Ras MAP kinase signal

Summary of Map kinase pathway

The growth factor ligand binds to its trans-membrane receptor and activates tyrosine kinases inherent in the receptor molecule (RTPK). A series of protein-protein complexes form involving Shc, GRB-2, and SOS. Subsequent to this, GDP-Ras is converted to GTP-Ras which activates Raf, MEK and then MAP kinase. Map kinases phosphorylate a number of transcription factors including TCFs(Elk,Sap1a and Net). (Contributed by Dr. Koji Nakade)

Human Resources

Icon Locus Gene Products Alternative Name
Raf ARAF v-raf murine sarcoma 3611 viral oncogene homolog A-RAF|ARAF1|PKS2|RAFA1
Raf BRAF v-raf murine sarcoma viral oncogene homolog B1 B-RAF1|BRAF1|FLJ95109|MGC126806|MGC138284|NS7|RAFB1
Growth factor EGFR epidermal growth factor receptor ERBB|ERBB1|HER1|PIG61|mENA
ELK1 ELK1 ELK1, member of ETS oncogene family
Net ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) ERP|NET|SAP2
GRB2 GRB2 growth factor receptor-bound protein 2 ASH|EGFRBP-GRB2|Grb3-3|MST084|MSTP084|NCKAP2
RAS HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog C-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|K-RAS|N-RAS|RASH1
RAS KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog C-K-RAS|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|KI-RAS|KRAS1|KRAS2|NS|NS3|RASK2
MEK1/2 MAP2K1 mitogen-activated protein kinase kinase 1 MAPKK1|MEK1|MKK1|PRKMK1
MEK1/2 MAP2K2 mitogen-activated protein kinase kinase 2 FLJ26075|MAPKK2|MEK2|MKK2|PRKMK2
ERK1/2 MAPK1 mitogen-activated protein kinase 1 ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk
ERK1/2 MAPK3 mitogen-activated protein kinase 3 ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3
RAS NRAS neuroblastoma RAS viral (v-ras) oncogene homolog ALPS4|N-ras|NRAS1|NS6
Raf RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 CRAF|NS5|Raf-1|c-Raf
GRB2 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 FLJ26504|SHC|SHCA
GRB2 SHC3 SHC (Src homology 2 domain containing) transforming protein 3 DKFZp686H1544|FLJ45325|N-Shc|NSHC|RAI|SHCC
GRB2 SHC4 SHC (Src homology 2 domain containing) family, member 4 MGC34023|RaLP|SHCD
GRB2 SHCBP1 SHC SH2-domain binding protein 1 FLJ22009|MGC26900|PAL
SOS SOS2 son of sevenless homolog 2 (Drosophila) FLJ25596
Sap1a SRF serum response factor (c-fos serum response element-binding transcription factor) MCM1

Other Resources

Locus RDB no. Type Name of clone Running title
Mapk1 2545 ShuttleVector pAxCAmERK2 (reverse) Shuttle vector to generate rAd harboring mouse ERK2
Mapk1 2544 ShuttleVector pAxCAmERK2 (forward) Shuttle vector to produce rAd expressing mouse extracellular signal-regulated kinase 2 (ERK2)
Mapk1 1796 DNA clone pZRmERK2 cDNA Mouse ERK2 cDNA
Elk3 6920 DNA clone H4069B01 Elk3, NIA/NIH Mouse 7.4K cDNA Clone
Elk1 6906 DNA clone H4062C03 Elk1, NIA/NIH Mouse 7.4K cDNA Clone

(GSB0006e, T.M.)

2018.09.24



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