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Clontech Laboratories, Inc. and RIKEN BioResource Center concluded license agreement on preservation and distribution of Fluorescent Proteins, DsRed2 and mCherry for academic use

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p53 dependent and independent G1 arrest


p53 dependent and independent G1 arrest

Summary of p53 dependent and independent G1 arrest in responce to stress

 

DNA damaging agent activates the kinases named Atm and Atr that phosphorylate chk1 and chk2. The phosphorylation of p53 on ser20 by chks induces p53 stabilization by inhibiting MDM2 binding. p21induced by p53 binds to Cyclin E/cdk2 complex to make it inactive form.Chks also help ubiquitination and degradation of CDC25A that is required for activation of Cyclin E/cdk2 complex. (Contributed by Dr. Koji Nakade)


Reporters

Catalog no. Name of clone Short description
RDB13080 pCAG-Fucci2a Fucci2a cell cycle reporter.
RDB13081 pROSA-floxNeo-Fucci2a Fucci2a cell cycle reporter. Targeting vector for R26 locus.

Locus RDB no. Type Name of clone Running title
Trp53 1285 DNA clone p53-LTR pUC18 (Anti Sense#9) Expression vector, Antisense p53, cDNA
Trp53 1284 DNA clone p53-LTR pUC18 (Sense#3) Expression vector, Sense p53, cDNA
TP53 5507 DNA clone pKM2L-phP53 Promoter Bank clone, Human p53 promoter
TP53 3187 Recombinant adenovirus AxCAhp53KP1065 Recombinant adenovirus harboring human p53 cDNA (Ser96Pro)
TP53 3186 Recombinant adenovirus AxCAhp53KP1010 Recombinant adenovirus harboring human p53 cDNA (Gly105Asp)
TP53 3185 Recombinant adenovirus AxCAhp53KP1007 Recombinant adenovirus harboring human p53 cDNA (Gly374Cys)
TP53 3184 Recombinant adenovirus AxCAhp53KP1094 Recombinant adenovirus harboring human p53 cDNA (Pro89His)
TP53 3183 Recombinant adenovirus AxCAhp53KP1070 Recombinant adenovirus harboring human p53 cDNA (Ser240Asn)
TP53 2807 Recombinant adenovirus AxCALNLhp53R273H (forward) Recombinant adenovirus harboring human p53 cDNA (R273H)
TP53 2802 Recombinant adenovirus AxCALNLhp53.clone 28 (forward) Recombinant adenovirus harboring human p53 cDNA (deletion)
TP53 2799 Recombinant adenovirus AxCALNLhp53P70 (forward) Recombinant adenovirus harboring human p53 cDNA (Pro128Thr)
TP53 2798 Recombinant adenovirus AxCALNLhp53P68 (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2795 Recombinant adenovirus AxCALNLhp53WT (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2785 Recombinant adenovirus AxCAhp53KP1070 (forward) Recombinant adenovirus harboring human p53 cDNA (Ser240Asn)
TP53 2784 Recombinant adenovirus AxCAhp53KP1065 (forward) Recombinant adenovirus harboring human p53 cDNA (Ser96Pro)
TP53 2783 Recombinant adenovirus AxCAhp53KP1010 (forward) Recombinant adenovirus harboring human p53 cDNA (Gly105Asp)
TP53 2782 Recombinant adenovirus AxCAhp53KP1007 (forward) Recombinant adenovirus harboring human p53 cDNA (Gly374Cys)
TP53 2771 Recombinant adenovirus AxCAhp53.clone 28 (forward) Recombinant adenovirus harboring human p53 cDNA (deletion)
TP53 2757 Recombinant adenovirus AxCAhp53P70 (forward) Recombinant adenovirus harboring human p53 cDNA (Pro128Thr)
TP53 2756 Recombinant adenovirus AxCAhp53P68 (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2755 Recombinant adenovirus AxCAhp53WT (forward) Recombinant adenovirus harboring human p53 cDNA
TP53 2713 ShuttleVector pAxCALNLhp53R273H (reverse) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2712 ShuttleVector pAxCALNLhp53R273H (forward) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2630 ShuttleVector pAxCAhp53R273H (reverse) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2629 ShuttleVector pAxCAhp53R273H (forward) Shuttle vector to produce rAd expressing human p53 (R273H)
TP53 2509 ShuttleVector pAxCAhp53P26 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2508 ShuttleVector pAxCAhp53P26 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2507 ShuttleVector pAxCAhp53P25 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2506 ShuttleVector pAxCAhp53P25 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2505 ShuttleVector pAxCAhp53P24 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2504 ShuttleVector pAxCAhp53P24 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2503 ShuttleVector pAxCAhp53P21 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2502 ShuttleVector pAxCAhp53P21 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2501 ShuttleVector pAxCAhp53P19 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2500 ShuttleVector pAxCAhp53P19 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2499 ShuttleVector pAxCAhp53P17 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2498 ShuttleVector pAxCAhp53P17 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2497 ShuttleVector pAxCAhp53P16 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2496 ShuttleVector pAxCAhp53P16 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2495 ShuttleVector pAxCAhp53P50 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2494 ShuttleVector pAxCAhp53P50 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2493 ShuttleVector pAxCAhp53P13 (reverse) Shuttle vector to generate rAd harboring human p53
TP53 2492 ShuttleVector pAxCAhp53P13 (forward) Shuttle vector to produce rAd expressing human p53
TP53 2437 DNA clone pCAGhp53R273H (Reverse) Mammalian vector expressing mutant of p53 gene (R273H)
TP53 2436 DNA clone pCAGhp53P70 (Reverse) Mammalian vector expressing mutant of p53 gene (Pro128Thr)
TP53 2435 DNA clone pCAGhp53P68 (Forward) Mammalian vector expressing mutant of p53 gene (Ile 162 Val, Gly 266 Asp, frame shift)
TP53 2434 DNA clone pCAGhp53WT (Reverse) Mammalian vector expressing wild type of p53 gene
TP53 2433 DNA clone pCAGhp53R273H (Forward) Mammalian vector expressing mutant of p53 gene (R273H)
TP53 2432 DNA clone pCAGhp53clone28 (Forward) Mammalian vector expressing the deletion mutant of p53 gene
TP53 2431 DNA clone pCAGhp53P70 (Forward) Mammalian vector expressing mutant of p53 gene (Pro128Thr)
TP53 2430 DNA clone pCAGhp53P68 (Reverse) Mammalian vector expressing mutant of p53 gene (Ile 162 Val, Gly 266 Asp, frame shift)
TP53 2429 DNA clone pCAGhp53WT (Forward) Mammalian vector expressing wild type p53 gene
TP53 1982 Recombinant Adenovirus AxCALNLhp53 Recombinant adenovirus expressing human p53
MDM2 2198 Recombinant Adenovirus AxCAhMDM2 Recombinant adenovirus expressing human MDM2 regulated by CAG promoter
chk1 2949 DNA clone chk1+ Plasmid clone of fission yeast Chk1
Chek1 6946 H3042B08 Chek1, NIA/NIH Mouse 15K cDNA Clone (full CDS)
CDKN1A 5893 DNA clone pKM2L-phP21 Promoter Bank clone, Human p21 cyclin dependent kinase inhibitor/WAF1/CIP1 promoter
CDKN1A 3576 ShuttleVector pAxCALNLhp21(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDKN1A 1999 ShuttleVector pAxCAhp21 Shuttle vector to generate rAd expressing human CDKI p21
CDK2 5250 ShuttleVector pAxCALNLhCDK2(reverse) Shuttle vector to generate rAd expressing human CDK2
CDK2 5249 ShuttleVector pAxCALNLhCDK2(forward) Shuttle vector to generate rAd expressing human CDK2
CDK2 4061 ShuttleVector pAxCALNLhCDK2 Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK2 3492 ShuttleVector pAxCALNLhCDK2(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
CDK2 3472 ShuttleVector pAxCALNLhCDK2(forward) Shuttle vector to generate rAd harboring Sugano full-length cDNA clone
Cdk2 6947 H3117F10 Cdk2, NIA/NIH Mouse 15K cDNA Clone (full CDS)
CDC25A 5476 DNA clone pKM2L-phCDC25A Promoter Bank clone, Human cdc25A promoter
CDC25A 4653 ShuttleVector pAxCALNLhCDC25A(forward) Shuttle vector to generate rAd expressing human CDC25A
CDC25A 4646 ShuttleVector pAxCALNLhCDC25A(reverse) Shuttle vector to generate rAd expressing human CDC25A

(GSB0009e,T.M. 2004.04.14)

2014.09.12