::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\nRIKEN BioResource Research Center DNA Bank Mail News No. 111
\n[HP] https:\/\/dna.brc.riken.jp\/ja\/news_archives\/mail
\n————————————————————————
\n\u25c6 CONTENT \u25c6
\n1. \u6ce8\u76ee\u30ea\u30bd\u30fc\u30b9
\n2. \u65b0\u898f\u516c\u958b\u30ea\u30bd\u30fc\u30b9
\n::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n\u3053\u306e\u30e1\u30fc\u30eb\u30cb\u30e5\u30fc\u30b9\u306f\u3001\u7406\u7814BRC\u907a\u4f1d\u5b50\u6750\u6599\u958b\u767a\u5ba4\uff08DNA Bank\uff09\u3092\u3054\u5229\u7528\u3044\u305f\u3060\u3044\u305f\u65b9\u3001\u306a\u3089\u3073\u306b\u30e1\u30fc\u30eb\u30cb\u30e5\u30fc\u30b9\u914d\u4fe1\u306e\u304a\u7533\u3057\u8fbc\u307f\u3092\u3044\u305f\u3060\u3044\u305f\u65b9\u306b\u304a\u9001\u308a\u3057\u3066\u3044\u307e\u3059\u3002
\n::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n1. \u6ce8\u76ee\u30ea\u30bd\u30fc\u30b9
\n::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n\u25c6 BAC\u30af\u30ed\u30fc\u30f3 \u25c6
\nhttps:\/\/dna.brc.riken.jp\/DataSheet\/GRP0055j#EXR0107j <\/p>\n
\u7406\u7814BRC DNA Bank\u306f\u3001\u63d0\u4f9b\u3059\u308b\u30de\u30a6\u30b9 (C57BL\/6N\u53ca\u3073MSM\/Ms\u7cfb\u7d71)\u3001\u30e9\u30c3\u30c8\uff08F344\/Stm\u53ca\u3073LE\/Stm\u7cfb\u7d71\uff09\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3001\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\uff08D. melanogaster\u306a\u30695\u7a2e\uff09\u306eBAC\uff08\u30d0\u30af\u30c6\u30ea\u30a2\u4eba\u5de5\u67d3\u8272\u4f53\uff09\u30af\u30ed\u30fc\u30f3\u3092\u6574\u5099\u3001\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u3054\u5e0c\u671b\u306eBAC\u30af\u30ed\u30fc\u30f3\u306f\u3001\u5c02\u7528\u306e\u30d6\u30e9\u30a6\u30b6\u30fc\u3092\u7528\u3044\u3066\u907a\u4f1d\u5b50\u540d\u3067\u691c\u7d22\u3067\u304d\u3001\u307e\u305f\u30b2\u30ce\u30e0\u9818\u57df\u4e0a\u306e\u30af\u30ed\u30fc\u30f3\u306e\u4f4d\u7f6e\u3092\u78ba\u8a8d\u3067\u304d\u307e\u3059\u3002<\/p>\n
BAC\u30af\u30ed\u30fc\u30f3\u306f\u3001\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u52d5\u7269\u6a39\u7acb\u7528\u306e\u30d9\u30af\u30bf\u30fc\u306e\u69cb\u7bc9\u3001\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u3084LacZ\u306b\u3088\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u30ec\u30dd\u30fc\u30bf\u30fc\u3092\u5c0e\u5165\u3057\u305f\u52d5\u7269\u306e\u4f5c\u88fd\u306a\u3069\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u3001\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0\u9818\u57df\u306e\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306b\u5229\u7528\u3055\u308c\u3066\u3044\u308bBAC\u30af\u30ed\u30fc\u30f3\u306e\u4f7f\u7528\u4f8b\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n
\u25bc \u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306f\u3001T\u7d30\u80de\u4e0a\u306ePD-1\u3092\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3059\u308b
\nT\u7d30\u80de\u306f\u3001\u8a98\u5c0e\u7684\u306b\u767a\u73fe\u3059\u308bPD-1\u3084\u514d\u75ab\u6291\u5236\u5264\u306e\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9(GC)\u306b\u3088\u308a\u6d3b\u6027\u5316\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u524d\u7530\u3089\u306f\u3001\u5404\u7a2e\u514d\u75ab\u6291\u5236\u5264\u306ePD-1\u767a\u73fe\u3078\u306e\u5f71\u97ff\u3092\u8abf\u3079\u308b\u7814\u7a76\u3067\u3001GC\u304cPD-1\u306e\u767a\u73fe\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002
\n\u3055\u3089\u306b\u3001PD-1\u306e\u767a\u73fe\u5897\u5f37\u306f\u3001PD-1\u907a\u4f1d\u5b50\u4e0a\u6d41\u306e\u8ee2\u5199\u8abf\u7bc0\u9818\u57df\u306b\u3042\u308bGC\u5fdc\u7b54\u914d\u5217\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u305fPD-1\u306e\u8ee2\u5199\u8abf\u7bc0\u9818\u57df\u3092\u542b\u3080\u30b2\u30ce\u30e0DNA\u306f\u3001\u5f53\u5ba4\u306eB6N BAC\u30af\u30ed\u30fc\u30f3(B6Ng01-240G08)\u304b\u3089\u3001PCR\u306b\u3088\u3063\u3066\u5897\u5e45\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n
[\u8ad6\u6587\u3001\u53c2\u8003web\u30b5\u30a4\u30c8]
\nMaeda, N. et al. Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells. J. Biol. Chem., 294 (52): 19896-19906, 2019. PMID: 31723031<\/p>\n
\u25bc \u30ea\u30bd\u30fc\u30b9\u60c5\u5831
\n[HP] https:\/\/dna.brc.riken.jp\/ja\/clonesetja<\/p>\n
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n2. \u65b0\u898f\u516c\u958b\u30ea\u30bd\u30fc\u30b9
\n::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n\u4e0b\u8a18\u306e\u907a\u4f1d\u5b50\u6750\u6599\u304c\u5bc4\u8a17\u3055\u308c\u3001\u65b0\u305f\u306b\u516c\u958b\u3044\u305f\u3057\u307e\u3057\u305f\u3002\u7686\u69d8\u306e\u3054\u5229\u7528\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n
\u25c6 \u5bc4\u8a17\u8005: The University of Edinburgh Dr. Ian Jackson and Dr. Richard Mort
\n\u7d30\u80de\u5468\u671f\u30a4\u30f3\u30b8\u30b1\u30fc\u30bf Fucci\u306e\u6539\u826f\u578b\u30d7\u30ed\u30fc\u30d6
\nFord, MJ. et al., Dev. Cell, 47(4):509-523, 2018. PMID: 30458140
\n\u25bc \u30af\u30ed\u30fc\u30f3\u60c5\u5831
\nhttps:\/\/rrc.nbrp.jp\/references\/54489<\/p>\n
\u25c6 \u5bc4\u8a17\u8005: \u7406\u7814BDR\u7ffb\u8a33\u69cb\u9020\u89e3\u6790\u7814\u7a76\u30c1\u30fc\u30e0\u3000\u4f0a\u85e4 \u62d3\u5b8f \u5148\u751f
\n\u30d2\u30c8\u7ffb\u8a33\u958b\u59cb\u56e0\u5b50eIF2B\u767a\u73fe\u30d9\u30af\u30bf\u30fc
\nKashiwagi, K. et al., Science, 364 (6439):495-499, 2019. PMID: 31048492
\n\u25bc \u30af\u30ed\u30fc\u30f3\u60c5\u5831
\nhttps:\/\/rrc.nbrp.jp\/references\/58308<\/p>\n
\u25c6 \u5bc4\u8a17\u8005: \u6771\u4eac\u85ac\u79d1\u5927\u5b66\u751f\u547d\u79d1\u5b66\u90e8\u3000\u591a\u8cc0\u8c37 \u5149\u7537 \u5148\u751f
\n\u30e9\u30c3\u30c8MAP1B-light chain 1\u767a\u73fe\u30d9\u30af\u30bf\u30fc
\nK Arasaki, K. et al., EMBO Rep., 19 (8). pii: e45584, 2018. PMID: 29925525
\n\u25bc \u30af\u30ed\u30fc\u30f3\u60c5\u5831
\nhttps:\/\/rrc.nbrp.jp\/references\/58322<\/p>\n
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n\u25cb \u672c\u30e1\u30fc\u30eb\u30cb\u30e5\u30fc\u30b9\u306e\u914d\u4fe1\u505c\u6b62\u3084\u30a2\u30c9\u30ec\u30b9\u306e\u5909\u66f4\u306a\u3069\u306f\u3001DNA Bank (dna_sec.brc@riken.jp)\u307e\u3067\u3054\u9023\u7d61\u4e0b\u3055\u3044\u3002
\n\u25cb \u914d\u4fe1\u6e08\u307f\u306e\u30e1\u30fc\u30eb\u30cb\u30e5\u30fc\u30b9\u306f\u4e0b\u8a18\u306eweb\u30b5\u30a4\u30c8\u306b\u63b2\u8f09\u3057\u3066\u304a\u308a\u307e\u3059\u3002
\nURL: https:\/\/dna.brc.riken.jp\/ja\/news_archives\/mail
\n————————————————————————
\n\u914d\u4fe1
\n\u7406\u5316\u5b66\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u7814\u7a76\u30bb\u30f3\u30bf\u30fc
\n\u907a\u4f1d\u5b50\u6750\u6599\u958b\u767a\u5ba4 (DNA Bank)
\ndna_sec.brc@riken.jp
\n[HP] https:\/\/dna.brc.riken.jp\/ja\/
\n::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
\n2020.03.05.<\/p>\n","protected":false},"excerpt":{"rendered":"
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: RIKEN BioResource Research Center DNA Bank Mail News No. 111 [HP] https:\/\/dna.brc.riken.jp\/ja\/news_archives\/mail —— […]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":4816,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-4870","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/4870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=4870"}],"version-history":[{"count":4,"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/4870\/revisions"}],"predecessor-version":[{"id":4908,"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/4870\/revisions\/4908"}],"up":[{"embeddable":true,"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/4816"}],"wp:attachment":[{"href":"http:\/\/dna.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=4870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}