HLA Clones

Outline

Alleles of human HLA class I, which are frequently observed in Japanese people, cloned into an expression vector were deposited by Dr. Yoshiki Akatsuka, Aichi Cancer Ctr. Res. Inst. The other classes of human HLA cDNA clones are also available.

 

HLA Clone List

HLA Class I – cDNA clone

Allele Cat. no. Name of Clone Frequency in Japanese population (*)
A*01:01 RDB03368 Human HLA-A*01:01 cDNA 0.439
A*01:01 HGY082896 IRAL007D24
A*02:01 RDB02866 Human HLA-A*02:01:01 cDNA 11.223
A*02:06 RDB02867 Human HLA-A*02:06 cDNA 9.432
A*02:07 RDB02868 Human HLA-A*02:07 cDNA 3.241
A*03:01 RDB03367 Human HLA-A*03:01 cDNA 0.434
A*11:01 RDB02869 Human HLA-A*11:01:01 cDNA 8.9
A*24:02 RDB02871 Human HLA-A*24:02:01 cDNA 36.266
A*24:20 RDB03365 Human HLA-A*24:20 cDNA 0.768
A*25:01 HGX004917 IRAK012E21 0.001
A*26:01 RDB02870 Human HLA-A*26:01 cDNA 7.592
A*26:03 RDB03366 Human HLA-A*26:03 cDNA 2.509
A*31:01 RDB02872 Human HLA-A*31:01:02 cDNA 8.642
A*33:03 RDB02873 Human HLA-A*33:03 cDNA 7.399
  HGY080967 IRAL002G23
RDB01176 pA01

*Major Histocompatibility Complex 30 (1): 17-19 (2023).
 

Allele Cat. no. Name of Clone Frequency in Japanese population (*)
B*07:02 RDB02874 Human HLA-B*07:02:01 cDNA 5.475
B*08:01 RDB03369 Human HLA-B*08:01 cDNA 0.018
B*15:01 RDB02875 Human HLA-B*15:01:01 cDNA 7.92
B*15:10 HGX010665 IRAK026L01
B*35:01 RDB02876 Human HLA-B*35:01:01 cDNA 8.357
B*38:01 RDB03370 Human HLA-B*38:01 cDNA 0.007
B*39:01 RDB03371 Human HLA-B*39:01:01 cDNA 3.387
B*40:01 RDB02877 Human HLA-B*40:01:02 cDNA 5.56
B*40:02 RDB02878 Human HLA-B*40:02 cDNA 7.801
B*44:03 RDB02879 Human HLA-B*44:03:01 cDNA 6.669
B*46:01 RDB02880 Human HLA-B*46:01 cDNA 4.502
B*48:01 RDB03372 Human HLA-B*48:01 cDNA 2.893
B*51:01 RDB02881 Human HLA-B*51:01:01 cDNA 8.743
B*52:01 RDB02882 Human HLA-B*52:01:01 cDNA 11.015
B*54:01 RDB03373 Human HLA-B*54:01 cDNA 7.577
B*55:02 RDB03374 Human HLA-B*55:02 cDNA 2.473
B*59:01 RDB03375 Human HLA-B*59:01 cDNA 2.012
  HGY088861 IRAL022C13
RDB01180 pB55

*Major Histocompatibility Complex 30 (1): 17-19 (2023).
 

Allele Cat. no. Name of Clone Frequency in Japanese population (*)
C*01:02 RDB02883 Human HLA-C*01:02 cDNA 17.225
C*01:03 RDB03376 Human HLA-C*01:03 cDNA 0.34
C*03:03 RDB02884 Human HLA-C*03:03:01 cDNA 13.753
C*03:04 RDB02885 Human HLA-C*03:04:01 cDNA 12.205
C*04:01 RDB02886 Human HLA-C*04:01:01 cDNA 4.324
C*06:02 RDB03377 Human HLA-C*06:02 cDNA 0.816
C*07:01 HGX011896 IRAK029M08 0.065
C*07:02 RDB02887 Human HLA-C*07:02 cDNA 12.705
C*07:02 HGY088291 IRAL020M03
C*08:01 RDB02888 Human HLA-C*08:01 cDNA 7.382
C*12:01 RDB01179 pC68
C*12:02 RDB02889 Human HLA-C*12:02:02 cDNA 11.003
C*12:03 HGX007733 IRAK019F13 0.087
C*14:02 RDB03378 Human HLA-C*14:02:01 cDNA 6.853
C*14:03 RDB02890 Human HLA-C*14:03 cDNA 6.514
C*15:02 RDB03379 Human HLA-C*15:02:01 cDNA 3.054
C*16:01 HGY082329 IRAL005N17 0.004
C*16:01 HGY085701 IRAL014E05
  HGY088506 IRAL021E10

*Major Histocompatibility Complex 30 (1): 17-19 (2023).
 

Allele Cat. no. Name of Clone
E*01:01 HGY081676 IRAL004D04
E*01:01 HGY085250 IRAL013C02
E*01:03 HGY096623 IRAL041J07
F*01:01 HGX054355 IRAK135O19
F*01:01 HGY090322 IRAL025N10
  HGY013281 IRAK033D09
  HGY094732 IRAL036N20

 

HLA Class I – genomic DNA clone

Antigen Allele Cat. No. Name of Clone
HLA-B44 B*44:01 RDB01178 AM2.60
HLA-Cx 52 (Cw 12) C*12:01 RDB01177 pAC201
HLA-G RDB01246 HLA-G.7.0 E

HLA Class II

Allele Cat. no. Name of Clone
DRB1*04:10 HGY096962 IRAL042G18
DRB1*07:01 HGY082333 IRAL005N21
DRB1*13:02 HGY088361 IRAL020P01
DRB1*13:03 HGY088606 IRAL021I14
DRB1*15:01 HGX027583 IRAK068P23
DRB3*01:01 HGX005065 IRAK012L01
DRB4*01:03 HGY086487 IRAL016D15
DRB5*01:01 HGY090353 IRAL025O17
DRB5*01:02 RDB01222 TOK H5 DR beta
DQB1*03:02 HGY091784 IRAL029H16
DPB1*01:01 HGX010616 IRAK026I24
DPB1*17:01 HGY093632 IRAL034B08
DPB1*23:01 HGY088362 IRAL020P02
DRA*01:02 HGX025864 IRAK064K24
DQA1*05:01 HGX005175 IRAK012P15
DQA1*05:03 RDB01239 DQA10501 AMALA-4
DPA1*02:01 HGY088364 IRAL020P04
DMA*01:01 HGY087766 IRAL019G22
DMA*01:01 HGY094834 IRAL037B10
DMB*01:01 HGX010628 IRAK026J12
DOA*01:01 HGX010612 IRAK026I20
DOB*01:01 HGY087568 IRAL018P08
  RDB01235 K^b DRB1 0803
  RDB01236 K^b DRB1 1201
  RDB01237 K^b DRB1 1302
  HGY096628 IRAL041J12
  RDB01238 DRB30301 EMJ-4
RDB01223 YT158
RDB01228 pg DQ1B
RDB01230 pg DQ1BS
RDB01242 DQB10503 EK2-4
  RDB01234 DPB0202
RDB01232 DRA2EH
  HGX044148 IRAK110G04
  HGX069737 IRAK174F17
RDB01241 DQA10101 KAS116 3-6
  RDB01233 DPA 02022

Link to HLA clones

Gene Symbol Product Name Synonyms
HLA-A major histocompatibility complex, class I, A HLAA
HLA-B major histocompatibility complex, class I, B AS|B-4901|HLAB
HLA-C major histocompatibility complex, class I, C D6S204|HLA-JY3|HLAC|HLC-C|MHC|PSORS1
HLA-E major histocompatibility complex, class I, E HLA-6.2|QA1
HLA-F major histocompatibility complex, class I, F CDA12|HLA-5.4|HLA-CDA12|HLAF
HLA-G major histocompatibility complex, class I, G MHC-G
HLA-DMA major histocompatibility complex, class II, DM alpha D6S222E|DMA|HLADM|RING6
HLA-DMB major histocompatibility complex, class II, DM beta D6S221E|RING7
HLA-DOA major histocompatibility complex, class II, DO alpha HLA-DNA|HLA-DZA|HLADZ
HLA-DOB major histocompatibility complex, class II, DO beta DOB|HLA_DOB
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 DP(W3)|DP(W4)|HLA-DP1A|HLADP|HLASB|PLT1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 DPB1|HLA-DP|HLA-DP1B|HLA-DPB
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) DP2B|DPB2|DPbeta2|HLA-DP2B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 CELIAC1|DQ-A1|HLA-DQA
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 CELIAC1|HLA-DQB|IDDM1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 HLA-DQB1|HLA-DXB
HLA-DRA major histocompatibility complex, class II, DR alpha HLA-DRA1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 DRB1|HLA-DR1B|HLA-DRB|SS1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 HLA-DR1B|HLA-DR3B
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 DR4|DRB4|HLA-DR4B
HLA-DRB5 major histocompatibility complex, class II, DR beta 5

Related information

Journals

  • Akatsuka Y., Morishima Y., Kuzushima K., Kodera Y., Takahashi T. (2007) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
    Cancer Science 98 (8): 1139-1146.
  • Nishida T, Akatsuka Y, Morishima Y, Hamajima N, Tsujimura K, Kuzushima K, Kodera Y, Takahashi T. (2004) Clinical relevance of a newly identified HLA-A24-restricted minor histocompatibility antigen epitope derived from BCL2A1, ACC-1, in patients receiving HLA genotypically matched unrelated bone marrow transplant.
    Br. J. Haematol. 124 (5): 629-635.
  • Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T. (2003) Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens.J. Exp. Med. 197 (11): 1489-1500.
  • Akatsuka Y, Goldberg TA, Kondo E, Martin EG, Obata Y, Morishima Y, Takahashi T, Hansen JA (2002) Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines.
    Tissue Antigens, 59 (6): 502-511.
  • Akatsuka Y, Kondo E, Taji H, Morishima Y, Yazaki M, Obata Y, Kodera Y, Riddell SR, Takahashi T. (2002) Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest.
    Transplantation, 74: 1773-1780.
  • Ando H, Miyata Y, Takata H, Inoko H. (1993) Identification of alloantisera reacting with HLA-C blank (Cx52) using a mouse L-cell transfected with the HLA-Cw*1201 allele.
    Hum Immunol. 36 (2): 76-80
  • Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. (1992) Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
    Immunogenetics 36 (5): 319-325.
  • Zemmour J, Parham P. (1991) HLA class I nucleotide sequences, 1991.
    Tissue Antigens 37 (4): 174-180.
    Erratum in: Tissue Antigens. 1992 Nov;40(5):221-228.
  • Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants.
    Eu.r J Immunol. 21 (10): 2341-2347.
  • Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. (1991) HLA-DQ-restricted CD4+ T cells specific to streptococcal antigen present in low but not in high responders.
    J Immunol. 146 (8): 2560-2567.
  • Tamaki J. (1992)[Analysis of polymorphism at the human class I MHC locus, HLA-G]
    Hokkaido Igaku Zasshi (Hokkaido J. Med. Sci.) 67 (5): 583-594. Japanese.
  • Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. (1990) Expression of the human MHC, HLA-DQW6 genes alters the immune response in C57BL/6 mice.
    J Immunol. 1990 Jul 1;145(1):353-60.
  • Takata H, Inoko H, Ando A, Haranaka M, Watanabe B, Tsuji K, Iri H. (1988) Cloning and analysis of HLA class I cDNA encoding a new HLA-C specificity Cx52.
    Immunogenetics 28 (4): 265-270.

Links

 

(GSB0016e 2004.08.23 T.M.)

2023.07.02



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