Comparison of MAP kinase pathways that are implicated in the control of the cell division cycle. The MAP kinase cascade is illustrated together with the main downstream substrates implicated in cell cycle control. Crosstalk may exist in vivo between human MAP3K enzymes and MAP3K components of other parallel pathways. For example, MEKK3, while being implicated in the regulation of MEK5 activity, is also a potent activator of the p38 pathway. Similarly, Tak1 can activate the JNK pathway. Studies reporting the promiscuous nature of MAP3K enzymes, however, are subject to certain experimental caveats and are therefore subject to debate. (Contributed by Dr. Koji Nakade)
| Catalog no. | Name of clone | Running title |
|---|---|---|
| RDB13254 | GL023 | Expression plasmid of GFP-tagged human c-RAF. |
| RDB13255 | GL348 | Expression plasmid of GFP-tagged human cRaf1 catalytic domain (CAD, 330-627) |
| RDB13256 | GL207 | Expression plasmid of GFP-tagged human cRaf1 CRDCAD (R89A S621A). |
| RDB13257 | GL107 | Expression plasmid of GFP-tagged human cRaf1 (R89A mutant). |
Human Resources
| Icon | Locus | Gene Products | Alternative Name |
|---|---|---|---|
| A-Raf | ARAF | v-raf murine sarcoma 3611 viral oncogene homolog | A-RAF|ARAF1|PKS2|RAFA1 |
| B-Raf | BRAF | v-raf murine sarcoma viral oncogene homolog B1 | B-RAF1|BRAF1|FLJ95109|MGC126806|MGC138284|NS7|RAFB1 |
| MEK1/2 | MAP2K1 | mitogen-activated protein kinase kinase 1 | MAPKK1|MEK1|MKK1|PRKMK1 |
| MEK1/2 | MAP2K2 | mitogen-activated protein kinase kinase 2 | FLJ26075|MAPKK2|MEK2|MKK2|PRKMK2 |
| MKK3,6 | MAP2K3 | mitogen-activated protein kinase kinase 3 | MAPKK3|MEK3|MKK3|PRKMK3 |
| MKK3,6 | MAP2K6 | mitogen-activated protein kinase kinase 6 | MAPKK6|MEK6|MKK6|PRKMK6|SAPKK3 |
| MKK4,7 | MAP2K4 | mitogen-activated protein kinase kinase 4 | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SEK1|SERK1 |
| MKK4,7 | MAP2K7 | mitogen-activated protein kinase kinase 7 | Jnkk2|MAPKK7|MKK7|PRKMK7 |
| MEK5 | MAP2K5 | mitogen-activated protein kinase kinase 5 | HsT17454|MAPKK5|MEK5|PRKMK5 |
| MLK3 | MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | MEKK11|MGC17114|MLK-3|MLK3|PTK1|SPRK |
| DLK | MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | DLK|MEKK12|MUK|ZPK|ZPKP1 |
| ERK1,2 | MAPK1 | mitogen-activated protein kinase 1 | ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk |
| ERK1,2 | MAPK3 | mitogen-activated protein kinase 3 | ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3 |
| MEKK2,3 | MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | MEKK2|MEKK2B |
| MEKK2,3 | MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | MAPKKK3|MEKK3 |
| ASK1 | MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | ASK1|MAPKKK5|MEKK5 |
| TAK | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | MEKK7|TAK1|TGF1a |
| Tpl2 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | COT|EST|ESTF|FLJ10486|MEKK8|TPL2|Tpl-2|c-COT |
| SAPK/JNK | MAPK10 | mitogen-activated protein kinase 10 | FLJ12099|FLJ33785|JNK3|JNK3A|MGC50974|PRKM10|p493F12|p54bSAPK |
| p38 MAPK | MAPK11 | mitogen-activated protein kinase 11 | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta |
| SAPK/JNK | MAPK11 | mitogen-activated protein kinase 11 | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta |
| p38 MAPK | MAPK12 | mitogen-activated protein kinase 12 | ERK3|ERK6|P38GAMMA|PRKM12|SAPK-3|SAPK3 |
| SAPK/JNK | MAPK12 | mitogen-activated protein kinase 12 | ERK3|ERK6|P38GAMMA|PRKM12|SAPK-3|SAPK3 |
| p38 MAPK | MAPK13 | mitogen-activated protein kinase 13 | MGC99536|PRKM13|SAPK4|p38delta |
| SAPK/JNK | MAPK13 | mitogen-activated protein kinase 13 | MGC99536|PRKM13|SAPK4|p38delta |
| p38 MAPK | MAPK14 | mitogen-activated protein kinase 14 | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA |
| SAPK/JNK | MAPK14 | mitogen-activated protein kinase 14 | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA |
| ERK5/BMK1 | MAPK7 | mitogen-activated protein kinase 7 | BMK1|ERK4|ERK5|PRKM7 |
| SAPK/JNK | MAPK8 | mitogen-activated protein kinase 8 | JNK|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1 |
| SAPK/JNK | MAPK9 | mitogen-activated protein kinase 9 | JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|p54a|p54aSAPK |
| MX1 | MX1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | IFI-78K|IFI78|MX|MxA |
| c-Raf | RAF1 | v-raf-1 murine leukemia viral oncogene homolog 1 | CRAF|NS5|Raf-1|c-Raf |
Mouse Resources
| Icon | Locus | Gene Products | Alternative Name |
|---|---|---|---|
| A-Raf | Araf | v-raf murine sarcoma 3611 viral oncogene homolog | 1200013E08Rik|A-Raf|AW495444|Araf1 |
| B-Raf | Braf | Braf transforming gene | 9930012E13Rik|AA120551|AA387315|AA473386|B-raf|Braf-2|Braf2|C230098H17|C87398|D6Ertd631e |
| c-Raf | Raf1 | v-raf-leukemia viral oncogene 1 | 6430402F14Rik|AA990557|BB129353|Craf1|D830050J10Rik|MGC102375|Raf-1|c-Raf|v-Raf |
| DLK | Map3k12 | mitogen-activated protein kinase kinase kinase 12 | DLK|MUK|Zpk |
| ERK1,2 | Mapk1 | mitogen-activated protein kinase 1 | 9030612K14Rik|AA407128|AU018647|C78273|ERK|Erk2|MAPK2|PRKM2|Prkm1|p41mapk|p42mapk |
| ERK1,2 | Mapk3 | mitogen-activated protein kinase 3 | Erk-1|Erk1|Ert2|Esrk1|Mnk1|Mtap2k|Prkm3|p44|p44erk1|p44mapk |
| MEK1/2 | Map2k1 | mitogen-activated protein kinase kinase 1 | MAPKK1|MEKK1|Mek1|Prkmk1 |
| MEK1/2 | Map2k2 | mitogen-activated protein kinase kinase 2 | AA589381|MEK2|MK2|Prkmk2 |
| MEKK2,3 | Map3k2 | mitogen-activated protein kinase kinase kinase 2 | 9630061B06Rik|AI585793|Mekk2|Mekk2b |
| MEKK2,3 | Map3k3 | mitogen-activated protein kinase kinase kinase 3 | AW548911|KIAA4031|MAPKKK3|Mekk3|mKIAA4031 |
| MKK3,6 | Map2k3 | mitogen-activated protein kinase kinase 3 | AW212142|MEK3|MKK3|Prkmk3|mMKK3b |
| MKK3,6 | Map2k6 | mitogen-activated protein kinase kinase 6 | MEK6|MKK6|Prkmk6|SAPKK3 |
| MKK4,7 | Map2k4 | mitogen-activated protein kinase kinase 4 | JNKK1|MEK4|MKK4|PRKMK4|Sek1|Serk1 |
| MKK4,7 | Map2k7 | mitogen-activated protein kinase kinase 7 | 5930412N11Rik|Jnkk2|MKK7|Prkmk7|sek2 |
| MX1 | Mx1 | myxovirus (influenza virus) resistance 1 | AI893580|Mx|Mx-1 |
| p38 MAPK | Mapk12 | mitogen-activated protein kinase 12 | AW123708|Erk6|P38gamma|Prkm12|Sapk3 |
| p38 MAPK | Mapk13 | mitogen-activated protein kinase 13 | SAPK4|Serk4 |
| p38 MAPK | Mapk14 | mitogen-activated protein kinase 14 | CSBP2|Crk1|Csbp1|MGC102436|Mxi2|PRKM14|PRKM15|p38|p38-alpha|p38MAPK|p38a|p38alpha |
| SAPK/JNK | Mapk8 | mitogen-activated protein kinase 8 | AI849689|JNK|JNK1|Prkm8|SAPK1 |
| SAPK/JNK | Mapk9 | mitogen-activated protein kinase 9 | AI851083|JNK2|Prkm9|p54aSAPK |
| SAPK/JNK | Mapk10 | mitogen-activated protein kinase 10 | C230008H04Rik|JNK3|JNK3B1|JNK3B2|SAPK(beta)|Serk2|p493F12|p54bSAPK |
| SAPK/JNK | Mapk13 | mitogen-activated protein kinase 13 | SAPK4|Serk4 |
| TAK | Map3k7 | mitogen-activated protein kinase kinase kinase 7 | B430101B05|C87327|Tak1 |
| Tpl2 | Map3k8 | mitogen-activated protein kinase kinase kinase 8 | Cot|Cot/Tpl2|Est|Estf|Tpl-2|Tpl2|c-COT |
(GSB0002e, T.M. 2004.04.27)
2014.10.22
