{"id":7824,"date":"2023-01-16T08:55:54","date_gmt":"2023-01-15T23:55:54","guid":{"rendered":"http:\/\/dna.brc.riken.jp\/en\/?page_id=7824"},"modified":"2024-12-05T08:33:31","modified_gmt":"2024-12-04T23:33:31","slug":"gsb0051en","status":"publish","type":"page","link":"http:\/\/dna.brc.riken.jp\/en\/gsb0000en\/gsb0051en","title":{"rendered":"Mitophagy"},"content":{"rendered":"<p><!-- js calling begin --><code><script type=\"text\/javascript\" src=\"\/en\/wp-content\/uploads\/js\/functions_list.js\"><\/script><\/code><!-- js calling end --><\/p>\n<ul style=\"line-height: 1.5em;\">\n<li><a href=\"#research tool\">Resarch Tools of Mitophagy<\/a><\/li>\n<li><a href=\"#gene resource\">List of gene resources<\/a><\/li>\n<li><a href=\"https:\/\/brc.riken.jp\/dna\/GSB0021e\">Resarch Tools of Autophagy (Gene Set Collection) [link]<\/a><\/li>\n<\/ul>\n<p><a name=\"research tool\"><\/a><\/p>\n<h3>Resarch Tools of Mitophagy<\/h3>\n<p style=\"text-decoration: underline;\">A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag.<\/p>\n<p>Yim, W.W., Yamamoto, H., Mizushima, N.<br \/>\nElife 11: e78923 (2022). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35938926\">PubMed PMID 35938926<\/a>.<\/p>\n<table border=\"1\" width=\"100%\" cellspacing=\"0\" cellpadding=\"5\" bgcolor=\"#FFFFFF\">\n<tbody>\n<tr>\n<td><strong>Catalog no.<\/strong><\/td>\n<td><strong>Name of resource<\/strong><\/td>\n<td><strong>Description<\/strong><\/td>\n<\/tr>\n<tr>\n<td>RDB19962<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB19962\">pMRX-IB-pSu9-HaloTag7-mGFP<\/a><\/td>\n<td>Retroviral vector for stable expression of pSu9-HaloTag7-mGFP to measure mitophagy activity.<\/td>\n<\/tr>\n<tr>\n<td>RDB19963<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB19963\">pMRX-IB-HaloTag7-mGFP-KDEL<\/a><\/td>\n<td>Retroviral vector for stable expression of HaloTag7-mGFP-KDEL to measure ER-phagy activity. <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr width=\"50%\" \/>\n<p style=\"text-decoration: underline;\">Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration.<\/p>\n<p>Katayama, H., Hama, H., Nagasawa, K., Kurokawa, H., Sugiyama, M., Ando, R., Funata, M., Yoshida, N., Homma, M., Nishimura, T., Takahashi, M., Ishida, Y., Hioki, H., Tsujihata, Y., Miyawaki, A. Cell 181 (5): 1176-1187.e16 (2020). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32437660\">PubMed PMID 32437660<\/a>.<\/p>\n<table border=\"1\" width=\"100%\" cellspacing=\"0\" cellpadding=\"5\" bgcolor=\"#FFFFFF\">\n<tbody>\n<tr>\n<td><strong>Catalog no.<\/strong><\/td>\n<td><strong>Name of resource<\/strong><\/td>\n<td><strong>Description<\/strong><\/td>\n<\/tr>\n<tr>\n<td>RDB18222<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB18222\">SRAI_pcDNA3<\/a><\/td>\n<td>Expression vector of fluorescent protein, SRAI (signal-retaining autophagy indicator) for autophagy sensor.<\/td>\n<\/tr>\n<tr>\n<td>RDB18223<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB18223\">mito-SRAI_pcDNA3<\/a><\/td>\n<td>Expression vector of fluorescent protein, mito-SRAI (signal-retaining autophagy indicator) for quantitative visualizing mitophagy.<\/td>\n<\/tr>\n<tr>\n<td>RDB18684<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB18684\">pAAV2-TRE-mito-SRAI-BGHpA<\/a><\/td>\n<td>AAV2 expression vector of mito-SRAI (signal-retaining autophagy indicator) driven by the tetracyclin-responsive element promoter.<\/td>\n<\/tr>\n<tr>\n<td>RDB20336<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB20336\">pcDNA3\/mCherry-Parkin<\/a><\/td>\n<td>Expression vector with mCehrry added to the N-terminus of mouse Parkin.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img decoding=\"async\" alt=\"\" width=\"600\" src=\"https:\/\/dnaconda.riken.jp\/images\/exr0112_900.png\" \/><\/p>\n<hr width=\"50%\" \/>\n<p style=\"text-decoration: underline;\">Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner.<\/p>\n<p>Shiratori, R., Furuichi, K., Yamaguchi, M., Miyazaki, N., Aoki, H., Chibana, H., Ito, K., Aoki, S.  Sci. Rep. 9 (1): 18699 (2019). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31822748\">PubMed PMID 31822748<\/a>.<\/p>\n<table border=\"1\" width=\"100%\" cellspacing=\"0\" cellpadding=\"5\" bgcolor=\"#FFFFFF\">\n<tbody>\n<tr>\n<td><strong>Catalog no.<\/strong><\/td>\n<td><strong>Name of resource<\/strong><\/td>\n<td><strong>Description<\/strong><\/td>\n<\/tr>\n<tr>\n<td><script>newImage(2021,3,24)<\/script>RDB18369<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB18369\">mitoKeima-Red<\/a><\/td>\n<td>Expression vector encoding mitochondrially targeted Keima-Red (mitoKeima-Red).<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr width=\"50%\" \/>\n<p style=\"text-decoration: underline;\">A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery.<\/p>\n<p>Katayama, H., Kogure, T., Mizushima, N., Yoshimori, T., Miyawaki, A.<br \/>\nChem. Biol. 18 (8): 1042-1052 (2011). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21867919\">PubMed PMID 21867919<\/a>.<\/p>\n<table border=\"1\" width=\"100%\" cellspacing=\"0\" cellpadding=\"5\" bgcolor=\"#FFFFFF\">\n<tbody>\n<tr>\n<td><strong>Catalog no.<\/strong><\/td>\n<td><strong>Name of resource<\/strong><\/td>\n<td><strong>Description<\/strong><\/td>\n<\/tr>\n<tr>\n<td>RDB15236<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB15236\">mKeima (h)\/pCS2<\/a><\/td>\n<td>Expression vector of monomeric Keima-Red (mKeima).<\/td>\n<\/tr>\n<tr>\n<td>RDB15237<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB15237\">dKeima (h)\/pCS2<\/a><\/td>\n<td>Expression vector of dimeric Keima-Red (dKeima).<\/td>\n<\/tr>\n<tr>\n<td>RDB15238<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB15238\">mt-mKeima (h)\/pIND(SP1)<\/a><\/td>\n<td>Expression vector of monomeric Keima-Red (mKeima) with mitochondria localization signal.<\/td>\n<\/tr>\n<tr>\n<td>RDB15456<\/td>\n<td><a href=\"https:\/\/brc.riken.jp\/dna\/RDB15456\">mt-mKeima\/pcDNA3<\/a><\/td>\n<td>Expression vector of monomeric Keima-Red (mKeima) with mitochondria localization signal.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><a name=\"gene resource\"><\/a><\/p>\n<h3>List of gene resources<\/h3>\n<p>Link to KEGG Pathway &#8211; <a href=\"https:\/\/www.kegg.jp\/kegg-bin\/show_pathway?ko04137\">Mitophagy &#8211; Animal Pathway<\/a><br \/>\nList of gene resources<\/p>\n<ul>\n<li>Human <a onclick=\"ShowHide('hsa04137');return false;\" href=\"#\">[open\/close]<\/a>\n<div id=\"hsa04137\" style=\"display: block;\">\n<table>\n<tbody>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000055\/GI000055626.html\">AMBRA1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000000\/GI000000468.html\">ATF4<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000009\/GI000009474.html\">ATG5<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000079\/GI000079065.html\">ATG9A<\/a><\/td>\n<\/tr>\n<tr>\n<td>ATG9B<\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000000\/GI000000598.html\">BCL2L1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000023\/GI000023786.html\">BCL2L13<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000008\/GI000008678.html\">BECN1<\/a><\/td>\n<\/tr>\n<tr>\n<td>BECN2<\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000000\/GI000000664.html\">BNIP3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000000\/GI000000665.html\">BNIP3L<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000010\/GI000010241.html\">CALCOCO2<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000010\/GI000010370.html\">CITED2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000001\/GI000001457.html\">CSNK2A1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000001\/GI000001459.html\">CSNK2A2<\/a><\/td>\n<td>CSNK2A3<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000001\/GI000001460.html\">CSNK2B<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000001\/GI000001869.html\">E2F1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000009\/GI000009451.html\">EIF2AK3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000051\/GI000051024.html\">FIS1<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000002\/GI000002309.html\">FOXO3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000139\/GI000139341.html\">FUNDC1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000011\/GI000011337.html\">GABARAP<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000023\/GI000023710.html\">GABARAPL1<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000011\/GI000011345.html\">GABARAPL2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000003\/GI000003091.html\">HIF1A<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000003\/GI000003265.html\">HRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000003\/GI000003725.html\">JUN<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000003\/GI000003845.html\">KRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000084\/GI000084557.html\">MAP1LC3A<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000081\/GI000081631.html\">MAP1LC3B<\/a><\/td>\n<td>MAP1LC3B2<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000440\/GI000440738.html\">MAP1LC3C<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000005\/GI000005602.html\">MAPK10<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000005\/GI000005599.html\">MAPK8<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000005\/GI000005601.html\">MAPK9<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000055\/GI000055669.html\">MFN1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000009\/GI000009927.html\">MFN2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000004\/GI000004286.html\">MITF<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000022\/GI000022808.html\">MRAS<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000004\/GI000004077.html\">NBR1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000004\/GI000004893.html\">NRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000010\/GI000010133.html\">OPTN<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000192\/GI000192111.html\">PGAM5<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000065\/GI000065018.html\">PINK1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000005\/GI000005071.html\">PRKN<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007879.html\">RAB7A<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000338\/GI000338382.html\">RAB7B<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000005\/GI000005970.html\">RELA<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000055\/GI000055288.html\">RHOT1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000089\/GI000089941.html\">RHOT2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000006\/GI000006233.html\">RPS27A<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000006\/GI000006237.html\">RRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000022\/GI000022800.html\">RRAS2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000006\/GI000006667.html\">SP1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000008\/GI000008878.html\">SQSTM1<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000006\/GI000006714.html\">SRC<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000008\/GI000008887.html\">TAX1BP1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000064\/GI000064786.html\">TBC1D15<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000079\/GI000079735.html\">TBC1D17<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000029\/GI000029110.html\">TBK1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007030.html\">TFE3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007942.html\">TFEB<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000054\/GI000054543.html\">TOMM7<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007157.html\">TP53<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007311.html\">UBA52<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007314.html\">UBB<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000007\/GI000007316.html\">UBC<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000008\/GI000008408.html\">ULK1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000009\/GI000009958.html\">USP15<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000084\/GI000084749.html\">USP30<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_hum\/GI000009\/GI000009101.html\">USP8<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/li>\n<li>Mouse <a onclick=\"ShowHide('mmu04137');return false;\" href=\"#\">[open\/close]<\/a>\n<div id=\"mmu04137\" style=\"display: none;\">\n<table>\n<tbody>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000228\/GI000228361.html\">Ambra1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000011\/GI000011911.html\">Atf4<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000011\/GI000011793.html\">Atg5<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000245\/GI000245860.html\">Atg9a<\/a><\/td>\n<\/tr>\n<tr>\n<td>Atg9b<\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000012\/GI000012048.html\">Bcl2l1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000094\/GI000094044.html\">Bcl2l13<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000056\/GI000056208.html\">Becn1<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000012\/GI000012176.html\">Bnip3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000012\/GI000012177.html\">Bnip3l<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000076\/GI000076815.html\">Calcoco2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000017\/GI000017684.html\">Cited2<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000012\/GI000012995.html\">Csnk2a1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000013\/GI000013000.html\">Csnk2a2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000013\/GI000013001.html\">Csnk2b<\/a><\/td>\n<td>E2f1<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000013\/GI000013666.html\">Eif2ak3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000066\/GI000066437.html\">Fis1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000056\/GI000056484.html\">Foxo3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000072\/GI000072018.html\">Fundc1<\/a><\/td>\n<\/tr>\n<tr>\n<td>Gabarap<\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000057\/GI000057436.html\">Gabarapl1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000093\/GI000093739.html\">Gabarapl2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000015\/GI000015251.html\">Hif1a<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000015\/GI000015461.html\">Hras<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000016\/GI000016476.html\">Jun<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000016\/GI000016653.html\">Kras<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000066\/GI000066734.html\">Map1lc3a<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000067\/GI000067443.html\">Map1lc3b<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000026\/GI000026414.html\">Mapk10<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000026\/GI000026419.html\">Mapk8<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000026\/GI000026420.html\">Mapk9<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000067\/GI000067414.html\">Mfn1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000170\/GI000170731.html\">Mfn2<\/a><\/td>\n<td>Mitf<\/td>\n<td>Mras<\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000017\/GI000017966.html\">Nbr1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000018\/GI000018176.html\">Nras<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000071\/GI000071648.html\">Optn<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000072\/GI000072542.html\">Pgam5<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000068\/GI000068943.html\">Pink1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000050\/GI000050873.html\">Prkn<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000019\/GI000019349.html\">Rab7<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000226\/GI000226421.html\">Rab7b<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000019\/GI000019697.html\">Rela<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000059\/GI000059040.html\">Rhot1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000214\/GI000214952.html\">Rhot2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000078\/GI000078294.html\">Rps27a<\/a><\/td>\n<\/tr>\n<tr>\n<td>Rras<\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000066\/GI000066922.html\">Rras2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000020\/GI000020683.html\">Sp1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000018\/GI000018412.html\">Sqstm1<\/a><\/td>\n<\/tr>\n<tr>\n<td>Src<\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000052\/GI000052440.html\">Tax1bp1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000066\/GI000066687.html\">Tbc1d15<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000233\/GI000233204.html\">Tbc1d17<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000056\/GI000056480.html\">Tbk1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000209\/GI000209446.html\">Tfe3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000021\/GI000021425.html\">Tfeb<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000066\/GI000066169.html\">Tomm7<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000022\/GI000022059.html\">Trp53<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000022\/GI000022186.html\">Uba52<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000022\/GI000022187.html\">Ubb<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000022\/GI000022190.html\">Ubc<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000022\/GI000022241.html\">Ulk1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000014\/GI000014479.html\">Usp15<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000100\/GI000100756.html\">Usp30<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/RDB_mus\/GI000084\/GI000084092.html\">Usp8<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/li>\n<li>KEGG orthology <a onclick=\"ShowHide('ko04137');return false;\" href=\"#\">[open\/close]<\/a>\n<div id=\"ko04137\" style=\"display: none;\">\n<table>\n<tbody>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17985.html\">AMBRA1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04374.html\">ATF4,CREB2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K08\/K08339.html\">ATG5<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17907.html\">ATG9<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04570.html\">BCL2L1,bcl-xL<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K15\/K15485.html\">BCL2L13,BCL-RAMBO<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K08\/K08334.html\">BECN,VPS30,ATG6<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K15\/K15464.html\">BNIP3<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K15\/K15465.html\">BNIP3L<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K21\/K21348.html\">CALCOCO2,NDP52<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K21\/K21361.html\">CITED2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K03\/K03097.html\">CSNK2A<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K03\/K03115.html\">CSNK2B<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17454.html\">E2F1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K08\/K08860.html\">EIF2AK3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17969.html\">FIS1,TTC11,MDV2<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K09\/K09408.html\">FOXO3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17986.html\">FUNDC1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K08\/K08341.html\">GABARAP,ATG8,LC3<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K08\/K08268.html\">HIF1A<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K02\/K02833.html\">HRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04440.html\">JNK<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04448.html\">JUN<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07827.html\">KRAS,KRAS2<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K10\/K10435.html\">MAP1LC<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K21\/K21356.html\">MFN1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K06\/K06030.html\">MFN2,FZO1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K09\/K09455.html\">MITF<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07831.html\">MRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17987.html\">NBR1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07828.html\">NRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K19\/K19946.html\">OPTN,FIP2<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04556.html\">PARK2<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K15\/K15637.html\">PGAM5<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K05\/K05688.html\">PINK1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07897.html\">RAB7A<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07898.html\">RAB7B<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04735.html\">RELA<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07870.html\">RHOT1,ARHT1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07871.html\">RHOT2,ARHT2<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K02\/K02927.html\">RP-L40e,RPL40,UBA52<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K02\/K02977.html\">RP-S27Ae,RPS27A,UBA80<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07829.html\">RRAS<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K07\/K07830.html\">RRAS2,TC21<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04684.html\">SP1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K14\/K14381.html\">SQSTM1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K05\/K05704.html\">SRC<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K21\/K21347.html\">TAX1BP1<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K20\/K20168.html\">TBC1D15<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K19\/K19945.html\">TBC1D17<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K05\/K05410.html\">TBK1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K09\/K09105.html\">TFE3<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K15\/K15590.html\">TFEB<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K17\/K17771.html\">TOM7<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04451.html\">TP53,P53<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K04\/K04551.html\">UBB<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K08\/K08770.html\">UBC<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K21\/K21357.html\">ULK1<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K21\/K21343.html\">USP15<\/a><\/td>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K11\/K11851.html\">USP30<\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/dnaconda.riken.jp\/search\/KO\/K11\/K11839.html\">USP8,UBP5<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/li>\n<\/ul>\n<p>Link to KEGG Pathway &#8211; <a href=\"https:\/\/www.kegg.jp\/kegg-bin\/show_pathway?ko04139\">Mitophagy &#8211; Yeast Pathway<\/a><\/p>\n<hr \/>\n<p style=\"text-align:right;\">(GSB0051e, T.M. 2014.10.13)<\/p>\n<p style=\"text-align:left;\">2024.12.04<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Resarch Tools of Mitophagy List of gene resources Resarch Tools of Autophagy (Gene Set Collection) [link] Resarch Tools of Mitophagy A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag. Yim, W.W., Yamamoto, H., Mizushima, N. Elife 11: e78923 (2022). PubMed PMID 35938926. Catalog no. Name of resource Description RDB19962 pMRX-IB-pSu9-HaloTag7-mGFP Retroviral vector for stable expression of pSu9-HaloTag7-mGFP to measure mitophagy activity. RDB19963 pMRX-IB-HaloTag7-mGFP-KDEL Retroviral vector for stable expression of HaloTag7-mGFP-KDEL to measure ER-phagy activity. Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration. Katayama, H., Hama, H., Nagasawa, K., Kurokawa, H., Sugiyama, M., Ando, R., Funata, M., Yoshida, N., Homma, M., Nishimura, T., Takahashi, M., Ishida, Y., Hioki, H., Tsujihata, Y., Miyawaki, A. Cell 181 (5): 1176-1187.e16 (2020). PubMed PMID 32437660. Catalog no. Name of resource Description RDB18222 SRAI_pcDNA3 Expression vector of fluorescent protein, SRAI (signal-retaining autophagy indicator) for autophagy sensor. RDB18223 mito-SRAI_pcDNA3 Expression vector of fluorescent protein, mito-SRAI (signal-retaining autophagy indicator) for quantitative visualizing mitophagy. RDB18684 pAAV2-TRE-mito-SRAI-BGHpA AAV2 expression vector of mito-SRAI (signal-retaining autophagy indicator) driven by the tetracyclin-responsive element promoter. RDB20336 pcDNA3\/mCherry-Parkin Expression vector with mCehrry added to the N-terminus of mouse Parkin. Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":3917,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-7824","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/7824","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/comments?post=7824"}],"version-history":[{"count":6,"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/7824\/revisions"}],"predecessor-version":[{"id":8319,"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/7824\/revisions\/8319"}],"up":[{"embeddable":true,"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/3917"}],"wp:attachment":[{"href":"http:\/\/dna.brc.riken.jp\/en\/wp-json\/wp\/v2\/media?parent=7824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}