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MAP kinases


Comparison of MAP kinase pathways that are implicated in the control of the cell division cycle. The MAP kinase cascade is illustrated together with the main downstream substrates implicated in cell cycle control. Crosstalk may exist in vivo between human MAP3K enzymes and MAP3K components of other parallel pathways. For example, MEKK3, while being implicated in the regulation of MEK5 activity, is also a potent activator of the p38 pathway. Similarly, Tak1 can activate the JNK pathway. Studies reporting the promiscuous nature of MAP3K enzymes, however, are subject to certain experimental caveats and are therefore subject to debate. (Contributed by Dr. Koji Nakade)

Catalog no. Name of clone Running title
RDB13254 GL023 Expression plasmid of GFP-tagged human c-RAF.
RDB13255 GL348 Expression plasmid of GFP-tagged human cRaf1 catalytic domain (CAD, 330-627)
RDB13256 GL207 Expression plasmid of GFP-tagged human cRaf1 CRDCAD (R89A S621A).
RDB13257 GL107 Expression plasmid of GFP-tagged human cRaf1 (R89A mutant).

Human Resources

Icon Locus Gene Products Alternative Name
A-Raf ARAF v-raf murine sarcoma 3611 viral oncogene homolog A-RAF|ARAF1|PKS2|RAFA1
B-Raf BRAF v-raf murine sarcoma viral oncogene homolog B1 B-RAF1|BRAF1|FLJ95109|MGC126806|MGC138284|NS7|RAFB1
MEK1/2 MAP2K1 mitogen-activated protein kinase kinase 1 MAPKK1|MEK1|MKK1|PRKMK1
MEK1/2 MAP2K2 mitogen-activated protein kinase kinase 2 FLJ26075|MAPKK2|MEK2|MKK2|PRKMK2
MKK3,6 MAP2K3 mitogen-activated protein kinase kinase 3 MAPKK3|MEK3|MKK3|PRKMK3
MKK3,6 MAP2K6 mitogen-activated protein kinase kinase 6 MAPKK6|MEK6|MKK6|PRKMK6|SAPKK3
MKK4,7 MAP2K4 mitogen-activated protein kinase kinase 4 JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SEK1|SERK1
MKK4,7 MAP2K7 mitogen-activated protein kinase kinase 7 Jnkk2|MAPKK7|MKK7|PRKMK7
MEK5 MAP2K5 mitogen-activated protein kinase kinase 5 HsT17454|MAPKK5|MEK5|PRKMK5
MLK3 MAP3K11 mitogen-activated protein kinase kinase kinase 11 MEKK11|MGC17114|MLK-3|MLK3|PTK1|SPRK
DLK MAP3K12 mitogen-activated protein kinase kinase kinase 12 DLK|MEKK12|MUK|ZPK|ZPKP1
ERK1,2 MAPK1 mitogen-activated protein kinase 1 ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk
ERK1,2 MAPK3 mitogen-activated protein kinase 3 ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3
MEKK2,3 MAP3K2 mitogen-activated protein kinase kinase kinase 2 MEKK2|MEKK2B
MEKK2,3 MAP3K3 mitogen-activated protein kinase kinase kinase 3 MAPKKK3|MEKK3
ASK1 MAP3K5 mitogen-activated protein kinase kinase kinase 5 ASK1|MAPKKK5|MEKK5
TAK MAP3K7 mitogen-activated protein kinase kinase kinase 7 MEKK7|TAK1|TGF1a
Tpl2 MAP3K8 mitogen-activated protein kinase kinase kinase 8 COT|EST|ESTF|FLJ10486|MEKK8|TPL2|Tpl-2|c-COT
SAPK/JNK MAPK10 mitogen-activated protein kinase 10 FLJ12099|FLJ33785|JNK3|JNK3A|MGC50974|PRKM10|p493F12|p54bSAPK
p38 MAPK MAPK11 mitogen-activated protein kinase 11 P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta
SAPK/JNK MAPK11 mitogen-activated protein kinase 11 P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta
p38 MAPK MAPK12 mitogen-activated protein kinase 12 ERK3|ERK6|P38GAMMA|PRKM12|SAPK-3|SAPK3
SAPK/JNK MAPK12 mitogen-activated protein kinase 12 ERK3|ERK6|P38GAMMA|PRKM12|SAPK-3|SAPK3
p38 MAPK MAPK13 mitogen-activated protein kinase 13 MGC99536|PRKM13|SAPK4|p38delta
SAPK/JNK MAPK13 mitogen-activated protein kinase 13 MGC99536|PRKM13|SAPK4|p38delta
p38 MAPK MAPK14 mitogen-activated protein kinase 14 CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA
SAPK/JNK MAPK14 mitogen-activated protein kinase 14 CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA
ERK5/BMK1 MAPK7 mitogen-activated protein kinase 7 BMK1|ERK4|ERK5|PRKM7
SAPK/JNK MAPK8 mitogen-activated protein kinase 8 JNK|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1
SAPK/JNK MAPK9 mitogen-activated protein kinase 9 JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|p54a|p54aSAPK
MX1 MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) IFI-78K|IFI78|MX|MxA
c-Raf RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 CRAF|NS5|Raf-1|c-Raf

Mouse Resources

Icon Locus Gene Products Alternative Name
A-Raf Araf v-raf murine sarcoma 3611 viral oncogene homolog 1200013E08Rik|A-Raf|AW495444|Araf1
B-Raf Braf Braf transforming gene 9930012E13Rik|AA120551|AA387315|AA473386|B-raf|Braf-2|Braf2|C230098H17|C87398|D6Ertd631e
c-Raf Raf1 v-raf-leukemia viral oncogene 1 6430402F14Rik|AA990557|BB129353|Craf1|D830050J10Rik|MGC102375|Raf-1|c-Raf|v-Raf
DLK Map3k12 mitogen-activated protein kinase kinase kinase 12 DLK|MUK|Zpk
ERK1,2 Mapk1 mitogen-activated protein kinase 1 9030612K14Rik|AA407128|AU018647|C78273|ERK|Erk2|MAPK2|PRKM2|Prkm1|p41mapk|p42mapk
ERK1,2 Mapk3 mitogen-activated protein kinase 3 Erk-1|Erk1|Ert2|Esrk1|Mnk1|Mtap2k|Prkm3|p44|p44erk1|p44mapk
MEK1/2 Map2k1 mitogen-activated protein kinase kinase 1 MAPKK1|MEKK1|Mek1|Prkmk1
MEK1/2 Map2k2 mitogen-activated protein kinase kinase 2 AA589381|MEK2|MK2|Prkmk2
MEKK2,3 Map3k2 mitogen-activated protein kinase kinase kinase 2 9630061B06Rik|AI585793|Mekk2|Mekk2b
MEKK2,3 Map3k3 mitogen-activated protein kinase kinase kinase 3 AW548911|KIAA4031|MAPKKK3|Mekk3|mKIAA4031
MKK3,6 Map2k3 mitogen-activated protein kinase kinase 3 AW212142|MEK3|MKK3|Prkmk3|mMKK3b
MKK3,6 Map2k6 mitogen-activated protein kinase kinase 6 MEK6|MKK6|Prkmk6|SAPKK3
MKK4,7 Map2k4 mitogen-activated protein kinase kinase 4 JNKK1|MEK4|MKK4|PRKMK4|Sek1|Serk1
MKK4,7 Map2k7 mitogen-activated protein kinase kinase 7 5930412N11Rik|Jnkk2|MKK7|Prkmk7|sek2
MX1 Mx1 myxovirus (influenza virus) resistance 1 AI893580|Mx|Mx-1
p38 MAPK Mapk12 mitogen-activated protein kinase 12 AW123708|Erk6|P38gamma|Prkm12|Sapk3
p38 MAPK Mapk13 mitogen-activated protein kinase 13 SAPK4|Serk4
p38 MAPK Mapk14 mitogen-activated protein kinase 14 CSBP2|Crk1|Csbp1|MGC102436|Mxi2|PRKM14|PRKM15|p38|p38-alpha|p38MAPK|p38a|p38alpha
SAPK/JNK Mapk8 mitogen-activated protein kinase 8 AI849689|JNK|JNK1|Prkm8|SAPK1
SAPK/JNK Mapk9 mitogen-activated protein kinase 9 AI851083|JNK2|Prkm9|p54aSAPK
SAPK/JNK Mapk10 mitogen-activated protein kinase 10 C230008H04Rik|JNK3|JNK3B1|JNK3B2|SAPK(beta)|Serk2|p493F12|p54bSAPK
SAPK/JNK Mapk13 mitogen-activated protein kinase 13 SAPK4|Serk4
TAK Map3k7 mitogen-activated protein kinase kinase kinase 7 B430101B05|C87327|Tak1
Tpl2 Map3k8 mitogen-activated protein kinase kinase kinase 8 Cot|Cot/Tpl2|Est|Estf|Tpl-2|Tpl2|c-COT

(GSB0002e, T.M. 2004.04.27)

2014.10.22