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gsb0013en


p53 dependent G2 arrest

DNA damaging agents induces accumulation and stimulation of p53 protein,which activate or inhibit several gene expression.
p53 activates p21,14-3-3 sigma and Gadd45 transcription. p21 binds Cyclin B/cdc2 complex to keep it inactive form. 14-3-3 sigma is a cytoplasmic protein that binds to Cyclin B/cdc2 complex to let it stay in cytoplasm, therefore Cyclin B/cdc2 can not act as an active complex. Gadd45 inhibits formation of Cyclin B/cdc2 complex.
p53 also inhibits G2-M transition by repressing the transcription of cdc2 and CyclinB. (Contributed by Dr. Koji Nakade)


Reporters

Catalog no. Name of clone Short description
RDB13080 pCAG-Fucci2a Fucci2a cell cycle reporter.
RDB13081 pROSA-floxNeo-Fucci2a Fucci2a cell cycle reporter. Targeting vector for R26 locus.

Locus RDB no. Type Name of clone Running title
Trp53 1285 DNA clone p53-LTR pUC18 (Anti Sense#9) Expression vector, Antisense p53, cDNA
Trp53 1284 DNA clone p53-LTR pUC18 (Sense#3) Expression vector, Sense p53, cDNA
TP53 5507 DNA clone pKM2L-phP53 Promoter Bank clone, Human p53 promoter
TP53 3187 Recombinant adenovirus AxCAhp53KP1065 Recombinant adenovirus harboring human p53 cDNA (Ser96Pro)
TP53 3186 Recombinant adenovirus AxCAhp53KP1010 Recombinant adenovirus harboring human p53 cDNA (Gly105Asp)
TP53 3185 Recombinant adenovirus AxCAhp53KP1007 Recombinant adenovirus harboring human p53 cDNA (Gly374Cys)
TP53 3184 Recombinant adenovirus AxCAhp53KP1094 Recombinant adenovirus harboring human p53 cDNA (Pro89His)
TP53 3183 Recombinant adenovirus AxCAhp53KP1070 Recombinant adenovirus harboring human p53 cDNA (Ser240Asn)
TP53 2807 Recombinant adenovirus AxCALNLhp53R273H (forward) Recombinant adenovirus harboring human p53 cDNA (R273H)
TP53 2802 Recombinant adenovirus AxCALNLhp53.clone 28 (forward) Recombinant adenovirus harboring human p53 cDNA (deletion)
TP53 2799 Recombinant adenovirus AxCALNLhp53P70 (forward) Recombinant adenovirus harboring human p53 cDNA (Pro128Thr)
TP53 2798 Recombinant adenovirus AxCALNLhp53P68 (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2795 Recombinant adenovirus AxCALNLhp53WT (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2785 Recombinant adenovirus AxCAhp53KP1070 (forward) Recombinant adenovirus harboring human p53 cDNA (Ser240Asn)
TP53 2784 Recombinant adenovirus AxCAhp53KP1065 (forward) Recombinant adenovirus harboring human p53 cDNA (Ser96Pro)
TP53 2783 Recombinant adenovirus AxCAhp53KP1010 (forward) Recombinant adenovirus harboring human p53 cDNA (Gly105Asp)
TP53 2782 Recombinant adenovirus AxCAhp53KP1007 (forward) Recombinant adenovirus harboring human p53 cDNA (Gly374Cys)
TP53 2771 Recombinant adenovirus AxCAhp53.clone 28 (forward) Recombinant adenovirus harboring human p53 cDNA (deletion)
TP53 2757 Recombinant adenovirus AxCAhp53P70 (forward) Recombinant adenovirus harboring human p53 cDNA (Pro128Thr)
TP53 2756 Recombinant adenovirus AxCAhp53P68 (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2755 Recombinant adenovirus AxCAhp53WT (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2713 ShuttleVector pAxCALNLhp53R273H (reverse) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2712 ShuttleVector pAxCALNLhp53R273H (forward) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2630 ShuttleVector pAxCAhp53R273H (reverse) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2629 ShuttleVector pAxCAhp53R273H (forward) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2509 ShuttleVector pAxCAhp53P26 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2508 ShuttleVector pAxCAhp53P26 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2507 ShuttleVector pAxCAhp53P25 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2506 ShuttleVector pAxCAhp53P25 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2505 ShuttleVector pAxCAhp53P24 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2504 ShuttleVector pAxCAhp53P24 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2503 ShuttleVector pAxCAhp53P21 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2502 ShuttleVector pAxCAhp53P21 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2501 ShuttleVector pAxCAhp53P19 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2500 ShuttleVector pAxCAhp53P19 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2499 ShuttleVector pAxCAhp53P17 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2498 ShuttleVector pAxCAhp53P17 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2497 ShuttleVector pAxCAhp53P16 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2496 ShuttleVector pAxCAhp53P16 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2495 ShuttleVector pAxCAhp53P50 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2494 ShuttleVector pAxCAhp53P50 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2493 ShuttleVector pAxCAhp53P13 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2492 ShuttleVector pAxCAhp53P13 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2437 DNA clone pCAGhp53R273H (Reverse) Mammalian vector expressing mutant of p53 gene (R273H)
TP53 2436 DNA clone pCAGhp53P70 (Reverse) Mammalian vector expressing mutant of p53 gene (Pro128Thr)
TP53 2435 DNA clone pCAGhp53P68 (Forward) Mammalian vector expressing mutant of p53 gene (Ile 162 Val, Gly 266 Asp, frame shift)
TP53 2434 DNA clone pCAGhp53WT (Reverse) Mammalian vector expressing wild type of p53 gene
TP53 2433 DNA clone pCAGhp53R273H (Forward) Mammalian vector expressing mutant of p53 gene (R273H)
TP53 2432 DNA clone pCAGhp53clone28 (Forward) Mammalian vector expressing the deletion mutant of p53 gene
TP53 2431 DNA clone pCAGhp53P70 (Forward) Mammalian vector expressing mutant of p53 gene (Pro128Thr)
TP53 2430 DNA clone pCAGhp53P68 (Reverse) Mammalian vector expressing mutant of p53 gene (Ile 162 Val, Gly 266 Asp, frame shift)
TP53 2429 DNA clone pCAGhp53WT (Forward) Mammalian vector expressing wild type p53 gene
TP53 1982 Recombinant Adenovirus AxCALNLhp53 Recombinant adenovirus expressing human p53
GADD45B 5377 ShuttleVector pAxCALNLhGADD45B(reverse) Shuttle vector to generate rAd harboring GADD45B Sugano full-length cDNA clone
GADD45B 5376 ShuttleVector pAxCALNLhGADD45B(forward) Shuttle vector to generate rAd harboring GADD45B Sugano full-length cDNA clone
GADD45B 5029 ShuttleVector pAxCALNLhGADD45B(reverse) Shuttle vector to generate rAd expressing human GADD45B
GADD45B 5028 ShuttleVector pAxCALNLhGADD45B(forward) Shuttle vector to generate rAd expressing human GADD45B
GADD45B 4151 ShuttleVector pAxCALNLhGADD45B Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
GADD45B 3584 ShuttleVector pAxCALNLhGADD45B(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDKN1A 5893 DNA clone pKM2L-phP21 Promoter Bank clone, Human p21 cyclin dependent kinase inhibitor/WAF1/CIP1 promoter
CDKN1A 3576 ShuttleVector pAxCALNLhp21(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDKN1A 1999 ShuttleVector pAxCAhp21 Shuttle vector to generate rAd expressing human CDKI p21
CDK7 4997 ShuttleVector pAxCALNLhCDK7(reverse) Shuttle vector to generate rAd expressing human CDK7
CDK7 4996 ShuttleVector pAxCALNLhCDK7(forward) Shuttle vector to generate rAd expressing human CDK7
CDK7 4113 ShuttleVector pAxCALNLhCDK7 Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK7 4087 ShuttleVector pAxCALNLhCDK7 Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK7 3539 ShuttleVector pAxCALNLhCDK7(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK7 3503 ShuttleVector pAxCALNLhCDK7(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
Cdk7 6948 H3002H05 Cdk7, NIA/NIH Mouse 15K cDNA Clone (full CDS)
cdc2 1570 DNA clone pIBI delta Xe-cdc2-33R Xenopus cdc2 (kinase-deficient) cDNA
cdc2 1569 DNA clone pIBI delta Xe-cdc2 Xenopus cdc2 cDNA
CCNH 6416 DNA clone pCMFlag_hsCCNH Expression vector of human CCNH
CCNH 4093 ShuttleVector pAxCALNLhCyclin H Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCNH 3510 ShuttleVector pAxCALNLhCyclin H(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CCND3 4589 DNA clone SEREX clone NGO-Br-20 (ID 859) #1 SEREX clone NGO-Br-20 (ID 859) #1

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(GSB0013e,T.M. 2004.04.05)

2014.08.29