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Ets transcription factor


Ets family proteins with other transcription factors and co-activators on various cellular promoters and enhancers

(a) Ets-1 or PEA-3 activates the MMP (matrix metalloproteinase) promoters in cooperation with AP1 (c-Fos/c-Jun) on the RRE (Ras-response element).
(b) TCF (Elk-1, Sap-1, Net) activates the c-fos promoter in cooperation with SRF (serum response factor).
(c) PU.1 activates myeloid-specific promoters in cooperation with AML1 and C/EBP.
(d) Fli-1 activates megakaryocyte-specific promoters in cooperation with GATA-1.
(e) PU.1 activates the immunoglobulin (Ig) heavy (H) chain enhancer in cooperation with E12, Ets-1, TFE3 and Oct-2.
(f) Ets-1 activates the T cell receptor (TCR) a enhancer in cooperation with CREB/ATF, TCF-1, AML1 and GATA-3.

Human Resources

Icon Locus Gene Products Alternative Name
ALY THOC4 THO complex 4 ALY|ALY/REF|BEF|REF
ATF ATF2 activating transcription factor 2 CRE-BP1|CREB2|HB16|MGC111558|TREB7
C/EBP CEBPA CCAAT/enhancer binding protein (C/EBP), alpha C/EBP-alpha|CEBP
CREB CREB1 cAMP responsive element binding protein 1 CREB|MGC9284
TCF ELK1 ELK1, member of ETS oncogene family
TCF ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) ERP|NET|SAP2
TCF ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) DKFZp434N185|SAP1
CBP/p300 EP300 E1A binding protein p300 KAT3B|RSTS2|p300
Ets-1 ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) ETS-1|EWSR2|FLJ10768
Ets-1 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) ETS2IT1
PEA3 ETV4 ets variant 4 E1A-F|E1AF|PEA3|PEAS3
Fli-1 FLI1 Friend leukemia virus integration 1 EWSR2|SIC-1
Ap-1/Jun/Fos FOS FBJ murine osteosarcoma viral oncogene homolog AP-1|C-FOS|p55
GATA-3 GATA3 GATA binding protein 3 HDR|HDRS|MGC2346|MGC5199|MGC5445
Ap-1/Jun/Fos JUN jun proto-oncogene AP-1|AP1|c-Jun
OCAB POU2AF1 POU class 2 associating factor 1 BOB1|OBF-1|OBF1|OCAB
Oct-2 POU2F2 POU class 2 homeobox 2 OCT2|OTF2|Oct-2
Sp1 SP1 Sp1 transcription factor
SRF SRF serum response factor (c-fos serum response element-binding transcription factor) MCM1
E12 TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) E2A|E47|ITF1|MGC129647|MGC129648|TCF-3|VDIR|bHLHb21
TCF-1 TCF7 transcription factor 7 (T-cell specific, HMG-box) FLJ36364|MGC47735|TCF-1
TEF3 TFE3 transcription factor binding to IGHM enhancer 3 RCCP2|RCCX1|TFEA|bHLHe33
TEF3 TRIM37 tripartite motif containing 37 KIAA0898|MUL|POB1|TEF3

Other Resources

Locus RDB no. Type Name of clone Running title
runx1 6420 DNA clone pZF-Runxa Plasmid clone of zebrafish runx1 (runxa) cDNA
Ep300 5790 DNA clone pU6_mmEP300_2505F Expression vector for mouse EP300 small RNA fragment
Ep300 5789 DNA clone pU6_mmEP300_0172R Expression vector for mouse EP300 small RNA fragment
Ep300 5783 DNA clone pU6_mmEP300_1926F Expression vector for mouse EP300 small RNA fragment
Ep300 5776 DNA clone pU6_mmEP300_2505R Expression vector for mouse EP300 small RNA fragment
Ep300 5774 DNA clone pU6_mmEP300_2308R Expression vector for mouse EP300 small RNA fragment
Ep300 5767 DNA clone pU6_mmEP300_2308F Expression vector for mouse EP300 small RNA fragment
Ep300 5749 DNA clone pU6_mmEP300_0172F Expression vector for mouse EP300 small RNA fragment
Elk3 6920 DNA clone H4069B01 Elk3, NIA/NIH Mouse 7.4K cDNA Clone
Elk1 6906 DNA clone H4062C03 Elk1, NIA/NIH Mouse 7.4K cDNA Clone
Crebbp 5778 DNA clone pU6_mmCREBBP-2_1638R Expression vector for mouse CREBBP-2 small RNA fragment
Crebbp 5777 DNA clone pU6_mmCREBBP-2_1068F Expression vector for mouse CREBBP-2 small RNA fragment
Crebbp 5769 DNA clone pU6_mmCREBBP-2_1068R Expression vector for mouse CREBBP-2 small RNA fragment
Crebbp 5768 DNA clone pU6_mmCREBBP-2_0168R Expression vector for mouse CREBBP-2 small RNA fragment
Crebbp 5760 DNA clone pU6_mmCREBBP-2_0374F Expression vector for mouse CREBBP-2 small RNA fragment

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(GSB0005e, T.M. 2004.04.27)

2018.09.24