALNLhCDC25B (reverse) Shuttle vector to produce rAd expressing human CDC25B
CDC25B 2667 ShuttleVector pAxCALNLhCDC25B (forward) Shuttle vector to produce rAd expressing human CDC25B
CDC25B 2334 ShuttleVector pAxCAhCDC25B (reverse) Shuttle vector to produce rAd expressing human CDC25B
CDC25B 2333 ShuttleVector pAxCAhCDC25B (forward) Shuttle vector to produce rAd expressing human CDC25B
CDC25B 1203 DNA clone CDC25Hu2 Human cdc 25B cDNA
CDC25A 5476 DNA clone pKM2L-phCDC25A Promoter Bank clone, Human cdc25A promoter
CDC25A 4653 ShuttleVector pAxCALNLhCDC25A(forward) Shuttle vector to generate rAd expressing human CDC25A
CDC25A 4646 ShuttleVector pAxCALNLhCDC25A(reverse) Shuttle vector to generate rAd expressing human CDC25A
cdc2 1570 DNA clone pIBI delta Xe-cdc2-33R Xenopus cdc2 (kinase-deficient) cDNA
cdc2 1569 DNA clone pIBI delta Xe-cdc2 Xenopus cdc2 cDNA
CCNH 6416 DNA clone pCMFlag_hsCCNH Expression vector of human CCNH
CCNH 4093 ShuttleVector pAxCALNLhCyclin H Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNH 3510 ShuttleVector pAxCALNLhCyclin H(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCND3 4589 DNA clone SEREX clone NGO-Br-20 (ID 859) #1 SEREX clone NGO-Br-20 (ID 859) #1
CCNB2 6415 DNA clone pCMFlag_hsCCNB2 Expression vector of human CCNB2
CCNB2 5448 ShuttleVector pAxCALNLhCCNB2(reverse) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 5447 ShuttleVector pAxCALNLhCCNB2(forward) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 5430 ShuttleVector pAxCALNLhCCNB2(forward) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 5425 ShuttleVector pAxCALNLhCCNB2(reverse) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 5424 ShuttleVector pAxCALNLhCCNB2(forward) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 5367 ShuttleVector pAxCALNLhCCNB2(reverse) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 5366 ShuttleVector pAxCALNLhCCNB2(forward) Shuttle vector to generate rAd harboring CCNB2 Sugano full-length cDNA clone
CCNB2 4098 ShuttleVector pAxCALNLhCCNB2 Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNB2 3515 ShuttleVector pAxCALNLhCCNB2(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNA2 6665 DNA clone pCMFlag_hsCCNA2 Expression vector of human CCNA2/Cyclin A2
CCNA2 4162 ShuttleVector pAxCALNLhCyclin A2 Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNA2 3595 ShuttleVector pAxCALNLhCyclin A2 (forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNA1 5482 DNA clone pKM2L-phCYCA1 Promoter Bank clone, Human cyclin A1 promoter
CCNA1 3557 ShuttleVector pAxCALNLhCCNA1(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNA1 3534 ShuttleVector pAxCALNLhCCNA1(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
BCCIP 2617 Recombinant adenovirus AxCALNLhTOK-1 alpha recombinant adenovirus expressing human TOK-1 alpha
BCCIP 2346 Recombinant Adenovirus AxCAhTOK-1 alpha Recombinant adenovirus expressing human TOK-1 alpha

(GSB0007e, T.M. 2004.04.05)

2018.09.24