Gene Set Collection

MAP kinases

Comparison of MAP kinase pathways that are implicated in the control of the cell division cycle. The MAP kinase cascade is illustrated together with the main downstream substrates implicated in cell cycle control. Crosstalk may exist in vivo between human MAP3K enzymes and MAP3K components of other parallel pathways. For example, MEKK3, while being implicated in the regulation of MEK5 activity, is also a potent activator of the p38 pathway. Similarly, Tak1 can activate the JNK pathway. Studies reporting the promiscuous nature of MAP3K enzymes, however, are subject to certain experimental caveats and are therefore subject to debate. (Contributed by Dr. Koji Nakade)

Human Resources

Icon	Locus	Gene Products	Alternative Name
A-Raf	ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	A-RAF\|ARAF1\|PKS2\|RAFA1
B-Raf	BRAF	v-raf murine sarcoma viral oncogene homolog B1	B-RAF1\|BRAF1\|FLJ95109\|MGC126806\|MGC138284\|NS7\|RAFB1
MEK1/2	MAP2K1	mitogen-activated protein kinase kinase 1	MAPKK1\|MEK1\|MKK1\|PRKMK1
MEK1/2	MAP2K2	mitogen-activated protein kinase kinase 2	FLJ26075\|MAPKK2\|MEK2\|MKK2\|PRKMK2
MKK3,6	MAP2K3	mitogen-activated protein kinase kinase 3	MAPKK3\|MEK3\|MKK3\|PRKMK3
MKK4,7	MAP2K4	mitogen-activated protein kinase kinase 4	JNKK\|JNKK1\|MAPKK4\|MEK4\|MKK4\|PRKMK4\|SEK1\|SERK1
MEK5	MAP2K5	mitogen-activated protein kinase kinase 5	HsT17454\|MAPKK5\|MEK5\|PRKMK5
MKK3,6	MAP2K6	mitogen-activated protein kinase kinase 6	MAPKK6\|MEK6\|MKK6\|PRKMK6\|SAPKK3
MKK4,7	MAP2K7	mitogen-activated protein kinase kinase 7	Jnkk2\|MAPKK7\|MKK7\|PRKMK7
MLK3	MAP3K11	mitogen-activated protein kinase kinase kinase 11	MEKK11\|MGC17114\|MLK-3\|MLK3\|PTK1\|SPRK
DLK	MAP3K12	mitogen-activated protein kinase kinase kinase 12	DLK\|MEKK12\|MUK\|ZPK\|ZPKP1
MEKK2,3	MAP3K2	mitogen-activated protein kinase kinase kinase 2	MEKK2\|MEKK2B
MEKK2,3	MAP3K3	mitogen-activated protein kinase kinase kinase 3	MAPKKK3\|MEKK3
ASK1	MAP3K5	mitogen-activated protein kinase kinase kinase 5	ASK1\|MAPKKK5\|MEKK5
TAK	MAP3K7	mitogen-activated protein kinase kinase kinase 7	MEKK7\|TAK1\|TGF1a
Tpl2	MAP3K8	mitogen-activated protein kinase kinase kinase 8	COT\|EST\|ESTF\|FLJ10486\|MEKK8\|TPL2\|Tpl-2\|c-COT
ERK1,2	MAPK1	mitogen-activated protein kinase 1	ERK\|ERK2\|ERT1\|MAPK2\|P42MAPK\|PRKM1\|PRKM2\|p38\|p40\|p41\|p41mapk
SAPK/JNK	MAPK10	mitogen-activated protein kinase 10	FLJ12099\|FLJ33785\|JNK3\|JNK3A\|MGC50974\|PRKM10\|p493F12\|p54bSAPK
p38 MAPK	MAPK11	mitogen-activated protein kinase 11	P38B\|P38BETA2\|PRKM11\|SAPK2\|SAPK2B\|p38-2\|p38Beta
SAPK/JNK	MAPK11	mitogen-activated protein kinase 11	P38B\|P38BETA2\|PRKM11\|SAPK2\|SAPK2B\|p38-2\|p38Beta
p38 MAPK	MAPK12	mitogen-activated protein kinase 12	ERK3\|ERK6\|P38GAMMA\|PRKM12\|SAPK-3\|SAPK3
SAPK/JNK	MAPK12	mitogen-activated protein kinase 12	ERK3\|ERK6\|P38GAMMA\|PRKM12\|SAPK-3\|SAPK3
p38 MAPK	MAPK13	mitogen-activated protein kinase 13	MGC99536\|PRKM13\|SAPK4\|p38delta
SAPK/JNK	MAPK13	mitogen-activated protein kinase 13	MGC99536\|PRKM13\|SAPK4\|p38delta
p38 MAPK	MAPK14	mitogen-activated protein kinase 14	CSBP\|CSBP1\|CSBP2\|CSPB1\|EXIP\|Mxi2\|PRKM14\|PRKM15\|RK\|SAPK2A\|p38\|p38ALPHA
SAPK/JNK	MAPK14	mitogen-activated protein kinase 14	CSBP\|CSBP1\|CSBP2\|CSPB1\|EXIP\|Mxi2\|PRKM14\|PRKM15\|RK\|SAPK2A\|p38\|p38ALPHA
ERK1,2	MAPK3	mitogen-activated protein kinase 3	ERK1\|HS44KDAP\|HUMKER1A\|MGC20180\|P44ERK1\|P44MAPK\|PRKM3
ERK5/BMK1	MAPK7	mitogen-activated protein kinase 7	BMK1\|ERK4\|ERK5\|PRKM7
SAPK/JNK	MAPK8	mitogen-activated protein kinase 8	JNK\|JNK1\|JNK1A2\|JNK21B1/2\|PRKM8\|SAPK1
SAPK/JNK	MAPK9	mitogen-activated protein kinase 9	JNK-55\|JNK2\|JNK2A\|JNK2ALPHA\|JNK2B\|JNK2BETA\|PRKM9\|SAPK\|p54a\|p54aSAPK
MX1	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	IFI-78K\|IFI78\|MX\|MxA
c-Raf	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	CRAF\|NS5\|Raf-1\|c-Raf

Other Resources

Locus	RDB no.	Type	Name of clone	Running title
Mapk1	2545	ShuttleVector	pAxCAmERK2 (reverse)	Shuttle vector to generate rAd harboring mouse ERK2
Mapk1	2544	ShuttleVector	pAxCAmERK2 (forward)	Shuttle vector to produce rAd expressing mouse extracellular signal-regulated kinase 2 (ERK2)
Mapk1	1796	DNA clone	pZRmERK2 cDNA	Mouse ERK2 cDNA
Map3k8	2767	Recombinant adenovirus	AxCAmCZ-21 (forward)	Recombinant adenovirus harboring mouse cot proto-oncogene (CZ-21) cDNA
Map3k8	2531	ShuttleVector	pAxCAmCZ-21 (reverse)	Shuttle vector to generate rAd harboring mous CZ-21
Map3k8	2530	ShuttleVector	pAxCAmCZ-21 (forward)	Shuttle vector to produce rAd expressing mouse cot proto-oncogene (CZ-21)
Map3k8	1397	DNA clone	Mouse cot proto-oncogene (CZ-21)	Plasmid clone of mouse cot cDNA
Map2k7	5951	DNA clone	MKK7	Expression vector of mouse MKK7/SEK2/JNKK2 cDNA, gamma2 isoform
Map2k4	5952	DNA clone	SEK1	Expression vector of mouse SEK1/MKK4/JNKK1 cDNA

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2012.03.04