Initiation of integrin signaling by cell adhesion to an extracellular matrix (ECM) results in a transient and relatively weak activation ERK while initiation of receptor tyrosine kinase signaling by strongly mitogenic concentrations of growth factors (GF) results in a strong, transient ERK signal sufficient to induce p21cip1. The sustained ERK signal associated with the induction of cyclin D1 arises from a cooperative effect between receptor tyrosine kinases and integrins. (Contributed by Dr. Koji Nakade)
| Icon | Locus | Gene Products | Alternative Name |
|---|
| CYCLIN D1 |
CCND1 |
cyclin D1 |
BCL1|D11S287E|PRAD1|U21B31 |
| CDK4 |
CDK4 |
cyclin-dependent kinase 4 |
CMM3|MGC14458|PSK-J3 |
| p21 |
CDKN1A |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 |
| ERK |
MAPK1 |
mitogen-activated protein kinase 1 |
ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk |
| ERK |
MAPK3 |
mitogen-activated protein kinase 3 |
ERK1|HS44KDAP|HUMKER1A|MGC20180|P44ERK1|P44MAPK|PRKM3 |
| Locus | RDB no. | Type | Name of clone | Running title |
|---|
| Mapk1 | 2545 | ShuttleVector | pAxCAmERK2 (reverse) | Shuttle vector to generate rAd harboring mouse ERK2 |
| Mapk1 | 2544 | ShuttleVector | pAxCAmERK2 (forward) | Shuttle vector to produce rAd expressing mouse extracellular signal-regulated kinase 2 (ERK2) |
| Mapk1 | 1796 | DNA clone | pZRmERK2 cDNA | Mouse ERK2 cDNA |
| Cdk4 | 6971 | DNA clone | H3147D06 | Cdk4, NIA/NIH Mouse 15K cDNA Clone (full CDS) |
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