Ets family proteins with other transcription factors and co-activators on various cellular promoters and enhancers
(a) Ets-1 or PEA-3 activates the MMP (matrix metalloproteinase) promoters in cooperation with AP1 (c-Fos/c-Jun) on the RRE (Ras-response element).
(b) TCF (Elk-1, Sap-1, Net) activates the c-fos promoter in cooperation with SRF (serum response factor).
(c) PU.1 activates myeloid-specific promoters in cooperation with AML1 and C/EBP.
(d) Fli-1 activates megakaryocyte-specific promoters in cooperation with GATA-1.
(e) PU.1 activates the immunoglobulin (Ig) heavy (H) chain enhancer in cooperation with E12, Ets-1, TFE3 and Oct-2.
(f) Ets-1 activates the T cell receptor (TCR) a enhancer in cooperation with CREB/ATF, TCF-1, AML1 and GATA-3.
Human Resources
| Icon | Locus | Gene Products | Alternative Name |
|---|---|---|---|
| ALY | THOC4 | THO complex 4 | ALY|ALY/REF|BEF|REF |
| ATF | ATF2 | activating transcription factor 2 | CRE-BP1|CREB2|HB16|MGC111558|TREB7 |
| C/EBP | CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | C/EBP-alpha|CEBP |
| CREB | CREB1 | cAMP responsive element binding protein 1 | CREB|MGC9284 |
| TCF | ELK1 | ELK1, member of ETS oncogene family | – |
| TCF | ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | ERP|NET|SAP2 |
| TCF | ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | DKFZp434N185|SAP1 |
| CBP/p300 | EP300 | E1A binding protein p300 | KAT3B|RSTS2|p300 |
| Ets-1 | ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | ETS-1|EWSR2|FLJ10768 |
| Ets-1 | ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | ETS2IT1 |
| PEA3 | ETV4 | ets variant 4 | E1A-F|E1AF|PEA3|PEAS3 |
| Fli-1 | FLI1 | Friend leukemia virus integration 1 | EWSR2|SIC-1 |
| Ap-1/Jun/Fos | FOS | FBJ murine osteosarcoma viral oncogene homolog | AP-1|C-FOS|p55 |
| GATA-3 | GATA3 | GATA binding protein 3 | HDR|HDRS|MGC2346|MGC5199|MGC5445 |
| Ap-1/Jun/Fos | JUN | jun proto-oncogene | AP-1|AP1|c-Jun |
| OCAB | POU2AF1 | POU class 2 associating factor 1 | BOB1|OBF-1|OBF1|OCAB |
| Oct-2 | POU2F2 | POU class 2 homeobox 2 | OCT2|OTF2|Oct-2 |
| Sp1 | SP1 | Sp1 transcription factor | – |
| SRF | SRF | serum response factor (c-fos serum response element-binding transcription factor) | MCM1 |
| E12 | TCF3 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | E2A|E47|ITF1|MGC129647|MGC129648|TCF-3|VDIR|bHLHb21 |
| TCF-1 | TCF7 | transcription factor 7 (T-cell specific, HMG-box) | FLJ36364|MGC47735|TCF-1 |
| TEF3 | TFE3 | transcription factor binding to IGHM enhancer 3 | RCCP2|RCCX1|TFEA|bHLHe33 |
| TEF3 | TRIM37 | tripartite motif containing 37 | KIAA0898|MUL|POB1|TEF3 |
Other Resources
| Locus | RDB no. | Type | Name of clone | Running title |
|---|---|---|---|---|
| runx1 | 6420 | DNA clone | pZF-Runxa | Plasmid clone of zebrafish runx1 (runxa) cDNA |
| Ep300 | 5790 | DNA clone | pU6_mmEP300_2505F | Expression vector for mouse EP300 small RNA fragment |
| Ep300 | 5789 | DNA clone | pU6_mmEP300_0172R | Expression vector for mouse EP300 small RNA fragment |
| Ep300 | 5783 | DNA clone | pU6_mmEP300_1926F | Expression vector for mouse EP300 small RNA fragment |
| Ep300 | 5776 | DNA clone | pU6_mmEP300_2505R | Expression vector for mouse EP300 small RNA fragment |
| Ep300 | 5774 | DNA clone | pU6_mmEP300_2308R | Expression vector for mouse EP300 small RNA fragment |
| Ep300 | 5767 | DNA clone | pU6_mmEP300_2308F | Expression vector for mouse EP300 small RNA fragment |
| Ep300 | 5749 | DNA clone | pU6_mmEP300_0172F | Expression vector for mouse EP300 small RNA fragment |
| Elk3 | 6920 | DNA clone | H4069B01 | Elk3, NIA/NIH Mouse 7.4K cDNA Clone |
| Elk1 | 6906 | DNA clone | H4062C03 | Elk1, NIA/NIH Mouse 7.4K cDNA Clone |
| Crebbp | 5778 | DNA clone | pU6_mmCREBBP-2_1638R | Expression vector for mouse CREBBP-2 small RNA fragment |
| Crebbp | 5777 | DNA clone | pU6_mmCREBBP-2_1068F | Expression vector for mouse CREBBP-2 small RNA fragment |
| Crebbp | 5769 | DNA clone | pU6_mmCREBBP-2_1068R | Expression vector for mouse CREBBP-2 small RNA fragment |
| Crebbp | 5768 | DNA clone | pU6_mmCREBBP-2_0168R | Expression vector for mouse CREBBP-2 small RNA fragment |
| Crebbp | 5760 | DNA clone | pU6_mmCREBBP-2_0374F | Expression vector for mouse CREBBP-2 small RNA fragment |
go to Head(GSB0005e, T.M. 2004.04.27)
2018.09.24
