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Gene Set Collection

Ets family proteins with other transcription factors and co-activators on various cellular promoters and enhancers


(a) Ets-1 or PEA-3 activates the MMP (matrix metalloproteinase) promoters in cooperation with AP1 (c-Fos/c-Jun) on the RRE (Ras-response element).
(b) TCF (Elk-1, Sap-1, Net) activates the c-fos promoter in cooperation with SRF (serum response factor).
(c) PU.1 activates myeloid-specific promoters in cooperation with AML1 and C/EBP.
(d) Fli-1 activates megakaryocyte-specific promoters in cooperation with GATA-1.
(e) PU.1 activates the immunoglobulin (Ig) heavy (H) chain enhancer in cooperation with E12, Ets-1, TFE3 and Oct-2.
(f) Ets-1 activates the T cell receptor (TCR) a enhancer in cooperation with CREB/ATF, TCF-1, AML1 and GATA-3.

Human Resources

IconLocusGene ProductsAlternative Name
ALY THOC4 THO complex 4 ALY|ALY/REF|BEF|REF
ATF ATF2 activating transcription factor 2 CRE-BP1|CREB2|HB16|MGC111558|TREB7
C/EBP CEBPA CCAAT/enhancer binding protein (C/EBP), alpha C/EBP-alpha|CEBP
CREB CREB1 cAMP responsive element binding protein 1 CREB|MGC9284
TCF ELK1 ELK1, member of ETS oncogene family -
TCF ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) ERP|NET|SAP2
TCF ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) DKFZp434N185|SAP1
CBP/p300 EP300 E1A binding protein p300 KAT3B|RSTS2|p300
Ets-1 ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) ETS-1|EWSR2|FLJ10768
Ets-1 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) ETS2IT1
PEA3 ETV4 ets variant 4 E1A-F|E1AF|PEA3|PEAS3
Fli-1 FLI1 Friend leukemia virus integration 1 EWSR2|SIC-1
Ap-1/Jun/Fos FOS FBJ murine osteosarcoma viral oncogene homolog AP-1|C-FOS|p55
GATA-3 GATA3 GATA binding protein 3 HDR|HDRS|MGC2346|MGC5199|MGC5445
Ap-1/Jun/Fos JUN jun proto-oncogene AP-1|AP1|c-Jun
OCAB POU2AF1 POU class 2 associating factor 1 BOB1|OBF-1|OBF1|OCAB
Oct-2 POU2F2 POU class 2 homeobox 2 OCT2|OTF2|Oct-2
Sp1 SP1 Sp1 transcription factor -
SRF SRF serum response factor (c-fos serum response element-binding transcription factor) MCM1
E12 TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) E2A|E47|ITF1|MGC129647|MGC129648|TCF-3|VDIR|bHLHb21
TCF-1 TCF7 transcription factor 7 (T-cell specific, HMG-box) FLJ36364|MGC47735|TCF-1
TEF3 TFE3 transcription factor binding to IGHM enhancer 3 RCCP2|RCCX1|TFEA|bHLHe33
TEF3 TRIM37 tripartite motif containing 37 KIAA0898|MUL|POB1|TEF3

Other Resources

LocusRDB no.TypeName of cloneRunning title
runx16420DNA clonepZF-RunxaPlasmid clone of zebrafish runx1 (runxa) cDNA
Ep3005790DNA clonepU6_mmEP300_2505FExpression vector for mouse EP300 small RNA fragment
Ep3005789DNA clonepU6_mmEP300_0172RExpression vector for mouse EP300 small RNA fragment
Ep3005783DNA clonepU6_mmEP300_1926FExpression vector for mouse EP300 small RNA fragment
Ep3005776DNA clonepU6_mmEP300_2505RExpression vector for mouse EP300 small RNA fragment
Ep3005774DNA clonepU6_mmEP300_2308RExpression vector for mouse EP300 small RNA fragment
Ep3005767DNA clonepU6_mmEP300_2308FExpression vector for mouse EP300 small RNA fragment
Ep3005749DNA clonepU6_mmEP300_0172FExpression vector for mouse EP300 small RNA fragment
Elk36920DNA cloneH4069B01Elk3, NIA/NIH Mouse 7.4K cDNA Clone (full CDS_MGC)
Elk16906DNA cloneH4062C03Elk1, NIA/NIH Mouse 7.4K cDNA Clone (full CDS_MGC)
Crebbp5778DNA clonepU6_mmCREBBP-2_1638RExpression vector for mouse CREBBP-2 small RNA fragment
Crebbp5777DNA clonepU6_mmCREBBP-2_1068FExpression vector for mouse CREBBP-2 small RNA fragment
Crebbp5769DNA clonepU6_mmCREBBP-2_1068RExpression vector for mouse CREBBP-2 small RNA fragment
Crebbp5768DNA clonepU6_mmCREBBP-2_0168RExpression vector for mouse CREBBP-2 small RNA fragment
Crebbp5760DNA clonepU6_mmCREBBP-2_0374FExpression vector for mouse CREBBP-2 small RNA fragment

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2012.03.04