ERK signal

Cooperative effects of integrins and growth factor receptors on ERK signal duration

Initiation of integrin signaling by cell adhesion to an extracellular matrix (ECM) results in a transient and relatively weak activation ERK while initiation of receptor tyrosine kinase signaling by strongly mitogenic concentrations of growth factors (GF) results in a strong, transient ERK signal sufficient to induce p21cip1. The sustained ERK signal associated with the induction of cyclin D1 arises from a cooperative effect between receptor tyrosine kinases and integrins. (Contributed by Dr. Koji Nakade)

Human Resources

Icon Locus Gene Products Alternative Name
CYCLIN D1 CCND1 cyclin D1 BCL1|D11S287E|PRAD1|U21B31
CDK4 CDK4 cyclin-dependent kinase 4 CMM3|MGC14458|PSK-J3
p21 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1
ERK MAPK1 mitogen-activated protein kinase 1 ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk
ERK MAPK3 mitogen-activated protein kinase 3 ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3

Other Resources

Locus RDB no. Type Name of clone Running title
Mapk1 2545 ShuttleVector pAxCAmERK2 (reverse) Shuttle vector to generate rAd harboring mouse ERK2
Mapk1 2544 ShuttleVector pAxCAmERK2 (forward) Shuttle vector to produce rAd expressing mouse extracellular signal-regulated kinase 2 (ERK2)
Mapk1 1796 DNA clone pZRmERK2 cDNA Mouse ERK2 cDNA
Cdk4 6971 DNA clone H3147D06 Cdk4, NIA/NIH Mouse 15K cDNA Clone

(GSB0004e, T.M.)


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