p53-dependent apoptosis
The inactivation of p53 by Mdm2 is counteracted by mechanisms involving post-translational modification of p53, or the Mdm2 inhbibitor ARF. Through its activity as a sequence-specific transcriptional activator, p53 increases the expression of pro-apoptotic Bcl-2 family proteins. Potential transcriptionindependent functions of p53 co-operate with the Bcl-2 protein to induce the release of apoptogenic factors (depicted as circles) from the mitochondrial outer membrane. Released apoptogenic factors facilitate the activation of the effector caspases through the Apaf-1-caspase 9-apoptosome. ATM, ataxia telangiectasia mutated protein ; ATR, ataxia telangiectasia-related ; PML, promyelocytic leukaemia protein ; ARF, alternative reading frame of p16 protein. (Contributed by Dr. Koji Nakade)
Human Resources
Icon | Locus | Gene Products | Alternative Name |
---|---|---|---|
Apaf1 | APAF1 | apoptotic peptidase activating factor 1 | APAF-1|CED4|DKFZp781B1145 |
ATM | ATM | ataxia telangiectasia mutated | AT1|ATA|ATC|ATD|ATDC|ATE|DKFZp781A0353|MGC74674|TEL1|TELO1 |
ATR | ATR | ataxia telangiectasia and Rad3 related | FRP1|MEC1|SCKL|SCKL1 |
Bax | BAX | BCL2-associated X protein | BCL2L4 |
PUMA | BBC3 | BCL2 binding component 3 | FLJ42994|JFY-1|JFY1|PUMA |
Caspase 9 | CASP9 | caspase 9, apoptosis-related cysteine peptidase | APAF-3|APAF3|CASPASE-9c|ICE-LAP6|MCH6 |
ARF | CDKN2A | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16 |
CHK1 | CHEK1 | CHK1 checkpoint homolog (S. pombe) | CHK1 |
CHK2 | CHEK2 | CHK2 checkpoint homolog (S. pombe) | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53 |
MDM2 | MDM2 | Mdm2 p53 binding protein homolog (mouse) | HDMX|MGC5370|MGC71221|hdm2 |
Noxa | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | APR|NOXA |
PML | PML | promyelocytic leukemia | MYL|PP8675|RNF71|TRIM19 |
p53 | TP53 | tumor protein p53 | FLJ92943|LFS1|P53|TRP53 |
Other Resources
Locus | RDB no. | Type | Name of clone | Running title |
---|---|---|---|---|
Trp53 | 1285 | DNA clone | p53-LTR pUC18 (Anti Sense#9) | Expression vector, Antisense p53, cDNA |
Trp53 | 1284 | DNA clone | p53-LTR pUC18 (Sense#3) | Expression vector, Sense p53, cDNA |
chk1 | 2949 | DNA clone | chk1+ | Plasmid clone of fission yeast Chk1 |
Chek1 | 6946 | H3042B08 | Chek1, NIA/NIH Mouse 15K cDNA Clone |
(GSB0012e, T.M. 2004.04.01)
2018.09.24