Mouse, Cell and DNA Resources of p38 MAP (mitogen-activated protein) kinase were originally developed and deposited by Dr. Tatsuhiko SUDO, RIKEN. Those resources are beneficial for the researches focusing on intra- and inter-cellular stress signaling. Also they may be utilized for physiological, pathological and hereditary studies. In addition, the specific DNA clones are designed for p38α inhibitor screening method using growth recovery of bacteria as an index (ref. 7).
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| ref. 1-6 | ref. 7 | ref. 8 |
References
1. Biochem. Biophys. Res. Commun. 269, 521-525 2000
2. Biochem. Biophys. Res. Commun. 291, 838-843 2002
3. FEBS Lett. 575, 136-140 2004
4. Biochem. Biophys. Res. Commun. 337, 415-421 2005
5. J. Biochem. 143, 765-772 2008
6. Chem. Asian J. 3, 1607-1612 2008
7. Anal. Biochem. 388, 128-133 2009
- Screening machine: Incubation Plate Reader “HiTS”
8. The Annual Meeting of MBSJ 2012
- p38γ and/or p38δ inhibitors: SU-002 & SU-005
For more publications, please refer “sudo t (p38 or p38alpha)” to PubMed.
DNA Resource
| Icon | Locus symbol | Name of clone | Short description | Cat No. |
|---|---|---|---|---|
| p38a | Mapk14 | pBlueScriptKS+p38 | Plasmid vector of mouse p38alpha MAPK cDNA | RDB08158 |
| p38a | Mapk14 | pcDNA3-p38 | Expression vector of mouse p38alpha MAPK cDNA | RDB08159 |
| p38a | Mapk14 | pcDNA3Flag-p38 | Expression vector of mouse p38alpha MAPK cDNA, FLAG-tagged | RDB08160 |
| p38a | Mapk14 | pcDNA3Flag-p38AF | Expression vector of mouse p38alpha MAPK cDNA, constitutive inactive form, FLAG-tagged | RDB08161 |
| p38a | Mapk14 | pcDNA3Flag-p38K53R | Expression vector of mouse p38alpha MAPK cDNA, kinase almost dead mutant, FLAG-tagged | RDB08162 |
| p38a | Mapk14 | pSRalpha3HA-p38 | Expression vector of mouse p38alpha MAPK cDNA, HA-tagged | RDB08163 |
| p38a | Mapk14 | pGEX-p38 | Bacterial expression vector of mouse p38alpha MAPK cDNA, GST-tagged | RDB08164 |
| p38a | MAPK14 | pGEM-hp38alpha | Plasmid vector of human p38alpha MAPK cDNA | RDB08165 |
| p38a | MAPK14 | pcDNA3Flag-hp38 | Expression vector of human p38alpha MAPK cDNA, FLAG-tagged | RDB08166 |
| p38a | MAPK14 | pcDNA3HA-hp38 | Expression vector of human p38alpha MAPK cDNA, HA-tagged | RDB08167 |
| p38a | MAPK14 | pcDNA3Flag-hp38AF | Expression vector of human p38alpha MAPK cDNA, constitutive inactive form, FLAG-tagged | RDB08168 |
| p38a | MAPK14 | pcDNA3Flag-hp38K53A | Expression vector of human p38alpha MAPK cDNA, kinase dead mutant, FLAG-tagged | RDB08169 |
| p38a | MAPK14 | pZeoSV2Flag-hp38 | Expression vector of human p38alpha MAPK cDNA, FLAG-tagged | RDB08170 |
| p38a | MAPK14 | pGEX-hp38 | Bacterial expression vector of human p38alpha MAPK cDNA, GST-tagged | RDB08171 |
| p38a | MAPK14 | pRSET-hp38 | Bacterial expression vector of human p38alpha MAPK cDNA, His6-tagged | RDB08172 |
| p38a | MAPK14 | pRSET-hp38K53A | Bacterial expression vector of human p38alpha MAPK cDNA, kinase dead mutant, His6-tagged | RDB08173 |
| p38a | MAPK14 | pRSET-hp38T106M | Bacterial expression vector of human p38alpha MAPK cDNA, T106M mutant, His6-tagged | RDB08174 |
| p38a | MAPK14 | pRSET-hp38Y323F | Bacterial expression vector of human p38alpha MAPK cDNA, Y323F mutant, His6-tagged | RDB08175 |
| p38a | MAPK14 | pRSET-hp38AF | Bacterial expression vector of human p38alpha MAPK cDNA, constitutive inactive form, His6-tagged | RDB08176 |
| p38a | MAPK14 | pRSET-hp38T180A/Y323F | Bacterial expression vector of human p38alpha MAPK cDNA, T180A/Y323F mutant, His6-tagged | RDB08177 |
| p38a | MAPK14 | pRSET-GST-hp38 | Bacterial expression vector of human p38alpha MAPK cDNA, GST-tagged | RDB08178 |
| p38a | MAPK14 | pEGFP-hp38alpha | Expression vector of human p38alpha MAPK cDNA, FLAG- and EGFP-tagged | RDB08179 |
| MAPK14 | pcDNA3Flag-hCSBP1 | Expression vector of human p38alpha MAPK cDNA, alternatively spliced, FLAG-tagged | RDB08180 | |
| p38b | MAPK11 | pcDNA3Flag-hp38beta2 | Expression vector of human p38beta MAPK cDNA, FLAG-tagged | RDB12359 |
| p38b | MAPK11 | pcDNA3Flag-hp38beta2T106M | Expression vector of human p38beta MAPK cDNA, FLAG-tagged | RDB12360 |
| p38g | MAPK12 | pcDNA3Flag-hp38gamma | Expression vector of human p38gamma MAPK cDNA, FLAG-tagged | RDB12361 |
| p38g | MAPK12 | pcDNA3Flag-hp38gammaM109T | Expression vector of human p38gamma MAPK cDNA, FLAG-tagged | RDB12362 |
| p38g | MAPK12 | pRSET-hp38gamma | Bacterial expression vector of human p38gamma, His6-tagged | RDB12366 |
| p38g | MAPK12 | pRSET-hp38gammaM109T | Bacterial expression vector of human p38gamma, His6-tagged | RDB12367 |
| p38d | MAPK13 | pcDNA3Flag-hp38delta | Expression vector of human p38delta MAPK cDNA, FLAG-tagged | RDB12363 |
| p38d | MAPK13 | pcDNA3Flag-hp38deltaM107T | Expression vector of human p38delta MAPK cDNA, FLAG-tagged | RDB12364 |
| p38d | MAPK13 | pcDNA3Flag-hp38deltaK54A | Expression vector of human p38delta MAPK cDNA, FLAG-tagged | RDB12365 |
| p38d | MAPK13 | pRSET-hp38delta | Bacterial expression vector of human p38delta, His6-tagged | RDB12368 |
| p38d | MAPK13 | pRSET-hp38deltaM107T | Bacterial expression vector of human p38delta, His6-tagged | RDB12369 |
| p38d | MAPK13 | pRSET-hp38deltaK54A | Bacterial expression vector of human p38delta, His6-tagged | RDB12370 |
| EXIP | MAPK14 | pGEM-hExip | Plasmid vector of human p38alpha MAPK splicing variant cDNA | RDB08181 |
| EXIP | MAPK14 | pcDNA3Flag-hExip | Expression vector of human p38alpha MAPK splicing variant cDNA, FLAG-tagged | RDB08182 |
| EXIP | MAPK14 | pcDNA3HA-hExip | Plasmid vector of human p38alpha MAPK splicing variant cDNA, HA-tagged | RDB08183 |
| EXIP | MAPK14 | pcDNA3Flag-hExipAF | Plasmid vector of human p38alpha MAPK splicing variant cDNA, FLAG-tagged | RDB08184 |
| EXIP | MAPK14 | pcDNA3Flag-hExipK53A | Plasmid vector of human p38alpha MAPK splicing variant cDNA, K53A mutant, FLAG-tagged | RDB08185 |
| EXIP | MAPK14 | pcDNA3Flag-hExipK53R | Plasmid vector of human p38alpha MAPK splicing variant cDNA, K53R mutant, FLAG-tagged | RDB08186 |
| EXIP | MAPK14 | pZeoSV2Flag-hExip | Plasmid vector of human p38alpha MAPK splicing variant cDNA, FLAG-tagged | RDB08187 |
| EXIP | MAPK14 | pEGFP-hExip | Plasmid vector of human p38alpha MAPK splicing variant cDNA, FLAG- and EGFP-tagged | RDB08188 |
| p62 | SQSTM1 | pBK-CMVp62Flag | Expression vector of human p62/SQSTM1 cDNA, FLAG-tagged | RDB08189 |
| p62 | SQSTM1 | pSRalpha3HA-p62 | Expression vector of human p62/SQSTM1 cDNA, HA-tagged | RDB08190 |
| p62 | SQSTM1 | pSRalpha3HA-p62-4A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08191 |
| p62 | SQSTM1 | pSRalpha3HA-p62-3A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08192 |
| p62 | SQSTM1 | pSRalpha3HA-p62-7A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08193 |
| p62 | SQSTM1 | pSRalpha3HA-p62-385 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08194 |
| p62 | SQSTM1 | pSRalpha3HA-p62-344 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08195 |
| p62 | SQSTM1 | pSRalpha3HA-p62-334 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08196 |
| p62 | SQSTM1 | pSRalpha3HA-p62-3N | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08197 |
| p62 | SQSTM1 | pSRalpha3HA-p62-H174A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08198 |
| p62 | SQSTM1 | pSRalpha3HA-p62-E177Q | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08199 |
| p62 | SQSTM1 | pSRalpha3HA-p62-S180A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08200 |
| p62 | SQSTM1 | pSRalpha3HA-p62-H181A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08201 |
| p62 | SQSTM1 | pSRalpha3HA-p62-S182A | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08202 |
| p62 | SQSTM1 | pcDNA3HA-p62 | Expression vector of human p62/SQSTM1 cDNA, HA-tagged | RDB08203 |
| p62 | SQSTM1 | pcDNA3HA-p62-delta257 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08204 |
| p62 | SQSTM1 | pcDNA3HA-p62-delta163 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08205 |
| p62 | SQSTM1 | pcDNA3HA-p62-delta172 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08206 |
| p62 | SQSTM1 | pcDNA3HA-p62-delta182 | Expression vector of human p62/SQSTM1 mutant cDNA, HA-tagged | RDB08207 |
| Tollip | TOLLIP | pcDNA3HA-Tollip | Expression vector of human Tollip cDNA, HA-tagged | RDB08208 |
| MKK6 | MAP2K6 | pcDNA3Flag-MKK6 | Expression vector of human MKK6 cDNA, FLAG-tagged | RDB08209 |
| MKK6 | MAP2K6 | pcDNA3Flag-MKK6D/D | Expression vector of human MKK6 cDNA, constitutive active form, FLAG-tagged | RDB08210 |
| MKK6 | MAP2K6 | pcDNA3Flag-MKK6K82A | Expression vector of human MKK6 cDNA, kinase dead mutant, FLAG-tagged | RDB08211 |
| MKK6 | MAP2K6 | pGEXMKK6 | Bacterial expression vector of human MKK6 cDNA, GST-tagged | RDB08212 |
| MKK6 | MAP2K6 | pGEXMKK6D/D | Bacterial expression vector of human MKK6 cDNA, GST-tagged | RDB08213 |
| MAPKAPK2 | MAPKAPK2 | pcDNA3Flag-hMAPKAPK2 | Expression vector of human MAPKAPK2 cDNA, FLAG-tagged | RDB08214 |
| MAPKAPK2 | MAPKAPK2 | pcDNA3Flag-hMAPKAPK2K93A | Expression vector of human MAPKAPK2 cDNA, kinase dead mutant, FLAG-tagged | RDB08215 |
Mouse Resource
Targeted Mutation Mouse
C57BL/6-TgH(p38)/118
Cell Resource
Mouse fibroblast-like cell line lacking p38 MAP kinase expression.
RCB2148 KOP
RCB2149 RKOP
RCB2150 EKOP
RCB2151 ZKOP
Find other related resources
Human Resources
| Locus | Gene Products | Alternative Name |
|---|---|---|
| MAPK14 | mitogen-activated protein kinase 14 | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA |
| MAPK11 | mitogen-activated protein kinase 11 | P38B|SAPK2|p38-2|PRKM11|SAPK2B|p38Beta|P38BETA2 |
| MAPK12 | mitogen-activated protein kinase 12 | ERK3|ERK6|SAPK3|PRKM12|SAPK-3|P38GAMMA |
| MAPK13 | mitogen-activated protein kinase 13 | SAPK4|PRKM13|MAPK 13|MAPK-13|p38delta |
| SQSTM1 | sequestosome 1 | A170|OSIL|PDB3|ZIP3|p60|p62|p62B |
| TOLLIP | toll interacting protein | FLJ33531|IL-1RAcPIP |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | MAPKK6|MEK6|MKK6|PRKMK6|SAPKK3 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | MK2 |
| DDIT3 | DNA-damage-inducible transcript 3 | CEBPZ|CHOP|CHOP-10|CHOP10|GADD153|MGC4154 |
| ATF2 | activating transcription factor 2 | CRE-BP1|CREB2|HB16|MGC111558|TREB7 |
| JUN | jun proto-oncogene | AP-1|AP1|c-Jun |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | MAPKK6|MEK6|MKK6|PRKMK6|SAPKK3 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | IRAK|pelle |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | ASRT5|FLJ13601|IRAKM |
| IRAK4 | interleukin-1 receptor-associated kinase 4 | IPD1|IRAK-4|NY-REN-64|REN64 |
| IL1A | interleukin 1, alpha | IL-1A|IL1|IL1-ALPHA|IL1F1 |
| IL1B | interleukin 1, beta | IL-1|IL1-BETA|IL1F2 |
| IL1R1 | interleukin 1 receptor, type I | CD121A|D2S1473|IL-1R-alpha|IL1R|IL1RA|P80 |
| IL1R2 | interleukin 1 receptor, type II | CD121b|IL1RB|MGC47725 |
| TLR2 | toll-like receptor 2 | CD282|TIL4 |
| TLR3 | toll-like receptor 3 | CD283 |
| TLR4 | toll-like receptor 4 | ARMD10|CD284|TOLL|hToll |
| TLR7 | toll-like receptor 7 | |
| TLR9 | toll-like receptor 9 | CD289 |
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